Q7LX66 - SULSO - GREMLIN Contacts

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Q7LX66 - Transposase ISC1078

UniProt:	Q7LX66	Sequences: MPKSRMHGIRLNKKQEEERRINAVKDVRNGMSIKDVAKKYDVSIFTVYKWLRKGDLSAKPRKGPTKLKDEEKLVRILEKSPRDFGLNYDFWTLKLIAYILDKEFGIKYNPRSLSPVLKKLGFKYKKGKRTYVRDDNAVERWVKEQGEKLFKKIREGYKVHIFDESYVSYINKGKGWMKVGGGIKVNPKRKRFAVVGGITISKEGITFSYSTYKKPSLNSKDIILYLRKVIKDEKTVIVMDNARIHGNEVREFLEENGVEFVYLPPYSPDKSPAEGPWAVLKKRLYSKIYTDFETLMWDATRFLRSISKRVNDLTYSVKRCGEPWTSILSEVFLPFKV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	337 (280)
Sequences:	1965 (1642)
Seq/√Len:	98.1

SULSO - Q7LX66 Q97TV5 Q97XL9 Q97TW3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
165_S	281_K	3.537	1.00
37_A	47_V	3.472	1.00
219_S	247_N	3.187	1.00
93_L	114_S	3.117	1.00
218_N	221_D	3.092	1.00
31_M	35_D	2.959	1.00
27_V	36_V	2.889	1.00
44_I	48_Y	2.857	1.00
222_I	239_M	2.830	1.00
109_N	115_P	2.810	1.00
236_V	261_V	2.600	1.00
27_V	51_L	2.521	1.00
223_I	227_R	2.410	1.00
229_V	232_D	2.395	1.00
196_G	277_W	2.383	1.00
112_S	116_V	2.311	1.00
162_F	237_I	2.306	1.00
26_D	36_V	2.253	1.00
26_D	40_Y	2.247	1.00
33_I	48_Y	2.231	1.00
31_M	39_K	2.223	1.00
133_R	141_W	2.179	1.00
271_S	274_E	2.154	1.00
110_P	114_S	2.142	1.00
34_K	44_I	2.135	1.00
252_F	256_N	2.114	1.00
45_F	48_Y	2.110	1.00
239_M	260_F	2.084	1.00
26_D	39_K	2.073	1.00
109_N	112_S	2.067	1.00
111_R	115_P	2.021	1.00
35_D	38_K	2.020	1.00
58_A	61_R	2.011	1.00
36_V	47_V	1.867	1.00
223_I	249_V	1.847	1.00
312_D	315_Y	1.842	1.00
199_T	202_K	1.820	1.00
141_W	144_E	1.803	1.00
302_F	306_I	1.782	1.00
43_S	46_T	1.780	1.00
108_Y	112_S	1.778	1.00
37_A	40_Y	1.767	1.00
74_V	120_L	1.766	1.00
35_D	39_K	1.756	1.00
167_V	194_V	1.752	1.00
58_A	62_K	1.712	1.00
176_W	180_G	1.703	1.00
111_R	114_S	1.697	1.00
34_K	38_K	1.693	1.00
67_L	71_E	1.688	1.00
31_M	36_V	1.670	1.00
196_G	273_A	1.665	1.00
139_E	143_K	1.659	1.00
138_V	142_V	1.652	1.00
93_L	110_P	1.628	1.00
164_E	245_H	1.620	1.00
26_D	31_M	1.613	1.00
238_V	263_L	1.599	1.00
222_I	226_L	1.595	1.00
166_Y	191_R	1.586	1.00
239_M	253_L	1.560	1.00
217_L	242_A	1.559	1.00
33_I	51_L	1.549	1.00
300_T	304_R	1.528	1.00
138_V	141_W	1.521	1.00
197_G	204_G	1.518	1.00
112_S	115_P	1.462	1.00
21_I	25_K	1.447	1.00
237_I	258_V	1.444	1.00
283_R	302_F	1.431	1.00
124_Y	174_K	1.430	1.00
17_E	24_V	1.423	1.00
19_R	40_Y	1.422	1.00
26_D	29_N	1.407	1.00
49_K	52_R	1.401	0.99
234_K	259_E	1.395	0.99
141_W	145_Q	1.382	0.99
278_A	282_K	1.381	0.99
172_K	176_W	1.379	0.99
248_E	251_E	1.355	0.99
19_R	42_V	1.346	0.99
68_K	71_E	1.346	0.99
18_E	21_I	1.343	0.99
45_F	49_K	1.327	0.99
152_K	155_E	1.322	0.99
33_I	44_I	1.317	0.99
296_M	300_T	1.315	0.99
290_T	294_T	1.313	0.99
162_F	197_G	1.312	0.99
273_A	277_W	1.286	0.99
177_M	181_G	1.284	0.99
32_S	35_D	1.265	0.99
134_D	138_V	1.259	0.99
166_Y	193_A	1.253	0.99
114_S	118_K	1.243	0.99
295_L	299_A	1.235	0.99
239_M	262_Y	1.229	0.99
94_K	110_P	1.227	0.99
253_L	260_F	1.227	0.99
224_L	228_K	1.227	0.99
307_S	312_D	1.219	0.99
175_G	178_K	1.214	0.99
77_L	117_L	1.207	0.98
16_E	19_R	1.198	0.98
172_K	175_G	1.196	0.98
161_I	263_L	1.185	0.98
297_W	301_R	1.181	0.98
92_T	95_L	1.175	0.98
174_K	182_G	1.171	0.98
219_S	223_I	1.169	0.98
230_I	258_V	1.151	0.98
73_L	96_I	1.135	0.98
23_A	42_V	1.134	0.98
61_R	64_P	1.123	0.98
176_W	179_V	1.114	0.97
76_I	81_P	1.111	0.97
36_V	51_L	1.108	0.97
173_G	176_W	1.106	0.97
108_Y	113_L	1.106	0.97
22_N	28_R	1.103	0.97
223_I	252_F	1.085	0.97
38_K	41_D	1.082	0.97
178_K	181_G	1.078	0.97
165_S	299_A	1.075	0.97
134_D	141_W	1.071	0.97
162_F	239_M	1.067	0.97
19_R	22_N	1.062	0.97
302_F	305_S	1.059	0.97
198_I	313_L	1.057	0.96
231_K	256_N	1.053	0.96
133_R	138_V	1.052	0.96
36_V	40_Y	1.048	0.96
209_Y	212_Y	1.045	0.96
313_L	316_S	1.044	0.96
17_E	57_S	1.038	0.96
279_V	283_R	1.038	0.96
161_I	238_V	1.036	0.96
60_P	66_K	1.028	0.96
274_E	277_W	1.027	0.96
165_S	169_Y	1.018	0.96
162_F	222_I	1.017	0.96
292_F	296_M	1.010	0.95
274_E	316_S	1.008	0.95
189_R	193_A	1.008	0.95
135_D	141_W	1.006	0.95
134_D	142_V	1.004	0.95
294_T	297_W	1.002	0.95
227_R	231_K	0.985	0.95
148_K	151_K	0.985	0.95
97_A	113_L	0.981	0.95
198_I	272_P	0.976	0.95
72_K	106_I	0.974	0.94
139_E	142_V	0.964	0.94
38_K	48_Y	0.962	0.94
312_D	316_S	0.960	0.94
161_I	271_S	0.960	0.94
301_R	305_S	0.955	0.94
135_D	138_V	0.952	0.94
25_K	29_N	0.951	0.94
76_I	80_S	0.943	0.93
197_G	225_Y	0.937	0.93
76_I	91_W	0.924	0.93
289_Y	298_D	0.915	0.92
208_S	211_T	0.910	0.92
23_A	50_W	0.907	0.92
93_L	113_L	0.904	0.92
175_G	181_G	0.901	0.92
280_L	302_F	0.900	0.92
116_V	120_L	0.895	0.92
43_S	49_K	0.888	0.91
176_W	268_P	0.881	0.91
176_W	266_Y	0.876	0.91
138_V	145_Q	0.873	0.91
227_R	252_F	0.872	0.90
163_D	245_H	0.871	0.90
166_Y	244_I	0.866	0.90
252_F	255_E	0.866	0.90
136_N	143_K	0.865	0.90
134_D	137_A	0.863	0.90
174_K	181_G	0.859	0.90
241_N	266_Y	0.858	0.90
29_N	39_K	0.858	0.90
166_Y	243_R	0.858	0.90
42_V	46_T	0.857	0.90
67_L	116_V	0.853	0.89
28_R	35_D	0.852	0.89
162_F	263_L	0.837	0.89
147_E	151_K	0.837	0.89
161_I	165_S	0.835	0.88
42_V	47_V	0.830	0.88
287_K	302_F	0.827	0.88
263_L	268_P	0.823	0.88
176_W	182_G	0.823	0.88
161_I	167_V	0.822	0.88
281_K	299_A	0.819	0.87
150_F	159_V	0.816	0.87
251_E	255_E	0.813	0.87
240_D	245_H	0.812	0.87
279_V	312_D	0.812	0.87
217_L	222_I	0.811	0.87
172_K	177_M	0.810	0.87
166_Y	170_I	0.809	0.87
140_R	144_E	0.809	0.87
298_D	302_F	0.805	0.87
246_G	249_V	0.799	0.86
46_T	50_W	0.799	0.86
33_I	37_A	0.799	0.86
75_R	79_K	0.798	0.86
292_F	295_L	0.797	0.86
175_G	179_V	0.794	0.86
77_L	96_I	0.792	0.86
177_M	182_G	0.792	0.86
177_M	180_G	0.791	0.86
174_K	177_M	0.788	0.85
27_V	33_I	0.785	0.85
17_E	21_I	0.783	0.85
162_F	225_Y	0.782	0.85
93_L	176_W	0.779	0.85
133_R	137_A	0.779	0.85
142_V	145_Q	0.777	0.85
24_V	28_R	0.776	0.85
173_G	179_V	0.776	0.85
194_V	201_S	0.773	0.84
25_K	28_R	0.771	0.84
160_H	199_T	0.770	0.84
196_G	274_E	0.768	0.84
146_G	149_L	0.767	0.84
226_L	252_F	0.767	0.84
69_D	72_K	0.766	0.84
100_L	113_L	0.762	0.83
145_Q	153_I	0.759	0.83
275_G	278_A	0.754	0.83
137_A	265_P	0.754	0.83
164_E	295_L	0.752	0.83
165_S	217_L	0.751	0.83
58_A	63_G	0.747	0.82
162_F	195_V	0.747	0.82
188_K	191_R	0.746	0.82
23_A	36_V	0.746	0.82
17_E	20_R	0.746	0.82
219_S	249_V	0.742	0.82
161_I	198_I	0.740	0.82
167_V	281_K	0.740	0.82
66_K	73_L	0.738	0.81
243_R	246_G	0.736	0.81
46_T	49_K	0.735	0.81
22_N	29_N	0.735	0.81
291_D	294_T	0.732	0.81
124_Y	176_W	0.727	0.80
218_N	230_I	0.721	0.80
118_K	199_T	0.718	0.80
34_K	37_A	0.713	0.79
74_V	122_F	0.711	0.79
50_W	53_K	0.709	0.79
74_V	249_V	0.703	0.78
76_I	79_K	0.702	0.78
34_K	304_R	0.702	0.78
173_G	178_K	0.697	0.78
32_S	38_K	0.691	0.77
22_N	26_D	0.690	0.77
23_A	47_V	0.689	0.77
74_V	77_L	0.688	0.77
97_A	110_P	0.687	0.77
126_K	282_K	0.687	0.77
130_T	137_A	0.683	0.76
117_L	176_W	0.682	0.76
194_V	299_A	0.681	0.76
53_K	59_K	0.680	0.76
216_S	221_D	0.674	0.75
218_N	244_I	0.673	0.75
253_L	257_G	0.672	0.75
168_S	295_L	0.672	0.75
167_V	299_A	0.671	0.75
17_E	31_M	0.670	0.75
301_R	304_R	0.669	0.75
131_Y	134_D	0.669	0.75
176_W	181_G	0.669	0.75
100_L	107_K	0.667	0.74
161_I	272_P	0.667	0.74
63_G	227_R	0.666	0.74
123_K	179_V	0.662	0.74
172_K	178_K	0.662	0.74
281_K	285_Y	0.661	0.74
254_E	259_E	0.661	0.74
217_L	244_I	0.660	0.74
16_E	22_N	0.659	0.74
69_D	73_L	0.657	0.73
166_Y	242_A	0.653	0.73
111_R	118_K	0.649	0.72
217_L	243_R	0.648	0.72
222_I	237_I	0.647	0.72
193_A	199_T	0.647	0.72
22_N	25_K	0.644	0.72
217_L	221_D	0.643	0.72
51_L	218_N	0.643	0.72
162_F	277_W	0.641	0.72
272_P	276_P	0.637	0.71
81_P	91_W	0.635	0.71
224_L	292_F	0.634	0.71
254_E	257_G	0.634	0.71
18_E	22_N	0.634	0.71
20_R	30_G	0.633	0.71
130_T	135_D	0.633	0.71
69_D	119_K	0.632	0.70
45_F	52_R	0.631	0.70
156_G	161_I	0.629	0.70
242_A	266_Y	0.629	0.70
264_P	270_K	0.628	0.70
293_E	296_M	0.626	0.70
55_D	173_G	0.625	0.70
133_R	269_D	0.625	0.70
35_D	48_Y	0.623	0.69
179_V	185_V	0.618	0.69
122_F	178_K	0.618	0.69
175_G	182_G	0.615	0.68
294_T	305_S	0.609	0.68
74_V	78_E	0.606	0.67
48_Y	51_L	0.604	0.67
149_L	154_R	0.602	0.67
188_K	192_F	0.600	0.67
176_W	277_W	0.600	0.67
133_R	144_E	0.600	0.67
30_G	121_G	0.599	0.66
194_V	209_Y	0.595	0.66
276_P	303_L	0.595	0.66
29_N	38_K	0.593	0.66
90_F	159_V	0.592	0.65
238_V	266_Y	0.592	0.65
160_H	197_G	0.591	0.65
157_Y	233_E	0.589	0.65
43_S	48_Y	0.589	0.65
238_V	271_S	0.589	0.65
183_I	186_N	0.588	0.65
172_K	180_G	0.588	0.65
78_E	178_K	0.587	0.65
141_W	146_G	0.586	0.65
220_K	224_L	0.586	0.65
290_T	298_D	0.585	0.65
141_W	147_E	0.584	0.64
230_I	256_N	0.584	0.64
40_Y	46_T	0.584	0.64
289_Y	292_F	0.583	0.64
242_A	265_P	0.581	0.64
282_K	289_Y	0.579	0.64
161_I	200_I	0.578	0.64
209_Y	296_M	0.576	0.63
76_I	99_I	0.575	0.63
239_M	263_L	0.573	0.63
216_S	227_R	0.572	0.63
149_L	152_K	0.572	0.63
293_E	297_W	0.571	0.63
253_L	258_V	0.571	0.63
49_K	55_D	0.568	0.62
67_L	73_L	0.566	0.62
125_K	175_G	0.565	0.62
125_K	263_L	0.562	0.62
298_D	301_R	0.561	0.61
48_Y	52_R	0.560	0.61
133_R	265_P	0.558	0.61
277_W	313_L	0.557	0.61
94_K	97_A	0.554	0.60
278_A	281_K	0.554	0.60
38_K	43_S	0.553	0.60
95_L	98_Y	0.552	0.60
181_G	251_E	0.548	0.60
56_L	60_P	0.548	0.60
155_E	158_K	0.548	0.60
130_T	133_R	0.547	0.59
47_V	291_D	0.547	0.59
74_V	178_K	0.546	0.59
33_I	40_Y	0.543	0.59
173_G	181_G	0.542	0.59
144_E	148_K	0.541	0.59
281_K	300_T	0.540	0.58
190_K	199_T	0.538	0.58
296_M	299_A	0.537	0.58
157_Y	236_V	0.534	0.58
65_T	81_P	0.533	0.57
160_H	230_I	0.533	0.57
133_R	145_Q	0.530	0.57
116_V	119_K	0.528	0.57
211_T	296_M	0.527	0.57
235_T	258_V	0.527	0.57
152_K	227_R	0.527	0.57
41_D	92_T	0.526	0.57
139_E	267_S	0.526	0.57
124_Y	127_G	0.526	0.57
241_N	274_E	0.524	0.56
16_E	27_V	0.523	0.56
250_R	254_E	0.523	0.56
190_K	292_F	0.522	0.56
96_I	113_L	0.522	0.56
22_N	40_Y	0.521	0.56
24_V	27_V	0.520	0.56
108_Y	116_V	0.520	0.56
246_G	250_R	0.520	0.56
168_S	289_Y	0.520	0.56
29_N	32_S	0.518	0.55
263_L	266_Y	0.517	0.55
21_I	29_N	0.516	0.55
241_N	246_G	0.515	0.55
66_K	227_R	0.514	0.55
158_K	259_E	0.514	0.55
297_W	305_S	0.514	0.55
135_D	145_Q	0.513	0.55
17_E	27_V	0.513	0.55
276_P	280_L	0.511	0.54
228_K	255_E	0.510	0.54
76_I	96_I	0.509	0.54
122_F	125_K	0.507	0.54
72_K	75_R	0.505	0.54
49_K	315_Y	0.505	0.54
226_L	243_R	0.504	0.53
275_G	279_V	0.504	0.53
81_P	271_S	0.502	0.53
160_H	298_D	0.502	0.53
265_P	268_P	0.501	0.53
22_N	39_K	0.500	0.53
34_K	140_R	0.500	0.53
228_K	301_R	0.500	0.53

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4u7bA	2	0.908	100	0.415	Contact Map
3f2kA	1	0.546	100	0.509	Contact Map
4mdaA	1	0.546	100	0.512	Contact Map
4fcyA	4	0.8605	99.8	0.733	Contact Map
1u78A	1	0.2938	99.6	0.777	Contact Map
1k78A	1	0.3294	99.4	0.803	Contact Map
1pdnC	1	0.3175	99.3	0.809	Contact Map
2k27A	1	0.4006	99.3	0.809	Contact Map
1hlvA	1	0.3353	98.6	0.856	Contact Map
2ao9A	7	0.3264	97.9	0.883	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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