GREMLIN Database
Q7LX77 - Uncharacterized protein
UniProt: Q7LX77 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 243 (237)
Sequences: 3181 (2247)
Seq/√Len: 146.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
132_D149_S3.8971.00
159_A188_I3.8221.00
107_I128_S2.8461.00
118_I190_V2.7941.00
124_M128_S2.7411.00
36_H78_E2.6981.00
168_I190_V2.6761.00
9_E72_I2.6161.00
189_E198_P2.6141.00
7_S72_I2.5261.00
130_R149_S2.4581.00
22_L225_K2.4041.00
96_S99_V2.4041.00
7_S74_S2.3831.00
160_I188_I2.3591.00
144_S158_V2.3511.00
102_D142_F2.2971.00
113_S116_D2.2751.00
125_V129_I2.2421.00
123_S127_D2.1691.00
9_E70_S2.1281.00
11_S70_S2.1131.00
128_S148_G2.0761.00
129_I155_Y2.0191.00
73_I225_K2.0011.00
123_S204_G1.9941.00
143_G147_M1.9941.00
35_L80_N1.9671.00
52_D56_N1.9561.00
131_Y202_T1.9201.00
5_K76_E1.9181.00
3_R76_E1.9111.00
175_G187_W1.8421.00
11_S237_S1.8351.00
107_I162_I1.8341.00
40_D74_S1.8321.00
132_D135_N1.8121.00
107_I145_L1.7671.00
163_L190_V1.7071.00
22_L61_F1.7061.00
107_I111_Y1.6931.00
3_R78_E1.6821.00
212_K215_I1.6731.00
129_I158_V1.6661.00
207_G210_Y1.6631.00
106_M110_R1.6581.00
111_Y124_M1.6441.00
171_R189_E1.6211.00
223_R226_I1.6061.00
5_K74_S1.5821.00
33_K80_N1.5151.00
7_S239_D1.4901.00
35_L78_E1.4721.00
126_R204_G1.4581.00
9_E237_S1.4551.00
188_I201_P1.4311.00
122_I199_V1.4271.00
156_S188_I1.4001.00
50_N58_H1.3911.00
11_S235_D1.3731.00
125_V159_A1.3581.00
105_K165_A1.3541.00
160_I170_A1.3341.00
49_I57_E1.3291.00
28_R33_K1.3111.00
95_S100_N1.3101.00
38_N76_E1.3081.00
83_S208_M1.3071.00
49_I59_L1.3021.00
163_L188_I1.2801.00
219_D223_R1.2801.00
108_N112_F1.2701.00
156_S160_I1.2671.00
192_I197_F1.2511.00
104_F161_G1.2371.00
141_A144_S1.2361.00
6_L176_L1.2291.00
177_I203_N1.2291.00
159_A163_L1.2281.00
116_D120_E1.2241.00
120_E123_S1.2151.00
105_K109_V1.2141.00
117_L166_L1.2111.00
129_I144_S1.2051.00
73_I77_V1.1951.00
118_I199_V1.1901.00
15_P69_F1.1831.00
131_Y185_H1.1831.00
83_S86_E1.1781.00
53_R91_V1.1661.00
140_S143_G1.1631.00
121_V166_L1.1591.00
99_V161_G1.1591.00
25_L59_L1.1491.00
104_F162_I1.1451.00
96_S218_D1.1360.99
162_I165_A1.1260.99
25_L37_F1.1230.99
118_I192_I1.1080.99
157_H218_D1.0960.99
122_I159_A1.0910.99
153_V172_Y1.0900.99
34_V37_F1.0870.99
125_V155_Y1.0850.99
119_D123_S1.0760.99
163_L199_V1.0730.99
10_V20_G1.0720.99
21_R58_H1.0670.99
145_L158_V1.0600.99
125_V158_V1.0580.99
159_A199_V1.0500.99
73_I79_V1.0430.99
111_Y120_E1.0400.99
89_E92_F1.0310.99
136_K153_V1.0300.99
136_K151_V1.0260.99
115_D197_F1.0140.99
39_I75_Y1.0070.99
160_I172_Y1.0070.99
5_K239_D1.0050.99
17_E67_D1.0050.99
186_A202_T0.9930.99
217_R221_D0.9920.99
110_R124_M0.9890.99
27_Y215_I0.9880.99
151_V172_Y0.9830.98
37_F77_V0.9810.98
172_Y222_V0.9780.98
104_F107_I0.9770.98
47_V59_L0.9760.98
145_L148_G0.9710.98
216_G221_D0.9700.98
14_K18_I0.9670.98
107_I124_M0.9660.98
114_F193_G0.9590.98
152_C202_T0.9520.98
138_V219_D0.9460.98
175_G210_Y0.9430.98
135_N149_S0.9420.98
89_E191_K0.9390.98
25_L49_I0.9350.98
141_A157_H0.9350.98
131_Y152_C0.9290.98
40_D76_E0.9250.98
71_I75_Y0.9200.98
133_K155_Y0.8960.97
39_I59_L0.8950.97
97_K220_N0.8870.97
152_C186_A0.8860.97
69_F75_Y0.8840.97
229_S232_V0.8780.97
108_N166_L0.8780.97
95_S101_V0.8740.97
81_S208_M0.8710.97
216_G222_V0.8630.97
129_I148_G0.8620.96
178_P240_W0.8560.96
125_V162_I0.8560.96
107_I110_R0.8540.96
93_L96_S0.8540.96
198_P212_K0.8540.96
153_V219_D0.8530.96
142_F146_I0.8530.96
151_V154_N0.8500.96
151_V203_N0.8480.96
99_V157_H0.8470.96
116_D119_D0.8450.96
131_Y155_Y0.8440.96
136_K172_Y0.8400.96
93_L168_I0.8340.96
25_L57_E0.8340.96
88_E91_V0.8320.96
91_V95_S0.8320.96
156_S186_A0.8300.96
130_R148_G0.8270.96
153_V184_A0.8230.95
23_Y58_H0.8220.95
81_S210_Y0.8220.95
110_R128_S0.8170.95
121_V163_L0.8160.95
179_F182_K0.8150.95
131_Y151_V0.8140.95
131_Y177_I0.8110.95
10_V225_K0.8080.95
13_S232_V0.8010.95
173_V212_K0.7960.95
236_F240_W0.7890.94
161_G165_A0.7890.94
108_N165_A0.7870.94
104_F145_L0.7790.94
190_V199_V0.7780.94
153_V183_E0.7780.94
98_Y218_D0.7760.94
6_L10_V0.7740.94
106_M109_V0.7730.94
92_F96_S0.7710.94
112_F166_L0.7680.93
44_F47_V0.7680.93
54_F91_V0.7660.93
118_I122_I0.7610.93
97_K100_N0.7510.93
25_L39_I0.7510.93
187_W210_Y0.7490.93
130_R155_Y0.7480.93
174_I214_A0.7480.93
12_F22_L0.7460.92
26_P32_Q0.7460.92
172_Y203_N0.7460.92
96_S157_H0.7380.92
230_K234_F0.7350.92
155_Y202_T0.7330.92
118_I163_L0.7330.92
119_D199_V0.7330.92
120_E124_M0.7190.91
91_V94_S0.7150.91
100_N142_F0.7150.91
235_D238_F0.7050.90
92_F95_S0.7010.90
138_V144_S0.6900.89
117_L120_E0.6890.89
151_V186_A0.6880.89
229_S233_S0.6880.89
151_V183_E0.6870.89
109_V112_F0.6870.89
54_F221_D0.6860.89
41_H61_F0.6860.89
94_S217_R0.6790.88
33_K82_F0.6780.88
8_A176_L0.6740.88
19_M22_L0.6690.88
135_N147_M0.6680.88
151_V216_G0.6680.88
41_H213_W0.6670.88
99_V141_A0.6630.87
51_Q57_E0.6620.87
193_G227_W0.6620.87
8_A236_F0.6610.87
189_E215_I0.6580.87
83_S207_G0.6580.87
174_I224_S0.6540.86
157_H221_D0.6510.86
93_L169_P0.6490.86
138_V145_L0.6490.86
153_V174_I0.6480.86
104_F141_A0.6470.86
138_V153_V0.6450.86
45_C64_N0.6440.86
108_N162_I0.6420.85
112_F117_L0.6410.85
18_I68_D0.6410.85
152_C203_N0.6400.85
32_Q212_K0.6390.85
224_S227_W0.6370.85
144_S153_V0.6370.85
103_K106_M0.6330.85
6_L12_F0.6290.84
69_F73_I0.6280.84
67_D73_I0.6270.84
155_Y203_N0.6260.84
182_K198_P0.6260.84
22_L59_L0.6260.84
185_H202_T0.6260.84
187_W224_S0.6240.84
22_L224_S0.6180.83
184_A219_D0.6180.83
20_G71_I0.6160.83
220_N226_I0.6150.83
109_V239_D0.6130.83
185_H203_N0.6120.83
137_S147_M0.6030.82
90_E97_K0.6020.82
64_N67_D0.6020.82
55_R192_I0.5990.81
92_F97_K0.5980.81
197_F205_I0.5980.81
136_K203_N0.5980.81
90_E94_S0.5960.81
122_I204_G0.5960.81
26_P34_V0.5960.81
141_A189_E0.5930.81
79_V85_S0.5930.81
151_V157_H0.5920.81
231_P235_D0.5920.81
129_I141_A0.5910.80
81_S84_K0.5900.80
174_I185_H0.5860.80
157_H160_I0.5860.80
114_F117_L0.5850.80
111_Y121_V0.5840.80
30_N33_K0.5830.80
135_N151_V0.5810.79
214_A226_I0.5800.79
153_V186_A0.5800.79
155_Y201_P0.5790.79
131_Y156_S0.5790.79
107_I112_F0.5780.79
97_K102_D0.5770.79
16_S68_D0.5760.79
227_W231_P0.5760.79
29_D212_K0.5760.79
28_R51_Q0.5730.78
77_V81_S0.5730.78
72_I123_S0.5720.78
172_Y186_A0.5720.78
218_D221_D0.5720.78
152_C185_H0.5710.78
136_K144_S0.5700.78
79_V84_K0.5700.78
155_Y179_F0.5670.78
97_K141_A0.5660.78
119_D122_I0.5580.77
153_V203_N0.5570.76
184_A213_W0.5560.76
116_D168_I0.5550.76
96_S221_D0.5540.76
32_Q185_H0.5520.76
89_E95_S0.5520.76
95_S161_G0.5510.76
79_V86_E0.5490.75
179_F203_N0.5490.75
4_Y211_L0.5470.75
42_P74_S0.5460.75
115_D191_K0.5460.75
158_V172_Y0.5410.74
136_K152_C0.5400.74
52_D55_R0.5390.74
27_Y212_K0.5390.74
198_P206_K0.5370.74
198_P210_Y0.5350.74
27_Y56_N0.5340.73
118_I159_A0.5330.73
177_I180_S0.5320.73
182_K203_N0.5280.73
12_F227_W0.5260.72
188_I199_V0.5250.72
96_S141_A0.5250.72
155_Y159_A0.5210.72
28_R32_Q0.5210.72
135_N138_V0.5180.71
178_P209_Q0.5170.71
114_F190_V0.5170.71
218_D238_F0.5160.71
4_Y240_W0.5120.70
81_S86_E0.5120.70
51_Q55_R0.5110.70
122_I126_R0.5110.70
180_S209_Q0.5100.70
113_S117_L0.5090.70
26_P187_W0.5070.70
152_C227_W0.5070.70
6_L227_W0.5070.70
7_S229_S0.5050.69
88_E92_F0.5050.69
177_I209_Q0.5050.69
184_A203_N0.5030.69
119_D197_F0.5000.68
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3isrA 3 0.9835 100 0.218 Contact Map
4xz7A 2 0.8889 100 0.485 Contact Map
2f4mA 2 0.7449 100 0.593 Contact Map
3kd4A 3 0.9095 100 0.595 Contact Map
4ktyA 1 0.9053 100 0.607 Contact Map
1g0dA 1 0.9342 99.9 0.611 Contact Map
2q3zA 2 0.9671 99.9 0.616 Contact Map
1l9mA 2 0.9588 99.9 0.63 Contact Map
1x3zA 1 0.8313 99.9 0.637 Contact Map
4fgqA 1 0.6543 99.9 0.64 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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