GREMLIN Database
Q7LX67 - Transcriptional regulator homolog (Lrp/AsnC family)
UniProt: Q7LX67 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 155 (138)
Sequences: 13680 (8750)
Seq/√Len: 744.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
19_I34_E2.9451.00
50_E58_Y2.8241.00
78_E137_T2.5911.00
106_G139_S2.5241.00
99_R112_H2.4251.00
116_K120_S2.2791.00
28_L46_I2.2501.00
65_V119_A2.0801.00
19_I26_K2.0281.00
13_D45_R2.0211.00
48_R52_A2.0201.00
56_R63_D1.9671.00
80_V136_K1.8951.00
94_I128_K1.8631.00
72_S112_H1.8241.00
74_V101_Y1.8061.00
56_R61_L1.7951.00
98_V114_I1.7821.00
12_T37_I1.7211.00
94_I124_F1.6741.00
19_I22_Y1.6721.00
47_K51_D1.6611.00
37_I41_T1.6511.00
76_E141_S1.6211.00
29_K33_D1.5891.00
26_K34_E1.5361.00
117_D120_S1.5311.00
90_D93_E1.5251.00
90_D132_I1.4821.00
29_K39_I1.4741.00
30_E33_D1.4641.00
120_S123_Q1.4541.00
37_I42_V1.4481.00
87_V91_L1.4261.00
38_P41_T1.4251.00
96_E120_S1.4231.00
16_I31_L1.4081.00
77_I111_V1.4021.00
88_A92_G1.3761.00
78_E106_G1.3701.00
83_S86_K1.3591.00
35_L42_V1.3451.00
28_L43_R1.3351.00
25_K58_Y1.3211.00
85_K89_Q1.3031.00
11_D15_K1.3001.00
76_E107_P1.2921.00
75_M113_M1.2651.00
71_V118_D1.2621.00
78_E136_K1.2571.00
69_L116_K1.2561.00
26_K31_L1.2451.00
20_L46_I1.2351.00
79_T87_V1.2311.00
30_E34_E1.2251.00
12_T15_K1.2201.00
47_K50_E1.2001.00
88_A145_E1.1961.00
22_Y34_E1.1951.00
122_H145_E1.1901.00
27_S30_E1.1801.00
96_E128_K1.1471.00
19_I31_L1.1051.00
23_N34_E1.1051.00
10_D45_R1.1021.00
57_G61_L1.0961.00
76_E139_S1.0921.00
12_T35_L1.0821.00
72_S114_I1.0721.00
15_K18_N1.0501.00
97_V113_M1.0331.00
28_L32_S1.0271.00
115_F120_S1.0131.00
15_K19_I1.0061.00
63_D66_N1.0041.00
100_I111_V1.0041.00
26_K30_E0.9891.00
86_K90_D0.9891.00
89_Q92_G0.9891.00
18_N22_Y0.9821.00
88_A109_L0.9711.00
32_S42_V0.9691.00
74_V110_H0.9641.00
43_R47_K0.9591.00
101_Y112_H0.9511.00
25_K50_E0.9491.00
24_A58_Y0.9411.00
15_K35_L0.9321.00
122_H126_A0.9311.00
113_M124_F0.9311.00
39_I43_R0.9231.00
115_F121_A0.9221.00
103_L110_H0.9131.00
74_V112_H0.9061.00
102_G126_A0.9051.00
89_Q93_E0.8951.00
9_L14_E0.8931.00
115_F124_F0.8901.00
106_G137_T0.8811.00
32_S37_I0.8781.00
80_V83_S0.8521.00
28_L39_I0.8501.00
24_A30_E0.8491.00
97_V100_I0.8491.00
70_N117_D0.8481.00
64_R114_I0.8401.00
97_V111_V0.8361.00
29_K43_R0.8351.00
14_E18_N0.8211.00
49_L54_I0.8151.00
74_V143_I0.8091.00
101_Y143_I0.8001.00
91_L100_I0.7991.00
90_D94_I0.7981.00
13_D48_R0.7941.00
76_E110_H0.7831.00
85_K88_A0.7801.00
16_I45_R0.7801.00
10_D13_D0.7741.00
77_I87_V0.7731.00
31_L42_V0.7691.00
125_I140_I0.7661.00
40_S44_Y0.7551.00
16_I42_V0.7541.00
101_Y146_R0.7461.00
9_L54_I0.7431.00
107_P139_S0.7401.00
24_A60_A0.7311.00
84_I109_L0.7281.00
76_E106_G0.7221.00
86_K89_Q0.7041.00
31_L46_I0.7041.00
96_E124_F0.7031.00
80_V134_G0.6951.00
104_D142_R0.6901.00
78_E107_P0.6891.00
23_N26_K0.6871.00
19_I23_N0.6811.00
11_D14_E0.6771.00
73_L121_A0.6731.00
130_Y138_V0.6731.00
88_A147_Y0.6661.00
69_L114_I0.6651.00
69_L96_E0.6581.00
54_I66_N0.6561.00
75_M111_V0.6541.00
16_I26_K0.6501.00
118_D142_R0.6471.00
119_A122_H0.6471.00
87_V109_L0.6431.00
72_S143_I0.6421.00
44_Y48_R0.6421.00
17_L49_L0.6411.00
13_D49_L0.6411.00
16_I19_I0.6341.00
86_K134_G0.6341.00
125_I138_V0.6331.00
75_M138_V0.6281.00
85_K126_A0.6271.00
32_S39_I0.6261.00
91_L111_V0.6231.00
44_Y47_K0.6191.00
16_I46_I0.6171.00
123_Q128_K0.6171.00
45_R49_L0.6161.00
63_D67_L0.6151.00
40_S43_R0.6141.00
96_E116_K0.6121.00
119_A123_Q0.6111.00
94_I132_I0.6101.00
53_Q56_R0.6101.00
120_S124_F0.6091.00
24_A57_G0.6071.00
124_F128_K0.6071.00
102_G109_L0.6001.00
73_L142_R0.6001.00
103_L107_P0.5821.00
62_I67_L0.5791.00
28_L42_V0.5761.00
72_S101_Y0.5751.00
55_I58_Y0.5741.00
77_I135_I0.5731.00
16_I49_L0.5671.00
128_K132_I0.5631.00
61_L64_R0.5621.00
118_D144_I0.5611.00
72_S146_R0.5481.00
103_L143_I0.5481.00
21_R59_V0.5431.00
83_S133_K0.5371.00
12_T41_T0.5311.00
130_Y137_T0.5301.00
76_E103_L0.5251.00
73_L140_I0.5211.00
48_R51_D0.5191.00
125_I144_I0.5191.00
103_L141_S0.5181.00
79_T108_R0.5141.00
81_P136_K0.5131.00
29_K32_S0.5081.00
90_D134_G0.5061.00
124_F129_L0.5051.00
78_E139_S0.5051.00
102_G108_R0.5041.00
85_K131_N0.5041.00
98_V112_H0.5021.00
90_D133_K0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ch7A 1 0.9355 100 0.152 Contact Map
4un1B 1 0.9613 100 0.186 Contact Map
2e1cA 1 0.9484 100 0.197 Contact Map
4pcqA 2 0.9548 100 0.199 Contact Map
4un1A 1 0.9161 100 0.201 Contact Map
2p5vA 5 0.9806 100 0.211 Contact Map
2ia0A 2 0.929 100 0.211 Contact Map
3i4pA 5 0.9419 100 0.238 Contact Map
2cg4A 6 0.9548 100 0.238 Contact Map
2pn6A 5 0.9419 100 0.243 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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