GREMLIN Database
Q7LX62 - Uncharacterized protein
UniProt: Q7LX62 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 395 (324)
Sequences: 7893 (6854)
Seq/√Len: 380.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
249_S283_L4.7321.00
32_V61_I4.2221.00
327_G362_S3.8091.00
245_D248_T3.7921.00
55_I214_S3.4121.00
182_F213_I3.3441.00
330_A362_S3.0981.00
31_L58_S2.9561.00
180_D214_S2.7701.00
55_I178_A2.6781.00
198_L202_K2.6231.00
337_L344_G2.4821.00
339_E389_K2.4611.00
246_K270_L2.4611.00
44_I238_P2.4491.00
330_A363_L2.4111.00
30_Q237_F2.4091.00
53_S57_K2.3461.00
59_L178_A2.3451.00
57_K60_K2.3161.00
186_K189_S2.2331.00
28_I57_K2.1801.00
45_G49_I2.1531.00
253_L287_G2.1061.00
250_F269_L2.0861.00
249_S273_I2.0601.00
25_E248_T2.0501.00
31_L41_V2.0481.00
331_R335_K2.0241.00
36_N65_P1.9631.00
35_M62_I1.9111.00
334_L363_L1.9081.00
327_G330_A1.8841.00
21_P57_K1.8701.00
29_K33_E1.7921.00
370_V378_A1.7661.00
272_A283_L1.7511.00
67_V172_L1.7341.00
248_T251_N1.7241.00
159_V164_E1.7001.00
228_K231_P1.6961.00
56_L70_S1.6941.00
44_I240_Y1.6911.00
57_K61_I1.6801.00
285_Y288_L1.6771.00
23_D248_T1.6751.00
156_I159_V1.6601.00
112_K115_G1.6471.00
47_R216_S1.6401.00
115_G119_L1.6311.00
153_K157_P1.6281.00
337_L379_I1.6271.00
44_I215_G1.6101.00
270_L274_E1.5981.00
84_S88_L1.5971.00
43_I55_I1.5911.00
82_L88_L1.5891.00
316_R390_S1.5821.00
246_K273_I1.5701.00
368_Y384_I1.5621.00
21_P53_S1.5611.00
254_K269_L1.5591.00
27_E239_I1.5561.00
285_Y322_E1.5461.00
333_I359_G1.5371.00
246_K250_F1.5231.00
115_G122_L1.5001.00
115_G118_L1.4981.00
43_I241_V1.4681.00
46_V49_I1.4611.00
34_M41_V1.4471.00
22_F255_Q1.4401.00
320_Q324_N1.4311.00
323_Y388_L1.4281.00
156_I160_L1.4261.00
271_L275_E1.4261.00
26_N29_K1.4251.00
162_L165_R1.4151.00
114_K118_L1.4121.00
164_E167_A1.4101.00
49_I280_P1.4091.00
180_D183_Q1.4001.00
70_S73_D1.3931.00
42_A213_I1.3911.00
63_E66_K1.3661.00
118_L121_K1.3621.00
297_T300_C1.3541.00
178_A214_S1.3481.00
361_K365_G1.3301.00
196_F202_K1.3131.00
271_L274_E1.3101.00
53_S284_N1.3081.00
250_F254_K1.3071.00
300_C303_K1.3021.00
329_N359_G1.3011.00
152_V155_S1.2981.00
158_Q162_L1.2891.00
297_T304_V1.2881.00
251_N255_Q1.2721.00
197_H201_S1.2661.00
82_L85_F1.2641.00
112_K116_K1.2601.00
27_E242_K1.2551.00
344_G377_Y1.2481.00
276_L286_F1.2431.00
199_L202_K1.2281.00
372_E378_A1.2101.00
68_Y73_D1.2081.00
246_K274_E1.1971.00
364_L369_I1.1941.00
116_K119_L1.1751.00
250_F266_D1.1751.00
161_E164_E1.1751.00
85_F88_L1.1691.00
250_F270_L1.1601.00
155_S158_Q1.1551.00
67_V70_S1.1541.00
176_V210_S1.1501.00
112_K119_L1.1411.00
344_G369_I1.1341.00
297_T301_A1.1341.00
55_I59_L1.1341.00
20_E53_S1.1341.00
198_L201_S1.1341.00
27_E54_V1.1301.00
114_K119_L1.1241.00
329_N355_S1.1221.00
202_K207_N1.1211.00
31_L54_V1.1201.00
352_S355_S1.1011.00
26_N30_Q1.0991.00
43_I239_I1.0961.00
30_Q33_E1.0951.00
71_V88_L1.0941.00
252_F283_L1.0891.00
197_H200_R1.0851.00
134_N138_V1.0801.00
382_P386_K1.0801.00
244_F252_F1.0791.00
116_K120_D1.0781.00
85_F189_S1.0671.00
35_M176_V1.0671.00
152_V156_I1.0671.00
364_L371_K1.0651.00
55_I212_V1.0631.00
330_A366_S1.0621.00
73_D84_S1.0591.00
84_S87_S1.0561.00
39_Q237_F1.0531.00
58_S212_V1.0521.00
155_S167_A1.0491.00
341_G344_G1.0461.00
32_V65_P1.0461.00
386_K390_S1.0421.00
269_L273_I1.0411.00
159_V167_A1.0401.00
351_L356_I1.0401.00
81_D84_S1.0401.00
20_E255_Q1.0371.00
153_K159_V1.0371.00
25_E251_N1.0351.00
298_S302_K1.0321.00
52_T56_L1.0321.00
347_K353_R1.0311.00
343_K376_K1.0291.00
296_V301_A1.0211.00
337_L369_I1.0201.00
351_L355_S1.0191.00
118_L122_L1.0141.00
382_P385_V1.0051.00
42_A215_G1.0041.00
265_E268_A1.0041.00
275_E386_K1.0041.00
32_V58_S1.0021.00
333_I360_L1.0001.00
266_D270_L0.9981.00
276_L283_L0.9941.00
67_V73_D0.9941.00
246_K276_L0.9861.00
323_Y331_R0.9811.00
228_K233_Y0.9741.00
160_L164_E0.9701.00
302_K306_E0.9691.00
300_C304_V0.9681.00
32_V36_N0.9631.00
54_V241_V0.9631.00
251_N254_K0.9591.00
47_R181_E0.9541.00
333_I349_L0.9531.00
324_N331_R0.9521.00
273_I276_L0.9501.00
329_N332_I0.9491.00
360_L377_Y0.9491.00
74_F77_G0.9431.00
151_G154_E0.9421.00
319_I384_I0.9411.00
34_M39_Q0.9391.00
256_G287_G0.9391.00
362_S366_S0.9371.00
28_I58_S0.9351.00
162_L167_A0.9351.00
216_S381_D0.9341.00
152_V157_P0.9331.00
155_S164_E0.9321.00
35_M58_S0.9311.00
245_D249_S0.9301.00
157_P161_E0.9281.00
333_I346_L0.9281.00
158_Q161_E0.9211.00
161_E165_R0.9211.00
49_I279_I0.9191.00
62_I66_K0.9191.00
333_I356_I0.9171.00
80_F83_V0.9111.00
151_G156_I0.9101.00
351_L359_G0.9081.00
338_A389_K0.8951.00
151_G159_V0.8941.00
115_G121_K0.8901.00
301_A304_V0.8901.00
30_Q34_M0.8881.00
347_K356_I0.8851.00
67_V71_V0.8841.00
229_K232_F0.8831.00
340_K343_K0.8831.00
59_L63_E0.8831.00
153_K156_I0.8821.00
298_S301_A0.8791.00
83_V88_L0.8771.00
244_F248_T0.8701.00
336_Y349_L0.8641.00
200_R203_W0.8621.00
58_S62_I0.8601.00
182_F185_L0.8551.00
299_E304_V0.8511.00
296_V299_E0.8511.00
53_S56_L0.8491.00
162_L166_L0.8431.00
253_L272_A0.8431.00
85_F89_Y0.8391.00
155_S162_L0.8371.00
303_K306_E0.8351.00
345_D348_G0.8341.00
302_K305_I0.8341.00
94_I98_L0.8331.00
281_A381_D0.8321.00
34_M237_F0.8311.00
115_G120_D0.8311.00
27_E30_Q0.8311.00
46_V243_Q0.8261.00
340_K344_G0.8261.00
243_Q276_L0.8261.00
277_D382_P0.8201.00
71_V179_I0.8171.00
301_A306_E0.8161.00
299_E302_K0.8131.00
385_V389_K0.8011.00
62_I65_P0.8011.00
156_I161_E0.7961.00
68_Y71_V0.7961.00
73_D185_L0.7951.00
86_L89_Y0.7951.00
371_K377_Y0.7941.00
58_S210_S0.7921.00
230_E233_Y0.7911.00
49_I241_V0.7871.00
328_K331_R0.7761.00
297_T306_E0.7761.00
29_K32_V0.7741.00
41_V210_S0.7711.00
203_W209_V0.7711.00
84_S189_S0.7671.00
177_V211_Y0.7671.00
25_E29_K0.7621.00
323_Y334_L0.7611.00
77_G80_F0.7571.00
380_I384_I0.7571.00
59_L68_Y0.7541.00
180_D382_P0.7521.00
163_P166_L0.7481.00
370_V380_I0.7481.00
59_L70_S0.7451.00
254_K266_D0.7431.00
157_P162_L0.7421.00
304_V309_T0.7411.00
196_F201_S0.7411.00
112_K118_L0.7411.00
218_V221_L0.7411.00
253_L283_L0.7381.00
273_I278_G0.7331.00
35_M210_S0.7311.00
281_A285_Y0.7261.00
22_F248_T0.7211.00
41_V237_F0.7181.00
87_S91_S0.7171.00
119_L122_L0.7161.00
27_E241_V0.7151.00
343_K378_A0.7141.00
117_E120_D0.7131.00
69_L72_E0.7121.00
157_P164_E0.7081.00
151_G155_S0.7081.00
58_S176_V0.7051.00
202_K205_F0.7051.00
303_K307_D0.7031.00
247_N250_F0.7010.99
355_S359_G0.7010.99
116_K121_K0.7010.99
272_A286_F0.7000.99
154_E158_Q0.6990.99
67_V175_I0.6990.99
228_K232_F0.6990.99
40_P236_F0.6980.99
257_F264_Y0.6940.99
68_Y72_E0.6920.99
32_V62_I0.6900.99
341_G385_V0.6900.99
181_E184_Y0.6880.99
114_K117_E0.6820.99
59_L176_V0.6810.99
159_V162_L0.6800.99
268_A272_A0.6800.99
353_R356_I0.6790.99
32_V35_M0.6780.99
152_V159_V0.6780.99
153_K158_Q0.6780.99
185_L189_S0.6780.99
244_F280_P0.6760.99
69_L73_D0.6720.99
282_W315_V0.6720.99
230_E238_P0.6720.99
31_L212_V0.6710.99
70_S74_F0.6690.99
157_P160_L0.6680.99
112_K117_E0.6610.99
346_L349_L0.6600.99
249_S278_G0.6560.99
71_V74_F0.6560.99
384_I387_V0.6560.99
151_G157_P0.6540.99
364_L377_Y0.6530.99
155_S166_L0.6530.99
28_I61_I0.6530.99
361_K364_L0.6490.99
155_S159_V0.6490.99
88_L177_V0.6470.99
184_Y216_S0.6470.99
316_R387_V0.6460.99
338_A379_I0.6450.99
154_E157_P0.6430.99
229_K233_Y0.6430.99
67_V72_E0.6380.99
47_R183_Q0.6370.99
347_K350_E0.6360.99
352_S356_I0.6350.99
220_L224_I0.6330.99
319_I387_V0.6330.99
253_L269_L0.6330.99
40_P211_Y0.6320.99
252_F284_N0.6220.99
153_K162_L0.6220.99
76_E79_S0.6220.99
243_Q277_D0.6210.99
40_P203_W0.6210.99
134_N137_L0.6210.99
170_F208_K0.6200.99
256_G284_N0.6200.99
334_L368_Y0.6200.99
201_S205_F0.6180.99
48_R181_E0.6180.99
321_E324_N0.6180.99
249_S287_G0.6170.99
198_L207_N0.6170.99
222_E225_F0.6160.99
360_L369_I0.6140.99
30_Q239_I0.6140.99
152_V164_E0.6140.99
254_K263_D0.6130.99
83_V87_S0.6130.99
34_M239_I0.6120.99
34_M210_S0.6110.99
47_R383_V0.6100.99
40_P213_I0.6080.99
31_L43_I0.6050.99
176_V212_V0.6050.99
80_F84_S0.6050.99
114_K120_D0.6040.99
279_I284_N0.6000.98
299_E303_K0.6000.98
222_E226_Y0.5990.98
296_V300_C0.5980.98
49_I243_Q0.5980.98
332_I335_K0.5980.98
82_L87_S0.5960.98
225_F230_E0.5950.98
49_I282_W0.5920.98
285_Y314_I0.5920.98
55_I180_D0.5900.98
276_L290_S0.5860.98
197_H203_W0.5830.98
42_A236_F0.5810.98
21_P248_T0.5800.98
28_I32_V0.5780.98
41_V239_I0.5750.98
116_K122_L0.5720.98
372_E376_K0.5700.98
154_E159_V0.5700.98
172_L208_K0.5700.98
301_A305_I0.5680.98
268_A290_S0.5670.98
329_N351_L0.5660.98
284_N288_L0.5650.98
298_S306_E0.5650.98
51_K281_A0.5640.98
80_F85_F0.5640.98
318_I322_E0.5630.98
117_E121_K0.5630.98
311_N314_I0.5630.98
197_H202_K0.5620.98
304_V308_I0.5610.98
47_R381_D0.5610.98
152_V162_L0.5580.98
285_Y289_K0.5570.97
337_L341_G0.5560.97
305_I308_I0.5560.97
183_Q186_K0.5550.97
94_I99_N0.5540.97
80_F86_L0.5520.97
112_K120_D0.5500.97
24_R27_E0.5500.97
369_I379_I0.5480.97
133_F138_V0.5470.97
277_D342_G0.5460.97
199_L203_W0.5430.97
270_L273_I0.5420.97
23_D245_D0.5410.97
296_V302_K0.5400.97
160_L163_P0.5390.97
80_F88_L0.5380.97
299_E307_D0.5370.97
60_K63_E0.5360.97
152_V158_Q0.5360.97
49_I216_S0.5360.97
334_L388_L0.5360.97
175_I209_V0.5350.97
320_Q387_V0.5350.97
201_S207_N0.5350.97
359_G362_S0.5340.97
78_K88_L0.5340.97
45_G48_R0.5320.97
379_I389_K0.5320.97
152_V167_A0.5290.97
363_L366_S0.5290.97
80_F87_S0.5280.97
51_K216_S0.5280.97
249_S276_L0.5260.96
185_L196_F0.5240.96
216_S386_K0.5230.96
93_L96_N0.5230.96
61_I64_T0.5230.96
289_K292_Q0.5220.96
279_I283_L0.5220.96
258_R261_G0.5210.96
272_A287_G0.5210.96
61_I65_P0.5200.96
133_F137_L0.5200.96
246_K269_L0.5190.96
253_L256_G0.5180.96
84_S185_L0.5170.96
297_T302_K0.5160.96
355_S358_E0.5140.96
297_T303_K0.5130.96
367_G380_I0.5120.96
281_A383_V0.5110.96
81_D87_S0.5100.96
62_I176_V0.5100.96
21_P25_E0.5080.96
52_T180_D0.5060.96
72_E180_D0.5060.96
56_L60_K0.5050.96
353_R357_N0.5050.96
220_L223_K0.5040.95
75_I385_V0.5040.95
160_L165_R0.5040.95
182_F215_G0.5040.95
286_F312_D0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2fnaA 1 0.8506 100 0.5 Contact Map
2qenA 1 0.8278 100 0.505 Contact Map
1z6tA 1 0.8101 100 0.556 Contact Map
2a5yB 2 0.8076 100 0.596 Contact Map
3sfzA 1 0.8051 99.9 0.62 Contact Map
1w5sA 1 0.8228 99.9 0.634 Contact Map
1fnnA 1 0.8051 99.9 0.639 Contact Map
2qbyA 1 0.8 99.9 0.651 Contact Map
1vt4I 4 0.7873 99.9 0.665 Contact Map
2v1uA 1 0.8152 99.9 0.669 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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