GREMLIN Database
Q7LX87 - Uncharacterized protein
UniProt: Q7LX87 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 121 (111)
Sequences: 107 (95)
Seq/√Len: 9.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
15_E112_R3.8400.98
66_F87_W2.6690.84
7_A10_Y2.6280.83
93_G96_E2.5300.81
92_E98_S2.3940.77
49_E54_V2.3500.75
14_A21_G2.3010.74
66_F99_L2.2490.72
89_L111_V2.1270.68
11_Y115_V2.1200.67
11_Y33_A2.0880.66
20_K52_N2.0770.66
90_H96_E1.9650.61
50_I54_V1.9230.59
47_L88_T1.8410.56
6_S59_R1.7790.53
7_A42_V1.7490.52
90_H95_H1.7350.51
84_K107_L1.7290.51
54_V88_T1.6620.48
65_L83_W1.6480.48
90_H93_G1.6110.46
53_N57_K1.5880.45
45_N72_L1.5630.44
90_H94_F1.5350.43
109_E113_K1.5330.43
69_S74_S1.5110.42
62_S66_F1.4870.41
14_A18_L1.3930.37
87_W90_H1.3810.36
34_A85_S1.3590.35
50_I98_S1.3490.35
66_F92_E1.3430.35
39_K60_W1.2770.32
19_S105_K1.2740.32
38_I67_K1.2680.32
41_L83_W1.2460.31
12_E52_N1.2380.31
104_V111_V1.2250.30
42_V48_K1.2240.30
6_S40_L1.2220.30
112_R116_I1.2130.30
74_S102_K1.1810.29
78_E117_F1.1790.29
87_W114_L1.1710.28
100_N106_K1.1230.27
105_K116_I1.1150.26
37_A114_L1.1020.26
72_L79_I1.1000.26
112_R115_V1.0960.26
24_V62_S1.0930.26
85_S107_L1.0450.24
66_F98_S1.0260.23
91_V95_H1.0250.23
59_R90_H1.0240.23
47_L58_G1.0130.23
44_E72_L0.9990.23
67_K100_N0.9850.22
57_K72_L0.9850.22
88_T99_L0.9790.22
101_E115_V0.9780.22
53_N56_N0.9670.22
91_V96_E0.9560.21
100_N105_K0.9290.21
74_S106_K0.9180.20
23_L73_R0.9150.20
73_R100_N0.9080.20
63_E72_L0.9010.20
80_P105_K0.8970.20
23_L30_Y0.8970.20
45_N115_V0.8780.19
110_D114_L0.8640.19
78_E111_V0.8570.19
47_L75_N0.8570.19
59_R65_L0.8440.18
11_Y112_R0.8430.18
29_K36_E0.8400.18
7_A11_Y0.8360.18
91_V94_F0.8340.18
27_C39_K0.8320.18
24_V42_V0.8150.18
33_A50_I0.8140.18
38_I77_T0.8130.17
9_V34_A0.8070.17
58_G73_R0.8040.17
8_E53_N0.7770.17
69_S87_W0.7760.17
54_V64_N0.7750.17
9_V38_I0.7650.16
49_E72_L0.7640.16
86_A102_K0.7630.16
37_A67_K0.7610.16
54_V89_L0.7610.16
41_L65_L0.7420.16
18_L105_K0.7420.16
87_W95_H0.7410.16
10_Y34_A0.7390.16
12_E38_I0.7320.16
24_V65_L0.7200.15
19_S111_V0.7200.15
91_V98_S0.7130.15
17_F43_I0.7120.15
21_G83_W0.7100.15
22_D47_L0.7030.15
33_A43_I0.7000.15
47_L99_L0.6980.15
45_N76_N0.6980.15
15_E116_I0.6970.15
46_N65_L0.6890.15
15_E49_E0.6880.15
43_I52_N0.6790.14
23_L104_V0.6690.14
102_K109_E0.6650.14
9_V12_E0.6640.14
56_N102_K0.6540.14
18_L23_L0.6510.14
38_I103_E0.6470.14
48_K52_N0.6470.14
66_F88_T0.6420.14
21_G79_I0.6420.14
34_A109_E0.6370.14
65_L73_R0.6280.13
85_S111_V0.6260.13
17_F48_K0.6220.13
87_W93_G0.6190.13
50_I64_N0.6180.13
7_A12_E0.6130.13
37_A66_F0.6120.13
26_A111_V0.5990.13
53_N64_N0.5980.13
59_R95_H0.5970.13
38_I64_N0.5960.13
34_A83_W0.5950.13
22_D39_K0.5950.13
57_K61_K0.5910.13
40_L97_L0.5900.13
12_E75_N0.5890.13
69_S101_E0.5820.12
38_I41_L0.5790.12
38_I114_L0.5750.12
48_K111_V0.5750.12
55_K79_I0.5730.12
16_E56_N0.5670.12
11_Y114_L0.5620.12
30_Y61_K0.5560.12
30_Y40_L0.5480.12
16_E52_N0.5450.12
59_R91_V0.5420.12
101_E113_K0.5400.12
10_Y35_E0.5390.12
87_W96_E0.5380.12
56_N74_S0.5350.12
9_V43_I0.5340.12
26_A36_E0.5280.11
13_E77_T0.5240.11
10_Y13_E0.5190.11
47_L116_I0.5160.11
98_S117_F0.5110.11
17_F76_N0.5110.11
97_L103_E0.5100.11
57_K67_K0.5100.11
38_I55_K0.5080.11
22_D28_E0.5060.11
49_E89_L0.5020.11
48_K86_A0.5010.11
114_L117_F0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2jpuA 1 1 100 0.22 Contact Map
2hsbA 2 0.9174 93.1 0.89 Contact Map
1wolA 1 0.9091 83.7 0.908 Contact Map
1o3uA 2 0.8843 76.5 0.915 Contact Map
1ufbA 3 0.9091 69.7 0.919 Contact Map
4nqfA 2 0.9091 61 0.923 Contact Map
3o10A 2 0.9174 59.5 0.924 Contact Map
4fzpA 2 0.405 30.9 0.936 Contact Map
4iwbA 1 0.7438 17.9 0.943 Contact Map
1knyA 2 0.8347 17.5 0.943 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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