GREMLIN Database
Q7LX63 - Uncharacterized protein
UniProt: Q7LX63 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 135 (121)
Sequences: 1019 (663)
Seq/√Len: 60.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
123_S127_E5.9151.00
74_A77_S3.8731.00
63_E71_K3.4911.00
16_T30_I3.3981.00
117_Y128_I3.2781.00
54_N58_E2.9391.00
120_R124_A2.7111.00
22_Q37_M2.5601.00
94_D122_I2.3101.00
23_S29_E2.2401.00
110_E113_K2.2181.00
33_D36_K2.0281.00
113_K116_E1.8941.00
79_E83_F1.7730.99
103_A128_I1.6850.99
10_G13_R1.6470.99
59_E72_I1.6260.99
7_R16_T1.6110.99
16_T49_I1.6030.99
78_E82_E1.5580.99
7_R42_W1.5370.98
13_R59_E1.5310.98
21_W84_L1.4900.98
53_L70_Y1.3930.97
94_D98_E1.3860.97
16_T52_L1.3830.97
21_W77_S1.3620.97
95_S122_I1.3620.97
123_S126_K1.3510.96
38_T42_W1.3500.96
81_K84_L1.3440.96
78_E81_K1.3150.96
36_K56_M1.3140.96
98_E122_I1.2770.95
61_V79_E1.2690.95
75_K78_E1.2650.95
121_I124_A1.2610.95
25_R33_D1.2460.94
96_V103_A1.1970.93
119_H126_K1.1970.93
13_R52_L1.1890.93
79_E82_E1.1700.92
66_S69_K1.1690.92
120_R127_E1.1680.92
48_S52_L1.1620.92
85_P89_I1.1450.91
122_I130_E1.1380.91
64_K71_K1.1230.91
43_K49_I1.1160.90
124_A128_I1.1080.90
32_D43_K1.0960.89
46_P70_Y1.0940.89
7_R12_L1.0890.89
25_R30_I1.0780.89
20_L72_I1.0710.88
52_L56_M1.0630.88
80_I83_F1.0580.88
92_I102_L1.0530.87
52_L55_K1.0170.86
25_R29_E0.9970.84
9_K12_L0.9930.84
55_K69_K0.9910.84
21_W34_I0.9870.84
65_T68_G0.9590.82
21_W74_A0.9470.81
34_I37_M0.9310.80
102_L105_F0.9290.80
111_R114_L0.9190.79
116_E119_H0.9110.79
97_Q104_Q0.8960.77
28_I124_A0.8930.77
55_K79_E0.8910.77
63_E74_A0.8820.76
126_K130_E0.8710.75
26_R42_W0.8640.75
96_V100_E0.8620.75
10_G73_T0.8570.74
16_T83_F0.8530.74
55_K58_E0.8480.73
10_G38_T0.8470.73
18_W22_Q0.8460.73
12_L129_E0.8430.73
91_S122_I0.8370.72
14_L80_I0.8350.72
8_Q16_T0.8250.71
19_L24_P0.8140.70
28_I42_W0.8060.70
91_S94_D0.8060.70
94_D97_Q0.7970.69
41_F70_Y0.7940.68
95_S121_I0.7710.66
57_E103_A0.7700.66
20_L25_R0.7640.65
34_I92_I0.7480.64
9_K68_G0.7470.64
126_K129_E0.7460.64
77_S81_K0.7320.62
10_G48_S0.7270.62
58_E61_V0.7200.61
7_R80_I0.7200.61
33_D37_M0.7190.61
28_I32_D0.7160.60
10_G28_I0.7110.60
125_I129_E0.7020.59
120_R123_S0.6990.59
94_D130_E0.6980.58
91_S120_R0.6910.58
34_I118_K0.6900.58
59_E79_E0.6890.57
93_E107_K0.6890.57
11_R33_D0.6860.57
74_A81_K0.6810.57
33_D114_L0.6800.56
100_E118_K0.6760.56
106_F117_Y0.6610.54
105_F126_K0.6600.54
9_K16_T0.6600.54
99_L124_A0.6570.54
54_N70_Y0.6550.54
118_K122_I0.6510.53
115_I123_S0.6490.53
115_I119_H0.6420.52
9_K29_E0.6410.52
105_F129_E0.6380.52
92_I96_V0.6340.51
55_K59_E0.6300.51
12_L15_M0.6280.51
95_S118_K0.6260.50
117_Y125_I0.6250.50
115_I122_I0.6220.50
33_D63_E0.6210.50
17_L80_I0.6170.49
32_D40_G0.6170.49
64_K67_D0.6150.49
90_N120_R0.6110.49
34_I96_V0.6050.48
101_G104_Q0.6040.48
122_I126_K0.6020.48
98_E103_A0.5990.47
60_G75_K0.5950.47
71_K77_S0.5940.47
13_R38_T0.5900.46
14_L34_I0.5830.46
92_I104_Q0.5830.46
42_W80_I0.5810.45
11_R23_S0.5760.45
91_S101_G0.5740.45
16_T20_L0.5730.44
22_Q112_N0.5730.44
104_Q108_E0.5730.44
42_W106_F0.5710.44
50_Y53_L0.5710.44
93_E101_G0.5610.43
32_D117_Y0.5570.43
84_L110_E0.5560.43
92_I100_E0.5550.42
19_L30_I0.5530.42
121_I126_K0.5530.42
27_G50_Y0.5520.42
75_K82_E0.5500.42
116_E127_E0.5450.41
14_L30_I0.5450.41
61_V73_T0.5420.41
112_N116_E0.5400.41
75_K81_K0.5370.41
89_I119_H0.5310.40
15_M83_F0.5300.40
18_W37_M0.5280.40
14_L72_I0.5250.39
69_K103_A0.5250.39
36_K49_I0.5230.39
40_G117_Y0.5210.39
29_E120_R0.5170.38
91_S102_L0.5110.38
29_E116_E0.5110.38
35_N40_G0.5080.37
14_L42_W0.5050.37
7_R15_M0.5040.37
7_R61_V0.5030.37
29_E100_E0.5030.37
122_I129_E0.5000.37
15_M38_T0.5000.37
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1bm9A 2 0.763 99.8 0.569 Contact Map
2rkhA 2 0.8963 99.8 0.584 Contact Map
3l9fA 2 0.8963 99.7 0.588 Contact Map
1yg2A 2 0.8963 99.6 0.625 Contact Map
2zfwA 2 0.6815 99.6 0.645 Contact Map
1xmaA 2 0.7185 99.6 0.647 Contact Map
2e1nA 2 0.6815 99.5 0.651 Contact Map
2dqlA 2 0.7037 99.5 0.663 Contact Map
2eshA 2 0.7704 99.4 0.671 Contact Map
3f8bA 2 0.7185 99.4 0.671 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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