GREMLIN Database
Q7LX75 - First ORF in transposon ISC1316
UniProt: Q7LX75 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 287 (268)
Sequences: 3486 (2207)
Seq/√Len: 134.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
278_H281_Q6.4081.00
256_D260_K6.1861.00
222_L239_A2.9041.00
158_V170_I2.8541.00
263_K267_E2.6941.00
197_L257_L2.6461.00
22_A70_Q2.4541.00
239_A243_L2.4141.00
215_A253_L2.4111.00
39_I97_F2.4081.00
82_R110_V2.3981.00
34_L80_A2.3901.00
134_L170_I2.3561.00
237_F240_K2.3511.00
229_K239_A2.2171.00
167_R248_E2.1431.00
35_R83_Y2.1311.00
74_Q113_Q2.1261.00
36_W40_Y2.1241.00
225_E229_K2.1131.00
259_M262_G2.0981.00
234_H237_F2.0931.00
200_T204_E2.0741.00
29_K67_E2.0531.00
156_K175_D2.0351.00
74_Q112_T2.0141.00
51_Q55_R1.9681.00
52_T55_R1.9601.00
222_L246_A1.9291.00
20_L168_I1.9141.00
226_L240_K1.8831.00
9_R167_R1.8781.00
87_K97_F1.8591.00
258_Y262_G1.8191.00
165_S248_E1.7761.00
89_R95_A1.7731.00
21_K168_I1.7691.00
51_Q81_D1.7471.00
196_K199_V1.7471.00
21_K162_L1.7391.00
219_V243_L1.7351.00
84_Y88_K1.6961.00
226_L239_A1.6391.00
5_G171_T1.6291.00
232_L236_W1.5971.00
215_A250_L1.5781.00
18_R22_A1.5701.00
219_V247_Y1.5491.00
85_E89_R1.5081.00
248_E252_N1.5031.00
36_W100_E1.5011.00
190_I198_L1.4971.00
14_E17_L1.4941.00
38_D54_L1.4801.00
24_L168_I1.4801.00
34_L83_Y1.4731.00
188_V201_S1.4661.00
39_I43_Q1.4631.00
222_L243_L1.4591.00
136_L160_V1.4571.00
264_W268_H1.4481.00
78_Q112_T1.4401.00
55_R80_A1.4241.00
89_R94_L1.4061.00
31_Y79_I1.4061.00
251_K255_T1.4041.00
184_T270_D1.3911.00
17_L21_K1.3831.00
223_H243_L1.3811.00
199_V205_Y1.3801.00
27_A79_I1.3801.00
220_K223_H1.3711.00
6_F174_V1.3431.00
240_K244_A1.3401.00
56_Q59_L1.3331.00
196_K205_Y1.3291.00
88_K92_E1.3251.00
196_K207_P1.3191.00
40_Y44_R1.3141.00
90_F97_F1.3011.00
133_T141_T1.3001.00
37_A57_L1.2921.00
226_L243_L1.2911.00
52_T56_Q1.2801.00
188_V200_T1.2781.00
20_L109_L1.2731.00
51_Q80_A1.2721.00
93_G96_R1.2711.00
110_V157_R1.2601.00
62_R76_V1.2581.00
50_T53_E1.2561.00
8_F148_R1.2451.00
190_I200_T1.2331.00
135_K141_T1.2131.00
222_L225_E1.2121.00
59_L62_R1.2071.00
266_A272_V1.2041.00
211_P253_L1.1840.99
13_D16_T1.1710.99
25_K28_C1.1640.99
249_H253_L1.1570.99
236_W240_K1.1530.99
68_Y76_V1.1490.99
206_F257_L1.1480.99
117_K135_K1.1470.99
58_A80_A1.1470.99
265_F272_V1.1370.99
229_K235_N1.1370.99
116_W120_H1.1320.99
39_I87_K1.1280.99
219_V250_L1.1270.99
110_V159_I1.1260.99
42_Y87_K1.1200.99
55_R81_D1.1150.99
42_Y46_G1.1120.99
220_K224_R1.1040.99
115_G137_S1.1040.99
167_R252_N1.0990.99
26_L67_E1.0960.99
186_K269_Y1.0960.99
218_K222_L1.0930.99
12_A16_T1.0880.99
208_N211_P1.0860.99
257_L261_L1.0700.99
134_L158_V1.0670.99
225_E228_R1.0660.99
187_E271_V1.0560.99
7_R161_K1.0420.99
223_H247_Y1.0410.99
78_Q110_V1.0380.99
222_L242_K1.0300.99
161_K171_T1.0300.99
29_K33_T1.0290.99
35_R87_K1.0220.98
72_Y111_Y1.0220.98
72_Y75_V1.0180.98
90_F98_P1.0040.98
78_Q81_D0.9980.98
111_Y136_L0.9950.98
38_D84_Y0.9910.98
74_Q114_S0.9910.98
215_A249_H0.9880.98
192_V279_A0.9840.98
78_Q82_R0.9790.98
146_I149_D0.9730.98
235_N238_K0.9730.98
215_A246_A0.9700.98
87_K90_F0.9700.98
212_L216_L0.9670.98
195_E199_V0.9630.98
246_A250_L0.9590.98
247_Y254_R0.9570.98
206_F261_L0.9520.98
198_L261_L0.9380.97
23_Q109_L0.9350.97
267_E271_V0.9340.97
243_L246_A0.9300.97
187_E273_V0.9290.97
12_A142_F0.9250.97
224_R227_S0.9140.97
41_F45_D0.9130.97
58_A77_Q0.9120.97
181_L184_T0.9110.97
33_T37_A0.9090.97
75_V109_L0.9070.97
198_L206_F0.9000.97
6_F148_R0.8990.97
277_I282_L0.8940.96
29_K65_D0.8920.96
10_A170_I0.8890.96
227_S243_L0.8890.96
5_G161_K0.8870.96
23_Q72_Y0.8830.96
204_E264_W0.8820.96
157_R173_V0.8820.96
134_L172_F0.8820.96
169_Y248_E0.8810.96
282_L285_V0.8790.96
252_N255_T0.8790.96
38_D87_K0.8770.96
31_Y83_Y0.8660.96
212_L215_A0.8630.96
226_L236_W0.8610.96
108_S159_I0.8560.95
202_D269_Y0.8540.95
26_L68_Y0.8530.95
261_L264_W0.8510.95
33_T61_L0.8490.95
136_L139_L0.8470.95
92_E95_A0.8440.95
12_A20_L0.8400.95
159_I171_T0.8360.95
190_I265_F0.8340.95
25_K29_K0.8250.94
38_D41_F0.8240.94
87_K91_F0.8230.94
117_K120_H0.8210.94
194_V283_V0.8200.94
136_L142_F0.8190.94
30_I79_I0.8140.94
37_A41_F0.8130.94
119_L135_K0.8120.94
81_D112_T0.8090.94
5_G173_V0.8090.94
211_P215_A0.8080.94
221_H225_E0.8050.94
247_Y251_K0.8020.94
73_S113_Q0.8020.94
185_G270_D0.8010.93
164_R248_E0.8000.93
102_K105_K0.7990.93
281_Q285_V0.7980.93
14_E18_R0.7980.93
27_A109_L0.7960.93
206_F264_W0.7950.93
186_K270_D0.7900.93
213_E216_L0.7890.93
23_Q111_Y0.7880.93
37_A40_Y0.7860.93
116_W137_S0.7820.93
89_R92_E0.7810.93
73_S115_G0.7740.92
47_K53_E0.7720.92
111_Y114_S0.7710.92
192_V198_L0.7650.92
233_S236_W0.7630.92
83_Y87_K0.7590.92
114_S117_K0.7540.91
74_Q77_Q0.7520.91
60_D64_Q0.7520.91
20_L24_L0.7510.91
220_K227_S0.7500.91
26_L71_L0.7490.91
102_K107_Y0.7450.91
179_P182_P0.7450.91
250_L254_R0.7440.91
194_V285_V0.7400.90
59_L80_A0.7350.90
19_A23_Q0.7340.90
72_Y112_T0.7310.90
220_K228_R0.7290.90
197_L258_Y0.7280.90
28_C67_E0.7220.89
7_R171_T0.7210.89
22_A26_L0.7190.89
42_Y48_G0.7130.89
220_K243_L0.7090.89
71_L76_V0.7050.88
225_E242_K0.7040.88
8_F170_I0.7000.88
252_N260_K0.6970.88
162_L168_I0.6950.88
80_A83_Y0.6940.87
74_Q78_Q0.6900.87
23_Q27_A0.6900.87
162_L166_E0.6880.87
263_K266_A0.6880.87
91_F98_P0.6840.87
43_Q46_G0.6830.87
23_Q71_L0.6830.87
30_I76_V0.6810.86
59_L63_K0.6790.86
11_Y145_I0.6790.86
224_R228_R0.6780.86
34_L54_L0.6770.86
219_V227_S0.6750.86
72_Y109_L0.6730.86
72_Y137_S0.6720.86
37_A54_L0.6670.85
31_Y86_A0.6630.85
220_K225_E0.6580.85
72_Y139_L0.6570.84
77_Q81_D0.6570.84
28_C103_P0.6560.84
54_L57_L0.6550.84
226_L229_K0.6520.84
42_Y90_F0.6500.84
86_A98_P0.6480.84
218_K246_A0.6480.84
209_L257_L0.6470.84
255_T259_M0.6450.83
39_I42_Y0.6420.83
17_L168_I0.6410.83
107_Y162_L0.6390.83
197_L262_G0.6390.83
232_L237_F0.6340.82
198_L274_M0.6340.82
252_N256_D0.6340.82
24_L109_L0.6330.82
193_G196_K0.6320.82
209_L212_L0.6300.82
194_V282_L0.6300.82
33_T67_E0.6290.82
279_A282_L0.6280.82
227_S247_Y0.6280.82
33_T54_L0.6270.82
189_A275_E0.6270.82
229_K242_K0.6260.81
72_Y113_Q0.6250.81
120_H132_I0.6250.81
236_W239_A0.6240.81
201_S205_Y0.6230.81
57_L61_L0.6180.81
281_Q284_W0.6150.80
80_A84_Y0.6140.80
165_S244_A0.6130.80
7_R255_T0.6120.80
45_D48_G0.6110.80
193_G199_V0.6100.80
144_V147_H0.6090.80
25_K67_E0.6080.80
72_Y155_V0.6070.79
41_F49_L0.6070.79
42_Y45_D0.6060.79
73_S112_T0.6050.79
146_I150_F0.6050.79
15_Q18_R0.6050.79
236_W243_L0.6020.79
89_R93_G0.6010.79
75_V111_Y0.6000.79
223_H226_L0.5990.79
31_Y208_N0.5970.78
8_F146_I0.5970.78
135_K139_L0.5970.78
59_L73_S0.5960.78
189_A201_S0.5940.78
7_R169_Y0.5940.78
34_L58_A0.5900.78
42_Y91_F0.5900.78
218_K221_H0.5890.77
154_K175_D0.5890.77
260_K263_K0.5870.77
48_G84_Y0.5870.77
25_K103_P0.5840.77
229_K233_S0.5840.77
19_A22_A0.5810.76
225_E239_A0.5800.76
217_W228_R0.5800.76
41_F47_K0.5790.76
10_A144_V0.5790.76
10_A142_F0.5790.76
266_A269_Y0.5730.75
26_L29_K0.5730.75
113_Q116_W0.5700.75
78_Q85_E0.5700.75
74_Q115_G0.5670.75
74_Q111_Y0.5640.74
259_M263_K0.5630.74
193_G198_L0.5630.74
258_Y274_M0.5580.74
15_Q19_A0.5560.73
235_N242_K0.5540.73
20_L142_F0.5520.73
227_S239_A0.5510.73
82_R101_K0.5480.72
22_A25_K0.5470.72
222_L229_K0.5450.72
134_L137_S0.5440.72
55_R84_Y0.5420.71
104_H107_Y0.5410.71
77_Q80_A0.5400.71
256_D259_M0.5390.71
53_E56_Q0.5390.71
115_G118_I0.5390.71
99_K102_K0.5390.71
74_Q80_A0.5370.71
186_K202_D0.5370.71
219_V223_H0.5330.70
183_N186_K0.5300.70
148_R151_P0.5300.70
5_G174_V0.5270.69
22_A71_L0.5260.69
217_W221_H0.5260.69
20_L160_V0.5250.69
55_R59_L0.5240.69
216_L220_K0.5240.69
58_A62_R0.5220.69
229_K236_W0.5220.69
194_V210_R0.5210.68
223_H227_S0.5200.68
5_G172_F0.5200.68
243_L247_Y0.5190.68
216_L253_L0.5190.68
23_Q26_L0.5190.68
114_S118_I0.5190.68
179_P185_G0.5180.68
197_L206_F0.5160.68
212_L253_L0.5150.68
21_K24_L0.5140.67
195_E205_Y0.5140.67
73_S77_Q0.5130.67
136_L158_V0.5130.67
218_K225_E0.5120.67
8_F149_D0.5120.67
200_T265_F0.5110.67
71_L74_Q0.5100.67
62_R68_Y0.5040.66
161_K173_V0.5030.66
30_I68_Y0.5010.65
40_Y43_Q0.5000.65
34_L61_L0.5000.65
150_F174_V0.5000.65
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ep4A 2 0.2822 42.2 0.95 Contact Map
1neiA 2 0.1812 27.7 0.955 Contact Map
1hjrA 2 0.2613 24.7 0.956 Contact Map
1kcfA 2 0.4042 21.7 0.957 Contact Map
4ogeA 1 0.2474 20 0.958 Contact Map
4ktwA 2 0.2578 19.7 0.958 Contact Map
2dnfA 1 0.324 16.8 0.959 Contact Map
4p47A 1 0.331 12.8 0.961 Contact Map
4mh6A 1 0.2962 7.6 0.965 Contact Map
1nu0A 1 0.2474 7.2 0.966 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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