GREMLIN Database
Q7LX69 - Pyruvate synthase alpha chain (Pyruvic-ferredoxin oxidoreductase alpha chain) (PorA-like)
UniProt: Q7LX69 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 415 (349)
Sequences: 4004 (2506)
Seq/√Len: 134.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
281_E332_R5.3761.00
275_Y299_K4.1191.00
298_I310_M3.7361.00
286_G294_M3.0001.00
251_K257_Y2.8931.00
282_V333_V2.8011.00
148_Q152_D2.8011.00
20_V150_A2.7631.00
277_I283_V2.7411.00
87_S92_W2.6731.00
247_Y251_K2.6651.00
283_V331_S2.6491.00
244_V248_E2.5921.00
99_I111_A2.5541.00
320_P323_D2.5441.00
142_V160_I2.5321.00
29_V158_Y2.4361.00
279_D307_K2.4141.00
190_P193_L2.4111.00
282_V306_Y2.3941.00
276_M299_K2.2131.00
144_V172_I2.1871.00
99_I139_W2.1791.00
76_A83_T2.1641.00
311_L324_V2.1561.00
140_L160_I2.1261.00
20_V154_A2.1011.00
24_A86_G2.0911.00
74_K102_T2.0841.00
26_Y151_F2.0711.00
50_L55_E2.0491.00
134_V171_G2.0391.00
151_F189_P1.9901.00
272_V320_P1.9751.00
32_V86_G1.9411.00
70_F98_A1.9381.00
360_L369_V1.9381.00
82_R162_E1.9361.00
154_A172_I1.9271.00
22_H50_L1.9041.00
73_V109_V1.8981.00
316_F355_E1.8871.00
163_D166_V1.8481.00
283_V328_L1.8441.00
163_D245_E1.8281.00
354_H358_S1.8171.00
281_E307_K1.8111.00
286_G310_M1.8061.00
24_A84_L1.7671.00
149_E312_R1.7661.00
33_A72_T1.7551.00
145_D291_S1.7401.00
11_E187_R1.7221.00
99_I171_G1.7121.00
282_V335_C1.7071.00
155_L194_V1.7051.00
74_K98_A1.6921.00
71_E98_A1.6861.00
284_L298_I1.6831.00
92_W171_G1.6761.00
117_A123_A1.6681.00
11_E185_I1.6671.00
286_G290_V1.6531.00
29_V84_L1.6411.00
33_A73_V1.6371.00
284_L294_M1.6291.00
30_D81_A1.6271.00
251_K256_R1.6171.00
240_R245_E1.6051.00
364_D367_P1.6031.00
254_F258_P1.5921.00
20_V174_M1.5851.00
166_V239_A1.5701.00
153_T314_R1.5401.00
27_A158_Y1.5301.00
102_T109_V1.5281.00
70_F111_A1.5021.00
27_A191_R1.4931.00
140_L168_L1.4921.00
249_E252_K1.4801.00
328_L334_V1.4801.00
279_D302_R1.4711.00
319_F359_S1.4621.00
204_G207_L1.4601.00
301_M306_Y1.4451.00
114_G174_M1.4431.00
156_L271_F1.4301.00
286_G291_S1.4291.00
283_V334_V1.4201.00
283_V327_Y1.4161.00
149_E314_R1.4111.00
134_V173_S1.3941.00
51_I58_A1.3881.00
114_G180_T1.3821.00
322_Q326_R1.3811.00
146_T292_K1.3811.00
291_S312_R1.3691.00
302_R308_V1.3561.00
248_E251_K1.3451.00
323_D326_R1.3261.00
357_R361_Y1.3231.00
226_M229_R1.3131.00
110_V157_A1.3081.00
349_G353_Y1.3011.00
109_V161_A1.2981.00
250_F254_F1.2801.00
249_E253_V1.2791.00
46_T49_K1.2751.00
255_G258_P1.2691.00
255_G259_G1.2591.00
296_V300_N1.2581.00
96_M134_V1.2471.00
73_V83_T1.2471.00
46_T50_L1.2421.00
277_I302_R1.2391.00
280_A309_G1.2381.00
251_K254_F1.2301.00
298_I302_R1.2291.00
358_S361_Y1.2261.00
110_V158_Y1.2191.00
209_H212_N1.2181.00
70_F109_V1.2171.00
295_K312_R1.2171.00
300_N303_R1.2051.00
283_V311_L1.1920.99
234_E238_R1.1890.99
143_W173_S1.1880.99
357_R362_D1.1880.99
31_V76_A1.1840.99
15_N18_Q1.1840.99
203_R207_L1.1810.99
203_R206_Y1.1790.99
18_Q46_T1.1780.99
241_S322_Q1.1760.99
251_K255_G1.1670.99
287_M340_D1.1670.99
21_A43_V1.1660.99
276_M302_R1.1640.99
285_I324_V1.1600.99
69_Q95_A1.1590.99
244_V323_D1.1500.99
282_V308_V1.1440.99
160_I246_A1.1440.99
248_E257_Y1.1410.99
32_V44_M1.1320.99
142_V170_L1.1280.99
166_V242_V1.1240.99
131_A143_W1.1200.99
14_M186_V1.1150.99
139_W171_G1.1090.99
362_D366_R1.1070.99
356_V359_S1.1030.99
311_L327_Y1.1000.99
12_V188_L1.1000.99
153_T156_L1.0980.99
360_L367_P1.0980.99
213_P217_A1.0970.99
145_D149_E1.0940.99
283_V309_G1.0930.99
294_M310_M1.0890.99
129_N225_V1.0880.99
21_A46_T1.0850.99
17_T42_E1.0750.99
126_V339_R1.0670.99
77_S107_A1.0620.99
323_D327_Y1.0580.99
117_A225_V1.0430.99
254_F341_Y1.0430.99
291_S294_M1.0430.99
362_D372_F1.0410.99
217_A220_V1.0370.99
277_I307_K1.0330.99
100_V136_D1.0300.99
141_L171_G1.0280.98
326_R329_A1.0230.98
40_Y86_G1.0230.98
30_D58_A1.0220.98
197_F200_P1.0190.98
215_T218_P1.0150.98
145_D312_R1.0140.98
275_Y298_I1.0040.98
300_N304_Q1.0010.98
131_A287_M1.0000.98
44_M48_S0.9940.98
273_E312_R0.9940.98
238_R241_S0.9930.98
220_V228_I0.9900.98
20_V172_I0.9890.98
82_R158_Y0.9890.98
319_F324_V0.9830.98
313_I324_V0.9810.98
142_V153_T0.9800.98
246_A249_E0.9770.98
22_H55_E0.9710.98
160_I243_I0.9700.98
239_A242_V0.9700.98
234_E237_E0.9690.98
29_V47_I0.9580.98
131_A173_S0.9500.97
294_M297_A0.9490.97
231_Q239_A0.9450.97
17_T40_Y0.9440.97
31_V81_A0.9420.97
196_N199_P0.9360.97
37_I90_V0.9330.97
23_A27_A0.9320.97
78_L216_V0.9260.97
294_M337_I0.9240.97
273_E314_R0.9170.97
246_A250_F0.9110.97
23_A154_A0.9090.97
277_I311_L0.9080.97
272_V311_L0.9020.97
285_I328_L0.8990.96
85_V111_A0.8980.96
280_A283_V0.8950.96
206_Y210_P0.8940.96
84_L112_I0.8930.96
326_R330_N0.8930.96
30_D56_L0.8890.96
365_Q368_R0.8880.96
277_I280_A0.8870.96
217_A221_N0.8870.96
251_K258_P0.8810.96
309_G331_S0.8800.96
248_E252_K0.8790.96
93_L118_L0.8770.96
295_K310_M0.8770.96
140_L170_L0.8730.96
311_L323_D0.8710.96
156_L160_I0.8710.96
156_L159_R0.8690.96
285_I334_V0.8620.96
353_Y357_R0.8610.95
93_L96_M0.8610.95
302_R306_Y0.8580.95
333_V368_R0.8540.95
61_I72_T0.8540.95
247_Y250_F0.8510.95
242_V245_E0.8510.95
142_V315_W0.8510.95
353_Y356_V0.8460.95
301_M374_G0.8420.95
205_K208_V0.8360.95
313_I352_I0.8350.95
364_D368_R0.8350.95
63_A72_T0.8320.95
349_G352_I0.8320.95
197_F246_A0.8290.94
307_K332_R0.8260.94
12_V186_V0.8220.94
349_G356_V0.8150.94
363_L366_R0.8140.94
243_I247_Y0.8140.94
23_A151_F0.8130.94
44_M47_I0.8110.94
213_P216_V0.8100.94
335_C370_M0.8100.94
253_V257_Y0.8080.94
275_Y295_K0.8080.94
142_V157_A0.8010.93
291_S295_K0.8010.93
200_P212_N0.7990.93
237_E240_R0.7990.93
163_D199_P0.7990.93
43_V112_I0.7980.93
193_L196_N0.7920.93
157_A172_I0.7920.93
25_M50_L0.7920.93
40_Y44_M0.7890.93
106_R235_A0.7880.93
355_E358_S0.7880.93
321_T359_S0.7860.93
285_I311_L0.7840.93
259_G273_E0.7830.93
78_L107_A0.7810.92
112_I154_A0.7800.92
357_R360_L0.7790.92
274_P309_G0.7760.92
297_A301_M0.7760.92
348_R354_H0.7750.92
294_M298_I0.7740.92
302_R305_G0.7700.92
285_I313_I0.7680.92
248_E255_G0.7670.92
27_A155_L0.7670.92
275_Y302_R0.7660.92
348_R351_V0.7650.92
34_A44_M0.7630.92
113_I134_V0.7600.91
253_V256_R0.7600.91
15_N183_E0.7580.91
277_I309_G0.7570.91
112_I157_A0.7570.91
191_R195_K0.7540.91
244_V271_F0.7520.91
213_P255_G0.7490.91
144_V153_T0.7470.91
355_E359_S0.7470.91
359_S362_D0.7450.91
215_T252_K0.7450.91
65_G124_Y0.7440.91
20_V112_I0.7430.91
302_R307_K0.7400.90
204_G210_P0.7390.90
176_G181_H0.7380.90
319_F344_G0.7380.90
84_L158_Y0.7370.90
327_Y330_N0.7320.90
302_R309_G0.7270.90
293_P297_A0.7270.90
149_E152_D0.7230.89
254_F257_Y0.7220.89
151_F188_L0.7210.89
44_M60_F0.7210.89
167_L206_Y0.7190.89
284_L297_A0.7180.89
73_V102_T0.7140.89
154_A158_Y0.7050.88
43_V114_G0.7010.88
240_R243_I0.7010.88
112_I174_M0.7000.88
175_D289_T0.6990.88
23_A194_V0.6990.88
96_M137_V0.6970.88
350_G353_Y0.6960.87
295_K299_K0.6910.87
362_D368_R0.6890.87
271_F323_D0.6860.87
15_N42_E0.6860.87
275_Y310_M0.6850.87
274_P277_I0.6850.87
29_V58_A0.6820.86
141_L316_F0.6820.86
21_A47_I0.6810.86
195_K198_L0.6790.86
85_V88_S0.6790.86
240_R323_D0.6770.86
32_V84_L0.6750.86
225_V228_I0.6750.86
121_P231_Q0.6750.86
13_L183_E0.6740.86
93_L133_M0.6720.86
26_Y189_P0.6720.86
361_Y366_R0.6710.85
208_V212_N0.6700.85
107_A161_A0.6700.85
250_F253_V0.6690.85
76_A81_A0.6690.85
192_E196_N0.6690.85
244_V247_Y0.6680.85
129_N340_D0.6630.85
235_A238_R0.6620.85
132_L351_V0.6610.85
252_K257_Y0.6610.85
248_E258_P0.6580.84
363_L367_P0.6570.84
352_I356_V0.6570.84
145_D295_K0.6550.84
101_V119_D0.6550.84
100_V137_V0.6530.84
161_A170_L0.6500.84
121_P232_H0.6500.84
135_R141_L0.6500.84
161_A168_L0.6480.83
321_T325_I0.6460.83
354_H357_R0.6460.83
152_D256_R0.6460.83
25_M55_E0.6450.83
88_S114_G0.6430.83
159_R196_N0.6420.83
322_Q325_I0.6420.83
349_G355_E0.6380.83
243_I315_W0.6370.82
276_M279_D0.6360.82
216_V220_V0.6350.82
110_V170_L0.6340.82
159_R249_E0.6330.82
279_D309_G0.6330.82
42_E46_T0.6310.82
335_C360_L0.6300.82
291_S310_M0.6290.82
106_R168_L0.6290.82
205_K210_P0.6260.81
361_Y367_P0.6250.81
106_R167_L0.6250.81
26_Y155_L0.6240.81
69_Q73_V0.6230.81
67_H118_L0.6210.81
119_D122_G0.6200.81
174_M180_T0.6200.81
101_V122_G0.6160.80
136_D342_S0.6130.80
281_E333_V0.6130.80
70_F73_V0.6120.80
205_K209_H0.6110.80
28_D158_Y0.6100.80
113_I171_G0.6070.79
102_T139_W0.6070.79
18_Q183_E0.6060.79
275_Y312_R0.6050.79
115_N173_S0.6020.79
244_V251_K0.6020.79
47_I51_I0.6020.79
295_K298_I0.6010.79
160_I242_V0.6000.79
18_Q22_H0.6000.79
131_A316_F0.5990.78
251_K363_L0.5980.78
17_T180_T0.5970.78
134_V141_L0.5970.78
324_V359_S0.5930.78
348_R360_L0.5930.78
66_E91_G0.5930.78
189_P254_F0.5910.77
195_K200_P0.5890.77
131_A141_L0.5890.77
241_S246_A0.5880.77
250_F257_Y0.5860.77
349_G357_R0.5850.77
229_R232_H0.5850.77
206_Y209_H0.5830.77
96_M136_D0.5820.76
43_V174_M0.5810.76
14_M19_A0.5810.76
115_N289_T0.5770.76
157_A170_L0.5760.76
100_V118_L0.5760.76
112_I172_I0.5750.76
210_P216_V0.5730.75
366_R369_V0.5700.75
250_F258_P0.5700.75
285_I336_V0.5700.75
135_R317_R0.5700.75
159_R163_D0.5690.75
147_A184_Q0.5680.75
24_A47_I0.5670.75
90_V119_D0.5670.75
327_Y331_S0.5650.74
120_D229_R0.5650.74
245_E249_E0.5640.74
107_A228_I0.5630.74
232_H235_A0.5630.74
145_D314_R0.5620.74
244_V257_Y0.5620.74
151_F186_V0.5600.74
31_V72_T0.5600.74
242_V246_A0.5600.74
233_E237_E0.5590.74
83_T98_A0.5590.74
77_S109_V0.5580.73
198_L201_Y0.5580.73
140_L166_V0.5560.73
155_L159_R0.5560.73
143_W287_M0.5550.73
28_D195_K0.5540.73
22_H151_F0.5540.73
228_I231_Q0.5540.73
16_G147_A0.5530.73
48_S60_F0.5520.73
365_Q369_V0.5510.72
271_F327_Y0.5510.72
101_V105_D0.5500.72
96_M133_M0.5500.72
327_Y334_V0.5480.72
26_Y191_R0.5480.72
33_A69_Q0.5480.72
132_L350_G0.5440.72
277_I331_S0.5430.71
207_L212_N0.5420.71
12_V22_H0.5400.71
204_G209_H0.5400.71
357_R369_V0.5390.71
366_R370_M0.5360.70
19_A23_A0.5360.70
162_E199_P0.5340.70
301_M308_V0.5340.70
156_L250_F0.5320.70
170_L239_A0.5310.70
22_H46_T0.5310.70
232_H253_V0.5310.70
90_V114_G0.5290.69
153_T271_F0.5270.69
276_M298_I0.5260.69
203_R209_H0.5260.69
93_L100_V0.5250.69
297_A300_N0.5250.69
321_T348_R0.5240.69
361_Y364_D0.5240.69
313_I316_F0.5240.69
355_E360_L0.5240.69
72_T98_A0.5220.68
37_I61_I0.5220.68
24_A158_Y0.5220.68
274_P278_D0.5210.68
78_L214_I0.5200.68
251_K259_G0.5180.68
24_A154_A0.5170.68
22_H26_Y0.5160.68
364_D369_V0.5160.68
158_Y162_E0.5160.68
19_A150_A0.5160.68
352_I355_E0.5150.67
126_V130_D0.5140.67
247_Y257_Y0.5130.67
145_D153_T0.5130.67
219_Q222_E0.5120.67
325_I329_A0.5120.67
235_A243_I0.5120.67
67_H95_A0.5110.67
331_S334_V0.5100.67
301_M304_Q0.5090.66
87_S95_A0.5090.66
118_L122_G0.5070.66
14_M18_Q0.5060.66
238_R246_A0.5060.66
152_D156_L0.5060.66
311_L328_L0.5040.66
206_Y212_N0.5040.66
259_G271_F0.5030.66
324_V328_L0.5020.65
289_T294_M0.5010.65
117_A120_D0.5000.65
184_Q292_K0.5000.65
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2c42A 2 0.9325 100 0.307 Contact Map
5c4iA 2 0.9422 100 0.391 Contact Map
1yd7A 1 0.4048 100 0.505 Contact Map
1qs0B 2 0.7398 100 0.728 Contact Map
1umdB 2 0.6843 100 0.74 Contact Map
1w85B 2 0.7133 100 0.753 Contact Map
2ozlB 2 0.6988 100 0.757 Contact Map
1ik6A 3 0.6289 100 0.758 Contact Map
3komA 2 0.7301 100 0.762 Contact Map
2bfdB 2 0.7277 99.9 0.77 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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