GREMLIN Database
Q7LX74 - Second ORF in transposon ISC1316
UniProt: Q7LX74 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 120 (95)
Sequences: 1580 (906)
Seq/√Len: 93.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
21_R37_L3.4291.00
86_S90_E3.2681.00
28_L35_L3.0911.00
19_E23_V2.8931.00
38_V83_I2.4491.00
48_A78_N2.4451.00
58_S61_D2.4201.00
45_K57_L2.3981.00
46_T53_V2.3821.00
12_L17_F2.2051.00
19_E22_D2.1691.00
6_R9_R1.9731.00
5_L9_R1.8801.00
54_K57_L1.8611.00
20_L24_L1.8401.00
23_V26_Y1.7721.00
64_F73_A1.7711.00
42_Y45_K1.6811.00
49_R71_W1.5781.00
65_V72_I1.5701.00
64_F71_W1.5691.00
54_K67_P1.5641.00
43_T83_I1.5431.00
5_L13_S1.5181.00
3_K13_S1.4741.00
63_V72_I1.3640.99
28_L33_K1.3520.99
62_R75_R1.2930.99
86_S91_R1.2820.99
59_L62_R1.2440.99
8_L12_L1.2270.98
85_K91_R1.2200.98
25_K37_L1.1870.98
45_K55_N1.1770.98
52_Y67_P1.1620.98
25_K29_E1.1040.97
26_Y30_K1.0940.97
81_L85_K1.0880.97
54_K58_S1.0870.96
27_Q30_K1.0860.96
57_L64_F1.0550.96
59_L75_R1.0310.95
40_P43_T1.0200.95
43_T86_S1.0130.95
23_V27_Q1.0030.95
95_P98_L0.9920.94
45_K56_D0.9830.94
8_L11_R0.9360.92
73_A81_L0.9320.92
57_L61_D0.9180.91
71_W81_L0.9090.91
91_R95_P0.9040.91
52_Y68_N0.8990.91
57_L75_R0.8970.90
3_K9_R0.8950.90
93_L96_V0.8840.90
4_S7_S0.8660.89
48_A81_L0.8620.89
94_V97_E0.8560.88
6_R13_S0.8550.88
62_R74_D0.8530.88
9_R13_S0.8330.87
54_K64_F0.8270.87
42_Y86_S0.8250.86
38_V86_S0.8220.86
25_K35_L0.8160.86
67_P75_R0.8110.85
5_L8_L0.7720.83
23_V30_K0.7710.82
3_K6_R0.7680.82
46_T86_S0.7650.82
77_Y81_L0.7630.82
92_S95_P0.7630.82
77_Y80_S0.7620.82
45_K53_V0.7610.82
36_I91_R0.7580.81
6_R11_R0.7560.81
43_T82_N0.7540.81
88_G92_S0.7510.81
11_R15_V0.7440.80
63_V73_A0.7360.79
48_A73_A0.7280.79
48_A79_A0.7080.77
22_D25_K0.7070.77
91_R94_V0.6950.75
45_K58_S0.6860.75
3_K7_S0.6840.74
14_D23_V0.6690.73
65_V73_A0.6670.72
4_S13_S0.6670.72
21_R25_K0.6660.72
19_E30_K0.6550.71
33_K88_G0.6540.71
18_G22_D0.6480.70
5_L12_L0.6460.70
54_K61_D0.6440.70
81_L84_L0.6400.69
18_G21_R0.6390.69
44_S54_K0.6310.68
57_L62_R0.6270.68
94_V98_L0.6190.67
47_C66_C0.6190.67
16_G30_K0.6160.66
38_V91_R0.6110.66
64_F75_R0.6080.65
21_R35_L0.6060.65
49_R81_L0.6040.65
61_D64_F0.6040.65
15_V18_G0.6030.65
46_T82_N0.5880.63
80_S84_L0.5830.62
36_I88_G0.5810.62
38_V42_Y0.5760.61
8_L44_S0.5740.61
48_A82_N0.5720.61
14_D59_L0.5720.61
40_P86_S0.5720.61
80_S93_L0.5710.61
25_K34_K0.5630.59
47_C69_C0.5630.59
73_A77_Y0.5610.59
83_I89_S0.5590.59
21_R46_T0.5560.59
24_L31_Y0.5550.58
59_L63_V0.5540.58
65_V95_P0.5530.58
30_K43_T0.5470.57
16_G22_D0.5450.57
17_F88_G0.5400.56
61_D75_R0.5330.55
58_S75_R0.5310.55
22_D37_L0.5310.55
89_S94_V0.5300.55
79_A82_N0.5280.55
52_Y56_D0.5220.54
38_V41_A0.5190.53
15_V33_K0.5180.53
38_V88_G0.5080.52
43_T46_T0.5060.52
18_G31_Y0.5050.52
91_R96_V0.5020.51
7_S13_S0.5000.51
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ffkW 1 0.5583 86 0.886 Contact Map
1gh9A 1 0.5 82.4 0.891 Contact Map
4aybP 1 0.3583 81.6 0.892 Contact Map
2k4xA 1 0.4583 81 0.893 Contact Map
4u3eA 2 0.825 79.6 0.894 Contact Map
1yuzA 2 0.625 76.8 0.897 Contact Map
1qypA 1 0.3833 75.1 0.898 Contact Map
4iloA 3 0.575 70.7 0.901 Contact Map
3j3w0 1 0.4583 69.2 0.902 Contact Map
3pwfA 4 0.6 66.7 0.904 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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