GREMLIN Database
Q7LX66 - Transposase ISC1078
UniProt: Q7LX66 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 337 (280)
Sequences: 1965 (1642)
Seq/√Len: 98.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
165_S281_K3.5371.00
37_A47_V3.4721.00
219_S247_N3.1871.00
93_L114_S3.1171.00
218_N221_D3.0921.00
31_M35_D2.9591.00
27_V36_V2.8891.00
44_I48_Y2.8571.00
222_I239_M2.8301.00
109_N115_P2.8101.00
236_V261_V2.6001.00
27_V51_L2.5211.00
223_I227_R2.4101.00
229_V232_D2.3951.00
196_G277_W2.3831.00
112_S116_V2.3111.00
162_F237_I2.3061.00
26_D36_V2.2531.00
26_D40_Y2.2471.00
33_I48_Y2.2311.00
31_M39_K2.2231.00
133_R141_W2.1791.00
271_S274_E2.1541.00
110_P114_S2.1421.00
34_K44_I2.1351.00
252_F256_N2.1141.00
45_F48_Y2.1101.00
239_M260_F2.0841.00
26_D39_K2.0731.00
109_N112_S2.0671.00
111_R115_P2.0211.00
35_D38_K2.0201.00
58_A61_R2.0111.00
36_V47_V1.8671.00
223_I249_V1.8471.00
312_D315_Y1.8421.00
199_T202_K1.8201.00
141_W144_E1.8031.00
302_F306_I1.7821.00
43_S46_T1.7801.00
108_Y112_S1.7781.00
37_A40_Y1.7671.00
74_V120_L1.7661.00
35_D39_K1.7561.00
167_V194_V1.7521.00
58_A62_K1.7121.00
176_W180_G1.7031.00
111_R114_S1.6971.00
34_K38_K1.6931.00
67_L71_E1.6881.00
31_M36_V1.6701.00
196_G273_A1.6651.00
139_E143_K1.6591.00
138_V142_V1.6521.00
93_L110_P1.6281.00
164_E245_H1.6201.00
26_D31_M1.6131.00
238_V263_L1.5991.00
222_I226_L1.5951.00
166_Y191_R1.5861.00
239_M253_L1.5601.00
217_L242_A1.5591.00
33_I51_L1.5491.00
300_T304_R1.5281.00
138_V141_W1.5211.00
197_G204_G1.5181.00
112_S115_P1.4621.00
21_I25_K1.4471.00
237_I258_V1.4441.00
283_R302_F1.4311.00
124_Y174_K1.4301.00
17_E24_V1.4231.00
19_R40_Y1.4221.00
26_D29_N1.4071.00
49_K52_R1.4010.99
234_K259_E1.3950.99
141_W145_Q1.3820.99
278_A282_K1.3810.99
172_K176_W1.3790.99
248_E251_E1.3550.99
19_R42_V1.3460.99
68_K71_E1.3460.99
18_E21_I1.3430.99
45_F49_K1.3270.99
152_K155_E1.3220.99
33_I44_I1.3170.99
296_M300_T1.3150.99
290_T294_T1.3130.99
162_F197_G1.3120.99
273_A277_W1.2860.99
177_M181_G1.2840.99
32_S35_D1.2650.99
134_D138_V1.2590.99
166_Y193_A1.2530.99
114_S118_K1.2430.99
295_L299_A1.2350.99
239_M262_Y1.2290.99
94_K110_P1.2270.99
253_L260_F1.2270.99
224_L228_K1.2270.99
307_S312_D1.2190.99
175_G178_K1.2140.99
77_L117_L1.2070.98
16_E19_R1.1980.98
172_K175_G1.1960.98
161_I263_L1.1850.98
297_W301_R1.1810.98
92_T95_L1.1750.98
174_K182_G1.1710.98
219_S223_I1.1690.98
230_I258_V1.1510.98
73_L96_I1.1350.98
23_A42_V1.1340.98
61_R64_P1.1230.98
176_W179_V1.1140.97
76_I81_P1.1110.97
36_V51_L1.1080.97
173_G176_W1.1060.97
108_Y113_L1.1060.97
22_N28_R1.1030.97
223_I252_F1.0850.97
38_K41_D1.0820.97
178_K181_G1.0780.97
165_S299_A1.0750.97
134_D141_W1.0710.97
162_F239_M1.0670.97
19_R22_N1.0620.97
302_F305_S1.0590.97
198_I313_L1.0570.96
231_K256_N1.0530.96
133_R138_V1.0520.96
36_V40_Y1.0480.96
209_Y212_Y1.0450.96
313_L316_S1.0440.96
17_E57_S1.0380.96
279_V283_R1.0380.96
161_I238_V1.0360.96
60_P66_K1.0280.96
274_E277_W1.0270.96
165_S169_Y1.0180.96
162_F222_I1.0170.96
292_F296_M1.0100.95
274_E316_S1.0080.95
189_R193_A1.0080.95
135_D141_W1.0060.95
134_D142_V1.0040.95
294_T297_W1.0020.95
227_R231_K0.9850.95
148_K151_K0.9850.95
97_A113_L0.9810.95
198_I272_P0.9760.95
72_K106_I0.9740.94
139_E142_V0.9640.94
38_K48_Y0.9620.94
312_D316_S0.9600.94
161_I271_S0.9600.94
301_R305_S0.9550.94
135_D138_V0.9520.94
25_K29_N0.9510.94
76_I80_S0.9430.93
197_G225_Y0.9370.93
76_I91_W0.9240.93
289_Y298_D0.9150.92
208_S211_T0.9100.92
23_A50_W0.9070.92
93_L113_L0.9040.92
175_G181_G0.9010.92
280_L302_F0.9000.92
116_V120_L0.8950.92
43_S49_K0.8880.91
176_W268_P0.8810.91
176_W266_Y0.8760.91
138_V145_Q0.8730.91
227_R252_F0.8720.90
163_D245_H0.8710.90
166_Y244_I0.8660.90
252_F255_E0.8660.90
136_N143_K0.8650.90
134_D137_A0.8630.90
174_K181_G0.8590.90
241_N266_Y0.8580.90
29_N39_K0.8580.90
166_Y243_R0.8580.90
42_V46_T0.8570.90
67_L116_V0.8530.89
28_R35_D0.8520.89
162_F263_L0.8370.89
147_E151_K0.8370.89
161_I165_S0.8350.88
42_V47_V0.8300.88
287_K302_F0.8270.88
263_L268_P0.8230.88
176_W182_G0.8230.88
161_I167_V0.8220.88
281_K299_A0.8190.87
150_F159_V0.8160.87
251_E255_E0.8130.87
240_D245_H0.8120.87
279_V312_D0.8120.87
217_L222_I0.8110.87
172_K177_M0.8100.87
166_Y170_I0.8090.87
140_R144_E0.8090.87
298_D302_F0.8050.87
246_G249_V0.7990.86
46_T50_W0.7990.86
33_I37_A0.7990.86
75_R79_K0.7980.86
292_F295_L0.7970.86
175_G179_V0.7940.86
77_L96_I0.7920.86
177_M182_G0.7920.86
177_M180_G0.7910.86
174_K177_M0.7880.85
27_V33_I0.7850.85
17_E21_I0.7830.85
162_F225_Y0.7820.85
93_L176_W0.7790.85
133_R137_A0.7790.85
142_V145_Q0.7770.85
24_V28_R0.7760.85
173_G179_V0.7760.85
194_V201_S0.7730.84
25_K28_R0.7710.84
160_H199_T0.7700.84
196_G274_E0.7680.84
146_G149_L0.7670.84
226_L252_F0.7670.84
69_D72_K0.7660.84
100_L113_L0.7620.83
145_Q153_I0.7590.83
275_G278_A0.7540.83
137_A265_P0.7540.83
164_E295_L0.7520.83
165_S217_L0.7510.83
58_A63_G0.7470.82
162_F195_V0.7470.82
188_K191_R0.7460.82
23_A36_V0.7460.82
17_E20_R0.7460.82
219_S249_V0.7420.82
161_I198_I0.7400.82
167_V281_K0.7400.82
66_K73_L0.7380.81
243_R246_G0.7360.81
46_T49_K0.7350.81
22_N29_N0.7350.81
291_D294_T0.7320.81
124_Y176_W0.7270.80
218_N230_I0.7210.80
118_K199_T0.7180.80
34_K37_A0.7130.79
74_V122_F0.7110.79
50_W53_K0.7090.79
74_V249_V0.7030.78
76_I79_K0.7020.78
34_K304_R0.7020.78
173_G178_K0.6970.78
32_S38_K0.6910.77
22_N26_D0.6900.77
23_A47_V0.6890.77
74_V77_L0.6880.77
97_A110_P0.6870.77
126_K282_K0.6870.77
130_T137_A0.6830.76
117_L176_W0.6820.76
194_V299_A0.6810.76
53_K59_K0.6800.76
216_S221_D0.6740.75
218_N244_I0.6730.75
253_L257_G0.6720.75
168_S295_L0.6720.75
167_V299_A0.6710.75
17_E31_M0.6700.75
301_R304_R0.6690.75
131_Y134_D0.6690.75
176_W181_G0.6690.75
100_L107_K0.6670.74
161_I272_P0.6670.74
63_G227_R0.6660.74
123_K179_V0.6620.74
172_K178_K0.6620.74
281_K285_Y0.6610.74
254_E259_E0.6610.74
217_L244_I0.6600.74
16_E22_N0.6590.74
69_D73_L0.6570.73
166_Y242_A0.6530.73
111_R118_K0.6490.72
217_L243_R0.6480.72
222_I237_I0.6470.72
193_A199_T0.6470.72
22_N25_K0.6440.72
217_L221_D0.6430.72
51_L218_N0.6430.72
162_F277_W0.6410.72
272_P276_P0.6370.71
81_P91_W0.6350.71
224_L292_F0.6340.71
254_E257_G0.6340.71
18_E22_N0.6340.71
20_R30_G0.6330.71
130_T135_D0.6330.71
69_D119_K0.6320.70
45_F52_R0.6310.70
156_G161_I0.6290.70
242_A266_Y0.6290.70
264_P270_K0.6280.70
293_E296_M0.6260.70
55_D173_G0.6250.70
133_R269_D0.6250.70
35_D48_Y0.6230.69
179_V185_V0.6180.69
122_F178_K0.6180.69
175_G182_G0.6150.68
294_T305_S0.6090.68
74_V78_E0.6060.67
48_Y51_L0.6040.67
149_L154_R0.6020.67
188_K192_F0.6000.67
176_W277_W0.6000.67
133_R144_E0.6000.67
30_G121_G0.5990.66
194_V209_Y0.5950.66
276_P303_L0.5950.66
29_N38_K0.5930.66
90_F159_V0.5920.65
238_V266_Y0.5920.65
160_H197_G0.5910.65
157_Y233_E0.5890.65
43_S48_Y0.5890.65
238_V271_S0.5890.65
183_I186_N0.5880.65
172_K180_G0.5880.65
78_E178_K0.5870.65
141_W146_G0.5860.65
220_K224_L0.5860.65
290_T298_D0.5850.65
141_W147_E0.5840.64
230_I256_N0.5840.64
40_Y46_T0.5840.64
289_Y292_F0.5830.64
242_A265_P0.5810.64
282_K289_Y0.5790.64
161_I200_I0.5780.64
209_Y296_M0.5760.63
76_I99_I0.5750.63
239_M263_L0.5730.63
216_S227_R0.5720.63
149_L152_K0.5720.63
293_E297_W0.5710.63
253_L258_V0.5710.63
49_K55_D0.5680.62
67_L73_L0.5660.62
125_K175_G0.5650.62
125_K263_L0.5620.62
298_D301_R0.5610.61
48_Y52_R0.5600.61
133_R265_P0.5580.61
277_W313_L0.5570.61
94_K97_A0.5540.60
278_A281_K0.5540.60
38_K43_S0.5530.60
95_L98_Y0.5520.60
181_G251_E0.5480.60
56_L60_P0.5480.60
155_E158_K0.5480.60
130_T133_R0.5470.59
47_V291_D0.5470.59
74_V178_K0.5460.59
33_I40_Y0.5430.59
173_G181_G0.5420.59
144_E148_K0.5410.59
281_K300_T0.5400.58
190_K199_T0.5380.58
296_M299_A0.5370.58
157_Y236_V0.5340.58
65_T81_P0.5330.57
160_H230_I0.5330.57
133_R145_Q0.5300.57
116_V119_K0.5280.57
211_T296_M0.5270.57
235_T258_V0.5270.57
152_K227_R0.5270.57
41_D92_T0.5260.57
139_E267_S0.5260.57
124_Y127_G0.5260.57
241_N274_E0.5240.56
16_E27_V0.5230.56
250_R254_E0.5230.56
190_K292_F0.5220.56
96_I113_L0.5220.56
22_N40_Y0.5210.56
24_V27_V0.5200.56
108_Y116_V0.5200.56
246_G250_R0.5200.56
168_S289_Y0.5200.56
29_N32_S0.5180.55
263_L266_Y0.5170.55
21_I29_N0.5160.55
241_N246_G0.5150.55
66_K227_R0.5140.55
158_K259_E0.5140.55
297_W305_S0.5140.55
135_D145_Q0.5130.55
17_E27_V0.5130.55
276_P280_L0.5110.54
228_K255_E0.5100.54
76_I96_I0.5090.54
122_F125_K0.5070.54
72_K75_R0.5050.54
49_K315_Y0.5050.54
226_L243_R0.5040.53
275_G279_V0.5040.53
81_P271_S0.5020.53
160_H298_D0.5020.53
265_P268_P0.5010.53
22_N39_K0.5000.53
34_K140_R0.5000.53
228_K301_R0.5000.53
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4u7bA 2 0.908 100 0.415 Contact Map
3f2kA 1 0.546 100 0.509 Contact Map
4mdaA 1 0.546 100 0.512 Contact Map
4fcyA 4 0.8605 99.8 0.733 Contact Map
1u78A 1 0.2938 99.6 0.777 Contact Map
1k78A 1 0.3294 99.4 0.803 Contact Map
1pdnC 1 0.3175 99.3 0.809 Contact Map
2k27A 1 0.4006 99.3 0.809 Contact Map
1hlvA 1 0.3353 98.6 0.856 Contact Map
2ao9A 7 0.3264 97.9 0.883 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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