Q7LX69 - SULSO - GREMLIN Contacts

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Q7LX69 - Pyruvate synthase alpha chain (Pyruvic-ferredoxin oxidoreductase alpha chain) (PorA-like)

UniProt:	Q7LX69	Sequences: MTEVKKLVEREVLMNGTQAVAHAAMYADVDVVAAYPIRPYTEVMDTISKLIADGELDAEFIVAEGEHGQFETVKHASLAGARTLVGSSGVGWLYAMEAIVVTATDRAPVVAIIGNRALDDPGAYGVEHNDALMVRDVGWLLVWVDTAQEAFDTALLAYRIAEDQRVLLPLGISMDGGFLTHSEQIVRLPPRELVKNFLPPYNRGKYLVHPDNPITVAPQVNEDWVMEIRRQHEEAMERARSVIVEAYEEFKKVFGRYPGSTSDLQMPENPFVEPYMIDDAEVVLIGMGTVSKPMKVAIKNMRRQGYKVGMLRIRWFRPFPTQDVIRYLANSRVVCVIDRDYSMGSPNRGGVIYHEVRSSLYDLDQRPRVMNFIGGLGGREITIQDVEKIIKIGYEHRDTPITKPVYWVGVRGDPW	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	415 (349)
Sequences:	4004 (2506)
Seq/√Len:	134.1

ECOLI - NIFJ
HALSA - Q9HQJ9 Q9HRZ5
SULSO - Q7LX69 Q97V78 Q97YU9 Q97V21 Q97WQ2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
281_E	332_R	5.376	1.00
275_Y	299_K	4.119	1.00
298_I	310_M	3.736	1.00
286_G	294_M	3.000	1.00
251_K	257_Y	2.893	1.00
282_V	333_V	2.801	1.00
148_Q	152_D	2.801	1.00
20_V	150_A	2.763	1.00
277_I	283_V	2.741	1.00
87_S	92_W	2.673	1.00
247_Y	251_K	2.665	1.00
283_V	331_S	2.649	1.00
244_V	248_E	2.592	1.00
99_I	111_A	2.554	1.00
320_P	323_D	2.544	1.00
142_V	160_I	2.532	1.00
29_V	158_Y	2.436	1.00
279_D	307_K	2.414	1.00
190_P	193_L	2.411	1.00
282_V	306_Y	2.394	1.00
276_M	299_K	2.213	1.00
144_V	172_I	2.187	1.00
99_I	139_W	2.179	1.00
76_A	83_T	2.164	1.00
311_L	324_V	2.156	1.00
140_L	160_I	2.126	1.00
20_V	154_A	2.101	1.00
24_A	86_G	2.091	1.00
74_K	102_T	2.084	1.00
26_Y	151_F	2.071	1.00
50_L	55_E	2.049	1.00
134_V	171_G	2.039	1.00
151_F	189_P	1.990	1.00
272_V	320_P	1.975	1.00
32_V	86_G	1.941	1.00
70_F	98_A	1.938	1.00
360_L	369_V	1.938	1.00
82_R	162_E	1.936	1.00
154_A	172_I	1.927	1.00
22_H	50_L	1.904	1.00
73_V	109_V	1.898	1.00
316_F	355_E	1.887	1.00
163_D	166_V	1.848	1.00
283_V	328_L	1.844	1.00
163_D	245_E	1.828	1.00
354_H	358_S	1.817	1.00
281_E	307_K	1.811	1.00
286_G	310_M	1.806	1.00
24_A	84_L	1.767	1.00
149_E	312_R	1.766	1.00
33_A	72_T	1.755	1.00
145_D	291_S	1.740	1.00
11_E	187_R	1.722	1.00
99_I	171_G	1.712	1.00
282_V	335_C	1.707	1.00
155_L	194_V	1.705	1.00
74_K	98_A	1.692	1.00
71_E	98_A	1.686	1.00
284_L	298_I	1.683	1.00
92_W	171_G	1.676	1.00
117_A	123_A	1.668	1.00
11_E	185_I	1.667	1.00
286_G	290_V	1.653	1.00
29_V	84_L	1.641	1.00
33_A	73_V	1.637	1.00
284_L	294_M	1.629	1.00
30_D	81_A	1.627	1.00
251_K	256_R	1.617	1.00
240_R	245_E	1.605	1.00
364_D	367_P	1.603	1.00
254_F	258_P	1.592	1.00
20_V	174_M	1.585	1.00
166_V	239_A	1.570	1.00
153_T	314_R	1.540	1.00
27_A	158_Y	1.530	1.00
102_T	109_V	1.528	1.00
70_F	111_A	1.502	1.00
27_A	191_R	1.493	1.00
140_L	168_L	1.492	1.00
249_E	252_K	1.480	1.00
328_L	334_V	1.480	1.00
279_D	302_R	1.471	1.00
319_F	359_S	1.462	1.00
204_G	207_L	1.460	1.00
301_M	306_Y	1.445	1.00
114_G	174_M	1.443	1.00
156_L	271_F	1.430	1.00
286_G	291_S	1.429	1.00
283_V	334_V	1.420	1.00
283_V	327_Y	1.416	1.00
149_E	314_R	1.411	1.00
134_V	173_S	1.394	1.00
51_I	58_A	1.388	1.00
114_G	180_T	1.382	1.00
322_Q	326_R	1.381	1.00
146_T	292_K	1.381	1.00
291_S	312_R	1.369	1.00
302_R	308_V	1.356	1.00
248_E	251_K	1.345	1.00
323_D	326_R	1.326	1.00
357_R	361_Y	1.323	1.00
226_M	229_R	1.313	1.00
110_V	157_A	1.308	1.00
349_G	353_Y	1.301	1.00
109_V	161_A	1.298	1.00
250_F	254_F	1.280	1.00
249_E	253_V	1.279	1.00
46_T	49_K	1.275	1.00
255_G	258_P	1.269	1.00
255_G	259_G	1.259	1.00
296_V	300_N	1.258	1.00
96_M	134_V	1.247	1.00
73_V	83_T	1.247	1.00
46_T	50_L	1.242	1.00
277_I	302_R	1.239	1.00
280_A	309_G	1.238	1.00
251_K	254_F	1.230	1.00
298_I	302_R	1.229	1.00
358_S	361_Y	1.226	1.00
110_V	158_Y	1.219	1.00
209_H	212_N	1.218	1.00
70_F	109_V	1.217	1.00
295_K	312_R	1.217	1.00
300_N	303_R	1.205	1.00
283_V	311_L	1.192	0.99
234_E	238_R	1.189	0.99
143_W	173_S	1.188	0.99
357_R	362_D	1.188	0.99
31_V	76_A	1.184	0.99
15_N	18_Q	1.184	0.99
203_R	207_L	1.181	0.99
203_R	206_Y	1.179	0.99
18_Q	46_T	1.178	0.99
241_S	322_Q	1.176	0.99
251_K	255_G	1.167	0.99
287_M	340_D	1.167	0.99
21_A	43_V	1.166	0.99
276_M	302_R	1.164	0.99
285_I	324_V	1.160	0.99
69_Q	95_A	1.159	0.99
244_V	323_D	1.150	0.99
282_V	308_V	1.144	0.99
160_I	246_A	1.144	0.99
248_E	257_Y	1.141	0.99
32_V	44_M	1.132	0.99
142_V	170_L	1.128	0.99
166_V	242_V	1.124	0.99
131_A	143_W	1.120	0.99
14_M	186_V	1.115	0.99
139_W	171_G	1.109	0.99
362_D	366_R	1.107	0.99
356_V	359_S	1.103	0.99
311_L	327_Y	1.100	0.99
12_V	188_L	1.100	0.99
153_T	156_L	1.098	0.99
360_L	367_P	1.098	0.99
213_P	217_A	1.097	0.99
145_D	149_E	1.094	0.99
283_V	309_G	1.093	0.99
294_M	310_M	1.089	0.99
129_N	225_V	1.088	0.99
21_A	46_T	1.085	0.99
17_T	42_E	1.075	0.99
126_V	339_R	1.067	0.99
77_S	107_A	1.062	0.99
323_D	327_Y	1.058	0.99
117_A	225_V	1.043	0.99
254_F	341_Y	1.043	0.99
291_S	294_M	1.043	0.99
362_D	372_F	1.041	0.99
217_A	220_V	1.037	0.99
277_I	307_K	1.033	0.99
100_V	136_D	1.030	0.99
141_L	171_G	1.028	0.98
326_R	329_A	1.023	0.98
40_Y	86_G	1.023	0.98
30_D	58_A	1.022	0.98
197_F	200_P	1.019	0.98
215_T	218_P	1.015	0.98
145_D	312_R	1.014	0.98
275_Y	298_I	1.004	0.98
300_N	304_Q	1.001	0.98
131_A	287_M	1.000	0.98
44_M	48_S	0.994	0.98
273_E	312_R	0.994	0.98
238_R	241_S	0.993	0.98
220_V	228_I	0.990	0.98
20_V	172_I	0.989	0.98
82_R	158_Y	0.989	0.98
319_F	324_V	0.983	0.98
313_I	324_V	0.981	0.98
142_V	153_T	0.980	0.98
246_A	249_E	0.977	0.98
22_H	55_E	0.971	0.98
160_I	243_I	0.970	0.98
239_A	242_V	0.970	0.98
234_E	237_E	0.969	0.98
29_V	47_I	0.958	0.98
131_A	173_S	0.950	0.97
294_M	297_A	0.949	0.97
231_Q	239_A	0.945	0.97
17_T	40_Y	0.944	0.97
31_V	81_A	0.942	0.97
196_N	199_P	0.936	0.97
37_I	90_V	0.933	0.97
23_A	27_A	0.932	0.97
78_L	216_V	0.926	0.97
294_M	337_I	0.924	0.97
273_E	314_R	0.917	0.97
246_A	250_F	0.911	0.97
23_A	154_A	0.909	0.97
277_I	311_L	0.908	0.97
272_V	311_L	0.902	0.97
285_I	328_L	0.899	0.96
85_V	111_A	0.898	0.96
280_A	283_V	0.895	0.96
206_Y	210_P	0.894	0.96
84_L	112_I	0.893	0.96
326_R	330_N	0.893	0.96
30_D	56_L	0.889	0.96
365_Q	368_R	0.888	0.96
277_I	280_A	0.887	0.96
217_A	221_N	0.887	0.96
251_K	258_P	0.881	0.96
309_G	331_S	0.880	0.96
248_E	252_K	0.879	0.96
93_L	118_L	0.877	0.96
295_K	310_M	0.877	0.96
140_L	170_L	0.873	0.96
311_L	323_D	0.871	0.96
156_L	160_I	0.871	0.96
156_L	159_R	0.869	0.96
285_I	334_V	0.862	0.96
353_Y	357_R	0.861	0.95
93_L	96_M	0.861	0.95
302_R	306_Y	0.858	0.95
333_V	368_R	0.854	0.95
61_I	72_T	0.854	0.95
247_Y	250_F	0.851	0.95
242_V	245_E	0.851	0.95
142_V	315_W	0.851	0.95
353_Y	356_V	0.846	0.95
301_M	374_G	0.842	0.95
205_K	208_V	0.836	0.95
313_I	352_I	0.835	0.95
364_D	368_R	0.835	0.95
63_A	72_T	0.832	0.95
349_G	352_I	0.832	0.95
197_F	246_A	0.829	0.94
307_K	332_R	0.826	0.94
12_V	186_V	0.822	0.94
349_G	356_V	0.815	0.94
363_L	366_R	0.814	0.94
243_I	247_Y	0.814	0.94
23_A	151_F	0.813	0.94
44_M	47_I	0.811	0.94
213_P	216_V	0.810	0.94
335_C	370_M	0.810	0.94
253_V	257_Y	0.808	0.94
275_Y	295_K	0.808	0.94
142_V	157_A	0.801	0.93
291_S	295_K	0.801	0.93
200_P	212_N	0.799	0.93
237_E	240_R	0.799	0.93
163_D	199_P	0.799	0.93
43_V	112_I	0.798	0.93
193_L	196_N	0.792	0.93
157_A	172_I	0.792	0.93
25_M	50_L	0.792	0.93
40_Y	44_M	0.789	0.93
106_R	235_A	0.788	0.93
355_E	358_S	0.788	0.93
321_T	359_S	0.786	0.93
285_I	311_L	0.784	0.93
259_G	273_E	0.783	0.93
78_L	107_A	0.781	0.92
112_I	154_A	0.780	0.92
357_R	360_L	0.779	0.92
274_P	309_G	0.776	0.92
297_A	301_M	0.776	0.92
348_R	354_H	0.775	0.92
294_M	298_I	0.774	0.92
302_R	305_G	0.770	0.92
285_I	313_I	0.768	0.92
248_E	255_G	0.767	0.92
27_A	155_L	0.767	0.92
275_Y	302_R	0.766	0.92
348_R	351_V	0.765	0.92
34_A	44_M	0.763	0.92
113_I	134_V	0.760	0.91
253_V	256_R	0.760	0.91
15_N	183_E	0.758	0.91
277_I	309_G	0.757	0.91
112_I	157_A	0.757	0.91
191_R	195_K	0.754	0.91
244_V	271_F	0.752	0.91
213_P	255_G	0.749	0.91
144_V	153_T	0.747	0.91
355_E	359_S	0.747	0.91
359_S	362_D	0.745	0.91
215_T	252_K	0.745	0.91
65_G	124_Y	0.744	0.91
20_V	112_I	0.743	0.91
302_R	307_K	0.740	0.90
204_G	210_P	0.739	0.90
176_G	181_H	0.738	0.90
319_F	344_G	0.738	0.90
84_L	158_Y	0.737	0.90
327_Y	330_N	0.732	0.90
302_R	309_G	0.727	0.90
293_P	297_A	0.727	0.90
149_E	152_D	0.723	0.89
254_F	257_Y	0.722	0.89
151_F	188_L	0.721	0.89
44_M	60_F	0.721	0.89
167_L	206_Y	0.719	0.89
284_L	297_A	0.718	0.89
73_V	102_T	0.714	0.89
154_A	158_Y	0.705	0.88
43_V	114_G	0.701	0.88
240_R	243_I	0.701	0.88
112_I	174_M	0.700	0.88
175_D	289_T	0.699	0.88
23_A	194_V	0.699	0.88
96_M	137_V	0.697	0.88
350_G	353_Y	0.696	0.87
295_K	299_K	0.691	0.87
362_D	368_R	0.689	0.87
271_F	323_D	0.686	0.87
15_N	42_E	0.686	0.87
275_Y	310_M	0.685	0.87
274_P	277_I	0.685	0.87
29_V	58_A	0.682	0.86
141_L	316_F	0.682	0.86
21_A	47_I	0.681	0.86
195_K	198_L	0.679	0.86
85_V	88_S	0.679	0.86
240_R	323_D	0.677	0.86
32_V	84_L	0.675	0.86
225_V	228_I	0.675	0.86
121_P	231_Q	0.675	0.86
13_L	183_E	0.674	0.86
93_L	133_M	0.672	0.86
26_Y	189_P	0.672	0.86
361_Y	366_R	0.671	0.85
208_V	212_N	0.670	0.85
107_A	161_A	0.670	0.85
250_F	253_V	0.669	0.85
76_A	81_A	0.669	0.85
192_E	196_N	0.669	0.85
244_V	247_Y	0.668	0.85
129_N	340_D	0.663	0.85
235_A	238_R	0.662	0.85
132_L	351_V	0.661	0.85
252_K	257_Y	0.661	0.85
248_E	258_P	0.658	0.84
363_L	367_P	0.657	0.84
352_I	356_V	0.657	0.84
145_D	295_K	0.655	0.84
101_V	119_D	0.655	0.84
100_V	137_V	0.653	0.84
161_A	170_L	0.650	0.84
121_P	232_H	0.650	0.84
135_R	141_L	0.650	0.84
161_A	168_L	0.648	0.83
321_T	325_I	0.646	0.83
354_H	357_R	0.646	0.83
152_D	256_R	0.646	0.83
25_M	55_E	0.645	0.83
88_S	114_G	0.643	0.83
159_R	196_N	0.642	0.83
322_Q	325_I	0.642	0.83
349_G	355_E	0.638	0.83
243_I	315_W	0.637	0.82
276_M	279_D	0.636	0.82
216_V	220_V	0.635	0.82
110_V	170_L	0.634	0.82
159_R	249_E	0.633	0.82
279_D	309_G	0.633	0.82
42_E	46_T	0.631	0.82
335_C	360_L	0.630	0.82
291_S	310_M	0.629	0.82
106_R	168_L	0.629	0.82
205_K	210_P	0.626	0.81
361_Y	367_P	0.625	0.81
106_R	167_L	0.625	0.81
26_Y	155_L	0.624	0.81
69_Q	73_V	0.623	0.81
67_H	118_L	0.621	0.81
119_D	122_G	0.620	0.81
174_M	180_T	0.620	0.81
101_V	122_G	0.616	0.80
136_D	342_S	0.613	0.80
281_E	333_V	0.613	0.80
70_F	73_V	0.612	0.80
205_K	209_H	0.611	0.80
28_D	158_Y	0.610	0.80
113_I	171_G	0.607	0.79
102_T	139_W	0.607	0.79
18_Q	183_E	0.606	0.79
275_Y	312_R	0.605	0.79
115_N	173_S	0.602	0.79
244_V	251_K	0.602	0.79
47_I	51_I	0.602	0.79
295_K	298_I	0.601	0.79
160_I	242_V	0.600	0.79
18_Q	22_H	0.600	0.79
131_A	316_F	0.599	0.78
251_K	363_L	0.598	0.78
17_T	180_T	0.597	0.78
134_V	141_L	0.597	0.78
324_V	359_S	0.593	0.78
348_R	360_L	0.593	0.78
66_E	91_G	0.593	0.78
189_P	254_F	0.591	0.77
195_K	200_P	0.589	0.77
131_A	141_L	0.589	0.77
241_S	246_A	0.588	0.77
250_F	257_Y	0.586	0.77
349_G	357_R	0.585	0.77
229_R	232_H	0.585	0.77
206_Y	209_H	0.583	0.77
96_M	136_D	0.582	0.76
43_V	174_M	0.581	0.76
14_M	19_A	0.581	0.76
115_N	289_T	0.577	0.76
157_A	170_L	0.576	0.76
100_V	118_L	0.576	0.76
112_I	172_I	0.575	0.76
210_P	216_V	0.573	0.75
366_R	369_V	0.570	0.75
250_F	258_P	0.570	0.75
285_I	336_V	0.570	0.75
135_R	317_R	0.570	0.75
159_R	163_D	0.569	0.75
147_A	184_Q	0.568	0.75
24_A	47_I	0.567	0.75
90_V	119_D	0.567	0.75
327_Y	331_S	0.565	0.74
120_D	229_R	0.565	0.74
245_E	249_E	0.564	0.74
107_A	228_I	0.563	0.74
232_H	235_A	0.563	0.74
145_D	314_R	0.562	0.74
244_V	257_Y	0.562	0.74
151_F	186_V	0.560	0.74
31_V	72_T	0.560	0.74
242_V	246_A	0.560	0.74
233_E	237_E	0.559	0.74
83_T	98_A	0.559	0.74
77_S	109_V	0.558	0.73
198_L	201_Y	0.558	0.73
140_L	166_V	0.556	0.73
155_L	159_R	0.556	0.73
143_W	287_M	0.555	0.73
28_D	195_K	0.554	0.73
22_H	151_F	0.554	0.73
228_I	231_Q	0.554	0.73
16_G	147_A	0.553	0.73
48_S	60_F	0.552	0.73
365_Q	369_V	0.551	0.72
271_F	327_Y	0.551	0.72
101_V	105_D	0.550	0.72
96_M	133_M	0.550	0.72
327_Y	334_V	0.548	0.72
26_Y	191_R	0.548	0.72
33_A	69_Q	0.548	0.72
132_L	350_G	0.544	0.72
277_I	331_S	0.543	0.71
207_L	212_N	0.542	0.71
12_V	22_H	0.540	0.71
204_G	209_H	0.540	0.71
357_R	369_V	0.539	0.71
366_R	370_M	0.536	0.70
19_A	23_A	0.536	0.70
162_E	199_P	0.534	0.70
301_M	308_V	0.534	0.70
156_L	250_F	0.532	0.70
170_L	239_A	0.531	0.70
22_H	46_T	0.531	0.70
232_H	253_V	0.531	0.70
90_V	114_G	0.529	0.69
153_T	271_F	0.527	0.69
276_M	298_I	0.526	0.69
203_R	209_H	0.526	0.69
93_L	100_V	0.525	0.69
297_A	300_N	0.525	0.69
321_T	348_R	0.524	0.69
361_Y	364_D	0.524	0.69
313_I	316_F	0.524	0.69
355_E	360_L	0.524	0.69
72_T	98_A	0.522	0.68
37_I	61_I	0.522	0.68
24_A	158_Y	0.522	0.68
274_P	278_D	0.521	0.68
78_L	214_I	0.520	0.68
251_K	259_G	0.518	0.68
24_A	154_A	0.517	0.68
22_H	26_Y	0.516	0.68
364_D	369_V	0.516	0.68
158_Y	162_E	0.516	0.68
19_A	150_A	0.516	0.68
352_I	355_E	0.515	0.67
126_V	130_D	0.514	0.67
247_Y	257_Y	0.513	0.67
145_D	153_T	0.513	0.67
219_Q	222_E	0.512	0.67
325_I	329_A	0.512	0.67
235_A	243_I	0.512	0.67
67_H	95_A	0.511	0.67
331_S	334_V	0.510	0.67
301_M	304_Q	0.509	0.66
87_S	95_A	0.509	0.66
118_L	122_G	0.507	0.66
14_M	18_Q	0.506	0.66
238_R	246_A	0.506	0.66
152_D	156_L	0.506	0.66
311_L	328_L	0.504	0.66
206_Y	212_N	0.504	0.66
259_G	271_F	0.503	0.66
324_V	328_L	0.502	0.65
289_T	294_M	0.501	0.65
117_A	120_D	0.500	0.65
184_Q	292_K	0.500	0.65

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2c42A	2	0.9325	100	0.307	Contact Map
5c4iA	2	0.9422	100	0.391	Contact Map
1yd7A	1	0.4048	100	0.505	Contact Map
1qs0B	2	0.7398	100	0.728	Contact Map
1umdB	2	0.6843	100	0.74	Contact Map
1w85B	2	0.7133	100	0.753	Contact Map
2ozlB	2	0.6988	100	0.757	Contact Map
1ik6A	3	0.6289	100	0.758	Contact Map
3komA	2	0.7301	100	0.762	Contact Map
2bfdB	2	0.7277	99.9	0.77	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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