Q7LXA2 - SULSO - GREMLIN Contacts

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Q7LXA2 - Carbon monoxide dehydrogenase, large chain (CutA-2)

UniProt:	Q7LXA2	Sequences: MRRIDAYDLLIGKGNYVDDISYKGKYAVFIRSPYAHARIVNINKEDAERRGALVLTGKDLVSRNVESGEREGASLTTPLMAINKALYVGQPVALVIANDPYEATDLAELVQIDYEPLEGIGNIEKALENKVTVFEDLKTNVVREQTFEFGKLSTQGRHLELDLYWSRSSGNPIEPYGAITIPTDDSLTIISNQQAGNVVSNEIQKALGVKVVHKNARQGGSFGEKFSLVRYLTVLGFAALKFKVPIKWIETRNEHLMASNGSGPERKFKIHAYYSSDGRVNSLDVHIWEDVGASRDAGQPFKPLAFLTGPYKIGGIRYTGTLVATNKNPAGAFRGAGTPPHTWALERTMDAIADDLGISKADVRKINAIDTFPYDSGFAYYDSGNPRGLLDLALSRKDIFALRNKNTGVGLALSTDPSTPSGSERVKIKVKNNKIVIGLGFGPEGQGNEHSAVVMASRLLGITPDDVAYEILDNTELPTSFGPGGSRMAIYTFGAVSGAVEELKARLRRKAEVVLNDKVIDYRDGYFIGENGGKVRITSLEGEEVDFTYTLQGKYRFNAYPFACDLAVVRIEDGKIKPIKHVVYIDPGTPIDEDLVKEQVIGGTAIGISLALYEHYVYDENANLLTTNLADYGMPTAADLPEIEVNIVPTPSPSTPYGAKGIGEIPVGIAAAAVTSAIEDVIKRRINRVPVSLEDLFE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	698 (685)
Sequences:	5602 (3651)
Seq/√Len:	139.5

ECOLI - XDHD XDHA YAGR
BACSU - XDHD
SULSO - Q7LXA2 Q7LX54 Q97TZ2 Q97VI4 Q97V74 Q97UK2 Q97UR0 Q97YU6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
50_R	109_L	4.577	1.00
160_E	271_H	4.211	1.00
30_I	110_V	4.140	1.00
99_D	102_E	3.779	1.00
34_Y	37_A	3.623	1.00
46_D	111_Q	3.611	1.00
365_K	391_D	3.609	1.00
162_D	269_K	3.504	1.00
398_D	401_A	3.416	1.00
274_Y	352_I	3.355	1.00
284_D	317_R	3.314	1.00
275_S	279_R	3.301	1.00
456_A	496_V	3.255	1.00
156_G	275_S	3.137	1.00
156_G	276_S	3.125	1.00
50_R	102_E	3.087	1.00
358_I	366_I	3.069	1.00
40_V	113_D	3.055	1.00
38_R	115_E	3.009	1.00
150_G	154_T	3.004	1.00
30_I	107_A	2.983	1.00
435_I	462_I	2.976	1.00
280_V	349_M	2.947	1.00
147_F	150_G	2.880	1.00
34_Y	116_P	2.863	1.00
37_A	114_Y	2.824	1.00
160_E	269_K	2.822	1.00
53_L	98_N	2.813	1.00
286_H	319_T	2.801	1.00
459_L	501_E	2.749	1.00
312_K	373_P	2.687	1.00
96_I	238_A	2.664	1.00
271_H	284_D	2.607	1.00
189_I	203_I	2.604	1.00
362_D	366_I	2.594	1.00
36_H	117_L	2.571	1.00
41_N	113_D	2.564	1.00
188_T	214_K	2.469	1.00
497_S	501_E	2.453	1.00
98_N	102_E	2.422	1.00
27_A	248_W	2.419	1.00
580_K	644_E	2.414	1.00
526_Y	534_K	2.414	1.00
279_R	366_I	2.409	1.00
152_L	273_Y	2.350	1.00
40_V	115_E	2.345	1.00
98_N	244_V	2.299	1.00
212_V	473_D	2.293	1.00
124_E	267_K	2.292	1.00
688_R	695_D	2.276	1.00
678_I	691_V	2.275	1.00
675_T	691_V	2.274	1.00
181_I	190_I	2.261	1.00
352_I	363_V	2.203	1.00
286_H	321_T	2.201	1.00
44_K	48_E	2.199	1.00
358_I	363_V	2.193	1.00
570_R	579_I	2.178	1.00
290_D	327_K	2.161	1.00
155_Q	273_Y	2.134	1.00
186_S	475_T	2.120	1.00
397_K	566_L	2.120	1.00
272_A	348_T	2.112	1.00
29_F	234_V	2.072	1.00
27_A	94_L	2.052	1.00
392_L	646_N	2.036	1.00
392_L	395_S	2.028	1.00
434_K	466_D	2.003	1.00
164_Y	688_R	1.995	1.00
393_A	566_L	1.986	1.00
125_K	128_E	1.964	1.00
279_R	312_K	1.950	1.00
362_D	365_K	1.939	1.00
428_I	437_I	1.933	1.00
604_T	643_I	1.927	1.00
38_R	83_N	1.916	1.00
43_N	111_Q	1.902	1.00
33_P	92_V	1.897	1.00
365_K	394_L	1.896	1.00
605_A	640_L	1.892	1.00
430_V	503_L	1.880	1.00
157_R	274_Y	1.879	1.00
44_K	54_V	1.878	1.00
96_I	242_F	1.866	1.00
157_R	276_S	1.858	1.00
18_D	247_K	1.855	1.00
370_D	387_R	1.854	1.00
455_M	493_F	1.851	1.00
434_K	468_A	1.838	1.00
536_R	539_S	1.838	1.00
270_I	348_T	1.837	1.00
122_N	125_K	1.835	1.00
504_K	508_R	1.823	1.00
567_A	673_A	1.803	1.00
431_K	436_V	1.800	1.00
45_E	48_E	1.789	1.00
38_R	84_K	1.780	1.00
407_T	570_R	1.779	1.00
370_D	373_P	1.774	1.00
391_D	395_S	1.772	1.00
186_S	210_K	1.767	1.00
489_A	591_I	1.744	1.00
47_A	110_V	1.730	1.00
177_G	249_I	1.723	1.00
463_T	466_D	1.719	1.00
453_V	469_Y	1.712	1.00
94_L	238_A	1.712	1.00
46_D	109_L	1.707	1.00
97_A	103_A	1.704	1.00
404_N	572_E	1.697	1.00
53_L	244_V	1.692	1.00
396_R	644_E	1.691	1.00
431_K	434_K	1.690	1.00
27_A	246_I	1.687	1.00
34_Y	114_Y	1.681	1.00
361_A	394_L	1.675	1.00
405_K	570_R	1.654	1.00
275_S	281_N	1.650	1.00
567_A	581_H	1.638	1.00
576_I	696_L	1.634	1.00
354_D	679_E	1.621	1.00
171_N	629_L	1.618	1.00
692_S	695_D	1.617	1.00
565_D	581_H	1.615	1.00
385_N	388_G	1.612	1.00
596_V	662_I	1.608	1.00
392_L	396_R	1.597	1.00
172_P	224_E	1.595	1.00
590_P	647_I	1.593	1.00
50_R	106_L	1.588	1.00
272_A	352_I	1.581	1.00
587_P	590_P	1.578	1.00
155_Q	281_N	1.575	1.00
581_H	604_T	1.574	1.00
365_K	387_R	1.566	1.00
52_A	97_A	1.563	1.00
437_I	456_A	1.563	1.00
426_V	496_V	1.561	1.00
589_T	649_P	1.553	1.00
162_D	267_K	1.551	1.00
435_I	460_L	1.542	1.00
152_L	271_H	1.533	1.00
596_V	647_I	1.533	1.00
414_S	563_A	1.531	1.00
269_K	286_H	1.529	1.00
272_A	280_V	1.527	1.00
94_L	234_V	1.521	1.00
459_L	657_Y	1.519	1.00
36_H	84_K	1.507	1.00
149_F	317_R	1.506	1.00
609_S	635_P	1.503	1.00
17_V	177_G	1.501	1.00
389_L	564_C	1.498	1.00
387_R	391_D	1.496	1.00
107_A	110_V	1.489	1.00
22_Y	25_K	1.480	1.00
428_I	500_V	1.479	1.00
157_R	355_D	1.474	1.00
84_K	135_E	1.470	1.00
46_D	49_R	1.457	1.00
580_K	642_E	1.448	1.00
188_T	212_V	1.434	1.00
350_D	676_S	1.428	1.00
164_Y	267_K	1.419	1.00
393_A	564_C	1.413	1.00
55_L	242_F	1.409	1.00
578_P	608_I	1.400	1.00
457_S	467_V	1.400	1.00
29_F	248_W	1.400	1.00
607_G	670_A	1.397	1.00
396_R	646_N	1.395	1.00
105_D	109_L	1.390	1.00
157_R	275_S	1.388	1.00
149_F	153_S	1.386	1.00
55_L	238_A	1.383	1.00
158_H	271_H	1.381	1.00
520_I	527_F	1.378	1.00
452_A	496_V	1.374	1.00
58_K	83_N	1.374	1.00
151_K	282_S	1.371	1.00
354_D	680_D	1.371	1.00
22_Y	179_I	1.369	1.00
152_L	282_S	1.367	1.00
576_I	678_I	1.364	1.00
498_G	502_E	1.359	1.00
459_L	497_S	1.354	1.00
18_D	249_I	1.349	1.00
523_R	528_I	1.343	1.00
25_K	247_K	1.341	1.00
454_V	592_D	1.338	1.00
157_R	352_I	1.336	1.00
280_V	313_I	1.333	1.00
148_E	152_L	1.333	1.00
203_I	211_V	1.333	1.00
151_K	315_G	1.330	1.00
157_R	356_L	1.327	1.00
207_L	236_G	1.327	1.00
502_E	505_A	1.323	1.00
333_F	606_I	1.319	1.00
274_Y	356_L	1.315	1.00
185_D	210_K	1.313	1.00
277_D	366_I	1.312	1.00
508_R	520_I	1.304	1.00
582_V	644_E	1.299	1.00
590_P	596_V	1.298	1.00
204_Q	211_V	1.292	1.00
451_S	489_A	1.292	1.00
39_I	42_I	1.290	1.00
427_K	438_G	1.288	1.00
455_M	489_A	1.282	1.00
39_I	112_I	1.281	1.00
161_L	351_A	1.276	1.00
14_G	217_R	1.274	1.00
180_T	235_L	1.269	1.00
238_A	246_I	1.268	1.00
187_L	236_G	1.263	1.00
148_E	151_K	1.255	1.00
102_E	106_L	1.253	1.00
346_E	364_R	1.249	1.00
394_L	400_F	1.249	1.00
180_T	239_A	1.248	1.00
33_P	114_Y	1.244	1.00
397_K	582_V	1.231	1.00
92_V	112_I	1.230	1.00
22_Y	181_I	1.228	1.00
617_V	626_T	1.227	1.00
161_L	355_D	1.227	1.00
28_V	107_A	1.225	1.00
31_R	254_E	1.224	1.00
396_R	584_Y	1.224	1.00
144_E	317_R	1.221	1.00
574_G	696_L	1.218	1.00
36_H	118_E	1.218	1.00
571_I	576_I	1.207	1.00
28_V	104_T	1.203	1.00
393_A	584_Y	1.203	1.00
494_G	497_S	1.202	1.00
268_F	344_A	1.201	1.00
600_V	604_T	1.199	1.00
180_T	189_I	1.198	1.00
8_D	13_K	1.188	1.00
584_Y	646_N	1.188	1.00
86_L	90_Q	1.184	1.00
21_S	25_K	1.181	1.00
4_I	450_H	1.179	1.00
106_L	109_L	1.179	1.00
405_K	577_K	1.179	1.00
502_E	506_R	1.178	1.00
28_V	100_P	1.177	1.00
368_A	390_L	1.176	1.00
356_L	363_V	1.175	1.00
80_M	234_V	1.172	1.00
274_Y	363_V	1.170	0.99
567_A	674_V	1.162	0.99
351_A	687_N	1.161	0.99
52_A	106_L	1.158	0.99
291_V	298_G	1.154	0.99
686_I	691_V	1.153	0.99
4_I	453_V	1.153	0.99
343_W	675_T	1.153	0.99
264_P	290_D	1.152	0.99
569_V	678_I	1.152	0.99
187_L	209_V	1.147	0.99
453_V	464_P	1.146	0.99
190_I	214_K	1.146	0.99
149_F	284_D	1.144	0.99
350_D	360_K	1.142	0.99
144_E	319_T	1.139	0.99
36_H	326_N	1.137	0.99
288_W	321_T	1.136	0.99
152_L	158_H	1.136	0.99
221_S	444_E	1.136	0.99
163_L	348_T	1.134	0.99
567_A	578_P	1.134	0.99
509_R	517_D	1.134	0.99
171_N	634_M	1.132	0.99
84_K	117_L	1.131	0.99
521_D	528_I	1.128	0.99
7_Y	11_I	1.123	0.99
304_L	318_Y	1.121	0.99
392_L	584_Y	1.119	0.99
92_V	114_Y	1.118	0.99
576_I	612_L	1.116	0.99
395_S	400_F	1.115	0.99
52_A	103_A	1.112	0.99
37_A	117_L	1.105	0.99
172_P	255_H	1.097	0.99
511_A	540_L	1.096	0.99
38_R	117_L	1.096	0.99
389_L	584_Y	1.096	0.99
123_I	288_W	1.095	0.99
60_L	237_F	1.095	0.99
183_T	188_T	1.094	0.99
438_G	470_E	1.093	0.99
28_V	103_A	1.093	0.99
272_A	283_L	1.091	0.99
24_G	244_V	1.085	0.99
182_P	240_L	1.084	0.99
450_H	454_V	1.083	0.99
42_I	112_I	1.083	0.99
505_A	509_R	1.082	0.99
134_F	324_A	1.075	0.99
57_G	82_I	1.075	0.99
25_K	179_I	1.075	0.99
454_V	593_E	1.068	0.99
56_T	80_M	1.068	0.99
405_K	572_E	1.065	0.99
41_N	111_Q	1.065	0.99
586_D	650_T	1.062	0.99
508_R	522_Y	1.060	0.99
127_L	323_V	1.053	0.99
388_G	392_L	1.052	0.99
150_G	153_S	1.052	0.99
436_V	470_E	1.052	0.99
402_L	568_V	1.050	0.99
528_I	534_K	1.047	0.99
260_N	331_G	1.045	0.99
501_E	505_A	1.045	0.99
55_L	241_K	1.044	0.99
124_E	164_Y	1.044	0.99
159_L	355_D	1.042	0.99
273_Y	281_N	1.039	0.99
50_R	105_D	1.034	0.99
53_L	102_E	1.032	0.99
156_G	281_N	1.032	0.99
181_I	188_T	1.030	0.99
691_V	695_D	1.029	0.99
53_L	96_I	1.029	0.99
182_P	239_A	1.027	0.99
148_E	284_D	1.027	0.99
178_A	235_L	1.026	0.99
29_F	94_L	1.023	0.99
288_W	323_V	1.020	0.99
362_D	400_F	1.019	0.99
361_A	411_L	1.019	0.99
274_Y	280_V	1.019	0.99
522_Y	527_F	1.015	0.99
612_L	674_V	1.015	0.99
516_N	519_V	1.013	0.99
349_M	363_V	1.011	0.99
85_A	114_Y	1.010	0.99
192_N	225_K	1.010	0.99
368_A	387_R	1.010	0.99
459_L	500_V	1.003	0.98
407_T	568_V	1.002	0.98
95_V	107_A	1.000	0.98
159_L	274_Y	1.000	0.98
456_A	500_V	0.998	0.98
273_Y	282_S	0.998	0.98
27_A	238_A	0.996	0.98
519_V	529_G	0.992	0.98
55_L	96_I	0.990	0.98
618_Y	624_L	0.984	0.98
613_Y	639_D	0.984	0.98
619_D	623_N	0.976	0.98
608_I	640_L	0.976	0.98
548_T	551_L	0.973	0.98
140_N	143_R	0.972	0.98
154_T	281_N	0.972	0.98
151_K	273_Y	0.972	0.98
183_T	186_S	0.968	0.98
39_I	92_V	0.967	0.98
628_N	631_D	0.967	0.98
235_L	248_W	0.965	0.98
170_G	224_E	0.963	0.98
218_Q	444_E	0.962	0.98
154_T	275_S	0.961	0.98
54_V	93_A	0.960	0.98
100_P	104_T	0.957	0.98
93_A	112_I	0.956	0.98
44_K	110_V	0.956	0.98
128_E	131_V	0.956	0.98
148_E	282_S	0.955	0.98
507_L	540_L	0.953	0.98
29_F	91_P	0.949	0.98
437_I	467_V	0.947	0.98
181_I	239_A	0.946	0.98
57_G	83_N	0.946	0.98
30_I	112_I	0.938	0.98
159_L	272_A	0.938	0.98
519_V	530_E	0.936	0.98
583_V	604_T	0.935	0.98
36_H	119_G	0.932	0.97
37_A	112_I	0.932	0.97
691_V	696_L	0.929	0.97
90_Q	294_S	0.929	0.97
607_G	667_V	0.924	0.97
459_L	504_K	0.923	0.97
169_S	616_Y	0.923	0.97
103_A	107_A	0.923	0.97
152_L	284_D	0.919	0.97
569_V	578_P	0.919	0.97
523_R	526_Y	0.915	0.97
124_E	162_D	0.915	0.97
597_K	601_I	0.915	0.97
93_A	110_V	0.914	0.97
8_D	449_E	0.913	0.97
26_Y	247_K	0.912	0.97
568_V	580_K	0.912	0.97
209_V	240_L	0.911	0.97
361_A	390_L	0.907	0.97
429_K	438_G	0.907	0.97
146_T	151_K	0.906	0.97
390_L	411_L	0.905	0.97
120_I	126_A	0.904	0.97
350_D	364_R	0.902	0.97
388_G	648_V	0.902	0.97
194_Q	221_S	0.902	0.97
265_E	303_P	0.900	0.97
127_L	288_W	0.899	0.97
148_E	315_G	0.897	0.97
155_Q	282_S	0.895	0.97
123_I	267_K	0.894	0.97
374_Y	380_Y	0.892	0.97
597_K	647_I	0.891	0.97
388_G	391_D	0.890	0.97
510_K	540_L	0.888	0.97
129_N	132_T	0.885	0.97
527_F	540_L	0.885	0.97
152_L	155_Q	0.881	0.96
436_V	468_A	0.881	0.96
55_L	237_F	0.881	0.96
187_L	240_L	0.879	0.96
456_A	467_V	0.879	0.96
615_H	695_D	0.879	0.96
262_S	265_E	0.877	0.96
311_Y	346_E	0.877	0.96
399_I	402_L	0.876	0.96
8_D	217_R	0.875	0.96
441_F	488_M	0.874	0.96
507_L	537_I	0.871	0.96
182_P	185_D	0.871	0.96
42_I	110_V	0.871	0.96
253_N	627_T	0.870	0.96
311_Y	364_R	0.870	0.96
211_V	236_G	0.867	0.96
37_A	85_A	0.866	0.96
521_D	530_E	0.863	0.96
406_N	571_I	0.863	0.96
446_Q	483_P	0.861	0.96
403_R	680_D	0.858	0.96
45_E	49_R	0.857	0.96
430_V	435_I	0.856	0.96
271_H	317_R	0.856	0.96
163_L	687_N	0.855	0.96
498_G	501_E	0.855	0.96
44_K	56_T	0.854	0.96
587_P	596_V	0.854	0.96
284_D	319_T	0.851	0.96
30_I	93_A	0.850	0.96
466_D	525_G	0.849	0.96
466_D	538_T	0.848	0.96
516_N	529_G	0.847	0.96
424_E	492_T	0.846	0.96
163_L	351_A	0.845	0.96
226_F	484_G	0.845	0.96
455_M	591_I	0.844	0.95
265_E	289_E	0.842	0.95
178_A	231_Y	0.842	0.95
274_Y	348_T	0.842	0.95
9_L	16_Y	0.839	0.95
619_D	625_L	0.838	0.95
624_L	627_T	0.837	0.95
62_S	66_E	0.835	0.95
407_T	579_I	0.834	0.95
160_E	284_D	0.832	0.95
451_S	595_L	0.832	0.95
44_K	47_A	0.831	0.95
462_I	466_D	0.830	0.95
192_N	218_Q	0.830	0.95
263_G	340_P	0.828	0.95
629_L	634_M	0.824	0.95
51_G	106_L	0.824	0.95
413_L	564_C	0.822	0.95
151_K	281_N	0.821	0.95
411_L	566_L	0.821	0.95
121_G	622_A	0.820	0.95
238_A	242_F	0.819	0.95
34_Y	85_A	0.819	0.95
347_R	675_T	0.818	0.95
428_I	503_L	0.818	0.95
278_G	358_I	0.818	0.95
526_Y	536_R	0.817	0.95
679_E	685_R	0.817	0.95
569_V	576_I	0.817	0.95
572_E	575_K	0.816	0.95
351_A	685_R	0.816	0.95
59_D	241_K	0.812	0.94
441_F	448_N	0.811	0.94
158_H	273_Y	0.811	0.94
58_K	82_I	0.811	0.94
348_T	352_I	0.811	0.94
187_L	211_V	0.811	0.94
4_I	464_P	0.810	0.94
281_N	315_G	0.807	0.94
535_V	540_L	0.805	0.94
148_E	317_R	0.804	0.94
39_I	114_Y	0.804	0.94
390_L	413_L	0.802	0.94
581_H	670_A	0.802	0.94
147_F	315_G	0.802	0.94
176_Y	255_H	0.801	0.94
435_I	503_L	0.801	0.94
268_F	285_V	0.801	0.94
343_W	689_V	0.799	0.94
102_E	105_D	0.799	0.94
454_V	458_R	0.795	0.94
293_A	326_N	0.791	0.94
676_S	685_R	0.790	0.94
120_I	326_N	0.789	0.94
655_T	659_A	0.788	0.94
43_N	47_A	0.788	0.94
17_V	20_I	0.788	0.94
437_I	496_V	0.787	0.93
139_T	142_V	0.787	0.93
345_L	348_T	0.787	0.93
616_Y	624_L	0.785	0.93
163_L	347_R	0.784	0.93
120_I	132_T	0.783	0.93
22_Y	190_I	0.782	0.93
458_R	589_T	0.782	0.93
447_G	595_L	0.782	0.93
343_W	347_R	0.781	0.93
640_L	643_I	0.781	0.93
97_A	106_L	0.780	0.93
86_L	294_S	0.780	0.93
48_E	106_L	0.779	0.93
31_R	258_A	0.779	0.93
250_E	255_H	0.778	0.93
100_P	251_T	0.778	0.93
451_S	591_I	0.778	0.93
212_V	475_T	0.778	0.93
505_A	517_D	0.777	0.93
95_V	110_V	0.776	0.93
185_D	240_L	0.775	0.93
48_E	58_K	0.774	0.93
428_I	456_A	0.774	0.93
182_P	187_L	0.773	0.93
193_Q	199_V	0.773	0.93
104_T	251_T	0.771	0.93
581_H	643_I	0.770	0.93
308_T	316_I	0.769	0.93
587_P	662_I	0.768	0.93
500_V	503_L	0.767	0.93
42_I	92_V	0.767	0.93
175_P	249_I	0.767	0.93
456_A	459_L	0.767	0.93
122_N	267_K	0.766	0.93
430_V	537_I	0.766	0.93
394_L	399_I	0.765	0.92
270_I	344_A	0.764	0.92
36_H	133_V	0.764	0.92
199_V	203_I	0.761	0.92
273_Y	284_D	0.760	0.92
428_I	499_A	0.760	0.92
667_V	671_A	0.760	0.92
118_E	125_K	0.759	0.92
283_L	313_I	0.758	0.92
504_K	522_Y	0.758	0.92
207_L	237_F	0.758	0.92
444_E	483_P	0.756	0.92
35_A	88_V	0.755	0.92
565_D	669_I	0.755	0.92
430_V	507_L	0.754	0.92
121_G	125_K	0.754	0.92
292_G	329_P	0.754	0.92
565_D	670_A	0.754	0.92
26_Y	100_P	0.753	0.92
303_P	341_H	0.751	0.92
39_I	85_A	0.750	0.92
151_K	154_T	0.749	0.92
51_G	98_N	0.747	0.92
291_V	322_L	0.746	0.92
212_V	474_N	0.745	0.91
359_S	399_I	0.745	0.91
15_N	20_I	0.744	0.91
358_I	362_D	0.744	0.91
156_G	277_D	0.744	0.91
418_S	559_A	0.742	0.91
151_K	155_Q	0.741	0.91
298_G	301_F	0.740	0.91
191_S	199_V	0.740	0.91
127_L	141_V	0.740	0.91
363_V	366_I	0.740	0.91
282_S	315_G	0.740	0.91
48_E	59_D	0.740	0.91
152_L	281_N	0.738	0.91
548_T	552_Q	0.738	0.91
240_L	243_K	0.737	0.91
81_A	85_A	0.736	0.91
432_N	468_A	0.736	0.91
426_V	495_A	0.733	0.91
514_V	535_V	0.732	0.91
348_T	351_A	0.730	0.91
515_L	535_V	0.729	0.91
200_S	474_N	0.728	0.91
21_S	247_K	0.727	0.90
571_I	696_L	0.727	0.90
272_A	363_V	0.723	0.90
191_S	232_L	0.722	0.90
179_I	247_K	0.721	0.90
280_V	352_I	0.721	0.90
585_I	600_V	0.721	0.90
34_Y	92_V	0.720	0.90
391_D	394_L	0.718	0.90
608_I	674_V	0.718	0.90
126_A	131_V	0.718	0.90
200_S	204_Q	0.717	0.90
42_I	54_V	0.717	0.90
124_E	288_W	0.716	0.90
368_A	384_G	0.716	0.90
43_N	46_D	0.716	0.90
385_N	648_V	0.714	0.90
351_A	355_D	0.713	0.90
242_F	246_I	0.712	0.90
601_I	645_V	0.711	0.89
35_A	119_G	0.711	0.89
368_A	413_L	0.711	0.89
168_S	610_L	0.710	0.89
251_T	254_E	0.708	0.89
508_R	517_D	0.706	0.89
280_V	363_V	0.704	0.89
160_E	355_D	0.704	0.89
41_N	45_E	0.704	0.89
17_V	249_I	0.702	0.89
8_D	14_G	0.701	0.89
571_I	678_I	0.701	0.89
24_G	245_P	0.699	0.89
85_A	112_I	0.699	0.89
156_G	279_R	0.699	0.89
494_G	655_T	0.699	0.89
101_Y	105_D	0.699	0.89
32_S	88_V	0.696	0.88
78_P	82_I	0.695	0.88
506_R	509_R	0.694	0.88
206_A	233_T	0.693	0.88
679_E	682_I	0.692	0.88
454_V	464_P	0.692	0.88
95_V	106_L	0.691	0.88
283_L	348_T	0.690	0.88
398_D	580_K	0.690	0.88
161_L	687_N	0.690	0.88
105_D	108_E	0.689	0.88
571_I	574_G	0.689	0.88
96_I	246_I	0.688	0.88
408_G	418_S	0.687	0.88
255_H	259_S	0.685	0.88
582_V	646_N	0.685	0.88
448_N	488_M	0.685	0.88
47_A	106_L	0.683	0.88
47_A	52_A	0.683	0.88
408_G	416_D	0.681	0.87
290_D	325_T	0.681	0.87
597_K	645_V	0.680	0.87
147_F	151_K	0.680	0.87
197_N	474_N	0.680	0.87
81_A	90_Q	0.680	0.87
283_L	345_L	0.679	0.87
505_A	508_R	0.677	0.87
374_Y	378_F	0.676	0.87
617_V	625_L	0.676	0.87
134_F	294_S	0.676	0.87
395_S	398_D	0.675	0.87
398_D	402_L	0.675	0.87
20_I	190_I	0.673	0.87
483_P	488_M	0.673	0.87
389_L	648_V	0.672	0.87
275_S	366_I	0.671	0.87
47_A	51_G	0.669	0.86
145_Q	316_I	0.669	0.86
3_R	9_L	0.667	0.86
151_K	156_G	0.667	0.86
88_V	623_N	0.667	0.86
289_E	322_L	0.666	0.86
517_D	522_Y	0.665	0.86
178_A	191_S	0.662	0.86
163_L	344_A	0.661	0.86
686_I	696_L	0.661	0.86
357_G	360_K	0.660	0.86
283_L	307_L	0.660	0.86
408_G	417_P	0.658	0.86
64_N	67_S	0.658	0.86
21_S	179_I	0.657	0.85
85_A	88_V	0.657	0.85
196_G	474_N	0.656	0.85
496_V	500_V	0.656	0.85
394_L	566_L	0.655	0.85
586_D	651_P	0.655	0.85
176_Y	224_E	0.654	0.85
150_G	315_G	0.654	0.85
165_W	610_L	0.652	0.85
522_Y	537_I	0.652	0.85
27_A	235_L	0.651	0.85
569_V	677_A	0.651	0.85
342_T	672_A	0.649	0.85
182_P	186_S	0.649	0.85
613_Y	633_G	0.647	0.85
428_I	435_I	0.646	0.84
583_V	600_V	0.646	0.84
452_A	456_A	0.645	0.84
151_K	314_G	0.645	0.84
508_R	527_F	0.643	0.84
287_I	303_P	0.643	0.84
488_M	492_T	0.643	0.84
56_T	59_D	0.641	0.84
25_K	245_P	0.641	0.84
127_L	321_T	0.641	0.84
116_P	119_G	0.641	0.84
140_N	144_E	0.640	0.84
509_R	513_V	0.640	0.84
313_I	316_I	0.639	0.84
127_L	267_K	0.638	0.84
466_D	520_I	0.636	0.84
9_L	217_R	0.634	0.83
166_S	264_P	0.633	0.83
124_E	127_L	0.633	0.83
57_G	61_V	0.633	0.83
578_P	581_H	0.632	0.83
354_D	685_R	0.632	0.83
51_G	102_E	0.631	0.83
508_R	512_E	0.630	0.83
267_K	288_W	0.629	0.83
62_S	67_S	0.628	0.83
347_R	679_E	0.627	0.83
180_T	246_I	0.627	0.83
171_N	616_Y	0.626	0.83
120_I	125_K	0.625	0.83
44_K	50_R	0.625	0.83
11_I	14_G	0.623	0.82
399_I	566_L	0.623	0.82
133_V	326_N	0.623	0.82
86_L	293_A	0.622	0.82
566_L	582_V	0.622	0.82
196_G	442_G	0.622	0.82
159_L	352_I	0.621	0.82
169_S	256_L	0.620	0.82
141_V	321_T	0.620	0.82
511_A	515_L	0.620	0.82
460_L	500_V	0.619	0.82
195_A	484_G	0.619	0.82
102_E	109_L	0.619	0.82
393_A	582_V	0.618	0.82
139_T	143_R	0.617	0.82
164_Y	264_P	0.617	0.82
441_F	492_T	0.617	0.82
54_V	58_K	0.617	0.82
6_A	9_L	0.617	0.82
6_A	10_L	0.616	0.82
121_G	327_K	0.616	0.82
150_G	276_S	0.616	0.82
30_I	33_P	0.616	0.82
270_I	352_I	0.615	0.81
431_K	468_A	0.615	0.81
404_N	408_G	0.615	0.81
124_E	128_E	0.615	0.81
165_W	265_E	0.615	0.81
347_R	685_R	0.614	0.81
600_V	645_V	0.614	0.81
461_G	504_K	0.614	0.81
327_K	618_Y	0.613	0.81
42_I	56_T	0.612	0.81
507_L	527_F	0.612	0.81
408_G	412_A	0.612	0.81
510_K	514_V	0.612	0.81
165_W	343_W	0.612	0.81
533_G	539_S	0.611	0.81
682_I	696_L	0.611	0.81
285_V	344_A	0.610	0.81
522_Y	526_Y	0.610	0.81
31_R	91_P	0.610	0.81
298_G	322_L	0.610	0.81
576_I	693_L	0.609	0.81
256_L	629_L	0.609	0.81
347_R	676_S	0.607	0.81
515_L	520_I	0.607	0.81
600_V	647_I	0.605	0.80
419_T	485_G	0.604	0.80
178_A	232_L	0.603	0.80
383_S	562_F	0.603	0.80
39_I	81_A	0.602	0.80
214_K	473_D	0.602	0.80
633_G	636_T	0.602	0.80
360_K	676_S	0.602	0.80
88_V	624_L	0.601	0.80
408_G	680_D	0.600	0.80
452_A	492_T	0.599	0.80
489_A	659_A	0.599	0.80
44_K	58_K	0.599	0.80
20_I	216_A	0.599	0.80
463_T	525_G	0.598	0.80
285_V	307_L	0.598	0.80
342_T	668_G	0.598	0.80
39_I	57_G	0.597	0.80
176_Y	259_S	0.596	0.79
529_G	533_G	0.595	0.79
429_K	436_V	0.595	0.79
512_E	516_N	0.595	0.79
145_Q	312_K	0.594	0.79
28_V	254_E	0.594	0.79
452_A	469_Y	0.593	0.79
405_K	408_G	0.591	0.79
122_N	288_W	0.591	0.79
146_T	149_F	0.591	0.79
510_K	513_V	0.590	0.79
278_G	363_V	0.590	0.79
165_W	268_F	0.590	0.79
512_E	515_L	0.589	0.79
385_N	650_T	0.589	0.79
41_N	276_S	0.589	0.79
54_V	95_V	0.589	0.79
514_V	540_L	0.588	0.79
481_F	484_G	0.588	0.79
156_G	274_Y	0.587	0.78
369_I	384_G	0.586	0.78
587_P	647_I	0.585	0.78
460_L	467_V	0.584	0.78
167_R	616_Y	0.583	0.78
338_T	416_D	0.583	0.78
92_V	110_V	0.583	0.78
271_H	286_H	0.582	0.78
542_G	545_V	0.582	0.78
190_I	216_A	0.582	0.78
159_L	363_V	0.580	0.78
352_I	355_D	0.580	0.78
199_V	232_L	0.580	0.78
352_I	358_I	0.578	0.77
399_I	411_L	0.578	0.77
409_V	680_D	0.577	0.77
312_K	370_D	0.577	0.77
60_L	80_M	0.577	0.77
49_R	111_Q	0.577	0.77
26_Y	249_I	0.576	0.77
402_L	409_V	0.576	0.77
202_E	228_L	0.575	0.77
125_K	130_K	0.575	0.77
421_S	487_R	0.574	0.77
157_R	358_I	0.574	0.77
405_K	579_I	0.574	0.77
600_V	666_P	0.574	0.77
116_P	621_N	0.573	0.77
412_A	673_A	0.572	0.77
77_T	90_Q	0.572	0.77
360_K	403_R	0.571	0.77
523_R	534_K	0.571	0.77
43_N	113_D	0.571	0.77
565_D	583_V	0.569	0.76
590_P	593_E	0.568	0.76
289_E	303_P	0.567	0.76
547_F	550_T	0.567	0.76
511_A	514_V	0.567	0.76
5_D	217_R	0.567	0.76
192_N	199_V	0.566	0.76
605_A	608_I	0.566	0.76
371_T	387_R	0.566	0.76
161_L	348_T	0.566	0.76
47_A	109_L	0.566	0.76
106_L	110_V	0.566	0.76
231_Y	250_E	0.564	0.76
685_R	690_P	0.564	0.76
264_P	327_K	0.563	0.76
141_V	144_E	0.563	0.76
589_T	651_P	0.562	0.75
443_P	449_E	0.561	0.75
360_K	364_R	0.561	0.75
512_E	517_D	0.561	0.75
147_F	155_Q	0.560	0.75
537_I	541_E	0.560	0.75
47_A	93_A	0.560	0.75
350_D	685_R	0.559	0.75
546_D	550_T	0.559	0.75
32_S	35_A	0.559	0.75
396_R	582_V	0.558	0.75
511_A	527_F	0.558	0.75
606_I	609_S	0.555	0.74
17_V	179_I	0.555	0.74
452_A	455_M	0.553	0.74
424_E	480_S	0.553	0.74
462_I	467_V	0.553	0.74
408_G	571_I	0.553	0.74
563_A	585_I	0.552	0.74
281_N	363_V	0.552	0.74
439_L	452_A	0.551	0.74
53_L	242_F	0.551	0.74
20_I	179_I	0.551	0.74
506_R	510_K	0.551	0.74
393_A	397_K	0.551	0.74
170_G	261_G	0.550	0.74
543_E	546_D	0.550	0.74
448_N	483_P	0.550	0.74
336_A	485_G	0.549	0.74
86_L	133_V	0.549	0.74
15_N	21_S	0.548	0.74
95_V	103_A	0.547	0.73
529_G	532_G	0.547	0.73
122_N	323_V	0.546	0.73
203_I	208_G	0.546	0.73
182_P	211_V	0.545	0.73
156_G	273_Y	0.545	0.73
363_V	367_N	0.543	0.73
291_V	330_A	0.543	0.73
355_D	685_R	0.542	0.73
41_N	46_D	0.542	0.73
94_L	248_W	0.541	0.73
297_A	300_P	0.540	0.72
397_K	564_C	0.539	0.72
281_N	314_G	0.539	0.72
402_L	580_K	0.538	0.72
35_A	121_G	0.538	0.72
149_F	152_L	0.538	0.72
113_D	116_P	0.537	0.72
48_E	52_A	0.537	0.72
684_R	696_L	0.537	0.72
399_I	403_R	0.537	0.72
578_P	674_V	0.536	0.72
568_V	579_I	0.536	0.72
126_A	129_N	0.535	0.72
195_A	198_V	0.535	0.72
295_R	324_A	0.535	0.72
279_R	314_G	0.534	0.72
416_D	668_G	0.534	0.72
424_E	495_A	0.534	0.72
353_A	363_V	0.533	0.72
409_V	570_R	0.533	0.72
626_T	631_D	0.533	0.72
33_P	85_A	0.532	0.71
607_G	611_A	0.532	0.71
193_Q	215_N	0.532	0.71
107_A	111_Q	0.532	0.71
180_T	187_L	0.531	0.71
585_I	665_I	0.531	0.71
277_D	281_N	0.531	0.71
428_I	496_V	0.531	0.71
661_G	666_P	0.530	0.71
152_L	156_G	0.530	0.71
86_L	324_A	0.530	0.71
5_D	9_L	0.529	0.71
174_E	225_K	0.529	0.71
417_P	560_Y	0.528	0.71
444_E	448_N	0.528	0.71
449_E	471_I	0.528	0.71
426_V	499_A	0.527	0.71
584_Y	648_V	0.527	0.71
397_K	409_V	0.527	0.71
368_A	386_P	0.527	0.71
609_S	613_Y	0.527	0.71
490_I	654_S	0.527	0.71
388_G	650_T	0.526	0.71
369_I	381_Y	0.525	0.70
274_Y	355_D	0.525	0.70
399_I	409_V	0.524	0.70
169_S	172_P	0.524	0.70
80_M	92_V	0.524	0.70
480_S	492_T	0.524	0.70
80_M	91_P	0.524	0.70
353_A	358_I	0.524	0.70
461_G	522_Y	0.524	0.70
168_S	333_F	0.524	0.70
159_L	356_L	0.524	0.70
36_H	85_A	0.523	0.70
171_N	255_H	0.523	0.70
22_Y	245_P	0.523	0.70
403_R	409_V	0.522	0.70
394_L	411_L	0.522	0.70
426_V	439_L	0.522	0.70
359_S	363_V	0.522	0.70
310_P	413_L	0.522	0.70
142_V	319_T	0.522	0.70
123_I	323_V	0.521	0.70
470_E	476_E	0.520	0.70
470_E	477_L	0.520	0.70
192_N	221_S	0.520	0.70
610_L	689_V	0.520	0.70
270_I	349_M	0.519	0.70
526_Y	539_S	0.519	0.70
264_P	330_A	0.519	0.70
613_Y	634_M	0.519	0.70
35_A	619_D	0.519	0.70
157_R	363_V	0.519	0.70
38_R	41_N	0.518	0.69
503_L	507_L	0.517	0.69
32_S	92_V	0.517	0.69
169_S	261_G	0.517	0.69
383_S	660_K	0.517	0.69
279_R	362_D	0.516	0.69
528_I	532_G	0.516	0.69
608_I	613_Y	0.516	0.69
159_L	348_T	0.516	0.69
308_T	313_I	0.516	0.69
424_E	491_Y	0.516	0.69
50_R	54_V	0.516	0.69
119_G	326_N	0.515	0.69
126_A	130_K	0.515	0.69
204_Q	209_V	0.514	0.69
133_V	136_D	0.514	0.69
127_L	131_V	0.513	0.69
563_A	665_I	0.513	0.69
151_K	158_H	0.513	0.69
601_I	643_I	0.513	0.69
455_M	657_Y	0.512	0.68
120_I	128_E	0.512	0.68
148_E	156_G	0.510	0.68
37_A	116_P	0.509	0.68
189_I	236_G	0.509	0.68
126_A	133_V	0.508	0.68
272_A	349_M	0.508	0.68
76_T	295_R	0.507	0.68
304_L	320_G	0.506	0.68
52_A	95_V	0.506	0.68
394_L	397_K	0.506	0.68
511_A	520_I	0.505	0.67
268_F	287_I	0.505	0.67
362_D	394_L	0.504	0.67
519_V	526_Y	0.504	0.67
97_A	102_E	0.503	0.67
520_I	529_G	0.502	0.67
443_P	448_N	0.502	0.67
500_V	504_K	0.502	0.67
178_A	189_I	0.502	0.67
34_Y	117_L	0.502	0.67
432_N	466_D	0.502	0.67
356_L	366_I	0.502	0.67
226_F	297_A	0.502	0.67
50_R	97_A	0.502	0.67
227_S	296_D	0.501	0.67
418_S	490_I	0.501	0.67
403_R	411_L	0.501	0.67
171_N	256_L	0.500	0.67
168_S	606_I	0.500	0.67

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1rm6A	2	0.9914	100	0.117	Contact Map
1t3qB	2	0.9971	100	0.119	Contact Map
1ffvB	2	0.9928	100	0.124	Contact Map
1n62B	2	0.9957	100	0.127	Contact Map
3uncA	2	0.9799	100	0.141	Contact Map
2w3sB	2	0.9857	100	0.141	Contact Map
3zyvA	3	0.9713	100	0.152	Contact Map
3nvzC	2	0.9799	100	0.154	Contact Map
4usaA	2	0.9613	100	0.162	Contact Map
1dgjA	1	0.9599	100	0.165	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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