GREMLIN Database
Q7LX84 - Uncharacterized protein
UniProt: Q7LX84 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 269 (242)
Sequences: 8221 (6016)
Seq/√Len: 386.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
124_L170_R4.2781.00
131_D173_N3.5671.00
255_D260_H3.5601.00
96_K129_I3.5121.00
45_E77_R3.4421.00
250_S253_I3.3251.00
224_D256_K3.2071.00
124_L171_F2.8481.00
129_I132_N2.7881.00
99_I135_L2.7831.00
81_F106_G2.6031.00
256_K260_H2.5401.00
259_K263_E2.4271.00
94_E97_R2.3271.00
65_R97_R2.3251.00
80_K104_P2.2981.00
223_S253_I2.2971.00
131_D171_F2.2111.00
223_S256_K2.1311.00
96_K133_H2.1061.00
82_I98_S2.0281.00
256_K264_K1.9891.00
129_I133_H1.9671.00
71_V80_K1.8971.00
116_F122_R1.8841.00
79_V105_V1.8671.00
51_R79_V1.8071.00
168_A176_I1.7961.00
128_E132_N1.7761.00
42_D46_S1.7711.00
227_L261_N1.6961.00
177_I265_L1.6611.00
128_E171_F1.6541.00
200_Y265_L1.6521.00
6_F52_F1.6421.00
253_I256_K1.6401.00
175_K265_L1.6351.00
131_D174_M1.6321.00
68_P72_I1.5901.00
124_L128_E1.5821.00
134_G175_K1.5711.00
36_G39_E1.5711.00
119_L166_E1.5691.00
251_Q255_D1.5531.00
69_N73_N1.5511.00
95_L126_I1.5401.00
68_P102_F1.5331.00
61_T94_E1.5281.00
50_K259_K1.5141.00
134_G173_N1.5081.00
92_D129_I1.5051.00
175_K200_Y1.4831.00
227_L265_L1.4711.00
255_D259_K1.4691.00
81_F266_V1.4651.00
99_I133_H1.4551.00
127_Y167_I1.4351.00
169_V196_K1.4261.00
251_Q254_K1.4041.00
97_R102_F1.3761.00
256_K261_N1.3741.00
130_I137_V1.3651.00
98_S104_P1.3621.00
41_L74_L1.3611.00
82_I104_P1.3511.00
97_R101_E1.3421.00
96_K132_N1.3201.00
242_E245_K1.3101.00
125_K128_E1.3001.00
260_H263_E1.2861.00
134_G267_K1.2661.00
245_K254_K1.2631.00
4_F227_L1.2521.00
41_L45_E1.2521.00
39_E42_D1.2481.00
159_G178_L1.2441.00
54_V78_I1.2441.00
241_L245_K1.2391.00
95_L107_V1.2381.00
185_W188_E1.2301.00
61_T65_R1.2281.00
208_P211_I1.2211.00
107_V130_I1.2191.00
66_R69_N1.2121.00
254_K258_L1.2021.00
25_I28_F1.1761.00
66_R70_Q1.1651.00
4_F266_V1.1641.00
136_I265_L1.1591.00
93_E96_K1.1581.00
95_L133_H1.1571.00
131_D134_G1.1561.00
238_E242_E1.1551.00
38_K73_N1.1471.00
200_Y264_K1.1381.00
128_E131_D1.1271.00
166_E169_V1.1211.00
40_T52_F1.1201.00
242_E246_S1.1131.00
187_E191_A1.1041.00
67_I80_K1.0971.00
68_P104_P1.0941.00
168_A199_V1.0921.00
252_D256_K1.0901.00
95_L130_I1.0831.00
263_E267_K1.0821.00
188_E191_A1.0761.00
262_A266_V1.0751.00
69_N72_I1.0601.00
168_A198_N1.0581.00
244_F258_L1.0521.00
84_V91_A1.0511.00
44_Y52_F1.0381.00
89_P92_D1.0331.00
92_D96_K1.0301.00
51_R263_E1.0221.00
223_S257_I1.0181.00
121_E124_L1.0151.00
43_Y46_S1.0141.00
90_N93_E1.0131.00
250_S254_K1.0031.00
189_A194_L1.0011.00
96_K101_E1.0001.00
127_Y137_V0.9891.00
138_V179_A0.9881.00
123_A127_Y0.9831.00
200_Y225_K0.9811.00
140_H231_D0.9801.00
249_L254_K0.9711.00
108_K111_P0.9701.00
240_W243_E0.9671.00
41_L77_R0.9631.00
98_S102_F0.9551.00
207_A210_Y0.9541.00
208_P212_P0.9521.00
239_R242_E0.9321.00
2_I262_A0.9311.00
92_D125_K0.9261.00
260_H264_K0.9221.00
127_Y171_F0.9211.00
127_Y174_M0.9181.00
249_L253_I0.9181.00
28_F31_K0.9171.00
52_F78_I0.9141.00
177_I227_L0.9131.00
38_K42_D0.9121.00
61_T97_R0.9091.00
227_L262_A0.9081.00
37_L73_N0.9041.00
94_E98_S0.9001.00
65_R69_N0.9001.00
215_I218_N0.9001.00
95_L129_I0.8971.00
81_F138_V0.8841.00
4_F177_I0.8831.00
200_Y261_N0.8821.00
244_F247_V0.8791.00
53_V79_V0.8781.00
248_N254_K0.8691.00
116_F123_A0.8681.00
71_V104_P0.8661.00
2_I263_E0.8631.00
107_V135_L0.8611.00
166_E170_R0.8551.00
6_F40_T0.8541.00
107_V137_V0.8501.00
191_A195_H0.8471.00
175_K264_K0.8421.00
136_I177_I0.8391.00
64_G68_P0.8381.00
252_D260_H0.8371.00
165_D169_V0.8301.00
121_E170_R0.8301.00
2_I51_R0.8291.00
82_I107_V0.8261.00
213_Q219_A0.8251.00
124_L127_Y0.8231.00
4_F262_A0.8231.00
186_T190_I0.8211.00
138_V266_V0.8191.00
189_A192_I0.8131.00
44_Y77_R0.8061.00
85_D94_E0.8021.00
75_D78_I0.8011.00
11_K34_V0.8001.00
91_A126_I0.7991.00
51_R76_D0.7991.00
116_F120_D0.7901.00
179_A202_D0.7901.00
212_P219_A0.7881.00
53_V81_F0.7871.00
224_D264_K0.7861.00
86_P126_I0.7721.00
226_L257_I0.7711.00
42_D45_E0.7701.00
185_W189_A0.7681.00
8_A67_I0.7671.00
62_F65_R0.7631.00
51_R78_I0.7631.00
218_N226_L0.7631.00
228_F258_L0.7621.00
125_K129_I0.7551.00
141_T182_G0.7541.00
214_V219_A0.7531.00
54_V67_I0.7511.00
181_F206_W0.7511.00
47_F238_E0.7471.00
159_G199_V0.7471.00
71_V78_I0.7461.00
119_L161_P0.7451.00
99_I129_I0.7431.00
259_K262_A0.7431.00
178_L199_V0.7411.00
46_S238_E0.7401.00
65_R94_E0.7351.00
8_A37_L0.7351.00
237_P240_W0.7341.00
53_V266_V0.7331.00
92_D132_N0.7331.00
201_L204_S0.7311.00
44_Y49_I0.7311.00
126_I130_I0.7301.00
84_V126_I0.7271.00
119_L163_Y0.7251.00
203_L257_I0.7251.00
201_L221_R0.7201.00
222_L253_I0.7091.00
162_I168_A0.7071.00
122_R125_K0.7071.00
106_G138_V0.7041.00
201_L226_L0.7041.00
37_L41_L0.7031.00
164_F178_L0.6971.00
25_I30_A0.6930.99
44_Y78_I0.6910.99
256_K259_K0.6870.99
165_D192_I0.6860.99
199_V202_D0.6860.99
38_K74_L0.6860.99
209_R213_Q0.6830.99
198_N203_L0.6810.99
212_P215_I0.6780.99
12_E62_F0.6770.99
139_F176_I0.6770.99
27_Y30_A0.6750.99
210_Y213_Q0.6740.99
211_I215_I0.6730.99
130_I133_H0.6700.99
245_K258_L0.6670.99
3_D230_S0.6650.99
41_L44_Y0.6590.99
261_N264_K0.6570.99
10_V34_V0.6560.99
35_K43_Y0.6550.99
198_N202_D0.6540.99
57_I60_T0.6540.99
188_E192_I0.6530.99
219_A253_I0.6520.99
241_L244_F0.6500.99
138_V177_I0.6500.99
67_I71_V0.6480.99
82_I95_L0.6480.99
209_R214_V0.6450.99
186_T191_A0.6440.99
175_K198_N0.6430.99
84_V107_V0.6390.99
239_R243_E0.6390.99
2_I259_K0.6380.99
3_D6_F0.6380.99
158_Y161_P0.6380.99
5_H202_D0.6380.99
81_F177_I0.6360.99
89_P125_K0.6350.99
95_L99_I0.6340.99
165_D196_K0.6330.99
55_L138_V0.6320.99
108_K180_H0.6310.99
202_D229_G0.6300.99
175_K225_K0.6290.99
37_L70_Q0.6270.99
119_L124_L0.6250.99
243_E246_S0.6250.99
136_I175_K0.6230.99
180_H231_D0.6230.99
249_L257_I0.6210.99
186_T189_A0.6200.99
162_I166_E0.6190.99
207_A211_I0.6170.99
26_K29_N0.6130.99
138_V202_D0.6100.99
68_P101_E0.6100.99
72_I102_F0.6080.99
38_K41_L0.6070.99
162_I167_I0.6070.99
235_I240_W0.6030.99
193_A201_L0.5990.98
168_A196_K0.5960.98
210_Y214_V0.5930.98
198_N204_S0.5920.98
63_L67_I0.5900.98
65_R102_F0.5890.98
65_R98_S0.5880.98
208_P214_V0.5860.98
209_R212_P0.5860.98
29_N32_V0.5850.98
199_V203_L0.5840.98
177_I266_V0.5760.98
10_V13_F0.5760.98
203_L226_L0.5760.98
108_K112_Q0.5760.98
192_I195_H0.5710.98
39_E43_Y0.5710.98
63_L66_R0.5700.98
187_E194_L0.5690.98
189_A193_A0.5680.98
124_L167_I0.5680.98
68_P80_K0.5650.98
29_N33_E0.5650.98
70_Q78_I0.5620.98
240_W244_F0.5590.98
84_V88_K0.5590.98
211_I214_V0.5580.98
223_S261_N0.5580.98
64_G80_K0.5540.98
41_L78_I0.5530.97
55_L81_F0.5520.97
199_V204_S0.5520.97
4_F53_V0.5520.97
45_E76_D0.5500.97
58_D110_H0.5470.97
165_D168_A0.5470.97
190_I194_L0.5450.97
211_I218_N0.5450.97
207_A214_V0.5400.97
137_V174_M0.5390.97
72_I103_E0.5350.97
5_H180_H0.5340.97
31_K39_E0.5330.97
185_W190_I0.5330.97
208_P246_S0.5260.97
109_L137_V0.5250.97
190_I193_A0.5250.97
28_F32_V0.5240.97
91_A94_E0.5240.97
240_W247_V0.5220.96
56_P59_S0.5210.96
238_E241_L0.5200.96
74_L77_R0.5190.96
56_P63_L0.5180.96
43_Y232_F0.5180.96
164_F168_A0.5160.96
141_T164_F0.5150.96
96_K99_I0.5150.96
141_T178_L0.5140.96
74_L78_I0.5130.96
33_E39_E0.5120.96
108_K179_A0.5110.96
58_D83_S0.5080.96
118_P163_Y0.5040.96
184_P187_E0.5020.96
184_P189_A0.5020.96
169_V195_H0.5010.96
26_K30_A0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2hbvA 3 0.9814 100 0.301 Contact Map
4lanA 2 0.9888 100 0.312 Contact Map
4ofcA 4 0.9888 100 0.316 Contact Map
3irsA 3 0.9703 100 0.322 Contact Map
4di9A 1 0.8959 100 0.329 Contact Map
4qrnA 2 0.9814 100 0.329 Contact Map
3nurA 2 0.9331 100 0.33 Contact Map
4qroA 5 0.9888 100 0.333 Contact Map
4l6dA 4 0.9851 100 0.335 Contact Map
2f6kA 4 0.9777 100 0.336 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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