Q7LX94 - SULSO - GREMLIN Contacts

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Q7LX94 - Uncharacterized protein

UniProt:	Q7LX94	Sequences: MVKFIFGRELTEEDEFFDREDYVNVLLSYINRRQPVAILAPRRMGKSSLLNYIKIKLGNEYIVAKISLEGITSIEEFADELTSKLVLEALSKSLKMRAKNTISSLVASLNQFLGSIKSLSIRMQNLELYIDRYSLFKENKLKPSEILDDVLLLPQRIAEDTGKNVVIMIDEFQKIRVLKQPFPKILELTRKRLQESKNVEIIVSGSETGIIEEMITEAKEPFYNYFKIERLKSFDKETSIRFLNEGLKGKCKEYYEKVYELTEGIPAWLNLAGLIFERECNIEAILEDPNVEIELKKDLEGLTKNEIKVLKGLAKGNKLSEIKVSNIYRVIKILKNRGLVDKINDEYKIIDPILSFYLKK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	360 (304)
Sequences:	8208 (7129)
Seq/√Len:	408.9

SULSO - Q7LX94 Q7LX62 Q97VA4 Q97X15 Q97Y08 Q97X37

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
239_S	269_L	4.724	1.00
27_L	56_K	3.844	1.00
235_D	238_T	3.812	1.00
303_T	333_I	3.617	1.00
200_E	204_S	3.609	1.00
200_E	206_S	3.567	1.00
318_K	321_E	3.205	1.00
26_L	53_I	2.770	1.00
306_E	333_I	2.714	1.00
25_V	227_K	2.526	1.00
48_S	52_Y	2.505	1.00
50_L	204_S	2.478	1.00
236_K	256_E	2.449	1.00
39_L	228_I	2.427	1.00
306_E	334_L	2.427	1.00
50_L	168_M	2.417	1.00
54_K	168_M	2.371	1.00
52_Y	55_I	2.370	1.00
20_E	238_T	2.343	1.00
199_V	206_S	2.338	1.00
176_R	179_K	2.289	1.00
40_A	44_M	2.264	1.00
243_L	273_G	2.208	1.00
26_L	36_V	2.140	1.00
239_S	259_Y	2.119	1.00
23_V	52_Y	2.116	1.00
240_I	255_Y	2.056	1.00
64_A	68_L	1.971	1.00
238_T	241_R	1.916	1.00
18_D	238_T	1.889	1.00
310_L	334_L	1.884	1.00
203_V	206_S	1.856	1.00
307_I	311_K	1.850	1.00
31_N	60_E	1.821	1.00
341_D	348_K	1.805	1.00
172_F	203_V	1.790	1.00
271_L	274_L	1.783	1.00
144_S	148_D	1.776	1.00
29_Y	36_V	1.775	1.00
303_T	306_E	1.756	1.00
236_K	259_Y	1.743	1.00
258_V	269_L	1.718	1.00
16_F	48_S	1.694	1.00
199_V	204_S	1.686	1.00
199_V	205_G	1.676	1.00
17_F	245_E	1.665	1.00
30_I	57_L	1.649	1.00
313_L	349_I	1.645	1.00
24_N	28_S	1.642	1.00
44_M	266_P	1.637	1.00
175_I	186_L	1.635	1.00
236_K	240_I	1.632	1.00
200_E	205_G	1.616	1.00
244_N	255_Y	1.589	1.00
16_F	52_Y	1.589	1.00
153_L	156_R	1.586	1.00
309_V	330_V	1.581	1.00
352_P	356_F	1.566	1.00
39_L	230_R	1.558	1.00
52_Y	56_K	1.549	1.00
271_L	298_D	1.538	1.00
332_K	336_N	1.536	1.00
170_D	173_Q	1.531	1.00
113_L	117_K	1.528	1.00
41_P	44_M	1.521	1.00
170_D	204_S	1.516	1.00
240_I	252_K	1.490	1.00
22_Y	229_E	1.475	1.00
256_E	260_E	1.470	1.00
67_S	70_G	1.463	1.00
150_V	155_Q	1.434	1.00
170_D	206_S	1.424	1.00
114_G	117_K	1.423	1.00
257_K	260_E	1.405	1.00
262_T	272_A	1.387	1.00
143_P	146_I	1.374	1.00
319_L	322_I	1.373	1.00
66_I	70_G	1.369	1.00
48_S	270_N	1.365	1.00
257_K	261_L	1.364	1.00
339_L	354_L	1.349	1.00
38_I	50_L	1.344	1.00
202_I	206_S	1.333	1.00
51_N	63_V	1.329	1.00
147_L	150_V	1.325	1.00
343_I	348_K	1.317	1.00
240_I	244_N	1.312	1.00
63_V	68_L	1.308	1.00
296_K	300_E	1.303	1.00
50_L	206_S	1.298	1.00
305_N	330_V	1.295	1.00
15_E	48_S	1.284	1.00
139_N	142_K	1.284	1.00
143_P	147_L	1.271	1.00
191_K	195_E	1.269	1.00
26_L	49_L	1.265	1.00
313_L	340_V	1.257	1.00
142_K	147_L	1.256	1.00
207_E	212_E	1.255	1.00
22_Y	232_K	1.226	1.00
262_T	269_L	1.222	1.00
144_S	147_L	1.216	1.00
234_F	238_T	1.215	1.00
318_K	322_I	1.211	1.00
146_I	149_D	1.204	1.00
188_L	192_R	1.203	1.00
208_T	212_E	1.195	1.00
200_E	203_V	1.194	1.00
21_D	25_V	1.194	1.00
149_D	153_L	1.189	1.00
251_C	254_Y	1.183	1.00
208_T	211_I	1.181	1.00
21_D	24_N	1.175	1.00
241_R	245_E	1.168	1.00
73_S	76_E	1.158	1.00
78_A	81_L	1.155	1.00
50_L	54_K	1.155	1.00
78_A	179_K	1.154	1.00
240_I	256_E	1.144	1.00
20_E	241_R	1.143	1.00
323_K	326_N	1.133	1.00
38_I	231_L	1.122	1.00
255_Y	259_Y	1.112	1.00
57_L	60_E	1.104	1.00
27_L	60_E	1.091	1.00
242_F	269_L	1.086	1.00
147_L	151_L	1.086	1.00
172_F	175_I	1.078	1.00
198_N	206_S	1.078	1.00
30_I	166_V	1.072	1.00
64_A	81_L	1.064	1.00
335_K	340_V	1.064	1.00
305_N	308_K	1.063	1.00
49_L	231_L	1.057	1.00
47_S	51_N	1.056	1.00
219_K	222_F	1.045	1.00
61_Y	64_A	1.045	1.00
295_L	354_L	1.039	1.00
35_P	193_L	1.039	1.00
309_V	331_I	1.035	1.00
335_K	342_K	1.020	1.00
112_F	115_S	1.018	1.00
124_Q	127_E	1.018	1.00
22_Y	49_L	1.015	1.00
148_D	152_L	1.009	1.00
198_N	204_S	1.009	1.00
19_R	22_Y	1.008	1.00
53_I	57_L	1.006	1.00
30_I	53_I	1.005	1.00
241_R	244_N	1.003	1.00
151_L	155_Q	1.002	1.00
149_D	152_L	1.002	1.00
142_K	146_I	1.001	1.00
112_F	117_K	0.999	1.00
54_K	63_V	0.998	1.00
61_Y	68_L	0.994	1.00
38_I	229_E	0.993	1.00
64_A	67_S	0.993	1.00
113_L	116_I	0.991	1.00
306_E	337_R	0.990	1.00
352_P	355_S	0.986	1.00
236_K	260_E	0.984	1.00
27_L	31_N	0.983	1.00
172_F	205_G	0.979	1.00
75_E	178_L	0.974	1.00
261_L	356_F	0.972	1.00
341_D	350_I	0.970	1.00
17_F	238_T	0.967	1.00
127_E	132_R	0.960	1.00
299_L	310_L	0.959	1.00
77_F	179_K	0.958	1.00
22_Y	231_L	0.958	1.00
155_Q	158_A	0.956	1.00
77_F	175_I	0.955	1.00
267_A	351_D	0.953	1.00
246_G	273_G	0.950	1.00
42_R	171_E	0.945	1.00
234_F	242_F	0.934	1.00
152_L	156_R	0.930	1.00
207_E	210_I	0.929	1.00
243_L	258_V	0.928	1.00
313_L	316_G	0.927	1.00
202_I	205_G	0.923	1.00
66_I	69_E	0.920	1.00
342_K	347_Y	0.918	1.00
236_K	262_T	0.917	1.00
29_Y	227_K	0.915	1.00
234_F	266_P	0.914	1.00
28_S	32_R	0.914	1.00
78_A	188_L	0.914	1.00
254_Y	276_F	0.908	1.00
282_I	285_I	0.902	1.00
127_E	130_I	0.901	1.00
25_V	29_Y	0.901	1.00
190_R	194_Q	0.900	1.00
39_L	205_G	0.889	1.00
323_K	327_I	0.887	1.00
76_E	80_E	0.886	1.00
235_D	239_S	0.877	1.00
142_K	145_E	0.877	1.00
35_P	226_F	0.876	1.00
15_E	245_E	0.869	1.00
243_L	246_G	0.868	1.00
25_V	28_S	0.862	1.00
191_K	194_Q	0.858	1.00
267_A	271_L	0.857	1.00
308_K	311_K	0.855	1.00
24_N	27_L	0.854	1.00
233_S	263_E	0.853	1.00
20_E	24_N	0.852	1.00
66_I	71_I	0.847	1.00
63_V	66_I	0.843	1.00
252_K	256_E	0.843	1.00
263_E	352_P	0.843	1.00
25_V	229_E	0.839	1.00
166_V	202_I	0.837	1.00
309_V	327_I	0.835	1.00
62_I	68_L	0.831	1.00
27_L	30_I	0.830	1.00
324_V	327_I	0.827	1.00
79_D	83_S	0.826	1.00
68_L	71_I	0.821	1.00
271_L	290_N	0.819	1.00
314_A	349_I	0.814	1.00
41_P	233_S	0.813	1.00
259_Y	262_T	0.812	1.00
23_V	53_I	0.811	1.00
44_M	265_I	0.807	1.00
187_E	190_R	0.807	1.00
300_E	307_I	0.807	1.00
81_L	85_L	0.806	1.00
46_K	267_A	0.805	1.00
44_M	231_L	0.801	1.00
112_F	116_I	0.800	1.00
54_K	166_V	0.798	1.00
283_E	287_E	0.794	1.00
22_Y	25_V	0.793	1.00
305_N	326_N	0.792	1.00
83_S	125_N	0.791	1.00
198_N	205_G	0.790	1.00
247_L	254_Y	0.788	1.00
207_E	211_I	0.788	1.00
220_E	228_I	0.787	1.00
297_K	300_E	0.783	1.00
144_S	187_E	0.781	1.00
292_E	357_Y	0.778	1.00
147_L	152_L	0.778	1.00
153_L	158_A	0.775	1.00
65_K	68_L	0.773	1.00
293_I	297_K	0.773	1.00
18_D	235_D	0.772	1.00
247_L	250_K	0.764	1.00
64_A	169_I	0.762	1.00
299_L	307_I	0.762	1.00
271_L	275_I	0.760	1.00
35_P	203_V	0.757	1.00
212_E	215_I	0.752	1.00
333_I	337_R	0.751	1.00
125_N	131_D	0.749	1.00
331_I	347_Y	0.748	1.00
326_N	330_V	0.747	1.00
343_I	346_E	0.747	1.00
36_V	227_K	0.747	1.00
267_A	291_V	0.743	1.00
144_S	150_V	0.742	1.00
123_M	127_E	0.742	1.00
62_I	66_I	0.741	1.00
145_E	148_D	0.737	1.00
148_D	191_K	0.728	1.00
233_S	262_T	0.728	1.00
56_K	60_E	0.727	1.00
243_L	269_L	0.727	1.00
335_K	347_Y	0.726	1.00
81_L	167_I	0.723	1.00
16_F	20_E	0.722	1.00
161_T	164_N	0.721	1.00
62_I	165_V	0.720	1.00
50_L	170_D	0.719	1.00
125_N	129_Y	0.715	1.00
124_Q	129_Y	0.715	1.00
285_I	288_D	0.714	1.00
350_I	354_L	0.712	1.00
36_V	229_E	0.711	1.00
170_D	352_P	0.711	1.00
332_K	335_K	0.710	1.00
210_I	214_M	0.708	1.00
331_I	340_V	0.708	1.00
338_G	350_I	0.704	1.00
67_S	71_I	0.703	1.00
152_L	155_Q	0.702	1.00
53_I	166_V	0.702	1.00
124_Q	131_D	0.701	1.00
199_V	203_V	0.700	1.00
16_F	19_R	0.699	1.00
57_L	166_V	0.697	1.00
200_E	207_E	0.697	1.00
37_A	205_G	0.696	1.00
81_L	169_I	0.695	1.00
217_E	220_E	0.694	1.00
86_V	90_L	0.693	1.00
310_L	313_L	0.693	1.00
44_M	233_S	0.693	1.00
217_E	221_P	0.690	1.00
23_V	56_K	0.689	1.00
28_S	31_N	0.686	1.00
47_S	170_D	0.686	1.00
43_R	171_E	0.684	1.00
243_L	255_Y	0.683	1.00
129_Y	132_R	0.681	1.00
283_E	286_L	0.678	1.00
239_S	273_G	0.678	1.00
208_T	214_M	0.675	0.99
239_S	264_G	0.674	0.99
138_E	142_K	0.674	0.99
17_F	241_R	0.673	0.99
146_I	150_V	0.670	0.99
75_E	78_A	0.668	0.99
310_L	339_L	0.666	0.99
237_E	240_I	0.666	0.99
74_I	176_R	0.665	0.99
145_E	149_D	0.662	0.99
142_K	150_V	0.658	0.99
70_G	73_S	0.657	0.99
284_A	287_E	0.654	0.99
263_E	317_N	0.654	0.99
48_S	246_G	0.654	0.99
38_I	49_L	0.653	0.99
268_W	291_V	0.652	0.99
126_L	129_Y	0.649	0.99
339_L	349_I	0.647	0.99
54_K	58_G	0.646	0.99
208_T	213_E	0.642	0.99
242_F	270_N	0.638	0.99
209_G	215_I	0.637	0.99
291_V	295_L	0.637	0.99
282_I	286_L	0.633	0.99
17_F	48_S	0.632	0.99
291_V	298_D	0.632	0.99
166_V	200_E	0.631	0.99
220_E	223_Y	0.630	0.99
153_L	157_I	0.628	0.99
313_L	347_Y	0.628	0.99
243_L	247_L	0.628	0.99
42_R	351_D	0.627	0.99
73_S	80_E	0.625	0.99
335_K	341_D	0.620	0.99
317_N	352_P	0.616	0.99
168_M	204_S	0.615	0.99
128_L	132_R	0.615	0.99
139_N	143_P	0.613	0.99
37_A	226_F	0.611	0.99
143_P	150_V	0.611	0.99
326_N	329_R	0.610	0.99
167_I	201_I	0.609	0.99
265_I	269_L	0.607	0.99
258_V	272_A	0.606	0.99
171_E	351_D	0.601	0.99
236_K	255_Y	0.600	0.99
42_R	206_S	0.600	0.99
29_Y	229_E	0.599	0.99
61_Y	67_S	0.596	0.99
114_G	123_M	0.594	0.99
148_D	153_L	0.593	0.99
281_N	284_A	0.593	0.99
246_G	270_N	0.591	0.99
304_K	307_I	0.590	0.99
212_E	216_T	0.590	0.99
48_S	51_N	0.590	0.99
262_T	276_F	0.589	0.99
143_P	149_D	0.589	0.99
334_L	337_R	0.587	0.99
267_A	353_I	0.587	0.99
354_L	357_Y	0.587	0.99
186_L	190_R	0.585	0.99
37_A	203_V	0.585	0.99
27_L	53_I	0.582	0.98
27_L	52_Y	0.582	0.98
254_Y	258_V	0.581	0.98
247_L	276_F	0.581	0.98
146_I	155_Q	0.580	0.98
306_E	330_V	0.579	0.98
147_L	153_L	0.579	0.98
50_L	202_I	0.578	0.98
209_G	212_E	0.572	0.98
125_N	132_R	0.571	0.98
56_K	59_N	0.569	0.98
254_Y	257_K	0.568	0.98
173_Q	176_R	0.567	0.98
143_P	148_D	0.567	0.98
125_N	128_L	0.565	0.98
349_I	355_S	0.564	0.98
64_A	69_E	0.563	0.98
281_N	285_I	0.560	0.98
197_K	200_E	0.559	0.98
210_I	215_I	0.559	0.98
23_V	27_L	0.559	0.98
352_P	357_Y	0.558	0.98
265_I	268_W	0.558	0.98
221_P	224_N	0.557	0.98
41_P	350_I	0.556	0.98
19_R	23_V	0.555	0.98
125_N	130_I	0.555	0.98
328_Y	332_K	0.555	0.98
312_G	315_K	0.553	0.98
177_V	187_E	0.553	0.98
66_I	175_I	0.551	0.98
187_E	191_K	0.551	0.98
310_L	340_V	0.550	0.98
75_E	179_K	0.550	0.98
62_I	65_K	0.549	0.98
17_F	242_F	0.549	0.98
63_V	71_I	0.547	0.98
324_V	328_Y	0.545	0.98
124_Q	132_R	0.545	0.98
146_I	153_L	0.543	0.98
259_Y	264_G	0.543	0.98
26_L	38_I	0.543	0.98
306_E	309_V	0.542	0.98
140_K	143_P	0.542	0.98
295_L	298_D	0.542	0.98
327_I	331_I	0.531	0.97
198_N	201_I	0.529	0.97
210_I	217_E	0.528	0.97
20_E	23_V	0.525	0.97
42_R	267_A	0.524	0.97
270_N	274_L	0.524	0.97
239_S	258_V	0.523	0.97
306_E	310_L	0.522	0.97
74_I	77_F	0.522	0.97
295_L	357_Y	0.520	0.97
66_I	77_F	0.520	0.97
22_Y	29_Y	0.517	0.97
146_I	151_L	0.517	0.97
154_P	157_I	0.517	0.97
140_K	146_I	0.516	0.97
124_Q	130_I	0.516	0.97
294_E	298_D	0.516	0.97
30_I	60_E	0.514	0.97
144_S	151_L	0.513	0.97
193_L	226_F	0.513	0.97
61_Y	66_I	0.512	0.97
42_R	353_I	0.510	0.97
138_E	141_L	0.509	0.97
51_N	65_K	0.508	0.96
35_P	225_Y	0.506	0.96
42_R	173_Q	0.506	0.96
77_F	81_L	0.505	0.96
16_F	238_T	0.505	0.96
51_N	54_K	0.505	0.96
65_K	69_E	0.504	0.96
64_A	70_G	0.502	0.96
256_E	259_Y	0.502	0.96
148_D	155_Q	0.502	0.96
267_A	270_N	0.501	0.96
207_E	213_E	0.500	0.96
269_L	273_G	0.500	0.96

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2qenA	1	0.9	100	0.469	Contact Map
2fnaA	1	0.9	100	0.478	Contact Map
1z6tA	1	0.8083	100	0.574	Contact Map
1w5sA	1	0.85	99.9	0.609	Contact Map
1fnnA	1	0.8167	99.9	0.613	Contact Map
2a5yB	2	0.8139	99.9	0.617	Contact Map
2qbyA	1	0.8222	99.9	0.649	Contact Map
3sfzA	1	0.8083	99.9	0.65	Contact Map
2v1uA	1	0.8194	99.9	0.658	Contact Map
3pfiA	3	0.725	99.9	0.659	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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