GREMLIN Database
Q7LX55 - Uncharacterized protein
UniProt: Q7LX55 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 127 (109)
Sequences: 176 (136)
Seq/√Len: 13.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
25_R99_N2.8430.95
70_I91_F2.7770.95
35_K75_D2.7560.94
24_L64_I2.6270.93
18_R100_D2.6080.93
73_D76_I2.5340.92
21_L24_L2.3450.88
88_K106_Y2.2300.85
22_P26_D2.1950.84
104_W118_T1.9570.76
90_A95_K1.9270.75
73_D77_G1.8580.72
14_L101_I1.8130.70
69_I79_V1.7250.66
21_L28_L1.6970.65
21_L101_I1.6870.65
95_K111_F1.6580.63
106_Y109_E1.6470.63
12_F68_G1.6300.62
24_L28_L1.6240.62
76_I96_I1.6100.61
72_R78_L1.6040.61
78_L110_G1.5560.58
41_L111_F1.5210.56
109_E115_K1.4930.55
50_L118_T1.4220.51
28_L73_D1.4150.51
21_L91_F1.4150.51
57_T112_R1.4010.50
15_E90_A1.4010.50
104_W115_K1.3940.50
26_D69_I1.3720.49
93_C114_R1.3440.47
27_R30_Q1.3060.45
72_R97_D1.2940.45
48_Y88_K1.2780.44
78_L113_G1.2560.43
15_E87_N1.2270.41
76_I117_L1.2180.41
24_L34_I1.2000.40
73_D96_I1.1750.38
21_L63_E1.1450.37
102_A116_R1.1450.37
72_R111_F1.1270.36
21_L99_N1.1230.36
91_F104_W1.1080.35
20_L64_I1.0990.35
83_A100_D1.0950.35
22_P82_P1.0950.35
54_A91_F1.0930.34
99_N102_A1.0800.34
79_V89_P1.0790.34
41_L49_A1.0770.34
27_R31_L1.0690.33
27_R71_L1.0520.33
50_L97_D1.0510.33
64_I69_I1.0440.32
10_P16_T1.0280.31
25_R96_I1.0240.31
61_I116_R1.0160.31
38_I54_A1.0150.31
20_L73_D1.0130.31
25_R97_D1.0090.31
28_L31_L0.9970.30
49_A107_M0.9930.30
18_R51_Q0.9660.29
22_P77_G0.9550.28
42_L106_Y0.9430.28
44_N48_Y0.9380.28
14_L70_I0.9380.28
80_D113_G0.9270.27
22_P98_E0.9270.27
18_R31_L0.9230.27
72_R113_G0.9220.27
13_D87_N0.9160.27
19_E26_D0.8880.26
54_A104_W0.8750.25
85_I90_A0.8720.25
49_A115_K0.8710.25
39_E58_K0.8490.24
62_D117_L0.8420.24
57_T71_L0.8400.24
71_L117_L0.8270.23
51_Q57_T0.8160.23
111_F118_T0.8070.22
42_L79_V0.7960.22
20_L23_W0.7920.22
110_G113_G0.7840.22
19_E66_S0.7720.21
101_I104_W0.7630.21
40_L62_D0.7600.21
72_R80_D0.7460.20
42_L109_E0.7430.20
71_L118_T0.7300.20
38_I85_I0.7300.20
72_R91_F0.7230.20
11_Y14_L0.7220.19
36_N48_Y0.7210.19
19_E56_E0.7180.19
67_K88_K0.7140.19
84_I89_P0.7040.19
11_Y84_I0.7030.19
27_R50_L0.7020.19
82_P117_L0.7000.19
73_D111_F0.6960.19
94_W98_E0.6950.19
38_I50_L0.6890.18
32_R101_I0.6840.18
86_N99_N0.6730.18
24_L81_F0.6720.18
28_L77_G0.6650.18
57_T75_D0.6580.17
26_D56_E0.6570.17
37_E58_K0.6570.17
52_Q91_F0.6570.17
21_L71_L0.6560.17
102_A111_F0.6540.17
16_T104_W0.6530.17
14_L34_I0.6420.17
11_Y89_P0.6410.17
58_K65_I0.6400.17
98_E114_R0.6380.17
30_Q60_I0.6370.17
23_W63_E0.6340.17
39_E61_I0.6290.17
37_E46_D0.6250.16
20_L28_L0.6250.16
14_L99_N0.6190.16
43_V112_R0.6100.16
12_F82_P0.6030.16
92_F98_E0.5970.16
51_Q106_Y0.5930.16
97_D102_A0.5910.16
64_I109_E0.5900.16
30_Q38_I0.5850.15
30_Q117_L0.5840.15
72_R90_A0.5780.15
49_A56_E0.5740.15
37_E91_F0.5720.15
25_R31_L0.5690.15
33_K117_L0.5690.15
11_Y79_V0.5670.15
36_N41_L0.5660.15
18_R45_G0.5660.15
61_I107_M0.5590.15
13_D16_T0.5560.15
48_Y79_V0.5520.14
16_T41_L0.5510.14
32_R96_I0.5470.14
55_S87_N0.5450.14
66_S117_L0.5310.14
77_G81_F0.5300.14
32_R91_F0.5290.14
55_S115_K0.5210.14
93_C98_E0.5180.14
61_I66_S0.5150.14
40_L45_G0.5140.14
70_I82_P0.5140.14
43_V106_Y0.5100.13
68_G95_K0.5070.13
24_L98_E0.5050.13
75_D90_A0.5040.13
35_K39_E0.5010.13
13_D73_D0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1r8dA 2 0.4724 12.5 0.944 Contact Map
1ccwB 2 0.9291 11.7 0.945 Contact Map
1rv3A 3 0.5669 11.2 0.946 Contact Map
4jrbA 1 0.5669 10.1 0.947 Contact Map
2vz4A 2 0.4173 10 0.947 Contact Map
2lvsA 1 0.5433 8.9 0.948 Contact Map
3smtA 2 0.7323 8.8 0.948 Contact Map
3h0gD 1 0.3622 8.7 0.948 Contact Map
2akfA 3 0.252 8.4 0.949 Contact Map
3gpvA 2 0.4882 7.3 0.95 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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