GREMLIN Database
Q7LX68 - Pyruvate synthase beta chain (Pyruvic-ferredoxin oxidoreductase beta chain) (PorB-like)
UniProt: Q7LX68 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 338 (300)
Sequences: 1784 (890)
Seq/√Len: 51.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
140_N224_G5.4791.00
190_P262_Y4.7441.00
205_M213_S3.8971.00
142_L227_T3.4641.00
222_T267_G3.3591.00
28_T66_A3.1621.00
245_F248_E3.0061.00
249_L294_K2.9911.00
43_M117_F2.8871.00
222_T265_I2.6291.00
134_A141_L2.5021.00
289_K310_Q2.4821.00
135_M193_I2.3651.00
95_A99_R2.3501.00
256_T286_K2.3421.00
317_Y321_E2.3351.00
162_T166_A2.2991.00
43_M146_Y2.2621.00
310_Q314_D2.2501.00
46_L217_I2.2141.00
240_D296_G2.1791.00
149_E185_K2.1731.00
131_V143_I2.1711.00
100_A103_R2.1691.00
116_A141_L2.0781.00
91_A116_A1.9771.00
55_I98_L1.9721.00
251_V255_E1.9661.00
206_T250_G1.9621.00
46_L117_F1.9480.99
218_R222_T1.9450.99
313_V317_Y1.9280.99
212_D216_K1.8940.99
135_M143_I1.8830.99
234_P246_S1.8750.99
308_Y311_R1.8750.99
315_E319_E1.8560.99
176_Q308_Y1.8350.99
205_M217_I1.8290.99
193_I228_F1.8230.99
249_L295_Q1.8180.99
252_L294_K1.8060.99
164_F319_E1.7850.99
276_K279_V1.7590.99
205_M231_S1.7390.99
311_R314_D1.7220.99
207_P247_H1.7110.99
99_R139_Y1.6850.99
268_E273_E1.6650.98
257_G285_R1.6440.98
289_K317_Y1.6400.98
316_M320_W1.6370.98
265_I268_E1.6310.98
206_T254_V1.6210.98
147_D185_K1.6060.98
55_I114_V1.5860.98
117_F146_Y1.5650.98
60_T81_H1.5550.97
239_W242_D1.5460.97
253_A291_Y1.5450.97
145_L228_F1.5430.97
293_E302_T1.5370.97
39_S146_Y1.5220.97
190_P228_F1.5160.97
296_G300_H1.5060.97
58_G79_W1.5030.97
46_L144_I1.5010.97
187_S191_M1.4990.97
138_D226_P1.4970.97
313_V320_W1.4890.97
317_Y320_W1.4860.97
237_K242_D1.4700.96
289_K293_E1.4340.96
57_I91_A1.4230.96
106_K110_E1.4110.95
173_P176_Q1.4100.95
80_V90_A1.4090.95
237_K240_D1.4060.95
100_A104_K1.4020.95
254_V261_L1.3930.95
142_L221_L1.3880.95
287_P290_E1.3690.95
135_M226_P1.3650.95
213_S217_I1.3610.95
318_E322_I1.3580.94
105_G109_Q1.3550.94
144_I229_I1.3500.94
216_K263_E1.3400.94
207_P213_S1.3380.94
50_A221_L1.3310.94
272_N275_T1.3170.93
92_L139_Y1.3080.93
255_E285_R1.2890.93
148_N152_A1.2840.93
255_E286_K1.2720.92
66_A146_Y1.2710.92
57_I94_T1.2630.92
269_I322_I1.2590.92
43_M66_A1.2450.91
60_T65_V1.2310.91
185_K204_T1.2310.91
94_T114_V1.2290.91
256_T287_P1.2270.91
191_M326_M1.2170.90
91_A114_V1.2140.90
124_A161_M1.1920.89
267_G278_I1.1920.89
287_P317_Y1.1850.89
265_I278_I1.1830.89
206_T232_L1.1810.89
268_E271_Y1.1760.89
33_T40_A1.1680.89
60_T64_Y1.1670.88
50_A142_L1.1670.88
281_G284_K1.1660.88
46_L54_T1.1650.88
64_Y86_G1.1560.88
288_V316_M1.1440.87
98_L114_V1.1420.87
87_T116_A1.1380.87
217_I229_I1.1380.87
44_R48_K1.1300.87
219_K265_I1.1260.87
43_M47_A1.1140.86
190_P204_T1.1120.86
95_A139_Y1.1060.86
71_Y84_L1.1060.86
104_K108_K1.1020.85
258_L288_V1.1010.85
258_L291_Y1.0950.85
42_V231_S1.0870.85
267_G270_V1.0860.85
321_E325_V1.0820.84
100_A107_I1.0710.84
268_E278_I1.0700.84
314_D318_E1.0700.84
313_V316_M1.0590.83
101_L105_G1.0560.83
193_I202_A1.0560.83
241_Y245_F1.0550.83
314_D317_Y1.0510.83
65_V81_H1.0460.82
84_L126_M1.0430.82
55_I94_T1.0430.82
50_A115_I1.0420.82
113_N221_L1.0420.82
135_M228_F1.0410.82
108_K111_P1.0320.81
302_T313_V1.0310.81
223_I227_T1.0310.81
224_G267_G1.0290.81
284_K287_P1.0250.81
105_G108_K1.0240.81
64_Y81_H1.0240.81
279_V283_M1.0210.81
249_L252_L1.0160.80
60_T79_W1.0050.80
27_Y67_N0.9990.79
315_E318_E0.9980.79
286_K290_E0.9980.79
128_L192_I0.9970.79
280_E283_M0.9900.79
38_E41_L0.9890.79
290_E293_E0.9880.78
191_M327_P0.9880.78
190_P202_A0.9870.78
244_K248_E0.9850.78
115_I221_L0.9710.77
164_F315_E0.9660.77
82_T90_A0.9590.76
280_E284_K0.9590.76
301_F309_V0.9530.76
246_S250_G0.9460.75
47_A75_W0.9420.75
83_Q86_G0.9380.75
63_M146_Y0.9350.75
167_Q301_F0.9320.74
288_V320_W0.9310.74
311_R315_E0.9310.74
191_M194_A0.9300.74
204_T230_H0.9260.74
97_A101_L0.9250.74
203_A216_K0.9240.74
43_M75_W0.9230.74
289_K314_D0.9210.73
302_T310_Q0.9200.73
101_L104_K0.9190.73
305_D308_Y0.9090.72
123_C145_L0.9090.72
131_V135_M0.9050.72
242_D245_F0.9040.72
54_T113_N0.8950.71
252_L255_E0.8910.71
115_I142_L0.8910.71
241_Y252_L0.8900.71
56_V117_F0.8890.71
177_R199_V0.8800.70
318_E321_E0.8780.70
138_D199_V0.8780.70
68_T86_G0.8770.70
147_D230_H0.8770.70
95_A114_V0.8720.69
167_Q300_H0.8720.69
158_E171_S0.8630.68
292_L298_F0.8570.68
161_M185_K0.8570.68
31_H44_R0.8540.68
322_I326_M0.8520.67
260_P324_G0.8500.67
288_V298_F0.8500.67
57_I116_A0.8430.67
41_L247_H0.8390.66
113_N140_N0.8350.66
136_T158_E0.8330.66
248_E252_L0.8320.66
320_W327_P0.8300.65
60_T86_G0.8270.65
241_Y294_K0.8220.65
33_T66_A0.8210.65
278_I281_G0.8190.64
185_K258_L0.8130.64
194_A264_Y0.8110.64
289_K303_E0.8100.64
149_E291_Y0.8090.63
238_G242_D0.8070.63
223_I267_G0.8060.63
42_V233_D0.8030.63
28_T43_M0.8020.63
204_T262_Y0.7990.62
252_L295_Q0.7990.62
135_M200_R0.7940.62
102_M106_K0.7930.62
288_V292_L0.7910.62
117_F144_I0.7900.62
194_A262_Y0.7890.61
279_V285_R0.7880.61
280_E285_R0.7840.61
212_D263_E0.7840.61
254_V291_Y0.7760.60
132_S196_H0.7740.60
65_V91_A0.7700.60
107_I110_E0.7690.59
255_E287_P0.7680.59
268_E276_K0.7660.59
82_T86_G0.7610.59
144_I217_I0.7510.58
310_Q317_Y0.7500.58
46_L213_S0.7500.58
124_A160_S0.7500.58
237_K241_Y0.7460.57
145_L189_V0.7460.57
293_E313_V0.7430.57
289_K302_T0.7400.57
124_A230_H0.7380.56
34_C37_C0.7370.56
310_Q313_V0.7350.56
241_Y249_L0.7260.55
91_A141_L0.7260.55
104_K107_I0.7240.55
213_S231_S0.7200.54
59_A118_C0.7180.54
31_H40_A0.7180.54
81_H90_A0.7170.54
60_T75_W0.7150.54
31_H81_H0.7100.53
296_G318_E0.7080.53
256_T322_I0.7030.53
279_V284_K0.7030.53
34_C235_C0.6990.52
64_Y75_W0.6980.52
121_L159_T0.6970.52
187_S190_P0.6950.52
289_K292_L0.6940.52
25_E76_I0.6940.52
165_G319_E0.6930.52
204_T260_P0.6930.52
288_V313_V0.6880.51
62_C235_C0.6880.51
316_M319_E0.6870.51
309_V313_V0.6860.51
31_H35_Q0.6840.51
109_Q112_I0.6840.51
150_S168_T0.6790.50
310_Q318_E0.6770.50
60_T84_L0.6760.50
67_N81_H0.6760.50
106_K141_L0.6760.50
264_Y299_S0.6730.50
309_V316_M0.6730.50
271_Y274_P0.6710.49
302_T309_V0.6670.49
256_T316_M0.6670.49
202_A228_F0.6660.49
150_S156_I0.6640.49
252_L286_K0.6640.49
20_D214_M0.6610.48
57_I90_A0.6610.48
149_E161_M0.6570.48
61_G86_G0.6540.48
201_Y219_K0.6540.48
88_G130_G0.6510.47
234_P250_G0.6500.47
306_I309_V0.6480.47
24_E191_M0.6480.47
163_P166_A0.6460.47
248_E255_E0.6450.47
137_Y199_V0.6440.47
162_T168_T0.6410.46
149_E204_T0.6400.46
173_P177_R0.6390.46
92_L137_Y0.6380.46
54_T102_M0.6370.46
206_T261_L0.6360.46
252_L316_M0.6350.46
293_E310_Q0.6350.46
73_T101_L0.6300.45
69_T72_T0.6290.45
210_P247_H0.6280.45
245_F294_K0.6270.45
55_I78_P0.6270.45
319_E322_I0.6250.45
64_Y68_T0.6240.45
70_Y73_T0.6240.45
185_K291_Y0.6230.44
318_E326_M0.6200.44
293_E299_S0.6190.44
154_T235_C0.6120.43
324_G327_P0.6110.43
95_A141_L0.6070.43
109_Q209_Y0.6060.43
173_P308_Y0.6030.42
307_E311_R0.5980.42
156_I240_D0.5980.42
87_T161_M0.5970.42
128_L195_G0.5960.42
116_A131_V0.5960.42
100_A108_K0.5960.42
53_R113_N0.5950.42
302_T306_I0.5940.41
103_R267_G0.5930.41
41_L45_F0.5930.41
123_C143_I0.5920.41
21_T45_F0.5900.41
140_N223_I0.5890.41
203_A225_G0.5890.41
167_Q173_P0.5860.41
108_K112_I0.5850.41
158_E161_M0.5850.41
191_M250_G0.5820.40
200_R223_I0.5780.40
202_A229_I0.5780.40
192_I195_G0.5760.40
92_L95_A0.5760.40
118_C143_I0.5750.40
60_T68_T0.5750.40
161_M292_L0.5740.39
321_E326_M0.5730.39
271_Y275_T0.5710.39
210_P214_M0.5710.39
307_E315_E0.5690.39
61_G83_Q0.5680.39
184_W195_G0.5660.39
299_S303_E0.5660.39
288_V326_M0.5650.39
282_R285_R0.5640.38
214_M218_R0.5630.38
208_A254_V0.5630.38
106_K319_E0.5620.38
192_I200_R0.5610.38
189_V230_H0.5610.38
199_V264_Y0.5610.38
72_T114_V0.5590.38
87_T141_L0.5570.38
214_M217_I0.5560.38
194_A269_I0.5530.37
69_T105_G0.5520.37
45_F213_S0.5510.37
167_Q172_R0.5510.37
80_V94_T0.5500.37
56_V75_W0.5500.37
268_E272_N0.5480.37
314_D323_P0.5480.37
219_K263_E0.5460.37
147_D161_M0.5450.37
288_V317_Y0.5450.37
61_G79_W0.5440.37
87_T123_C0.5430.36
89_A130_G0.5430.36
142_L217_I0.5430.36
125_D153_N0.5420.36
283_M321_E0.5410.36
94_T97_A0.5400.36
50_A113_N0.5400.36
53_R259_W0.5400.36
302_T315_E0.5370.36
164_F184_W0.5360.36
165_G308_Y0.5360.36
45_F214_M0.5360.36
126_M155_D0.5360.36
184_W319_E0.5350.36
156_I166_A0.5330.35
166_A298_F0.5330.35
313_V319_E0.5320.35
110_E311_R0.5320.35
116_A143_I0.5310.35
234_P239_W0.5300.35
21_T24_E0.5300.35
34_C62_C0.5290.35
248_E251_V0.5270.35
121_L155_D0.5260.35
56_V273_E0.5250.35
50_A54_T0.5250.35
22_P44_R0.5240.35
148_N276_K0.5230.35
53_R110_E0.5230.35
311_R321_E0.5220.34
53_R78_P0.5220.34
312_M317_Y0.5220.34
98_L101_L0.5210.34
51_G54_T0.5210.34
57_I87_T0.5210.34
194_A215_N0.5210.34
69_T140_N0.5200.34
48_K214_M0.5180.34
302_T317_Y0.5170.34
294_K298_F0.5160.34
143_I200_R0.5150.34
64_Y79_W0.5130.34
194_A251_V0.5130.34
215_N218_R0.5130.34
222_T273_E0.5120.34
124_A145_L0.5090.33
278_I282_R0.5080.33
65_V68_T0.5080.33
50_A217_I0.5080.33
319_E323_P0.5070.33
211_L215_N0.5070.33
239_W295_Q0.5050.33
306_I312_M0.5050.33
47_A67_N0.5050.33
156_I167_Q0.5050.33
315_E322_I0.5030.33
314_D325_V0.5030.33
173_P305_D0.5030.33
24_E101_L0.5020.33
39_S63_M0.5020.33
101_L325_V0.5020.33
39_S232_L0.5010.33
58_G64_Y0.5000.32
252_L290_E0.5000.32
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2c42A 2 0.9734 100 0.348 Contact Map
5c4iC 2 0.9083 100 0.525 Contact Map
4kgdA 4 0.7485 99.9 0.775 Contact Map
1v5eA 4 0.7515 99.9 0.791 Contact Map
2panA 3 0.7426 99.9 0.809 Contact Map
4rjjA 5 0.6509 99.8 0.817 Contact Map
1ybhA 4 0.6923 99.8 0.82 Contact Map
1w85A 2 0.8136 99.8 0.821 Contact Map
4k9qA 4 0.6065 99.8 0.824 Contact Map
1umdA 2 0.7899 99.8 0.824 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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