GREMLIN Database
Q7LX59 - Second ORF in transposon ISC1316
UniProt: Q7LX59 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 213 (201)
Sequences: 4755 (2884)
Seq/√Len: 203.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
99_D103_K4.6601.00
173_A203_N3.7251.00
121_H124_Q3.3671.00
153_L160_L3.1771.00
146_R162_L2.7291.00
144_E148_L2.6211.00
106_K110_E2.4981.00
40_L145_L2.4581.00
183_S186_D2.4481.00
126_I138_S2.4311.00
117_M149_I2.3511.00
171_T178_V2.2041.00
59_L135_R2.1321.00
150_K162_L2.1201.00
109_A153_L2.0941.00
167_Y170_K2.0351.00
163_V208_I2.0251.00
168_T208_I1.9611.00
58_A96_L1.9171.00
102_M151_Y1.9091.00
102_M148_L1.9081.00
190_V197_I1.8781.00
170_K182_L1.8621.00
144_E147_D1.8231.00
115_A153_L1.8141.00
131_R134_R1.8101.00
33_I41_I1.7271.00
65_L82_A1.7241.00
98_R144_E1.7151.00
145_L149_I1.6961.00
101_Y148_L1.6821.00
102_M152_Q1.6681.00
105_G148_L1.6431.00
40_L100_L1.6371.00
113_D158_K1.6071.00
102_M105_G1.6071.00
101_Y144_E1.5951.00
117_M160_L1.5791.00
175_C194_C1.5781.00
174_K196_W1.5471.00
187_R200_R1.5111.00
117_M162_L1.4761.00
69_L83_K1.4711.00
172_C175_C1.4631.00
189_F198_A1.4461.00
175_C191_C1.4361.00
191_C194_C1.4271.00
179_K189_F1.4141.00
117_M146_R1.4051.00
150_K154_E1.4031.00
118_E165_P1.4001.00
82_A86_L1.3941.00
72_K82_A1.3731.00
43_T47_E1.3711.00
172_C194_C1.3541.00
172_C191_C1.3491.00
6_T9_E1.3411.00
179_K182_L1.3361.00
189_F196_W1.3341.00
75_L79_W1.3271.00
179_K192_P1.3171.00
39_K42_V1.3151.00
31_V112_Y1.3081.00
30_E209_L1.3041.00
80_F83_K1.3001.00
91_E95_N1.2901.00
77_N80_F1.2891.00
42_V48_Y1.2681.00
10_R91_E1.2591.00
68_E72_K1.2511.00
206_L210_R1.2381.00
65_L68_E1.2321.00
177_Y192_P1.2311.00
119_G162_L1.2301.00
173_A206_L1.2261.00
105_G151_Y1.2011.00
105_G152_Q1.1921.00
30_E114_V1.1871.00
42_V202_Y1.1851.00
121_H165_P1.1821.00
109_A156_Y1.1741.00
8_S91_E1.1721.00
61_K65_L1.1711.00
33_I43_T1.1701.00
107_W111_H1.1601.00
137_L142_F1.1531.00
65_L89_A1.1361.00
182_L186_D1.1341.00
148_L151_Y1.1291.00
188_V197_I1.1281.00
35_V142_F1.1241.00
31_V43_T1.1171.00
62_V90_Y1.1021.00
184_L187_R1.0921.00
105_G145_L1.0921.00
35_V146_R1.0801.00
173_A198_A1.0561.00
32_A209_L1.0421.00
150_K160_L1.0371.00
58_A93_L1.0281.00
101_Y145_L1.0261.00
110_E156_Y1.0231.00
6_T10_R1.0211.00
66_H70_S1.0161.00
98_R148_L1.0141.00
109_A158_K1.0061.00
69_L86_L1.0021.00
37_I140_V0.9881.00
54_P96_L0.9771.00
202_Y206_L0.9741.00
152_Q155_K0.9711.00
177_Y193_N0.9600.99
62_V86_L0.9600.99
10_R95_N0.9600.99
6_T91_E0.9580.99
106_K156_Y0.9390.99
69_L82_A0.9360.99
101_Y105_G0.9360.99
179_K183_S0.9360.99
147_D150_K0.9310.99
153_L158_K0.9250.99
62_V93_L0.9160.99
29_K113_D0.9060.99
165_P168_T0.9060.99
183_S200_R0.9050.99
116_V208_I0.9050.99
182_L189_F0.9040.99
27_T113_D0.8990.99
92_H96_L0.8930.99
114_V159_K0.8910.99
64_H68_E0.8900.99
39_K48_Y0.8900.99
114_V161_I0.8880.99
184_L200_R0.8870.99
183_S187_R0.8800.99
198_A202_Y0.8800.99
30_E116_V0.8790.99
48_Y199_D0.8780.99
198_A206_L0.8660.99
170_K181_D0.8660.99
131_R138_S0.8580.99
126_I134_R0.8550.99
143_S147_D0.8510.99
116_V161_I0.8450.99
94_K98_R0.8450.99
119_G165_P0.8380.99
108_F115_A0.8360.99
66_H90_Y0.8150.98
66_H86_L0.8100.98
170_K178_V0.8070.98
85_K88_R0.8050.98
203_N207_N0.8030.98
202_Y205_S0.8010.98
37_I136_R0.8010.98
101_Y141_A0.7940.98
47_E107_W0.7870.98
187_R199_D0.7820.98
104_L107_W0.7800.98
173_A204_A0.7780.98
75_L80_F0.7780.98
105_G149_I0.7760.98
24_L27_T0.7660.97
24_L158_K0.7640.97
51_N140_V0.7610.97
83_K87_A0.7610.97
55_L59_L0.7580.97
65_L86_L0.7510.97
109_A115_A0.7510.97
26_N29_K0.7500.97
119_G146_R0.7460.97
72_K78_N0.7450.97
65_L85_K0.7430.97
170_K179_K0.7410.97
171_T207_N0.7400.97
122_V143_S0.7400.97
79_W83_K0.7400.97
36_G42_V0.7390.97
95_N99_D0.7390.97
100_L104_L0.7390.97
62_V70_S0.7370.97
173_A196_W0.7360.97
151_Y155_K0.7340.97
186_D200_R0.7270.96
54_P58_A0.7220.96
63_K66_H0.7180.96
44_S205_S0.7120.96
63_K67_R0.7100.96
98_R102_M0.7060.96
37_I126_I0.7040.96
48_Y202_Y0.7000.96
67_R70_S0.6980.96
188_V198_A0.6930.95
55_L58_A0.6890.95
106_K152_Q0.6890.95
116_V209_L0.6850.95
112_Y115_A0.6830.95
110_E114_V0.6820.95
41_I104_L0.6780.95
204_A207_N0.6750.95
122_V142_F0.6740.95
125_L137_L0.6690.94
186_D189_F0.6680.94
69_L79_W0.6660.94
32_A116_V0.6630.94
184_L199_D0.6630.94
62_V66_H0.6610.94
39_K50_P0.6580.94
51_N54_P0.6580.94
133_L137_L0.6470.93
89_A93_L0.6420.93
31_V115_A0.6390.93
103_K106_K0.6370.93
126_I131_R0.6360.93
170_K183_S0.6340.93
182_L200_R0.6340.93
167_Y178_V0.6310.93
68_E71_R0.6250.92
93_L139_D0.6240.92
206_L209_L0.6230.92
21_F154_E0.6190.92
49_F104_L0.6170.92
166_A170_K0.6160.92
40_L140_V0.6160.92
95_N98_R0.6150.92
32_A44_S0.6150.92
133_L136_R0.6130.91
90_Y97_R0.6100.91
40_L105_G0.6090.91
164_N167_Y0.6090.91
35_V41_I0.6060.91
171_T176_G0.6060.91
42_V49_F0.6020.91
58_A62_V0.6020.91
38_E42_V0.5990.91
134_R138_S0.5980.90
97_R139_D0.5980.90
181_D186_D0.5950.90
189_F200_R0.5950.90
67_R71_R0.5900.90
58_A89_A0.5900.90
126_I132_S0.5870.90
21_F155_K0.5870.90
124_Q165_P0.5870.90
61_K89_A0.5860.90
19_H22_P0.5850.89
12_Y91_E0.5850.89
56_E136_R0.5830.89
120_I165_P0.5830.89
167_Y171_T0.5810.89
102_M106_K0.5800.89
72_K76_S0.5790.89
149_I160_L0.5770.89
45_D112_Y0.5770.89
40_L101_Y0.5750.89
174_K206_L0.5740.89
148_L152_Q0.5740.89
115_A149_I0.5720.88
58_A92_H0.5720.88
174_K198_A0.5680.88
198_A203_N0.5650.88
171_T189_F0.5650.88
28_G113_D0.5620.88
43_T108_F0.5600.87
169_S182_L0.5600.87
9_E91_E0.5600.87
175_C179_K0.5590.87
106_K148_L0.5580.87
70_S86_L0.5570.87
32_A205_S0.5550.87
76_S79_W0.5550.87
146_R150_K0.5530.87
179_K200_R0.5510.87
104_L145_L0.5500.86
64_H67_R0.5480.86
31_V44_S0.5480.86
78_N81_K0.5440.86
86_L90_Y0.5440.86
90_Y94_K0.5420.86
124_Q137_L0.5390.85
146_R160_L0.5380.85
105_G108_F0.5340.85
143_S146_R0.5330.85
39_K199_D0.5300.84
19_H23_K0.5260.84
29_K45_D0.5260.84
141_A144_E0.5260.84
80_F84_V0.5250.84
33_I108_F0.5240.84
47_E50_P0.5230.84
177_Y181_D0.5230.84
68_E82_A0.5220.83
6_T11_I0.5210.83
38_E199_D0.5210.83
55_L135_R0.5200.83
63_K70_S0.5180.83
93_L97_R0.5170.83
58_A61_K0.5140.83
182_L187_R0.5120.82
41_I145_L0.5060.82
196_W203_N0.5020.81
25_P29_K0.5020.81
174_K177_Y0.5000.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1iv0A 1 0.4554 89.6 0.908 Contact Map
1vq8Z 1 0.3146 86.3 0.913 Contact Map
1vhxA 2 0.6244 84 0.916 Contact Map
4c2mI 1 0.2347 81 0.918 Contact Map
3j20Y 1 0.2347 81 0.919 Contact Map
1vd4A 1 0.2629 80.9 0.919 Contact Map
2k4xA 1 0.2582 80.6 0.919 Contact Map
4aybP 1 0.2019 80.5 0.919 Contact Map
1nu0A 1 0.5915 80 0.919 Contact Map
1qypA 1 0.216 79.8 0.919 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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