Q7LX84 - SULSO - GREMLIN Contacts

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Q7LX84 - Uncharacterized protein

UniProt:	Q7LX84	Sequences: MIDFHFHAPVKEFLDFLGEFGEPAIKYFNAKVEVKGLKETLDYYESFGIKRFVVLPIDSTTFLGRRIPNQVINLDDRIVKFISVDPSKPNADEELKRSIKEFEPVGVKLHPQLQGFHPLDERALKIYEIIDNHGLIVVFHTGTSGIGAGVKSSIRLDYGRPIYFDEIAVRFQNMKIILAHFGWPWTEEAIAIALHKPNVYLDLSGWAPRYIPQVIWSNAKRLSDKLLFGSDFPLIRPERWLEEFKSVNLSQDIKDKILKHNAEKLVKKS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	269 (242)
Sequences:	8221 (6016)
Seq/√Len:	386.7

SULSO - Q7LX84 Q97YW2 Q97UJ5 Q97XR6 Q97Z10

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
124_L	170_R	4.278	1.00
131_D	173_N	3.567	1.00
255_D	260_H	3.560	1.00
96_K	129_I	3.512	1.00
45_E	77_R	3.442	1.00
250_S	253_I	3.325	1.00
224_D	256_K	3.207	1.00
124_L	171_F	2.848	1.00
129_I	132_N	2.788	1.00
99_I	135_L	2.783	1.00
81_F	106_G	2.603	1.00
256_K	260_H	2.540	1.00
259_K	263_E	2.427	1.00
94_E	97_R	2.327	1.00
65_R	97_R	2.325	1.00
80_K	104_P	2.298	1.00
223_S	253_I	2.297	1.00
131_D	171_F	2.211	1.00
223_S	256_K	2.131	1.00
96_K	133_H	2.106	1.00
82_I	98_S	2.028	1.00
256_K	264_K	1.989	1.00
129_I	133_H	1.967	1.00
71_V	80_K	1.897	1.00
116_F	122_R	1.884	1.00
79_V	105_V	1.867	1.00
51_R	79_V	1.807	1.00
168_A	176_I	1.796	1.00
128_E	132_N	1.776	1.00
42_D	46_S	1.771	1.00
227_L	261_N	1.696	1.00
177_I	265_L	1.661	1.00
128_E	171_F	1.654	1.00
200_Y	265_L	1.652	1.00
6_F	52_F	1.642	1.00
253_I	256_K	1.640	1.00
175_K	265_L	1.635	1.00
131_D	174_M	1.632	1.00
68_P	72_I	1.590	1.00
124_L	128_E	1.582	1.00
134_G	175_K	1.571	1.00
36_G	39_E	1.571	1.00
119_L	166_E	1.569	1.00
251_Q	255_D	1.553	1.00
69_N	73_N	1.551	1.00
95_L	126_I	1.540	1.00
68_P	102_F	1.533	1.00
61_T	94_E	1.528	1.00
50_K	259_K	1.514	1.00
134_G	173_N	1.508	1.00
92_D	129_I	1.505	1.00
175_K	200_Y	1.483	1.00
227_L	265_L	1.471	1.00
255_D	259_K	1.469	1.00
81_F	266_V	1.465	1.00
99_I	133_H	1.455	1.00
127_Y	167_I	1.435	1.00
169_V	196_K	1.426	1.00
251_Q	254_K	1.404	1.00
97_R	102_F	1.376	1.00
256_K	261_N	1.374	1.00
130_I	137_V	1.365	1.00
98_S	104_P	1.362	1.00
41_L	74_L	1.361	1.00
82_I	104_P	1.351	1.00
97_R	101_E	1.342	1.00
96_K	132_N	1.320	1.00
242_E	245_K	1.310	1.00
125_K	128_E	1.300	1.00
260_H	263_E	1.286	1.00
134_G	267_K	1.266	1.00
245_K	254_K	1.263	1.00
4_F	227_L	1.252	1.00
41_L	45_E	1.252	1.00
39_E	42_D	1.248	1.00
159_G	178_L	1.244	1.00
54_V	78_I	1.244	1.00
241_L	245_K	1.239	1.00
95_L	107_V	1.238	1.00
185_W	188_E	1.230	1.00
61_T	65_R	1.228	1.00
208_P	211_I	1.221	1.00
107_V	130_I	1.219	1.00
66_R	69_N	1.212	1.00
254_K	258_L	1.202	1.00
25_I	28_F	1.176	1.00
66_R	70_Q	1.165	1.00
4_F	266_V	1.164	1.00
136_I	265_L	1.159	1.00
93_E	96_K	1.158	1.00
95_L	133_H	1.157	1.00
131_D	134_G	1.156	1.00
238_E	242_E	1.155	1.00
38_K	73_N	1.147	1.00
200_Y	264_K	1.138	1.00
128_E	131_D	1.127	1.00
166_E	169_V	1.121	1.00
40_T	52_F	1.120	1.00
242_E	246_S	1.113	1.00
187_E	191_A	1.104	1.00
67_I	80_K	1.097	1.00
68_P	104_P	1.094	1.00
168_A	199_V	1.092	1.00
252_D	256_K	1.090	1.00
95_L	130_I	1.083	1.00
263_E	267_K	1.082	1.00
188_E	191_A	1.076	1.00
262_A	266_V	1.075	1.00
69_N	72_I	1.060	1.00
168_A	198_N	1.058	1.00
244_F	258_L	1.052	1.00
84_V	91_A	1.051	1.00
44_Y	52_F	1.038	1.00
89_P	92_D	1.033	1.00
92_D	96_K	1.030	1.00
51_R	263_E	1.022	1.00
223_S	257_I	1.018	1.00
121_E	124_L	1.015	1.00
43_Y	46_S	1.014	1.00
90_N	93_E	1.013	1.00
250_S	254_K	1.003	1.00
189_A	194_L	1.001	1.00
96_K	101_E	1.000	1.00
127_Y	137_V	0.989	1.00
138_V	179_A	0.988	1.00
123_A	127_Y	0.983	1.00
200_Y	225_K	0.981	1.00
140_H	231_D	0.980	1.00
249_L	254_K	0.971	1.00
108_K	111_P	0.970	1.00
240_W	243_E	0.967	1.00
41_L	77_R	0.963	1.00
98_S	102_F	0.955	1.00
207_A	210_Y	0.954	1.00
208_P	212_P	0.952	1.00
239_R	242_E	0.932	1.00
2_I	262_A	0.931	1.00
92_D	125_K	0.926	1.00
260_H	264_K	0.922	1.00
127_Y	171_F	0.921	1.00
127_Y	174_M	0.918	1.00
249_L	253_I	0.918	1.00
28_F	31_K	0.917	1.00
52_F	78_I	0.914	1.00
177_I	227_L	0.913	1.00
38_K	42_D	0.912	1.00
61_T	97_R	0.909	1.00
227_L	262_A	0.908	1.00
37_L	73_N	0.904	1.00
94_E	98_S	0.900	1.00
65_R	69_N	0.900	1.00
215_I	218_N	0.900	1.00
95_L	129_I	0.897	1.00
81_F	138_V	0.884	1.00
4_F	177_I	0.883	1.00
200_Y	261_N	0.882	1.00
244_F	247_V	0.879	1.00
53_V	79_V	0.878	1.00
248_N	254_K	0.869	1.00
116_F	123_A	0.868	1.00
71_V	104_P	0.866	1.00
2_I	263_E	0.863	1.00
107_V	135_L	0.861	1.00
166_E	170_R	0.855	1.00
6_F	40_T	0.854	1.00
107_V	137_V	0.850	1.00
191_A	195_H	0.847	1.00
175_K	264_K	0.842	1.00
136_I	177_I	0.839	1.00
64_G	68_P	0.838	1.00
252_D	260_H	0.837	1.00
165_D	169_V	0.830	1.00
121_E	170_R	0.830	1.00
2_I	51_R	0.829	1.00
82_I	107_V	0.826	1.00
213_Q	219_A	0.825	1.00
124_L	127_Y	0.823	1.00
4_F	262_A	0.823	1.00
186_T	190_I	0.821	1.00
138_V	266_V	0.819	1.00
189_A	192_I	0.813	1.00
44_Y	77_R	0.806	1.00
85_D	94_E	0.802	1.00
75_D	78_I	0.801	1.00
11_K	34_V	0.800	1.00
91_A	126_I	0.799	1.00
51_R	76_D	0.799	1.00
116_F	120_D	0.790	1.00
179_A	202_D	0.790	1.00
212_P	219_A	0.788	1.00
53_V	81_F	0.787	1.00
224_D	264_K	0.786	1.00
86_P	126_I	0.772	1.00
226_L	257_I	0.771	1.00
42_D	45_E	0.770	1.00
185_W	189_A	0.768	1.00
8_A	67_I	0.767	1.00
62_F	65_R	0.763	1.00
51_R	78_I	0.763	1.00
218_N	226_L	0.763	1.00
228_F	258_L	0.762	1.00
125_K	129_I	0.755	1.00
141_T	182_G	0.754	1.00
214_V	219_A	0.753	1.00
54_V	67_I	0.751	1.00
181_F	206_W	0.751	1.00
47_F	238_E	0.747	1.00
159_G	199_V	0.747	1.00
71_V	78_I	0.746	1.00
119_L	161_P	0.745	1.00
99_I	129_I	0.743	1.00
259_K	262_A	0.743	1.00
178_L	199_V	0.741	1.00
46_S	238_E	0.740	1.00
65_R	94_E	0.735	1.00
8_A	37_L	0.735	1.00
237_P	240_W	0.734	1.00
53_V	266_V	0.733	1.00
92_D	132_N	0.733	1.00
201_L	204_S	0.731	1.00
44_Y	49_I	0.731	1.00
126_I	130_I	0.730	1.00
84_V	126_I	0.727	1.00
119_L	163_Y	0.725	1.00
203_L	257_I	0.725	1.00
201_L	221_R	0.720	1.00
222_L	253_I	0.709	1.00
162_I	168_A	0.707	1.00
122_R	125_K	0.707	1.00
106_G	138_V	0.704	1.00
201_L	226_L	0.704	1.00
37_L	41_L	0.703	1.00
164_F	178_L	0.697	1.00
25_I	30_A	0.693	0.99
44_Y	78_I	0.691	0.99
256_K	259_K	0.687	0.99
165_D	192_I	0.686	0.99
199_V	202_D	0.686	0.99
38_K	74_L	0.686	0.99
209_R	213_Q	0.683	0.99
198_N	203_L	0.681	0.99
212_P	215_I	0.678	0.99
12_E	62_F	0.677	0.99
139_F	176_I	0.677	0.99
27_Y	30_A	0.675	0.99
210_Y	213_Q	0.674	0.99
211_I	215_I	0.673	0.99
130_I	133_H	0.670	0.99
245_K	258_L	0.667	0.99
3_D	230_S	0.665	0.99
41_L	44_Y	0.659	0.99
261_N	264_K	0.657	0.99
10_V	34_V	0.656	0.99
35_K	43_Y	0.655	0.99
198_N	202_D	0.654	0.99
57_I	60_T	0.654	0.99
188_E	192_I	0.653	0.99
219_A	253_I	0.652	0.99
241_L	244_F	0.650	0.99
138_V	177_I	0.650	0.99
67_I	71_V	0.648	0.99
82_I	95_L	0.648	0.99
209_R	214_V	0.645	0.99
186_T	191_A	0.644	0.99
175_K	198_N	0.643	0.99
84_V	107_V	0.639	0.99
239_R	243_E	0.639	0.99
2_I	259_K	0.638	0.99
3_D	6_F	0.638	0.99
158_Y	161_P	0.638	0.99
5_H	202_D	0.638	0.99
81_F	177_I	0.636	0.99
89_P	125_K	0.635	0.99
95_L	99_I	0.634	0.99
165_D	196_K	0.633	0.99
55_L	138_V	0.632	0.99
108_K	180_H	0.631	0.99
202_D	229_G	0.630	0.99
175_K	225_K	0.629	0.99
37_L	70_Q	0.627	0.99
119_L	124_L	0.625	0.99
243_E	246_S	0.625	0.99
136_I	175_K	0.623	0.99
180_H	231_D	0.623	0.99
249_L	257_I	0.621	0.99
186_T	189_A	0.620	0.99
162_I	166_E	0.619	0.99
207_A	211_I	0.617	0.99
26_K	29_N	0.613	0.99
138_V	202_D	0.610	0.99
68_P	101_E	0.610	0.99
72_I	102_F	0.608	0.99
38_K	41_L	0.607	0.99
162_I	167_I	0.607	0.99
235_I	240_W	0.603	0.99
193_A	201_L	0.599	0.98
168_A	196_K	0.596	0.98
210_Y	214_V	0.593	0.98
198_N	204_S	0.592	0.98
63_L	67_I	0.590	0.98
65_R	102_F	0.589	0.98
65_R	98_S	0.588	0.98
208_P	214_V	0.586	0.98
209_R	212_P	0.586	0.98
29_N	32_V	0.585	0.98
199_V	203_L	0.584	0.98
177_I	266_V	0.576	0.98
10_V	13_F	0.576	0.98
203_L	226_L	0.576	0.98
108_K	112_Q	0.576	0.98
192_I	195_H	0.571	0.98
39_E	43_Y	0.571	0.98
63_L	66_R	0.570	0.98
187_E	194_L	0.569	0.98
189_A	193_A	0.568	0.98
124_L	167_I	0.568	0.98
68_P	80_K	0.565	0.98
29_N	33_E	0.565	0.98
70_Q	78_I	0.562	0.98
240_W	244_F	0.559	0.98
84_V	88_K	0.559	0.98
211_I	214_V	0.558	0.98
223_S	261_N	0.558	0.98
64_G	80_K	0.554	0.98
41_L	78_I	0.553	0.97
55_L	81_F	0.552	0.97
199_V	204_S	0.552	0.97
4_F	53_V	0.552	0.97
45_E	76_D	0.550	0.97
58_D	110_H	0.547	0.97
165_D	168_A	0.547	0.97
190_I	194_L	0.545	0.97
211_I	218_N	0.545	0.97
207_A	214_V	0.540	0.97
137_V	174_M	0.539	0.97
72_I	103_E	0.535	0.97
5_H	180_H	0.534	0.97
31_K	39_E	0.533	0.97
185_W	190_I	0.533	0.97
208_P	246_S	0.526	0.97
109_L	137_V	0.525	0.97
190_I	193_A	0.525	0.97
28_F	32_V	0.524	0.97
91_A	94_E	0.524	0.97
240_W	247_V	0.522	0.96
56_P	59_S	0.521	0.96
238_E	241_L	0.520	0.96
74_L	77_R	0.519	0.96
56_P	63_L	0.518	0.96
43_Y	232_F	0.518	0.96
164_F	168_A	0.516	0.96
141_T	164_F	0.515	0.96
96_K	99_I	0.515	0.96
141_T	178_L	0.514	0.96
74_L	78_I	0.513	0.96
33_E	39_E	0.512	0.96
108_K	179_A	0.511	0.96
58_D	83_S	0.508	0.96
118_P	163_Y	0.504	0.96
184_P	187_E	0.502	0.96
184_P	189_A	0.502	0.96
169_V	195_H	0.501	0.96
26_K	30_A	0.500	0.95

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2hbvA	3	0.9814	100	0.301	Contact Map
4lanA	2	0.9888	100	0.312	Contact Map
4ofcA	4	0.9888	100	0.316	Contact Map
3irsA	3	0.9703	100	0.322	Contact Map
4di9A	1	0.8959	100	0.329	Contact Map
4qrnA	2	0.9814	100	0.329	Contact Map
3nurA	2	0.9331	100	0.33	Contact Map
4qroA	5	0.9888	100	0.333	Contact Map
4l6dA	4	0.9851	100	0.335	Contact Map
2f6kA	4	0.9777	100	0.336	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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