Q7LX62 - SULSO - GREMLIN Contacts

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Q7LX62 - Uncharacterized protein

UniProt:	Q7LX62	Sequences: MGTHISRVPMKFIFGKPVDEPFDRENEIKQLVEMMNRRQPVAIIGVRRIGKTSVILKSLKIIETPKVYLSVEDFIEGKSFDLVSFLSLYSSLLITNTLNYVDPKRKISQIVKQKGKELLDKLRELIGYVKLSFNINLVEVEVFLNSVKRGGVKESIPQVLELPERLAEEFGLNTIVVAIDEFQYLKLASQNYPGIFHLLRSKWQFHNKVSYVISGSSVGLLEKIFYDKKEPFYQFFFPIYVKQFDKNTSFNFLKQGFRDEGKDYEDNALLLAIEELDGIPAWLNYFGLKSLQCNEVTSECAKKVIEDITFNDPIVRGIIQEEYNKLGKNARIILKYLAEKGGKGDLKGLELSRASINEGLKSLLGSGYIVKEERGKYAIIDPVIVKVLKSSTQII	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	395 (324)
Sequences:	7893 (6854)
Seq/√Len:	380.8

ECOLI - MALT
SULSO - Q7LX62 Q97VA4 Q7LX94 Q97X15 Q97Y08 Q97X37

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
249_S	283_L	4.732	1.00
32_V	61_I	4.222	1.00
327_G	362_S	3.809	1.00
245_D	248_T	3.792	1.00
55_I	214_S	3.412	1.00
182_F	213_I	3.344	1.00
330_A	362_S	3.098	1.00
31_L	58_S	2.956	1.00
180_D	214_S	2.770	1.00
55_I	178_A	2.678	1.00
198_L	202_K	2.623	1.00
337_L	344_G	2.482	1.00
339_E	389_K	2.461	1.00
246_K	270_L	2.461	1.00
44_I	238_P	2.449	1.00
330_A	363_L	2.411	1.00
30_Q	237_F	2.409	1.00
53_S	57_K	2.346	1.00
59_L	178_A	2.345	1.00
57_K	60_K	2.316	1.00
186_K	189_S	2.233	1.00
28_I	57_K	2.180	1.00
45_G	49_I	2.153	1.00
253_L	287_G	2.106	1.00
250_F	269_L	2.086	1.00
249_S	273_I	2.060	1.00
25_E	248_T	2.050	1.00
31_L	41_V	2.048	1.00
331_R	335_K	2.024	1.00
36_N	65_P	1.963	1.00
35_M	62_I	1.911	1.00
334_L	363_L	1.908	1.00
327_G	330_A	1.884	1.00
21_P	57_K	1.870	1.00
29_K	33_E	1.792	1.00
370_V	378_A	1.766	1.00
272_A	283_L	1.751	1.00
67_V	172_L	1.734	1.00
248_T	251_N	1.724	1.00
159_V	164_E	1.700	1.00
228_K	231_P	1.696	1.00
56_L	70_S	1.694	1.00
44_I	240_Y	1.691	1.00
57_K	61_I	1.680	1.00
285_Y	288_L	1.677	1.00
23_D	248_T	1.675	1.00
156_I	159_V	1.660	1.00
112_K	115_G	1.647	1.00
47_R	216_S	1.640	1.00
115_G	119_L	1.631	1.00
153_K	157_P	1.628	1.00
337_L	379_I	1.627	1.00
44_I	215_G	1.610	1.00
270_L	274_E	1.598	1.00
84_S	88_L	1.597	1.00
43_I	55_I	1.591	1.00
82_L	88_L	1.589	1.00
316_R	390_S	1.582	1.00
246_K	273_I	1.570	1.00
368_Y	384_I	1.562	1.00
21_P	53_S	1.561	1.00
254_K	269_L	1.559	1.00
27_E	239_I	1.556	1.00
285_Y	322_E	1.546	1.00
333_I	359_G	1.537	1.00
246_K	250_F	1.523	1.00
115_G	122_L	1.500	1.00
115_G	118_L	1.498	1.00
43_I	241_V	1.468	1.00
46_V	49_I	1.461	1.00
34_M	41_V	1.447	1.00
22_F	255_Q	1.440	1.00
320_Q	324_N	1.431	1.00
323_Y	388_L	1.428	1.00
156_I	160_L	1.426	1.00
271_L	275_E	1.426	1.00
26_N	29_K	1.425	1.00
162_L	165_R	1.415	1.00
114_K	118_L	1.412	1.00
164_E	167_A	1.410	1.00
49_I	280_P	1.409	1.00
180_D	183_Q	1.400	1.00
70_S	73_D	1.393	1.00
42_A	213_I	1.391	1.00
63_E	66_K	1.366	1.00
118_L	121_K	1.362	1.00
297_T	300_C	1.354	1.00
178_A	214_S	1.348	1.00
361_K	365_G	1.330	1.00
196_F	202_K	1.313	1.00
271_L	274_E	1.310	1.00
53_S	284_N	1.308	1.00
250_F	254_K	1.307	1.00
300_C	303_K	1.302	1.00
329_N	359_G	1.301	1.00
152_V	155_S	1.298	1.00
158_Q	162_L	1.289	1.00
297_T	304_V	1.288	1.00
251_N	255_Q	1.272	1.00
197_H	201_S	1.266	1.00
82_L	85_F	1.264	1.00
112_K	116_K	1.260	1.00
27_E	242_K	1.255	1.00
344_G	377_Y	1.248	1.00
276_L	286_F	1.243	1.00
199_L	202_K	1.228	1.00
372_E	378_A	1.210	1.00
68_Y	73_D	1.208	1.00
246_K	274_E	1.197	1.00
364_L	369_I	1.194	1.00
116_K	119_L	1.175	1.00
250_F	266_D	1.175	1.00
161_E	164_E	1.175	1.00
85_F	88_L	1.169	1.00
250_F	270_L	1.160	1.00
155_S	158_Q	1.155	1.00
67_V	70_S	1.154	1.00
176_V	210_S	1.150	1.00
112_K	119_L	1.141	1.00
344_G	369_I	1.134	1.00
297_T	301_A	1.134	1.00
55_I	59_L	1.134	1.00
20_E	53_S	1.134	1.00
198_L	201_S	1.134	1.00
27_E	54_V	1.130	1.00
114_K	119_L	1.124	1.00
329_N	355_S	1.122	1.00
202_K	207_N	1.121	1.00
31_L	54_V	1.120	1.00
352_S	355_S	1.101	1.00
26_N	30_Q	1.099	1.00
43_I	239_I	1.096	1.00
30_Q	33_E	1.095	1.00
71_V	88_L	1.094	1.00
252_F	283_L	1.089	1.00
197_H	200_R	1.085	1.00
134_N	138_V	1.080	1.00
382_P	386_K	1.080	1.00
244_F	252_F	1.079	1.00
116_K	120_D	1.078	1.00
85_F	189_S	1.067	1.00
35_M	176_V	1.067	1.00
152_V	156_I	1.067	1.00
364_L	371_K	1.065	1.00
55_I	212_V	1.063	1.00
330_A	366_S	1.062	1.00
73_D	84_S	1.059	1.00
84_S	87_S	1.056	1.00
39_Q	237_F	1.053	1.00
58_S	212_V	1.052	1.00
155_S	167_A	1.049	1.00
341_G	344_G	1.046	1.00
32_V	65_P	1.046	1.00
386_K	390_S	1.042	1.00
269_L	273_I	1.041	1.00
159_V	167_A	1.040	1.00
351_L	356_I	1.040	1.00
81_D	84_S	1.040	1.00
20_E	255_Q	1.037	1.00
153_K	159_V	1.037	1.00
25_E	251_N	1.035	1.00
298_S	302_K	1.032	1.00
52_T	56_L	1.032	1.00
347_K	353_R	1.031	1.00
343_K	376_K	1.029	1.00
296_V	301_A	1.021	1.00
337_L	369_I	1.020	1.00
351_L	355_S	1.019	1.00
118_L	122_L	1.014	1.00
382_P	385_V	1.005	1.00
42_A	215_G	1.004	1.00
265_E	268_A	1.004	1.00
275_E	386_K	1.004	1.00
32_V	58_S	1.002	1.00
333_I	360_L	1.000	1.00
266_D	270_L	0.998	1.00
276_L	283_L	0.994	1.00
67_V	73_D	0.994	1.00
246_K	276_L	0.986	1.00
323_Y	331_R	0.981	1.00
228_K	233_Y	0.974	1.00
160_L	164_E	0.970	1.00
302_K	306_E	0.969	1.00
300_C	304_V	0.968	1.00
32_V	36_N	0.963	1.00
54_V	241_V	0.963	1.00
251_N	254_K	0.959	1.00
47_R	181_E	0.954	1.00
333_I	349_L	0.953	1.00
324_N	331_R	0.952	1.00
273_I	276_L	0.950	1.00
329_N	332_I	0.949	1.00
360_L	377_Y	0.949	1.00
74_F	77_G	0.943	1.00
151_G	154_E	0.942	1.00
319_I	384_I	0.941	1.00
34_M	39_Q	0.939	1.00
256_G	287_G	0.939	1.00
362_S	366_S	0.937	1.00
28_I	58_S	0.935	1.00
162_L	167_A	0.935	1.00
216_S	381_D	0.934	1.00
152_V	157_P	0.933	1.00
155_S	164_E	0.932	1.00
35_M	58_S	0.931	1.00
245_D	249_S	0.930	1.00
157_P	161_E	0.928	1.00
333_I	346_L	0.928	1.00
158_Q	161_E	0.921	1.00
161_E	165_R	0.921	1.00
49_I	279_I	0.919	1.00
62_I	66_K	0.919	1.00
333_I	356_I	0.917	1.00
80_F	83_V	0.911	1.00
151_G	156_I	0.910	1.00
351_L	359_G	0.908	1.00
338_A	389_K	0.895	1.00
151_G	159_V	0.894	1.00
115_G	121_K	0.890	1.00
301_A	304_V	0.890	1.00
30_Q	34_M	0.888	1.00
347_K	356_I	0.885	1.00
67_V	71_V	0.884	1.00
229_K	232_F	0.883	1.00
340_K	343_K	0.883	1.00
59_L	63_E	0.883	1.00
153_K	156_I	0.882	1.00
298_S	301_A	0.879	1.00
83_V	88_L	0.877	1.00
244_F	248_T	0.870	1.00
336_Y	349_L	0.864	1.00
200_R	203_W	0.862	1.00
58_S	62_I	0.860	1.00
182_F	185_L	0.855	1.00
299_E	304_V	0.851	1.00
296_V	299_E	0.851	1.00
53_S	56_L	0.849	1.00
162_L	166_L	0.843	1.00
253_L	272_A	0.843	1.00
85_F	89_Y	0.839	1.00
155_S	162_L	0.837	1.00
303_K	306_E	0.835	1.00
345_D	348_G	0.834	1.00
302_K	305_I	0.834	1.00
94_I	98_L	0.833	1.00
281_A	381_D	0.832	1.00
34_M	237_F	0.831	1.00
115_G	120_D	0.831	1.00
27_E	30_Q	0.831	1.00
46_V	243_Q	0.826	1.00
340_K	344_G	0.826	1.00
243_Q	276_L	0.826	1.00
277_D	382_P	0.820	1.00
71_V	179_I	0.817	1.00
301_A	306_E	0.816	1.00
299_E	302_K	0.813	1.00
385_V	389_K	0.801	1.00
62_I	65_P	0.801	1.00
156_I	161_E	0.796	1.00
68_Y	71_V	0.796	1.00
73_D	185_L	0.795	1.00
86_L	89_Y	0.795	1.00
371_K	377_Y	0.794	1.00
58_S	210_S	0.792	1.00
230_E	233_Y	0.791	1.00
49_I	241_V	0.787	1.00
328_K	331_R	0.776	1.00
297_T	306_E	0.776	1.00
29_K	32_V	0.774	1.00
41_V	210_S	0.771	1.00
203_W	209_V	0.771	1.00
84_S	189_S	0.767	1.00
177_V	211_Y	0.767	1.00
25_E	29_K	0.762	1.00
323_Y	334_L	0.761	1.00
77_G	80_F	0.757	1.00
380_I	384_I	0.757	1.00
59_L	68_Y	0.754	1.00
180_D	382_P	0.752	1.00
163_P	166_L	0.748	1.00
370_V	380_I	0.748	1.00
59_L	70_S	0.745	1.00
254_K	266_D	0.743	1.00
157_P	162_L	0.742	1.00
304_V	309_T	0.741	1.00
196_F	201_S	0.741	1.00
112_K	118_L	0.741	1.00
218_V	221_L	0.741	1.00
253_L	283_L	0.738	1.00
273_I	278_G	0.733	1.00
35_M	210_S	0.731	1.00
281_A	285_Y	0.726	1.00
22_F	248_T	0.721	1.00
41_V	237_F	0.718	1.00
87_S	91_S	0.717	1.00
119_L	122_L	0.716	1.00
27_E	241_V	0.715	1.00
343_K	378_A	0.714	1.00
117_E	120_D	0.713	1.00
69_L	72_E	0.712	1.00
157_P	164_E	0.708	1.00
151_G	155_S	0.708	1.00
58_S	176_V	0.705	1.00
202_K	205_F	0.705	1.00
303_K	307_D	0.703	1.00
247_N	250_F	0.701	0.99
355_S	359_G	0.701	0.99
116_K	121_K	0.701	0.99
272_A	286_F	0.700	0.99
154_E	158_Q	0.699	0.99
67_V	175_I	0.699	0.99
228_K	232_F	0.699	0.99
40_P	236_F	0.698	0.99
257_F	264_Y	0.694	0.99
68_Y	72_E	0.692	0.99
32_V	62_I	0.690	0.99
341_G	385_V	0.690	0.99
181_E	184_Y	0.688	0.99
114_K	117_E	0.682	0.99
59_L	176_V	0.681	0.99
159_V	162_L	0.680	0.99
268_A	272_A	0.680	0.99
353_R	356_I	0.679	0.99
32_V	35_M	0.678	0.99
152_V	159_V	0.678	0.99
153_K	158_Q	0.678	0.99
185_L	189_S	0.678	0.99
244_F	280_P	0.676	0.99
69_L	73_D	0.672	0.99
282_W	315_V	0.672	0.99
230_E	238_P	0.672	0.99
31_L	212_V	0.671	0.99
70_S	74_F	0.669	0.99
157_P	160_L	0.668	0.99
112_K	117_E	0.661	0.99
346_L	349_L	0.660	0.99
249_S	278_G	0.656	0.99
71_V	74_F	0.656	0.99
384_I	387_V	0.656	0.99
151_G	157_P	0.654	0.99
364_L	377_Y	0.653	0.99
155_S	166_L	0.653	0.99
28_I	61_I	0.653	0.99
361_K	364_L	0.649	0.99
155_S	159_V	0.649	0.99
88_L	177_V	0.647	0.99
184_Y	216_S	0.647	0.99
316_R	387_V	0.646	0.99
338_A	379_I	0.645	0.99
154_E	157_P	0.643	0.99
229_K	233_Y	0.643	0.99
67_V	72_E	0.638	0.99
47_R	183_Q	0.637	0.99
347_K	350_E	0.636	0.99
352_S	356_I	0.635	0.99
220_L	224_I	0.633	0.99
319_I	387_V	0.633	0.99
253_L	269_L	0.633	0.99
40_P	211_Y	0.632	0.99
252_F	284_N	0.622	0.99
153_K	162_L	0.622	0.99
76_E	79_S	0.622	0.99
243_Q	277_D	0.621	0.99
40_P	203_W	0.621	0.99
134_N	137_L	0.621	0.99
170_F	208_K	0.620	0.99
256_G	284_N	0.620	0.99
334_L	368_Y	0.620	0.99
201_S	205_F	0.618	0.99
48_R	181_E	0.618	0.99
321_E	324_N	0.618	0.99
249_S	287_G	0.617	0.99
198_L	207_N	0.617	0.99
222_E	225_F	0.616	0.99
360_L	369_I	0.614	0.99
30_Q	239_I	0.614	0.99
152_V	164_E	0.614	0.99
254_K	263_D	0.613	0.99
83_V	87_S	0.613	0.99
34_M	239_I	0.612	0.99
34_M	210_S	0.611	0.99
47_R	383_V	0.610	0.99
40_P	213_I	0.608	0.99
31_L	43_I	0.605	0.99
176_V	212_V	0.605	0.99
80_F	84_S	0.605	0.99
114_K	120_D	0.604	0.99
279_I	284_N	0.600	0.98
299_E	303_K	0.600	0.98
222_E	226_Y	0.599	0.98
296_V	300_C	0.598	0.98
49_I	243_Q	0.598	0.98
332_I	335_K	0.598	0.98
82_L	87_S	0.596	0.98
225_F	230_E	0.595	0.98
49_I	282_W	0.592	0.98
285_Y	314_I	0.592	0.98
55_I	180_D	0.590	0.98
276_L	290_S	0.586	0.98
197_H	203_W	0.583	0.98
42_A	236_F	0.581	0.98
21_P	248_T	0.580	0.98
28_I	32_V	0.578	0.98
41_V	239_I	0.575	0.98
116_K	122_L	0.572	0.98
372_E	376_K	0.570	0.98
154_E	159_V	0.570	0.98
172_L	208_K	0.570	0.98
301_A	305_I	0.568	0.98
268_A	290_S	0.567	0.98
329_N	351_L	0.566	0.98
284_N	288_L	0.565	0.98
298_S	306_E	0.565	0.98
51_K	281_A	0.564	0.98
80_F	85_F	0.564	0.98
318_I	322_E	0.563	0.98
117_E	121_K	0.563	0.98
311_N	314_I	0.563	0.98
197_H	202_K	0.562	0.98
304_V	308_I	0.561	0.98
47_R	381_D	0.561	0.98
152_V	162_L	0.558	0.98
285_Y	289_K	0.557	0.97
337_L	341_G	0.556	0.97
305_I	308_I	0.556	0.97
183_Q	186_K	0.555	0.97
94_I	99_N	0.554	0.97
80_F	86_L	0.552	0.97
112_K	120_D	0.550	0.97
24_R	27_E	0.550	0.97
369_I	379_I	0.548	0.97
133_F	138_V	0.547	0.97
277_D	342_G	0.546	0.97
199_L	203_W	0.543	0.97
270_L	273_I	0.542	0.97
23_D	245_D	0.541	0.97
296_V	302_K	0.540	0.97
160_L	163_P	0.539	0.97
80_F	88_L	0.538	0.97
299_E	307_D	0.537	0.97
60_K	63_E	0.536	0.97
152_V	158_Q	0.536	0.97
49_I	216_S	0.536	0.97
334_L	388_L	0.536	0.97
175_I	209_V	0.535	0.97
320_Q	387_V	0.535	0.97
201_S	207_N	0.535	0.97
359_G	362_S	0.534	0.97
78_K	88_L	0.534	0.97
45_G	48_R	0.532	0.97
379_I	389_K	0.532	0.97
152_V	167_A	0.529	0.97
363_L	366_S	0.529	0.97
80_F	87_S	0.528	0.97
51_K	216_S	0.528	0.97
249_S	276_L	0.526	0.96
185_L	196_F	0.524	0.96
216_S	386_K	0.523	0.96
93_L	96_N	0.523	0.96
61_I	64_T	0.523	0.96
289_K	292_Q	0.522	0.96
279_I	283_L	0.522	0.96
258_R	261_G	0.521	0.96
272_A	287_G	0.521	0.96
61_I	65_P	0.520	0.96
133_F	137_L	0.520	0.96
246_K	269_L	0.519	0.96
253_L	256_G	0.518	0.96
84_S	185_L	0.517	0.96
297_T	302_K	0.516	0.96
355_S	358_E	0.514	0.96
297_T	303_K	0.513	0.96
367_G	380_I	0.512	0.96
281_A	383_V	0.511	0.96
81_D	87_S	0.510	0.96
62_I	176_V	0.510	0.96
21_P	25_E	0.508	0.96
52_T	180_D	0.506	0.96
72_E	180_D	0.506	0.96
56_L	60_K	0.505	0.96
353_R	357_N	0.505	0.96
220_L	223_K	0.504	0.95
75_I	385_V	0.504	0.95
160_L	165_R	0.504	0.95
182_F	215_G	0.504	0.95
286_F	312_D	0.500	0.95

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2fnaA	1	0.8506	100	0.5	Contact Map
2qenA	1	0.8278	100	0.505	Contact Map
1z6tA	1	0.8101	100	0.556	Contact Map
2a5yB	2	0.8076	100	0.596	Contact Map
3sfzA	1	0.8051	99.9	0.62	Contact Map
1w5sA	1	0.8228	99.9	0.634	Contact Map
1fnnA	1	0.8051	99.9	0.639	Contact Map
2qbyA	1	0.8	99.9	0.651	Contact Map
1vt4I	4	0.7873	99.9	0.665	Contact Map
2v1uA	1	0.8152	99.9	0.669	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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