GREMLIN Database
Q7LX94 - Uncharacterized protein
UniProt: Q7LX94 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 360 (304)
Sequences: 8208 (7129)
Seq/√Len: 408.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
239_S269_L4.7241.00
27_L56_K3.8441.00
235_D238_T3.8121.00
303_T333_I3.6171.00
200_E204_S3.6091.00
200_E206_S3.5671.00
318_K321_E3.2051.00
26_L53_I2.7701.00
306_E333_I2.7141.00
25_V227_K2.5261.00
48_S52_Y2.5051.00
50_L204_S2.4781.00
236_K256_E2.4491.00
39_L228_I2.4271.00
306_E334_L2.4271.00
50_L168_M2.4171.00
54_K168_M2.3711.00
52_Y55_I2.3701.00
20_E238_T2.3431.00
199_V206_S2.3381.00
176_R179_K2.2891.00
40_A44_M2.2641.00
243_L273_G2.2081.00
26_L36_V2.1401.00
239_S259_Y2.1191.00
23_V52_Y2.1161.00
240_I255_Y2.0561.00
64_A68_L1.9711.00
238_T241_R1.9161.00
18_D238_T1.8891.00
310_L334_L1.8841.00
203_V206_S1.8561.00
307_I311_K1.8501.00
31_N60_E1.8211.00
341_D348_K1.8051.00
172_F203_V1.7901.00
271_L274_L1.7831.00
144_S148_D1.7761.00
29_Y36_V1.7751.00
303_T306_E1.7561.00
236_K259_Y1.7431.00
258_V269_L1.7181.00
16_F48_S1.6941.00
199_V204_S1.6861.00
199_V205_G1.6761.00
17_F245_E1.6651.00
30_I57_L1.6491.00
313_L349_I1.6451.00
24_N28_S1.6421.00
44_M266_P1.6371.00
175_I186_L1.6351.00
236_K240_I1.6321.00
200_E205_G1.6161.00
244_N255_Y1.5891.00
16_F52_Y1.5891.00
153_L156_R1.5861.00
309_V330_V1.5811.00
352_P356_F1.5661.00
39_L230_R1.5581.00
52_Y56_K1.5491.00
271_L298_D1.5381.00
332_K336_N1.5361.00
170_D173_Q1.5311.00
113_L117_K1.5281.00
41_P44_M1.5211.00
170_D204_S1.5161.00
240_I252_K1.4901.00
22_Y229_E1.4751.00
256_E260_E1.4701.00
67_S70_G1.4631.00
150_V155_Q1.4341.00
170_D206_S1.4241.00
114_G117_K1.4231.00
257_K260_E1.4051.00
262_T272_A1.3871.00
143_P146_I1.3741.00
319_L322_I1.3731.00
66_I70_G1.3691.00
48_S270_N1.3651.00
257_K261_L1.3641.00
339_L354_L1.3491.00
38_I50_L1.3441.00
202_I206_S1.3331.00
51_N63_V1.3291.00
147_L150_V1.3251.00
343_I348_K1.3171.00
240_I244_N1.3121.00
63_V68_L1.3081.00
296_K300_E1.3031.00
50_L206_S1.2981.00
305_N330_V1.2951.00
15_E48_S1.2841.00
139_N142_K1.2841.00
143_P147_L1.2711.00
191_K195_E1.2691.00
26_L49_L1.2651.00
313_L340_V1.2571.00
142_K147_L1.2561.00
207_E212_E1.2551.00
22_Y232_K1.2261.00
262_T269_L1.2221.00
144_S147_L1.2161.00
234_F238_T1.2151.00
318_K322_I1.2111.00
146_I149_D1.2041.00
188_L192_R1.2031.00
208_T212_E1.1951.00
200_E203_V1.1941.00
21_D25_V1.1941.00
149_D153_L1.1891.00
251_C254_Y1.1831.00
208_T211_I1.1811.00
21_D24_N1.1751.00
241_R245_E1.1681.00
73_S76_E1.1581.00
78_A81_L1.1551.00
50_L54_K1.1551.00
78_A179_K1.1541.00
240_I256_E1.1441.00
20_E241_R1.1431.00
323_K326_N1.1331.00
38_I231_L1.1221.00
255_Y259_Y1.1121.00
57_L60_E1.1041.00
27_L60_E1.0911.00
242_F269_L1.0861.00
147_L151_L1.0861.00
172_F175_I1.0781.00
198_N206_S1.0781.00
30_I166_V1.0721.00
64_A81_L1.0641.00
335_K340_V1.0641.00
305_N308_K1.0631.00
49_L231_L1.0571.00
47_S51_N1.0561.00
219_K222_F1.0451.00
61_Y64_A1.0451.00
295_L354_L1.0391.00
35_P193_L1.0391.00
309_V331_I1.0351.00
335_K342_K1.0201.00
112_F115_S1.0181.00
124_Q127_E1.0181.00
22_Y49_L1.0151.00
148_D152_L1.0091.00
198_N204_S1.0091.00
19_R22_Y1.0081.00
53_I57_L1.0061.00
30_I53_I1.0051.00
241_R244_N1.0031.00
151_L155_Q1.0021.00
149_D152_L1.0021.00
142_K146_I1.0011.00
112_F117_K0.9991.00
54_K63_V0.9981.00
61_Y68_L0.9941.00
38_I229_E0.9931.00
64_A67_S0.9931.00
113_L116_I0.9911.00
306_E337_R0.9901.00
352_P355_S0.9861.00
236_K260_E0.9841.00
27_L31_N0.9831.00
172_F205_G0.9791.00
75_E178_L0.9741.00
261_L356_F0.9721.00
341_D350_I0.9701.00
17_F238_T0.9671.00
127_E132_R0.9601.00
299_L310_L0.9591.00
77_F179_K0.9581.00
22_Y231_L0.9581.00
155_Q158_A0.9561.00
77_F175_I0.9551.00
267_A351_D0.9531.00
246_G273_G0.9501.00
42_R171_E0.9451.00
234_F242_F0.9341.00
152_L156_R0.9301.00
207_E210_I0.9291.00
243_L258_V0.9281.00
313_L316_G0.9271.00
202_I205_G0.9231.00
66_I69_E0.9201.00
342_K347_Y0.9181.00
236_K262_T0.9171.00
29_Y227_K0.9151.00
234_F266_P0.9141.00
28_S32_R0.9141.00
78_A188_L0.9141.00
254_Y276_F0.9081.00
282_I285_I0.9021.00
127_E130_I0.9011.00
25_V29_Y0.9011.00
190_R194_Q0.9001.00
39_L205_G0.8891.00
323_K327_I0.8871.00
76_E80_E0.8861.00
235_D239_S0.8771.00
142_K145_E0.8771.00
35_P226_F0.8761.00
15_E245_E0.8691.00
243_L246_G0.8681.00
25_V28_S0.8621.00
191_K194_Q0.8581.00
267_A271_L0.8571.00
308_K311_K0.8551.00
24_N27_L0.8541.00
233_S263_E0.8531.00
20_E24_N0.8521.00
66_I71_I0.8471.00
63_V66_I0.8431.00
252_K256_E0.8431.00
263_E352_P0.8431.00
25_V229_E0.8391.00
166_V202_I0.8371.00
309_V327_I0.8351.00
62_I68_L0.8311.00
27_L30_I0.8301.00
324_V327_I0.8271.00
79_D83_S0.8261.00
68_L71_I0.8211.00
271_L290_N0.8191.00
314_A349_I0.8141.00
41_P233_S0.8131.00
259_Y262_T0.8121.00
23_V53_I0.8111.00
44_M265_I0.8071.00
187_E190_R0.8071.00
300_E307_I0.8071.00
81_L85_L0.8061.00
46_K267_A0.8051.00
44_M231_L0.8011.00
112_F116_I0.8001.00
54_K166_V0.7981.00
283_E287_E0.7941.00
22_Y25_V0.7931.00
305_N326_N0.7921.00
83_S125_N0.7911.00
198_N205_G0.7901.00
247_L254_Y0.7881.00
207_E211_I0.7881.00
220_E228_I0.7871.00
297_K300_E0.7831.00
144_S187_E0.7811.00
292_E357_Y0.7781.00
147_L152_L0.7781.00
153_L158_A0.7751.00
65_K68_L0.7731.00
293_I297_K0.7731.00
18_D235_D0.7721.00
247_L250_K0.7641.00
64_A169_I0.7621.00
299_L307_I0.7621.00
271_L275_I0.7601.00
35_P203_V0.7571.00
212_E215_I0.7521.00
333_I337_R0.7511.00
125_N131_D0.7491.00
331_I347_Y0.7481.00
326_N330_V0.7471.00
343_I346_E0.7471.00
36_V227_K0.7471.00
267_A291_V0.7431.00
144_S150_V0.7421.00
123_M127_E0.7421.00
62_I66_I0.7411.00
145_E148_D0.7371.00
148_D191_K0.7281.00
233_S262_T0.7281.00
56_K60_E0.7271.00
243_L269_L0.7271.00
335_K347_Y0.7261.00
81_L167_I0.7231.00
16_F20_E0.7221.00
161_T164_N0.7211.00
62_I165_V0.7201.00
50_L170_D0.7191.00
125_N129_Y0.7151.00
124_Q129_Y0.7151.00
285_I288_D0.7141.00
350_I354_L0.7121.00
36_V229_E0.7111.00
170_D352_P0.7111.00
332_K335_K0.7101.00
210_I214_M0.7081.00
331_I340_V0.7081.00
338_G350_I0.7041.00
67_S71_I0.7031.00
152_L155_Q0.7021.00
53_I166_V0.7021.00
124_Q131_D0.7011.00
199_V203_V0.7001.00
16_F19_R0.6991.00
57_L166_V0.6971.00
200_E207_E0.6971.00
37_A205_G0.6961.00
81_L169_I0.6951.00
217_E220_E0.6941.00
86_V90_L0.6931.00
310_L313_L0.6931.00
44_M233_S0.6931.00
217_E221_P0.6901.00
23_V56_K0.6891.00
28_S31_N0.6861.00
47_S170_D0.6861.00
43_R171_E0.6841.00
243_L255_Y0.6831.00
129_Y132_R0.6811.00
283_E286_L0.6781.00
239_S273_G0.6781.00
208_T214_M0.6750.99
239_S264_G0.6740.99
138_E142_K0.6740.99
17_F241_R0.6730.99
146_I150_V0.6700.99
75_E78_A0.6680.99
310_L339_L0.6660.99
237_E240_I0.6660.99
74_I176_R0.6650.99
145_E149_D0.6620.99
142_K150_V0.6580.99
70_G73_S0.6570.99
284_A287_E0.6540.99
263_E317_N0.6540.99
48_S246_G0.6540.99
38_I49_L0.6530.99
268_W291_V0.6520.99
126_L129_Y0.6490.99
339_L349_I0.6470.99
54_K58_G0.6460.99
208_T213_E0.6420.99
242_F270_N0.6380.99
209_G215_I0.6370.99
291_V295_L0.6370.99
282_I286_L0.6330.99
17_F48_S0.6320.99
291_V298_D0.6320.99
166_V200_E0.6310.99
220_E223_Y0.6300.99
153_L157_I0.6280.99
313_L347_Y0.6280.99
243_L247_L0.6280.99
42_R351_D0.6270.99
73_S80_E0.6250.99
335_K341_D0.6200.99
317_N352_P0.6160.99
168_M204_S0.6150.99
128_L132_R0.6150.99
139_N143_P0.6130.99
37_A226_F0.6110.99
143_P150_V0.6110.99
326_N329_R0.6100.99
167_I201_I0.6090.99
265_I269_L0.6070.99
258_V272_A0.6060.99
171_E351_D0.6010.99
236_K255_Y0.6000.99
42_R206_S0.6000.99
29_Y229_E0.5990.99
61_Y67_S0.5960.99
114_G123_M0.5940.99
148_D153_L0.5930.99
281_N284_A0.5930.99
246_G270_N0.5910.99
304_K307_I0.5900.99
212_E216_T0.5900.99
48_S51_N0.5900.99
262_T276_F0.5890.99
143_P149_D0.5890.99
334_L337_R0.5870.99
267_A353_I0.5870.99
354_L357_Y0.5870.99
186_L190_R0.5850.99
37_A203_V0.5850.99
27_L53_I0.5820.98
27_L52_Y0.5820.98
254_Y258_V0.5810.98
247_L276_F0.5810.98
146_I155_Q0.5800.98
306_E330_V0.5790.98
147_L153_L0.5790.98
50_L202_I0.5780.98
209_G212_E0.5720.98
125_N132_R0.5710.98
56_K59_N0.5690.98
254_Y257_K0.5680.98
173_Q176_R0.5670.98
143_P148_D0.5670.98
125_N128_L0.5650.98
349_I355_S0.5640.98
64_A69_E0.5630.98
281_N285_I0.5600.98
197_K200_E0.5590.98
210_I215_I0.5590.98
23_V27_L0.5590.98
352_P357_Y0.5580.98
265_I268_W0.5580.98
221_P224_N0.5570.98
41_P350_I0.5560.98
19_R23_V0.5550.98
125_N130_I0.5550.98
328_Y332_K0.5550.98
312_G315_K0.5530.98
177_V187_E0.5530.98
66_I175_I0.5510.98
187_E191_K0.5510.98
310_L340_V0.5500.98
75_E179_K0.5500.98
62_I65_K0.5490.98
17_F242_F0.5490.98
63_V71_I0.5470.98
324_V328_Y0.5450.98
124_Q132_R0.5450.98
146_I153_L0.5430.98
259_Y264_G0.5430.98
26_L38_I0.5430.98
306_E309_V0.5420.98
140_K143_P0.5420.98
295_L298_D0.5420.98
327_I331_I0.5310.97
198_N201_I0.5290.97
210_I217_E0.5280.97
20_E23_V0.5250.97
42_R267_A0.5240.97
270_N274_L0.5240.97
239_S258_V0.5230.97
306_E310_L0.5220.97
74_I77_F0.5220.97
295_L357_Y0.5200.97
66_I77_F0.5200.97
22_Y29_Y0.5170.97
146_I151_L0.5170.97
154_P157_I0.5170.97
140_K146_I0.5160.97
124_Q130_I0.5160.97
294_E298_D0.5160.97
30_I60_E0.5140.97
144_S151_L0.5130.97
193_L226_F0.5130.97
61_Y66_I0.5120.97
42_R353_I0.5100.97
138_E141_L0.5090.97
51_N65_K0.5080.96
35_P225_Y0.5060.96
42_R173_Q0.5060.96
77_F81_L0.5050.96
16_F238_T0.5050.96
51_N54_K0.5050.96
65_K69_E0.5040.96
64_A70_G0.5020.96
256_E259_Y0.5020.96
148_D155_Q0.5020.96
267_A270_N0.5010.96
207_E213_E0.5000.96
269_L273_G0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qenA 1 0.9 100 0.469 Contact Map
2fnaA 1 0.9 100 0.478 Contact Map
1z6tA 1 0.8083 100 0.574 Contact Map
1w5sA 1 0.85 99.9 0.609 Contact Map
1fnnA 1 0.8167 99.9 0.613 Contact Map
2a5yB 2 0.8139 99.9 0.617 Contact Map
2qbyA 1 0.8222 99.9 0.649 Contact Map
3sfzA 1 0.8083 99.9 0.65 Contact Map
2v1uA 1 0.8194 99.9 0.658 Contact Map
3pfiA 3 0.725 99.9 0.659 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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