GREMLIN Database
Q7LX83 - Metabolite permease, putative
UniProt: Q7LX83 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 526 (460)
Sequences: 11669 (7377)
Seq/√Len: 343.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
458_G501_I5.7801.00
389_S392_T4.1471.00
447_L502_G3.8581.00
289_S292_S3.8101.00
458_G497_I3.4721.00
23_F27_Y3.4421.00
503_L507_A3.2541.00
183_A405_K3.2451.00
214_I218_L3.2301.00
381_I388_M3.2251.00
225_G228_H3.1001.00
455_G502_G3.0911.00
448_N509_A3.0371.00
454_G505_G3.0261.00
501_I505_G3.0171.00
385_K392_T2.9751.00
505_G509_A2.9351.00
462_S497_I2.9301.00
450_Y509_A2.8481.00
391_S395_A2.8211.00
395_A399_W2.7531.00
216_V316_L2.7121.00
120_K129_A2.6211.00
170_A173_L2.6071.00
440_L502_G2.6001.00
451_A506_T2.5801.00
179_F409_L2.4851.00
16_I20_I2.3751.00
399_W403_A2.3521.00
17_L21_F2.3441.00
40_H47_R2.3441.00
49_L195_A2.3301.00
191_L286_S2.3111.00
288_D292_S2.3041.00
454_G501_I2.1811.00
317_V336_A2.1811.00
225_G229_N2.1601.00
228_H232_T2.1451.00
450_Y454_G2.1101.00
41_E46_G2.1001.00
19_V23_F2.0781.00
388_M392_T2.0781.00
448_N451_A2.0551.00
385_K388_M2.0311.00
176_L180_I2.0191.00
120_K126_R2.0181.00
127_I453_V2.0111.00
444_T447_L1.9991.00
118_F441_G1.9861.00
437_S452_L1.9771.00
210_I214_I1.9671.00
381_I385_K1.9651.00
73_S334_A1.9441.00
500_A504_I1.9201.00
123_F447_L1.9121.00
378_R382_K1.9071.00
65_A150_G1.9011.00
82_G85_A1.8851.00
461_F465_Y1.8791.00
406_F410_A1.8711.00
292_S295_L1.8601.00
231_Q234_S1.8591.00
291_K295_L1.8501.00
124_N127_I1.8451.00
339_A343_Y1.8401.00
228_H231_Q1.8401.00
448_N506_T1.8341.00
208_T356_G1.8241.00
446_K507_A1.8181.00
381_I396_L1.8121.00
444_T507_A1.7971.00
112_Y121_D1.7961.00
440_L499_L1.7901.00
182_L365_A1.7821.00
53_L199_V1.7761.00
24_L200_Y1.7541.00
451_A455_G1.7521.00
451_A505_G1.7501.00
382_K393_E1.7491.00
224_S228_H1.7471.00
291_K294_K1.7151.00
395_A398_K1.7071.00
321_S343_Y1.6921.00
44_L47_R1.6771.00
392_T395_A1.6761.00
189_S193_G1.6591.00
51_P292_S1.6051.00
376_L400_I1.5921.00
444_T503_L1.5881.00
376_L380_I1.5761.00
56_F199_V1.5721.00
351_G355_L1.5671.00
229_N232_T1.5601.00
180_I184_A1.5381.00
172_D413_F1.5341.00
369_A405_K1.5231.00
454_G458_G1.5181.00
99_F439_F1.5091.00
11_V15_I1.5051.00
381_I392_T1.5011.00
446_K510_Y1.5001.00
21_F25_G1.4981.00
458_G462_S1.4981.00
388_M393_E1.4781.00
496_L500_A1.4531.00
124_N449_G1.4471.00
117_D379_N1.4331.00
328_A331_H1.4291.00
54_M287_S1.4191.00
152_Q175_L1.4171.00
135_T460_M1.3941.00
227_F231_Q1.3931.00
372_A404_F1.3841.00
126_R130_G1.3841.00
20_I24_L1.3781.00
175_L409_L1.3661.00
15_I19_V1.3481.00
448_N510_Y1.3411.00
117_D378_R1.3351.00
173_L176_L1.3301.00
465_Y469_L1.3181.00
446_K511_G1.3051.00
497_I501_I1.3031.00
223_F227_F1.3021.00
122_R441_G1.3011.00
179_F405_K1.2881.00
43_A397_A1.2871.00
182_L362_L1.2871.00
198_A283_A1.2831.00
173_L177_V1.2731.00
38_K41_E1.2721.00
22_V25_G1.2701.00
126_R383_E1.2671.00
153_V332_S1.2591.00
134_I138_V1.2501.00
114_T374_N1.2481.00
197_T366_A1.2421.00
462_S501_I1.2401.00
376_L381_I1.2361.00
493_L496_L1.2311.00
224_S227_F1.2311.00
221_G225_G1.2271.00
132_V456_W1.2251.00
496_L499_L1.2211.00
12_A16_I1.2201.00
172_D176_L1.2191.00
10_S348_W1.2131.00
220_F226_A1.2131.00
21_F200_Y1.2121.00
392_T396_L1.2111.00
169_L174_S1.2101.00
61_D367_I1.2081.00
120_K383_E1.2011.00
55_W299_L1.1951.00
151_M178_A1.1951.00
410_A414_A1.1891.00
128_L453_V1.1891.00
222_G225_G1.1791.00
394_S398_K1.1751.00
148_I179_F1.1621.00
260_R263_Y1.1591.00
17_L25_G1.1571.00
377_T396_L1.1551.00
499_L503_L1.1451.00
450_Y505_G1.1431.00
131_L453_V1.1431.00
134_I380_I1.1411.00
57_L367_I1.1401.00
338_P341_I1.1361.00
109_N290_K1.1281.00
215_Y219_A1.1211.00
45_A191_L1.1201.00
455_G498_N1.1191.00
422_Q426_L1.1181.00
156_L171_S1.1181.00
118_F122_R1.1151.00
377_T397_A1.1141.00
59_T303_Y1.1131.00
203_I207_G1.1121.00
176_L409_L1.1121.00
388_M396_L1.1091.00
397_A401_S1.1061.00
390_P393_E1.1011.00
449_G453_V1.1001.00
198_A366_A1.0971.00
234_S237_I1.0951.00
229_N233_L1.0941.00
129_A379_N1.0911.00
176_L413_F1.0911.00
128_L452_L1.0891.00
448_N505_G1.0861.00
326_F330_T1.0821.00
207_G211_S1.0731.00
144_I408_A1.0711.00
20_I200_Y1.0691.00
341_I353_A1.0601.00
446_K512_A1.0571.00
87_F91_V1.0561.00
185_F366_A1.0531.00
437_S456_W1.0481.00
81_V84_F1.0461.00
254_P257_L1.0441.00
396_L400_I1.0431.00
339_A342_G1.0391.00
219_A320_N1.0371.00
491_G495_T1.0351.00
12_A15_I1.0281.00
483_T486_G1.0281.00
101_P294_K1.0261.00
45_A49_L1.0241.00
187_F402_T1.0221.00
148_I175_L1.0171.00
455_G459_G1.0141.00
332_S335_V1.0131.00
433_Q498_N1.0101.00
201_K366_A1.0101.00
447_L451_A1.0091.00
185_F362_L1.0081.00
211_S349_F1.0051.00
57_L60_A1.0011.00
501_I504_I1.0011.00
26_F30_R0.9991.00
75_V82_G0.9981.00
110_R121_D0.9971.00
40_H111_G0.9971.00
457_A461_F0.9961.00
229_N319_A0.9951.00
51_P55_W0.9941.00
400_I403_A0.9931.00
20_I23_F0.9881.00
450_Y508_I0.9871.00
441_G452_L0.9851.00
211_S215_Y0.9851.00
101_P290_K0.9801.00
130_G384_F0.9771.00
123_F441_G0.9741.00
127_I449_G0.9741.00
314_G318_Y0.9711.00
127_I131_L0.9681.00
17_L362_L0.9631.00
119_I132_V0.9621.00
504_I507_A0.9591.00
262_A266_L0.9581.00
373_A377_T0.9581.00
36_L41_E0.9561.00
447_L506_T0.9551.00
43_A374_N0.9511.00
131_L456_W0.9471.00
22_V26_F0.9471.00
182_L366_A0.9441.00
227_F230_A0.9411.00
341_I350_V0.9411.00
316_L320_N0.9381.00
376_L404_F0.9341.00
145_A411_L0.9331.00
198_A367_I0.9291.00
218_L223_F0.9281.00
403_A407_L0.9261.00
74_L78_S0.9241.00
77_A333_G0.9241.00
440_L447_L0.9241.00
217_P222_G0.9221.00
18_F21_F0.9201.00
440_L503_L0.9171.00
23_F26_F0.9161.00
51_P295_L0.9151.00
226_A229_N0.9151.00
490_I494_S0.9131.00
260_R265_S0.9071.00
370_I373_A0.9071.00
61_D198_A0.8991.00
163_G170_A0.8981.00
94_F98_L0.8971.00
287_S293_L0.8941.00
162_L169_L0.8931.00
53_L195_A0.8911.00
436_P499_L0.8891.00
137_V376_L0.8871.00
119_I128_L0.8851.00
93_P97_L0.8851.00
424_Q428_G0.8841.00
135_T456_W0.8821.00
459_G463_G0.8811.00
45_A286_S0.8801.00
219_A344_S0.8791.00
65_A361_G0.8771.00
423_L427_G0.8691.00
92_T96_A0.8691.00
327_I330_T0.8651.00
56_F202_D0.8641.00
156_L163_G0.8621.00
60_A283_A0.8611.00
197_T201_K0.8601.00
226_A230_A0.8591.00
25_G29_S0.8591.00
498_N502_G0.8581.00
21_F29_S0.8561.00
466_L493_L0.8531.00
212_I216_V0.8521.00
503_L506_T0.8481.00
298_A302_F0.8471.00
453_V457_A0.8451.00
57_L195_A0.8441.00
499_L502_G0.8431.00
437_S498_N0.8421.00
169_L177_V0.8401.00
465_Y468_L0.8391.00
253_L256_T0.8351.00
75_V315_I0.8351.00
406_F409_L0.8341.00
194_A197_T0.8341.00
363_V366_A0.8341.00
50_G292_S0.8291.00
444_T448_N0.8291.00
143_Y278_P0.8281.00
330_T333_G0.8261.00
22_V29_S0.8261.00
57_L283_A0.8251.00
224_S229_N0.8201.00
510_Y513_G0.8191.00
335_V339_A0.8171.00
175_L412_V0.8161.00
497_I500_A0.8151.00
201_K359_I0.8141.00
36_L394_S0.8141.00
123_F502_G0.8121.00
451_A454_G0.8111.00
27_Y196_L0.8111.00
185_F363_V0.8111.00
420_A424_Q0.8111.00
230_A234_S0.8111.00
444_T506_T0.8091.00
315_I318_Y0.8091.00
27_Y30_R0.8081.00
489_Y493_L0.8071.00
459_G498_N0.8041.00
122_R444_T0.8041.00
17_L359_I0.8031.00
307_L310_I0.7991.00
401_S405_K0.7951.00
124_N513_G0.7841.00
152_Q171_S0.7841.00
253_L257_L0.7831.00
64_T143_Y0.7821.00
424_Q431_I0.7811.00
18_F22_V0.7811.00
209_I310_I0.7801.00
504_I508_I0.7791.00
116_A132_V0.7791.00
233_L318_Y0.7781.00
185_F201_K0.7771.00
258_A261_T0.7751.00
174_S178_A0.7751.00
450_Y510_Y0.7741.00
462_S466_L0.7721.00
494_S498_N0.7691.00
313_F340_L0.7691.00
220_F319_A0.7681.00
100_M293_L0.7681.00
212_I337_V0.7681.00
21_F28_G0.7671.00
14_F18_F0.7661.00
39_L43_A0.7661.00
26_F188_T0.7641.00
399_W402_T0.7631.00
97_L298_A0.7621.00
317_V321_S0.7621.00
51_P299_L0.7611.00
196_L199_V0.7611.00
233_L236_Q0.7601.00
376_L396_L0.7591.00
462_S465_Y0.7571.00
382_K390_P0.7551.00
315_I319_A0.7551.00
194_A367_I0.7541.00
216_V219_A0.7541.00
171_S175_L0.7531.00
215_Y218_L0.7521.00
80_P315_I0.7511.00
409_L413_F0.7481.00
458_G505_G0.7471.00
326_F329_K0.7451.00
22_V184_A0.7451.00
393_E397_A0.7441.00
16_I23_F0.7431.00
153_V156_L0.7401.00
68_F353_A0.7390.99
102_R443_Y0.7360.99
335_V338_P0.7360.99
201_K362_L0.7350.99
127_I130_G0.7340.99
460_M464_I0.7320.99
57_L61_D0.7310.99
89_S304_S0.7300.99
30_R35_D0.7290.99
89_S301_P0.7270.99
500_A503_L0.7250.99
423_L431_I0.7230.99
263_Y266_L0.7230.99
10_S350_V0.7220.99
12_A19_V0.7210.99
426_L429_I0.7210.99
10_S13_L0.7200.99
130_G133_A0.7200.99
452_L459_G0.7190.99
448_N511_G0.7190.99
201_K363_V0.7170.99
14_F358_F0.7170.99
444_T451_A0.7160.99
151_M361_G0.7120.99
117_D121_D0.7090.99
186_V366_A0.7080.99
26_F29_S0.7070.99
440_L444_T0.7050.99
21_F26_F0.7040.99
425_L467_T0.7040.99
137_V372_A0.7030.99
83_F86_A0.7030.99
377_T393_E0.7010.99
123_F440_L0.7000.99
381_I386_P0.7000.99
345_M349_F0.6990.99
495_T499_L0.6990.99
76_L330_T0.6980.99
68_F209_I0.6980.99
126_R129_A0.6980.99
348_W352_I0.6980.99
484_P487_P0.6980.99
505_G508_I0.6980.99
382_K386_P0.6970.99
64_T68_F0.6960.99
147_Q364_P0.6960.99
446_K449_G0.6940.99
287_S292_S0.6930.99
49_L54_M0.6920.99
258_A262_A0.6890.99
185_F193_G0.6880.99
364_P368_M0.6880.99
206_L210_I0.6870.99
37_S41_E0.6870.99
495_T498_N0.6860.99
130_G134_I0.6850.99
91_V95_I0.6850.99
492_V496_L0.6840.99
485_L493_L0.6840.99
508_I511_G0.6820.99
459_G462_S0.6800.99
149_V153_V0.6800.99
423_L430_I0.6800.99
417_S421_I0.6800.99
310_I313_F0.6790.99
231_Q237_I0.6780.99
226_A316_L0.6770.99
462_S494_S0.6760.99
13_L351_G0.6750.99
373_A400_I0.6750.99
312_L316_L0.6750.99
52_Y199_V0.6740.99
217_P223_F0.6710.99
25_G28_G0.6670.99
183_A402_T0.6660.99
24_L28_G0.6660.99
153_V334_A0.6660.99
104_W290_K0.6650.99
454_G457_A0.6620.99
131_L457_A0.6610.99
340_L344_S0.6610.99
509_A512_A0.6600.99
201_K364_P0.6600.99
29_S188_T0.6580.99
114_T379_N0.6570.99
13_L348_W0.6570.99
482_I486_G0.6560.99
191_L195_A0.6540.99
317_V340_L0.6540.99
368_M371_G0.6520.99
260_R264_I0.6520.99
147_Q365_A0.6500.99
116_A136_G0.6500.99
230_A233_L0.6480.99
52_Y56_F0.6470.99
409_L412_V0.6470.99
373_A401_S0.6450.99
155_L174_S0.6450.99
410_A413_F0.6420.99
308_A314_G0.6420.99
28_G196_L0.6410.99
50_G53_L0.6400.99
153_V157_I0.6390.99
261_T265_S0.6380.99
67_T307_L0.6360.98
270_S274_L0.6340.98
87_F90_A0.6340.98
427_G430_I0.6330.98
10_S351_G0.6330.98
220_F225_G0.6320.98
464_I468_L0.6320.98
192_R196_L0.6270.98
232_T236_Q0.6270.98
211_S214_I0.6270.98
207_G210_I0.6250.98
234_S318_Y0.6240.98
90_A268_I0.6230.98
313_F317_V0.6230.98
59_T202_D0.6220.98
113_V117_D0.6210.98
347_D350_V0.6200.98
119_I437_S0.6190.98
249_F253_L0.6190.98
456_W459_G0.6190.98
60_A201_K0.6170.98
136_G375_L0.6160.98
485_L488_M0.6150.98
148_I193_G0.6150.98
467_T490_I0.6140.98
74_L77_A0.6130.98
381_I384_F0.6110.98
42_W398_K0.6100.98
284_S297_L0.6100.98
313_F316_L0.6080.98
124_N128_L0.6070.98
223_F226_A0.6060.98
362_L366_A0.6060.98
53_L196_L0.6050.98
272_F435_L0.6040.98
213_A309_V0.6030.98
295_L299_L0.6020.98
35_D41_E0.5990.98
223_F229_N0.5990.98
217_P226_A0.5990.98
311_A315_I0.5990.98
57_L198_A0.5970.98
54_M57_L0.5970.98
461_F464_I0.5960.98
123_F452_L0.5950.98
233_L237_I0.5940.98
143_Y368_M0.5930.98
220_F320_N0.5920.98
436_P502_G0.5900.98
39_L393_E0.5890.98
407_L410_A0.5890.98
71_V75_V0.5880.98
256_T259_A0.5880.98
304_S308_A0.5880.98
55_W59_T0.5880.98
144_I365_A0.5870.97
279_H282_N0.5870.97
210_I213_A0.5870.97
113_V378_R0.5860.97
169_L173_L0.5860.97
93_P298_A0.5860.97
373_A397_A0.5860.97
136_G434_T0.5850.97
92_T99_F0.5850.97
17_L201_K0.5850.97
176_L179_F0.5830.97
198_A363_V0.5820.97
183_A187_F0.5800.97
446_K506_T0.5800.97
283_A367_I0.5790.97
128_L449_G0.5790.97
447_L452_L0.5770.97
212_I353_A0.5770.97
195_A198_A0.5740.97
42_W401_S0.5720.97
507_A510_Y0.5720.97
60_A202_D0.5720.97
141_L407_L0.5720.97
424_Q427_G0.5720.97
61_D279_H0.5710.97
290_K294_K0.5710.97
295_L298_A0.5710.97
435_L439_F0.5700.97
147_Q150_G0.5700.97
258_A265_S0.5690.97
41_E192_R0.5680.97
157_I335_V0.5680.97
129_A383_E0.5650.97
423_L428_G0.5650.97
446_K450_Y0.5640.97
175_L179_F0.5640.97
230_A236_Q0.5620.97
329_K332_S0.5590.97
425_L429_I0.5570.97
307_L311_A0.5570.97
296_S300_Q0.5560.97
176_L406_F0.5560.97
487_P490_I0.5560.97
132_V434_T0.5540.96
97_L294_K0.5540.96
91_V96_A0.5540.96
115_A438_V0.5530.96
349_F352_I0.5530.96
179_F412_V0.5520.96
377_T400_I0.5520.96
433_Q460_M0.5520.96
447_L455_G0.5510.96
463_G494_S0.5510.96
56_F303_Y0.5500.96
156_L170_A0.5490.96
259_A262_A0.5480.96
288_D291_K0.5480.96
377_T381_I0.5470.96
17_L30_R0.5460.96
298_A301_P0.5460.96
346_P349_F0.5450.96
402_T406_F0.5450.96
149_V171_S0.5450.96
408_A412_V0.5440.96
450_Y453_V0.5420.96
92_T95_I0.5420.96
218_L222_G0.5410.96
98_L101_P0.5400.96
38_K46_G0.5400.96
213_A312_L0.5400.96
448_N452_L0.5390.96
229_N234_S0.5380.96
70_A143_Y0.5370.96
345_M353_A0.5360.96
63_Y300_Q0.5360.96
122_R445_S0.5350.96
103_L281_V0.5350.96
68_F73_S0.5350.96
148_I408_A0.5340.96
132_V136_G0.5340.96
259_A263_Y0.5340.96
486_G489_Y0.5330.96
13_L355_L0.5330.96
157_I338_P0.5320.96
489_Y494_S0.5310.95
157_I339_A0.5310.95
263_Y270_S0.5310.95
102_R109_N0.5310.95
489_Y492_V0.5310.95
226_A319_A0.5290.95
40_H390_P0.5290.95
220_F229_N0.5280.95
209_I309_V0.5280.95
126_R384_F0.5270.95
222_G229_N0.5260.95
39_L42_W0.5250.95
141_L411_L0.5240.95
386_P389_S0.5220.95
35_D192_R0.5220.95
144_I404_F0.5220.95
59_T63_Y0.5210.95
49_L93_P0.5210.95
62_L428_G0.5210.95
393_E396_L0.5200.95
225_G319_A0.5200.95
330_T335_V0.5200.95
381_I393_E0.5200.95
61_D186_V0.5190.95
466_L490_I0.5180.95
61_D283_A0.5170.95
458_G461_F0.5170.95
49_L286_S0.5170.95
185_F189_S0.5160.95
39_L390_P0.5160.95
226_A233_L0.5160.95
265_S278_P0.5160.95
313_F337_V0.5150.95
483_T487_P0.5150.95
99_F276_L0.5150.95
248_I253_L0.5150.95
76_L336_A0.5140.95
219_A223_F0.5130.95
73_S333_G0.5120.95
446_K503_L0.5110.94
143_Y147_Q0.5100.94
66_Y150_G0.5090.94
310_I315_I0.5080.94
342_G350_V0.5070.94
194_A370_I0.5060.94
76_L318_Y0.5060.94
490_I493_L0.5050.94
265_S489_Y0.5050.94
333_G336_A0.5040.94
139_A430_I0.5040.94
451_A501_I0.5030.94
230_A318_Y0.5030.94
221_G226_A0.5030.94
452_L455_G0.5020.94
488_M491_G0.5020.94
69_I150_G0.5010.94
147_Q368_M0.5000.94
391_S399_W0.5000.94
72_P354_L0.5000.94
398_K401_S0.5000.94
173_L180_I0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2xq2A 2 0.8802 100 0.274 Contact Map
3dh4A 3 0.8441 100 0.318 Contact Map
3l1lA 2 0.7814 99.3 0.864 Contact Map
3giaA 1 0.8004 99 0.88 Contact Map
4wgvA 2 0.6996 98.9 0.886 Contact Map
4djkA 2 0.7852 98.8 0.89 Contact Map
2jlnA 1 0.8099 98.5 0.9 Contact Map
4c7rA 3 0.8441 97.2 0.925 Contact Map
2wswA 3 0.7928 97 0.928 Contact Map
4us3A 1 0.7529 95.3 0.938 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0122 seconds.