GREMLIN Database
Q7LX90 - Uncharacterized protein
UniProt: Q7LX90 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 132 (119)
Sequences: 97 (93)
Seq/√Len: 8.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
109_R113_E4.7070.99
26_E120_Q4.4180.99
97_R101_Q3.5820.96
43_I97_R3.2750.93
42_E46_Q3.2480.93
43_I101_Q3.1690.92
41_S119_A2.7170.84
39_L101_Q2.7060.83
28_S40_N2.6180.81
39_L97_R2.6100.81
20_D33_L2.4590.77
39_L43_I2.2760.71
21_Y36_A2.1190.65
27_L31_H2.1170.65
17_T35_E1.9700.59
50_I79_I1.8010.52
21_Y43_I1.7210.49
37_S112_A1.6440.45
21_Y101_Q1.6200.44
57_P103_G1.5870.43
82_F86_N1.5390.41
33_L100_S1.5330.41
21_Y97_R1.5250.40
62_G94_E1.4950.39
38_A115_A1.4190.36
18_A88_E1.4170.36
45_A119_A1.4050.36
67_L90_L1.3910.35
35_E51_F1.3270.33
22_L119_A1.3240.33
62_G122_I1.3060.32
21_Y39_L1.3050.32
40_N107_V1.2660.30
82_F112_A1.2220.29
29_F37_S1.1990.28
76_D127_E1.1890.28
37_S116_L1.1840.28
67_L83_T1.1580.27
15_L126_V1.1400.26
96_V122_I1.1340.26
60_T126_V1.0890.25
112_A116_L1.0720.24
23_K125_L1.0580.24
62_G65_E1.0580.24
38_A85_E1.0500.23
110_D124_K1.0340.23
35_E115_A1.0310.23
16_T35_E1.0270.23
49_L52_K1.0030.22
97_R107_V1.0020.22
64_R94_E0.9930.22
72_A118_T0.9860.21
35_E96_V0.9800.21
67_L110_D0.9750.21
22_L26_E0.9720.21
59_R93_L0.9720.21
49_L74_L0.9630.21
37_S119_A0.9610.21
9_T59_R0.9380.20
10_T60_T0.9380.20
17_T111_E0.9360.20
23_K30_E0.9350.20
24_A37_S0.9240.20
101_Q107_V0.9230.20
62_G98_G0.9230.20
93_L96_V0.9190.20
86_N95_N0.9160.19
38_A92_I0.9030.19
28_S126_V0.8900.19
81_D85_E0.8810.19
57_P60_T0.8700.18
48_S123_L0.8550.18
32_N109_R0.8510.18
40_N110_D0.8470.18
9_T118_T0.8420.18
85_E121_E0.8360.17
30_E63_I0.8210.17
98_G104_L0.8140.17
33_L58_P0.8040.17
77_K120_Q0.8030.17
63_I73_K0.8020.17
9_T37_S0.8000.17
55_I97_R0.7940.16
99_K107_V0.7920.16
109_R119_A0.7890.16
54_G118_T0.7750.16
19_K123_L0.7730.16
23_K33_L0.7710.16
44_S87_R0.7640.16
16_T56_E0.7610.16
70_I121_E0.7570.16
82_F92_I0.7520.15
24_A29_F0.7410.15
36_A39_L0.7350.15
24_A79_I0.7340.15
24_A28_S0.7330.15
27_L50_I0.7290.15
60_T104_L0.7290.15
42_E59_R0.7280.15
55_I101_Q0.7190.15
109_R112_A0.7110.15
30_E72_A0.7060.15
79_I121_E0.7040.14
51_F86_N0.7000.14
94_E125_L0.6960.14
12_R104_L0.6860.14
28_S111_E0.6840.14
68_S71_Y0.6780.14
67_L86_N0.6770.14
20_D35_E0.6740.14
43_I66_L0.6700.14
44_S93_L0.6650.14
62_G71_Y0.6640.14
16_T30_E0.6640.14
29_F77_K0.6640.14
48_S51_F0.6590.14
62_G126_V0.6550.13
27_L70_I0.6460.13
15_L19_K0.6460.13
60_T94_E0.6410.13
53_L74_L0.6380.13
88_E125_L0.6350.13
77_K81_D0.6310.13
107_V115_A0.6280.13
50_I73_K0.6260.13
45_A78_R0.6250.13
29_F33_L0.6230.13
31_H107_V0.6160.13
26_E69_L0.6130.13
14_L81_D0.6120.13
46_Q64_R0.6110.13
16_T106_P0.6090.13
11_Y122_I0.6070.13
113_E116_L0.6050.13
85_E122_I0.6040.12
22_L29_F0.6030.12
57_P126_V0.5970.12
27_L40_N0.5930.12
40_N111_E0.5920.12
27_L67_L0.5880.12
74_L127_E0.5850.12
32_N58_P0.5850.12
106_P120_Q0.5820.12
35_E62_G0.5810.12
11_Y87_R0.5790.12
9_T77_K0.5720.12
29_F78_R0.5710.12
86_N89_K0.5700.12
91_I95_N0.5700.12
95_N116_L0.5680.12
39_L110_D0.5630.12
95_N98_G0.5600.12
72_A78_R0.5550.12
32_N113_E0.5550.12
95_N105_P0.5530.12
43_I107_V0.5510.12
50_I113_E0.5510.12
18_A95_N0.5480.11
20_D78_R0.5460.11
36_A51_F0.5430.11
70_I123_L0.5410.11
75_G82_F0.5390.11
63_I123_L0.5380.11
42_E66_L0.5370.11
36_A101_Q0.5340.11
76_D106_P0.5270.11
67_L118_T0.5270.11
114_I117_S0.5250.11
36_A60_T0.5240.11
18_A47_L0.5170.11
51_F93_L0.5130.11
18_A55_I0.5110.11
12_R24_A0.5070.11
36_A43_I0.5050.11
19_K108_S0.5030.11
52_K74_L0.5020.11
117_S120_Q0.5010.11
15_L110_D0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4nqfA 2 0.9924 99.9 0.558 Contact Map
1ufbA 3 0.8788 99.8 0.579 Contact Map
3o10A 2 0.9621 99.8 0.583 Contact Map
1o3uA 2 0.8182 99.8 0.593 Contact Map
1wolA 1 0.8409 99.8 0.595 Contact Map
2hsbA 2 0.9015 99.7 0.618 Contact Map
2jpuA 1 0.7803 61.4 0.919 Contact Map
3jz0A 2 0.8636 26.2 0.935 Contact Map
3n71A 1 0.9697 17.6 0.94 Contact Map
2v6yA 1 0.5606 14.5 0.942 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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