Q7LX75 - SULSO - GREMLIN Contacts

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Q7LX75 - First ORF in transposon ISC1316

UniProt:	Q7LX75	Sequences: MPTLGFRFRAYADEQTLRALKAQLKLACKIYNTLRWADIYFYQRDGKGLTQTELRQLALDLRKQDDEYKQLYSQVVQQIADRYYEAKKRFFEGLARFPKEKKPHKHYSLVYTQSGWKILHVREIRKGKKKLITLKLSNLGTFKVIIHRDFPLDKVKRVIVKLTRSERIYITFVVDHEFPKLPNTGKEVAIDVGVEKLLVTSDGEYFPNLRPLEKALWKVKHLHRELSRKKFLSHNWFKAKVKLARAYEHLKNLRTDLYMKLGKWFAEHYDVVVMEGIHAKQLVWVSP	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	287 (268)
Sequences:	3486 (2207)
Seq/√Len:	134.8

ECOLI - INSQ
HALSA - Q9HSW9 Q9HHJ9 Q9HM87 Q9HHG8 Q9HSW7 Q9HSD4
SULSO - Q7LX75 Q97XQ8 Q97V25 Q7LXH9 Q97Y44 Q97YI2 Q97V47 Q97YW4 Q97XP1 Q97V53 Q97XA4 Q97YI5 Q97U68 Q97XB6 Q97UQ8 Q7LXD9 Q97YU1 Q97Z61 Q97Y48 Q7LXH2 Q97U51 Q97XQ0 Q97YW9 Q97Y67 Q97WY6 Q97X39 Q97WZ3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
278_H	281_Q	6.408	1.00
256_D	260_K	6.186	1.00
222_L	239_A	2.904	1.00
158_V	170_I	2.854	1.00
263_K	267_E	2.694	1.00
197_L	257_L	2.646	1.00
22_A	70_Q	2.454	1.00
239_A	243_L	2.414	1.00
215_A	253_L	2.411	1.00
39_I	97_F	2.408	1.00
82_R	110_V	2.398	1.00
34_L	80_A	2.390	1.00
134_L	170_I	2.356	1.00
237_F	240_K	2.351	1.00
229_K	239_A	2.217	1.00
167_R	248_E	2.143	1.00
35_R	83_Y	2.131	1.00
74_Q	113_Q	2.126	1.00
36_W	40_Y	2.124	1.00
225_E	229_K	2.113	1.00
259_M	262_G	2.098	1.00
234_H	237_F	2.093	1.00
200_T	204_E	2.074	1.00
29_K	67_E	2.053	1.00
156_K	175_D	2.035	1.00
74_Q	112_T	2.014	1.00
51_Q	55_R	1.968	1.00
52_T	55_R	1.960	1.00
222_L	246_A	1.929	1.00
20_L	168_I	1.914	1.00
226_L	240_K	1.883	1.00
9_R	167_R	1.878	1.00
87_K	97_F	1.859	1.00
258_Y	262_G	1.819	1.00
165_S	248_E	1.776	1.00
89_R	95_A	1.773	1.00
21_K	168_I	1.769	1.00
51_Q	81_D	1.747	1.00
196_K	199_V	1.747	1.00
21_K	162_L	1.739	1.00
219_V	243_L	1.735	1.00
84_Y	88_K	1.696	1.00
226_L	239_A	1.639	1.00
5_G	171_T	1.629	1.00
232_L	236_W	1.597	1.00
215_A	250_L	1.578	1.00
18_R	22_A	1.570	1.00
219_V	247_Y	1.549	1.00
85_E	89_R	1.508	1.00
248_E	252_N	1.503	1.00
36_W	100_E	1.501	1.00
190_I	198_L	1.497	1.00
14_E	17_L	1.494	1.00
38_D	54_L	1.480	1.00
24_L	168_I	1.480	1.00
34_L	83_Y	1.473	1.00
188_V	201_S	1.466	1.00
39_I	43_Q	1.463	1.00
222_L	243_L	1.459	1.00
136_L	160_V	1.457	1.00
264_W	268_H	1.448	1.00
78_Q	112_T	1.440	1.00
55_R	80_A	1.424	1.00
89_R	94_L	1.406	1.00
31_Y	79_I	1.406	1.00
251_K	255_T	1.404	1.00
184_T	270_D	1.391	1.00
17_L	21_K	1.383	1.00
223_H	243_L	1.381	1.00
199_V	205_Y	1.380	1.00
27_A	79_I	1.380	1.00
220_K	223_H	1.371	1.00
6_F	174_V	1.343	1.00
240_K	244_A	1.340	1.00
56_Q	59_L	1.333	1.00
196_K	205_Y	1.329	1.00
88_K	92_E	1.325	1.00
196_K	207_P	1.319	1.00
40_Y	44_R	1.314	1.00
90_F	97_F	1.301	1.00
133_T	141_T	1.300	1.00
37_A	57_L	1.292	1.00
226_L	243_L	1.291	1.00
52_T	56_Q	1.280	1.00
188_V	200_T	1.278	1.00
20_L	109_L	1.273	1.00
51_Q	80_A	1.272	1.00
93_G	96_R	1.271	1.00
110_V	157_R	1.260	1.00
62_R	76_V	1.258	1.00
50_T	53_E	1.256	1.00
8_F	148_R	1.245	1.00
190_I	200_T	1.233	1.00
135_K	141_T	1.213	1.00
222_L	225_E	1.212	1.00
59_L	62_R	1.207	1.00
266_A	272_V	1.204	1.00
211_P	253_L	1.184	0.99
13_D	16_T	1.171	0.99
25_K	28_C	1.164	0.99
249_H	253_L	1.157	0.99
236_W	240_K	1.153	0.99
68_Y	76_V	1.149	0.99
206_F	257_L	1.148	0.99
117_K	135_K	1.147	0.99
58_A	80_A	1.147	0.99
265_F	272_V	1.137	0.99
229_K	235_N	1.137	0.99
116_W	120_H	1.132	0.99
39_I	87_K	1.128	0.99
219_V	250_L	1.127	0.99
110_V	159_I	1.126	0.99
42_Y	87_K	1.120	0.99
55_R	81_D	1.115	0.99
42_Y	46_G	1.112	0.99
220_K	224_R	1.104	0.99
115_G	137_S	1.104	0.99
167_R	252_N	1.099	0.99
26_L	67_E	1.096	0.99
186_K	269_Y	1.096	0.99
218_K	222_L	1.093	0.99
12_A	16_T	1.088	0.99
208_N	211_P	1.086	0.99
257_L	261_L	1.070	0.99
134_L	158_V	1.067	0.99
225_E	228_R	1.066	0.99
187_E	271_V	1.056	0.99
7_R	161_K	1.042	0.99
223_H	247_Y	1.041	0.99
78_Q	110_V	1.038	0.99
222_L	242_K	1.030	0.99
161_K	171_T	1.030	0.99
29_K	33_T	1.029	0.99
35_R	87_K	1.022	0.98
72_Y	111_Y	1.022	0.98
72_Y	75_V	1.018	0.98
90_F	98_P	1.004	0.98
78_Q	81_D	0.998	0.98
111_Y	136_L	0.995	0.98
38_D	84_Y	0.991	0.98
74_Q	114_S	0.991	0.98
215_A	249_H	0.988	0.98
192_V	279_A	0.984	0.98
78_Q	82_R	0.979	0.98
146_I	149_D	0.973	0.98
235_N	238_K	0.973	0.98
215_A	246_A	0.970	0.98
87_K	90_F	0.970	0.98
212_L	216_L	0.967	0.98
195_E	199_V	0.963	0.98
246_A	250_L	0.959	0.98
247_Y	254_R	0.957	0.98
206_F	261_L	0.952	0.98
198_L	261_L	0.938	0.97
23_Q	109_L	0.935	0.97
267_E	271_V	0.934	0.97
243_L	246_A	0.930	0.97
187_E	273_V	0.929	0.97
12_A	142_F	0.925	0.97
224_R	227_S	0.914	0.97
41_F	45_D	0.913	0.97
58_A	77_Q	0.912	0.97
181_L	184_T	0.911	0.97
33_T	37_A	0.909	0.97
75_V	109_L	0.907	0.97
198_L	206_F	0.900	0.97
6_F	148_R	0.899	0.97
277_I	282_L	0.894	0.96
29_K	65_D	0.892	0.96
10_A	170_I	0.889	0.96
227_S	243_L	0.889	0.96
5_G	161_K	0.887	0.96
23_Q	72_Y	0.883	0.96
204_E	264_W	0.882	0.96
157_R	173_V	0.882	0.96
134_L	172_F	0.882	0.96
169_Y	248_E	0.881	0.96
282_L	285_V	0.879	0.96
252_N	255_T	0.879	0.96
38_D	87_K	0.877	0.96
31_Y	83_Y	0.866	0.96
212_L	215_A	0.863	0.96
226_L	236_W	0.861	0.96
108_S	159_I	0.856	0.95
202_D	269_Y	0.854	0.95
26_L	68_Y	0.853	0.95
261_L	264_W	0.851	0.95
33_T	61_L	0.849	0.95
136_L	139_L	0.847	0.95
92_E	95_A	0.844	0.95
12_A	20_L	0.840	0.95
159_I	171_T	0.836	0.95
190_I	265_F	0.834	0.95
25_K	29_K	0.825	0.94
38_D	41_F	0.824	0.94
87_K	91_F	0.823	0.94
117_K	120_H	0.821	0.94
194_V	283_V	0.820	0.94
136_L	142_F	0.819	0.94
30_I	79_I	0.814	0.94
37_A	41_F	0.813	0.94
119_L	135_K	0.812	0.94
81_D	112_T	0.809	0.94
5_G	173_V	0.809	0.94
211_P	215_A	0.808	0.94
221_H	225_E	0.805	0.94
247_Y	251_K	0.802	0.94
73_S	113_Q	0.802	0.94
185_G	270_D	0.801	0.93
164_R	248_E	0.800	0.93
102_K	105_K	0.799	0.93
281_Q	285_V	0.798	0.93
14_E	18_R	0.798	0.93
27_A	109_L	0.796	0.93
206_F	264_W	0.795	0.93
186_K	270_D	0.790	0.93
213_E	216_L	0.789	0.93
23_Q	111_Y	0.788	0.93
37_A	40_Y	0.786	0.93
116_W	137_S	0.782	0.93
89_R	92_E	0.781	0.93
73_S	115_G	0.774	0.92
47_K	53_E	0.772	0.92
111_Y	114_S	0.771	0.92
192_V	198_L	0.765	0.92
233_S	236_W	0.763	0.92
83_Y	87_K	0.759	0.92
114_S	117_K	0.754	0.91
74_Q	77_Q	0.752	0.91
60_D	64_Q	0.752	0.91
20_L	24_L	0.751	0.91
220_K	227_S	0.750	0.91
26_L	71_L	0.749	0.91
102_K	107_Y	0.745	0.91
179_P	182_P	0.745	0.91
250_L	254_R	0.744	0.91
194_V	285_V	0.740	0.90
59_L	80_A	0.735	0.90
19_A	23_Q	0.734	0.90
72_Y	112_T	0.731	0.90
220_K	228_R	0.729	0.90
197_L	258_Y	0.728	0.90
28_C	67_E	0.722	0.89
7_R	171_T	0.721	0.89
22_A	26_L	0.719	0.89
42_Y	48_G	0.713	0.89
220_K	243_L	0.709	0.89
71_L	76_V	0.705	0.88
225_E	242_K	0.704	0.88
8_F	170_I	0.700	0.88
252_N	260_K	0.697	0.88
162_L	168_I	0.695	0.88
80_A	83_Y	0.694	0.87
74_Q	78_Q	0.690	0.87
23_Q	27_A	0.690	0.87
162_L	166_E	0.688	0.87
263_K	266_A	0.688	0.87
91_F	98_P	0.684	0.87
43_Q	46_G	0.683	0.87
23_Q	71_L	0.683	0.87
30_I	76_V	0.681	0.86
59_L	63_K	0.679	0.86
11_Y	145_I	0.679	0.86
224_R	228_R	0.678	0.86
34_L	54_L	0.677	0.86
219_V	227_S	0.675	0.86
72_Y	109_L	0.673	0.86
72_Y	137_S	0.672	0.86
37_A	54_L	0.667	0.85
31_Y	86_A	0.663	0.85
220_K	225_E	0.658	0.85
72_Y	139_L	0.657	0.84
77_Q	81_D	0.657	0.84
28_C	103_P	0.656	0.84
54_L	57_L	0.655	0.84
226_L	229_K	0.652	0.84
42_Y	90_F	0.650	0.84
86_A	98_P	0.648	0.84
218_K	246_A	0.648	0.84
209_L	257_L	0.647	0.84
255_T	259_M	0.645	0.83
39_I	42_Y	0.642	0.83
17_L	168_I	0.641	0.83
107_Y	162_L	0.639	0.83
197_L	262_G	0.639	0.83
232_L	237_F	0.634	0.82
198_L	274_M	0.634	0.82
252_N	256_D	0.634	0.82
24_L	109_L	0.633	0.82
193_G	196_K	0.632	0.82
209_L	212_L	0.630	0.82
194_V	282_L	0.630	0.82
33_T	67_E	0.629	0.82
279_A	282_L	0.628	0.82
227_S	247_Y	0.628	0.82
33_T	54_L	0.627	0.82
189_A	275_E	0.627	0.82
229_K	242_K	0.626	0.81
72_Y	113_Q	0.625	0.81
120_H	132_I	0.625	0.81
236_W	239_A	0.624	0.81
201_S	205_Y	0.623	0.81
57_L	61_L	0.618	0.81
281_Q	284_W	0.615	0.80
80_A	84_Y	0.614	0.80
165_S	244_A	0.613	0.80
7_R	255_T	0.612	0.80
45_D	48_G	0.611	0.80
193_G	199_V	0.610	0.80
144_V	147_H	0.609	0.80
25_K	67_E	0.608	0.80
72_Y	155_V	0.607	0.79
41_F	49_L	0.607	0.79
42_Y	45_D	0.606	0.79
73_S	112_T	0.605	0.79
146_I	150_F	0.605	0.79
15_Q	18_R	0.605	0.79
236_W	243_L	0.602	0.79
89_R	93_G	0.601	0.79
75_V	111_Y	0.600	0.79
223_H	226_L	0.599	0.79
31_Y	208_N	0.597	0.78
8_F	146_I	0.597	0.78
135_K	139_L	0.597	0.78
59_L	73_S	0.596	0.78
189_A	201_S	0.594	0.78
7_R	169_Y	0.594	0.78
34_L	58_A	0.590	0.78
42_Y	91_F	0.590	0.78
218_K	221_H	0.589	0.77
154_K	175_D	0.589	0.77
260_K	263_K	0.587	0.77
48_G	84_Y	0.587	0.77
25_K	103_P	0.584	0.77
229_K	233_S	0.584	0.77
19_A	22_A	0.581	0.76
225_E	239_A	0.580	0.76
217_W	228_R	0.580	0.76
41_F	47_K	0.579	0.76
10_A	144_V	0.579	0.76
10_A	142_F	0.579	0.76
266_A	269_Y	0.573	0.75
26_L	29_K	0.573	0.75
113_Q	116_W	0.570	0.75
78_Q	85_E	0.570	0.75
74_Q	115_G	0.567	0.75
74_Q	111_Y	0.564	0.74
259_M	263_K	0.563	0.74
193_G	198_L	0.563	0.74
258_Y	274_M	0.558	0.74
15_Q	19_A	0.556	0.73
235_N	242_K	0.554	0.73
20_L	142_F	0.552	0.73
227_S	239_A	0.551	0.73
82_R	101_K	0.548	0.72
22_A	25_K	0.547	0.72
222_L	229_K	0.545	0.72
134_L	137_S	0.544	0.72
55_R	84_Y	0.542	0.71
104_H	107_Y	0.541	0.71
77_Q	80_A	0.540	0.71
256_D	259_M	0.539	0.71
53_E	56_Q	0.539	0.71
115_G	118_I	0.539	0.71
99_K	102_K	0.539	0.71
74_Q	80_A	0.537	0.71
186_K	202_D	0.537	0.71
219_V	223_H	0.533	0.70
183_N	186_K	0.530	0.70
148_R	151_P	0.530	0.70
5_G	174_V	0.527	0.69
22_A	71_L	0.526	0.69
217_W	221_H	0.526	0.69
20_L	160_V	0.525	0.69
55_R	59_L	0.524	0.69
216_L	220_K	0.524	0.69
58_A	62_R	0.522	0.69
229_K	236_W	0.522	0.69
194_V	210_R	0.521	0.68
223_H	227_S	0.520	0.68
5_G	172_F	0.520	0.68
243_L	247_Y	0.519	0.68
216_L	253_L	0.519	0.68
23_Q	26_L	0.519	0.68
114_S	118_I	0.519	0.68
179_P	185_G	0.518	0.68
197_L	206_F	0.516	0.68
212_L	253_L	0.515	0.68
21_K	24_L	0.514	0.67
195_E	205_Y	0.514	0.67
73_S	77_Q	0.513	0.67
136_L	158_V	0.513	0.67
218_K	225_E	0.512	0.67
8_F	149_D	0.512	0.67
200_T	265_F	0.511	0.67
71_L	74_Q	0.510	0.67
62_R	68_Y	0.504	0.66
161_K	173_V	0.503	0.66
30_I	68_Y	0.501	0.65
40_Y	43_Q	0.500	0.65
34_L	61_L	0.500	0.65
150_F	174_V	0.500	0.65

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4ep4A	2	0.2822	42.2	0.95	Contact Map
1neiA	2	0.1812	27.7	0.955	Contact Map
1hjrA	2	0.2613	24.7	0.956	Contact Map
1kcfA	2	0.4042	21.7	0.957	Contact Map
4ogeA	1	0.2474	20	0.958	Contact Map
4ktwA	2	0.2578	19.7	0.958	Contact Map
2dnfA	1	0.324	16.8	0.959	Contact Map
4p47A	1	0.331	12.8	0.961	Contact Map
4mh6A	1	0.2962	7.6	0.965	Contact Map
1nu0A	1	0.2474	7.2	0.966	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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