GREMLIN Database
Q7LX64 - ABC transporter, ATP binding protein
UniProt: Q7LX64 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 339 (268)
Sequences: 30020 (21315)
Seq/√Len: 1302.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
38_E212_R3.8651.00
25_V28_D3.7881.00
16_N29_H3.6921.00
13_K33_E3.1671.00
40_F214_A3.1471.00
15_I67_T3.0221.00
85_S162_R2.9361.00
225_G229_E2.9161.00
20_R25_V2.8571.00
14_A17_L2.8391.00
101_G143_Y2.8241.00
207_D228_K2.7461.00
41_G210_G2.7301.00
18_T65_E2.6671.00
19_K56_M2.5891.00
28_D220_K2.4991.00
13_K69_T2.3921.00
188_L194_M2.3311.00
35_Y38_E2.3301.00
18_T25_V2.2201.00
54_I199_T2.1951.00
135_A138_R2.1811.00
138_R142_T2.1641.00
36_E162_R2.1611.00
18_T29_H2.1531.00
226_S229_E2.1311.00
102_W136_A2.1271.00
17_L63_P2.1131.00
200_T206_A2.0401.00
54_I165_F2.0281.00
214_A221_I2.0001.00
19_K64_S1.9661.00
115_P118_I1.9541.00
212_R224_I1.9101.00
16_N31_N1.8881.00
186_M208_M1.8811.00
128_E133_T1.8391.00
14_A32_F1.8141.00
160_R194_M1.8121.00
102_W137_K1.8001.00
98_D141_E1.7211.00
15_I69_T1.6981.00
34_V40_F1.6861.00
100_T103_E1.6831.00
122_R125_E1.6631.00
19_K61_L1.6591.00
20_R64_S1.6321.00
102_W106_M1.6291.00
27_V56_M1.6101.00
140_V151_L1.5771.00
127_L136_A1.5731.00
229_E233_K1.5461.00
55_K60_V1.5421.00
32_F214_A1.5401.00
41_G206_A1.5261.00
18_T28_D1.4761.00
287_S291_N1.4651.00
56_M63_P1.4621.00
55_K61_L1.4521.00
124_K136_A1.4281.00
122_R160_R1.4281.00
99_L104_N1.4191.00
130_V154_A1.3851.00
126_L154_A1.3781.00
129_M187_K1.3671.00
104_N140_V1.3591.00
229_E232_E1.3581.00
21_F26_A1.3581.00
71_S162_R1.3501.00
278_E282_P1.3341.00
212_R223_A1.3241.00
91_Q145_G1.3091.00
40_F224_I1.2901.00
58_T165_F1.2851.00
182_W208_M1.2761.00
38_E211_D1.2641.00
99_L107_M1.2641.00
116_K119_A1.2521.00
89_V156_S1.2181.00
15_I31_N1.2111.00
239_V242_Q1.2071.00
42_F197_F1.2051.00
71_S85_S1.2021.00
125_E129_M1.1961.00
139_K142_T1.1951.00
42_F53_T1.1931.00
227_P231_K1.1841.00
102_W124_K1.1731.00
97_E141_E1.1701.00
173_L181_I1.1561.00
30_I53_T1.1531.00
40_F197_F1.1471.00
198_V210_G1.1421.00
272_I275_R1.1331.00
108_M155_M1.1311.00
131_E180_A1.1231.00
104_N155_M1.1221.00
100_T104_N1.1201.00
15_I33_E1.1141.00
14_A57_L1.1121.00
285_L289_V1.1101.00
282_P285_L1.1051.00
240_S243_T1.0991.00
210_G213_I1.0881.00
287_S290_K1.0871.00
240_S244_S1.0801.00
106_M120_E1.0771.00
143_Y151_L1.0721.00
285_L291_N1.0711.00
16_N65_E1.0691.00
133_T136_A1.0671.00
87_G156_S1.0641.00
286_E290_K1.0591.00
87_G161_P1.0551.00
56_M68_A1.0541.00
121_E125_E1.0381.00
214_A224_I1.0331.00
106_M123_A1.0291.00
285_L288_L1.0231.00
271_R275_R1.0191.00
96_D99_L1.0071.00
131_E134_Y1.0061.00
17_L56_M1.0061.00
40_F212_R1.0041.00
228_K232_E1.0041.00
271_R274_V1.0021.00
118_I121_E1.0021.00
48_A216_I0.9981.00
185_I196_I0.9911.00
58_T88_V0.9881.00
178_R202_Y0.9881.00
237_D240_S0.9861.00
20_R23_K0.9851.00
99_L103_E0.9831.00
231_K234_V0.9811.00
35_Y212_R0.9801.00
183_Q186_M0.9801.00
265_K268_D0.9751.00
259_G262_D0.9751.00
257_K261_L0.9631.00
238_V242_Q0.9571.00
182_W205_E0.9561.00
102_W123_A0.9501.00
230_L234_V0.9461.00
124_K128_E0.9381.00
278_E281_A0.9381.00
256_S259_G0.9291.00
179_A183_Q0.9271.00
215_I230_L0.9201.00
109_A119_A0.9171.00
278_E284_I0.9161.00
215_I234_V0.9141.00
164_L194_M0.9081.00
34_V195_T0.9081.00
286_E289_V0.9061.00
276_N279_E0.9051.00
27_V53_T0.9021.00
165_F197_F0.9011.00
183_Q187_K0.9001.00
14_A68_A0.8971.00
118_I122_R0.8921.00
59_T62_K0.8911.00
21_F52_T0.8871.00
217_D222_L0.8871.00
275_R278_E0.8831.00
106_M110_G0.8831.00
263_V266_A0.8821.00
279_E282_P0.8801.00
266_A270_I0.8741.00
45_P48_A0.8711.00
30_I221_I0.8711.00
60_V90_P0.8691.00
19_K52_T0.8681.00
274_V278_E0.8661.00
241_L244_S0.8621.00
283_E287_S0.8611.00
262_D265_K0.8611.00
282_P286_E0.8601.00
126_L158_I0.8561.00
97_E148_R0.8551.00
204_E208_M0.8521.00
27_V30_I0.8501.00
270_I273_K0.8491.00
268_D271_R0.8481.00
261_L264_R0.8461.00
278_E285_L0.8451.00
257_K260_I0.8421.00
213_I227_P0.8351.00
267_S270_I0.8331.00
280_K283_E0.8321.00
163_I195_T0.8321.00
21_F61_L0.8301.00
101_G151_L0.8231.00
105_M158_I0.8191.00
100_T139_K0.8191.00
273_K277_G0.8181.00
207_D227_P0.8151.00
217_D220_K0.8151.00
124_K132_L0.8151.00
120_E124_K0.8131.00
143_Y147_M0.8121.00
11_A71_S0.8111.00
248_L251_K0.8101.00
231_K235_G0.8061.00
239_V243_T0.8041.00
12_I70_V0.8011.00
29_H65_E0.7991.00
116_K120_E0.7991.00
153_I181_I0.7981.00
37_G195_T0.7961.00
95_A104_N0.7951.00
107_M111_L0.7941.00
281_A285_L0.7851.00
284_I288_L0.7831.00
32_F53_T0.7821.00
98_D139_K0.7811.00
126_L129_M0.7781.00
12_I57_L0.7761.00
227_P230_L0.7761.00
56_M64_S0.7711.00
117_R121_E0.7711.00
73_Y85_S0.7711.00
260_I264_R0.7691.00
184_Y187_K0.7651.00
136_A139_K0.7631.00
71_S163_I0.7621.00
225_G230_L0.7611.00
115_P119_A0.7581.00
264_R267_S0.7581.00
277_G280_K0.7581.00
170_T181_I0.7531.00
259_G263_V0.7501.00
106_M119_A0.7471.00
238_V241_L0.7461.00
270_I274_V0.7441.00
17_L68_A0.7421.00
89_V153_I0.7411.00
56_M61_L0.7401.00
198_V209_Y0.7391.00
255_S259_G0.7311.00
233_K236_G0.7281.00
207_D231_K0.7231.00
101_G104_N0.7231.00
12_I163_I0.7231.00
228_K231_K0.7221.00
14_A53_T0.7211.00
96_D104_N0.7181.00
178_R205_E0.7171.00
266_A269_G0.7161.00
122_R126_L0.7151.00
135_A147_M0.7151.00
237_D241_L0.7141.00
280_K284_I0.7091.00
36_E71_S0.7091.00
109_A112_Y0.7051.00
108_M112_Y0.7011.00
284_I287_S0.6981.00
110_G119_A0.6971.00
264_R268_D0.6941.00
249_A252_I0.6931.00
241_L245_N0.6931.00
112_Y159_S0.6931.00
283_E286_E0.6921.00
254_S257_K0.6911.00
242_Q245_N0.6911.00
262_D266_A0.6861.00
221_I224_I0.6861.00
269_G272_I0.6831.00
246_D250_I0.6831.00
180_A183_Q0.6821.00
126_L130_V0.6821.00
258_D261_L0.6781.00
103_E106_M0.6771.00
268_D272_I0.6731.00
256_S260_I0.6721.00
29_H220_K0.6721.00
267_S271_R0.6711.00
70_V84_Q0.6711.00
11_A36_E0.6701.00
245_N248_L0.6701.00
90_P93_Y0.6701.00
109_A158_I0.6671.00
277_G281_A0.6671.00
39_I196_I0.6601.00
253_I256_S0.6581.00
277_G285_L0.6581.00
95_A140_V0.6571.00
265_K269_G0.6561.00
272_I276_N0.6521.00
105_M127_L0.6521.00
168_E201_H0.6521.00
259_G264_R0.6511.00
162_R194_M0.6481.00
123_A126_L0.6461.00
119_A123_A0.6461.00
278_E291_N0.6441.00
270_I275_R0.6401.00
39_I198_V0.6381.00
276_N280_K0.6371.00
274_V277_G0.6331.00
263_V267_S0.6301.00
263_V268_D0.6301.00
106_M109_A0.6291.00
71_S84_Q0.6271.00
234_V237_D0.6271.00
264_R269_G0.6241.00
165_F199_T0.6241.00
264_R270_I0.6231.00
254_S260_I0.6181.00
87_G159_S0.6181.00
258_D262_D0.6171.00
264_R278_E0.6171.00
253_I257_K0.6161.00
63_P68_A0.6151.00
252_I255_S0.6151.00
132_L135_A0.6151.00
20_R28_D0.6101.00
100_T137_K0.6061.00
89_V149_R0.6051.00
124_K134_Y0.6051.00
117_R120_E0.6031.00
51_S55_K0.6031.00
108_M111_L0.6031.00
147_M150_R0.6021.00
163_I197_F0.6011.00
234_V238_V0.6001.00
140_V148_R0.6001.00
236_G240_S0.5991.00
233_K237_D0.5981.00
109_A113_G0.5981.00
265_K270_I0.5981.00
281_A284_I0.5981.00
268_D273_K0.5941.00
186_M209_Y0.5931.00
260_I263_V0.5921.00
93_Y152_E0.5871.00
57_L165_F0.5871.00
87_G91_Q0.5871.00
36_E193_K0.5851.00
281_A288_L0.5841.00
128_E134_Y0.5841.00
111_L115_P0.5811.00
277_G284_I0.5771.00
239_V244_S0.5761.00
261_L265_K0.5761.00
247_E251_K0.5751.00
232_E235_G0.5751.00
275_R279_E0.5751.00
188_L196_I0.5741.00
273_K276_N0.5721.00
102_W105_M0.5701.00
288_L291_N0.5661.00
86_I163_I0.5601.00
28_D219_G0.5591.00
161_P188_L0.5581.00
246_D249_A0.5571.00
19_K27_V0.5571.00
170_T205_E0.5531.00
271_R291_N0.5521.00
270_I278_E0.5521.00
185_I209_Y0.5491.00
198_V206_A0.5481.00
226_S230_L0.5471.00
256_S263_V0.5461.00
206_A210_G0.5441.00
57_L68_A0.5401.00
267_S272_I0.5391.00
150_R177_T0.5381.00
89_V166_L0.5381.00
69_T73_Y0.5371.00
220_K224_I0.5371.00
239_V245_N0.5361.00
125_E128_E0.5331.00
52_T61_L0.5321.00
275_R285_L0.5301.00
17_L53_T0.5301.00
237_D244_S0.5301.00
278_E283_E0.5291.00
94_T97_E0.5281.00
278_E288_L0.5271.00
251_K254_S0.5251.00
11_A195_T0.5241.00
248_L252_I0.5241.00
166_L169_P0.5231.00
22_G25_V0.5221.00
18_T64_S0.5201.00
269_G273_K0.5201.00
119_A122_R0.5181.00
166_L185_I0.5181.00
284_I291_N0.5181.00
247_E250_I0.5161.00
34_V163_I0.5161.00
251_K255_S0.5101.00
20_R26_A0.5091.00
265_K271_R0.5071.00
242_Q247_E0.5071.00
274_V280_K0.5061.00
272_I285_L0.5051.00
54_I88_V0.5041.00
276_N285_L0.5021.00
57_L197_F0.5011.00
267_S275_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4yerA 2 0.8407 100 0.176 Contact Map
3tuiC 2 0.9705 100 0.229 Contact Map
4rvcA 4 0.708 100 0.244 Contact Map
1vplA 2 0.6962 100 0.244 Contact Map
4u00A 1 0.7021 100 0.248 Contact Map
4ymuJ 2 0.6962 100 0.248 Contact Map
4mkiB 2 0.8112 100 0.249 Contact Map
2oljA 2 0.7021 100 0.252 Contact Map
1b0uA 2 0.7139 100 0.252 Contact Map
1g291 4 0.8437 100 0.258 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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