GREMLIN Database
Q7LX54 - Carbon monoxide dehydrogenase, large chain (CutA-3)
UniProt: Q7LX54 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 729 (711)
Sequences: 5279 (3459)
Seq/√Len: 129.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
57_V109_L4.6451.00
163_E276_K4.2161.00
37_V110_I4.1511.00
32_L61_V3.9911.00
99_D102_V3.7801.00
371_K398_E3.6501.00
41_V44_A3.6011.00
53_D111_Q3.5321.00
165_K274_K3.5281.00
280_K284_T3.3841.00
279_A358_I3.3831.00
289_I323_R3.3361.00
471_V511_A3.2151.00
159_D280_K3.2021.00
159_D281_R3.1551.00
47_K113_D3.1311.00
364_L372_R3.1291.00
45_K115_E3.1211.00
285_L355_M3.0951.00
57_V102_V3.0621.00
450_V477_I2.9881.00
153_K157_N2.9631.00
37_V107_A2.9531.00
543_K552_T2.8611.00
44_A114_Y2.8401.00
150_D153_K2.8151.00
163_E274_K2.8091.00
61_V98_T2.8021.00
474_E516_R2.7521.00
41_V116_E2.7311.00
291_D325_N2.7261.00
318_K379_P2.7141.00
43_H117_L2.6421.00
276_K289_I2.6231.00
368_Y372_R2.6211.00
48_Y113_D2.6201.00
192_V206_L2.5341.00
96_L244_A2.5051.00
98_T102_V2.4331.00
512_L516_R2.4321.00
707_I723_S2.3761.00
612_D676_K2.3651.00
34_L254_W2.3641.00
284_T372_R2.3451.00
51_V55_L2.3201.00
364_L369_V2.3051.00
720_R727_D2.2981.00
47_K115_E2.2961.00
710_I723_S2.2951.00
191_L220_I2.2831.00
98_T250_R2.2551.00
291_D327_Y2.2211.00
184_V193_Y2.2181.00
189_S490_A2.2121.00
124_E272_I2.2051.00
601_E611_L2.1931.00
358_I369_V2.1621.00
155_L278_G2.1171.00
218_R488_D2.1161.00
554_S557_E2.1041.00
295_D333_K2.0951.00
36_I240_I2.0601.00
125_K128_K2.0581.00
399_N402_K2.0291.00
277_F354_I2.0251.00
40_N92_I2.0231.00
368_Y371_K2.0171.00
34_L94_A2.0081.00
399_N678_E1.9991.00
444_I518_V1.9981.00
147_S323_R1.9891.00
400_A597_V1.9661.00
398_E402_K1.9641.00
158_S278_G1.9571.00
449_K481_D1.9551.00
371_K401_E1.9501.00
160_I281_R1.9411.00
636_V675_I1.9391.00
442_V452_V1.9311.00
284_T318_K1.9291.00
160_I279_A1.9281.00
51_V63_V1.9221.00
598_V705_A1.9101.00
519_K523_L1.9071.00
167_E720_R1.9041.00
275_V354_I1.8941.00
421_V601_E1.8611.00
637_I672_A1.8571.00
376_T379_P1.8491.00
7_V479_V1.8261.00
45_K83_D1.8181.00
533_D536_E1.8121.00
50_D111_Q1.8091.00
504_L623_V1.8051.00
52_R55_L1.7901.00
468_A484_V1.7831.00
122_N125_K1.7721.00
53_D109_L1.7711.00
45_K84_E1.7691.00
404_Y407_F1.7651.00
96_L248_Y1.7631.00
470_I508_G1.7621.00
445_K451_Q1.7571.00
189_S216_D1.7541.00
419_R601_E1.7461.00
54_A110_I1.7421.00
61_V250_R1.7351.00
367_I401_E1.7321.00
478_S481_D1.7251.00
449_K483_E1.7221.00
94_A244_A1.7161.00
34_L252_V1.7161.00
280_K286_T1.7101.00
403_V676_K1.7011.00
24_D253_K1.6991.00
376_T394_L1.6881.00
41_V114_Y1.6841.00
608_V728_L1.6661.00
628_A694_I1.6651.00
180_G255_V1.6631.00
174_S661_L1.6551.00
147_S150_D1.6471.00
97_A103_A1.6461.00
445_K449_K1.6451.00
724_R727_D1.6371.00
450_V475_L1.6351.00
8_K626_M1.6331.00
596_H613_Y1.6261.00
62_G247_Q1.6191.00
399_N403_V1.6081.00
277_F285_L1.6071.00
175_P230_A1.6061.00
152_E156_S1.6051.00
442_V515_A1.6031.00
360_D711_E1.6001.00
43_H84_E1.5891.00
94_A240_I1.5701.00
158_S286_T1.5591.00
155_L276_K1.5581.00
621_T681_E1.5571.00
277_F358_I1.5571.00
452_V471_V1.5561.00
165_K272_I1.5481.00
23_I180_G1.5351.00
107_A110_I1.5301.00
57_V106_A1.5301.00
622_V679_Y1.5211.00
392_N395_K1.5191.00
160_I361_E1.5181.00
28_Y31_T1.5181.00
440_A511_A1.5161.00
613_Y636_V1.5161.00
53_D56_K1.5061.00
428_Y594_G1.5061.00
152_E323_R1.5021.00
191_L218_R1.4831.00
274_K291_D1.4811.00
403_V678_E1.4741.00
394_L398_E1.4691.00
67_L83_D1.4691.00
160_I280_K1.4571.00
598_V613_Y1.4541.00
161_V276_K1.4451.00
420_R604_N1.4421.00
418_G603_D1.4371.00
639_G702_T1.4351.00
628_A679_Y1.4291.00
36_I254_W1.4271.00
371_K394_L1.4261.00
160_I362_L1.4181.00
400_A595_S1.4181.00
160_I358_I1.4111.00
155_L287_A1.4101.00
523_L537_L1.4061.00
526_A558_V1.4051.00
619_I622_V1.4051.00
207_L217_I1.3971.00
60_V97_A1.3951.00
610_I640_F1.3931.00
46_I49_I1.3911.00
474_E689_L1.3901.00
360_D712_K1.3871.00
608_V710_I1.3851.00
31_T253_K1.3831.00
472_A482_V1.3811.00
537_L544_V1.3711.00
212_N217_I1.3711.00
55_L62_G1.3701.00
28_Y184_V1.3661.00
517_R520_D1.3591.00
513_L517_R1.3581.00
282_D372_R1.3561.00
206_L217_I1.3551.00
413_E417_Q1.3541.00
285_L319_V1.3541.00
64_I248_Y1.3531.00
467_I511_A1.3511.00
28_Y182_L1.3461.00
143_K325_N1.3461.00
213_K216_D1.3451.00
356_D708_R1.3401.00
396_L595_S1.3371.00
210_F242_V1.3361.00
24_D255_V1.3361.00
154_A287_A1.3351.00
470_I504_L1.3341.00
474_E512_L1.3311.00
190_L242_V1.3231.00
612_D674_N1.3221.00
524_R534_V1.3201.00
46_I112_V1.3201.00
466_G504_L1.3121.00
362_L369_V1.3111.00
339_Y638_Q1.3071.00
296_L302_G1.3011.00
164_E357_I1.3011.00
183_S192_V1.2981.00
614_Y676_K1.2971.00
352_E370_R1.2901.00
167_E272_I1.2881.00
279_A362_L1.2861.00
190_L212_N1.2851.00
105_D109_L1.2831.00
151_P155_L1.2801.00
546_N549_T1.2711.00
64_I244_A1.2681.00
641_G667_P1.2631.00
84_E117_L1.2621.00
273_H350_V1.2591.00
244_A252_V1.2581.00
32_L250_R1.2561.00
405_R408_E1.2541.00
403_V616_I1.2541.00
356_D366_P1.2531.00
143_K327_Y1.2511.00
155_L161_V1.2471.00
92_I112_V1.2461.00
20_G223_D1.2451.00
602_V608_V1.2401.00
374_L397_L1.2391.00
86_L90_H1.2371.00
270_G295_D1.2351.00
154_A321_D1.2311.00
183_S245_S1.2291.00
622_V628_A1.2251.00
266_Y337_D1.2231.00
66_G82_K1.2070.99
35_Y100_K1.2040.99
43_H118_P1.2030.99
145_T325_N1.2020.99
608_V644_V1.2010.99
151_P154_A1.1990.99
45_K117_L1.1980.99
616_I678_E1.1880.99
632_V636_V1.1870.99
204_R214_V1.1870.99
649_V658_T1.1870.99
46_I92_I1.1800.99
38_R260_E1.1760.99
310_A324_V1.1740.99
517_R521_K1.1690.99
174_S666_I1.1680.99
419_R609_K1.1640.99
10_K465_T1.1630.99
293_I327_Y1.1620.99
43_H332_N1.1600.99
127_L140_I1.1580.99
404_Y597_V1.1570.99
357_I719_T1.1560.99
40_N114_Y1.1540.99
35_Y107_A1.1540.99
106_A109_L1.1510.99
65_T80_M1.1480.99
413_E416_K1.1440.99
523_L539_Y1.1420.99
509_N512_L1.1380.99
522_V558_V1.1370.99
31_T182_L1.1360.99
600_A710_I1.1360.99
402_K405_R1.1360.99
400_A616_I1.1360.99
598_V610_I1.1330.99
35_Y104_A1.1310.99
349_F707_I1.1300.99
10_K468_A1.1290.99
193_Y220_I1.1260.99
13_L17_T1.1240.99
396_L616_I1.1190.99
598_V706_L1.1140.99
27_E31_T1.1140.99
164_E361_E1.1120.99
409_K413_E1.1120.99
152_E289_I1.1120.99
185_Y246_L1.1040.99
401_E405_R1.1020.99
92_I114_Y1.1000.99
36_I94_A1.1000.99
175_P261_D1.0990.99
277_F288_I1.0990.99
279_A369_V1.0980.99
529_F561_R1.0970.99
80_M240_I1.0970.99
468_A479_V1.0960.99
157_N286_T1.0940.99
441_S453_I1.0940.99
718_L723_S1.0930.99
183_S241_T1.0910.99
419_R603_D1.0880.99
48_Y111_Q1.0870.99
188_D216_D1.0840.99
545_I549_T1.0820.99
124_E167_E1.0820.99
278_G286_T1.0800.99
406_E409_K1.0790.99
153_K156_S1.0790.99
395_K399_N1.0790.99
85_I114_Y1.0780.99
650_Y656_L1.0750.99
14_K19_S1.0740.99
279_A285_L1.0690.99
539_Y544_V1.0690.99
61_V102_V1.0690.99
155_L289_I1.0670.99
35_Y103_A1.0650.99
469_Q624_N1.0580.99
123_P293_I1.0570.99
399_N616_I1.0510.99
102_V106_A1.0510.99
145_T323_R1.0470.98
618_D682_E1.0450.98
162_L361_E1.0440.98
58_N98_T1.0430.98
49_I112_V1.0420.98
481_D542_G1.0410.98
44_A117_L1.0390.98
408_E411_A1.0380.98
181_L241_T1.0380.98
522_V555_L1.0380.98
186_Q191_L1.0340.98
481_D556_K1.0340.98
421_V599_L1.0320.98
100_K104_A1.0300.98
520_D524_R1.0290.98
159_D286_T1.0290.98
162_L279_A1.0280.98
60_V103_A1.0250.98
723_S727_D1.0240.98
186_Q189_S1.0240.98
69_I243_Y1.0220.98
536_E546_N1.0210.98
395_K680_M1.0170.98
61_V96_L1.0150.98
62_G248_Y1.0140.98
525_L558_V1.0120.98
224_V459_H1.0100.98
644_V706_L1.0100.98
451_Q485_I1.0050.98
195_S231_K1.0050.98
355_M369_V1.0010.98
278_G287_A1.0000.98
645_L671_E0.9980.98
157_N280_K0.9950.98
640_F672_A0.9940.98
452_V482_V0.9940.98
471_V515_A0.9930.98
57_V105_D0.9920.98
154_A278_G0.9890.98
600_A610_I0.9870.98
529_F532_S0.9860.98
128_K131_V0.9850.98
90_H299_A0.9830.98
606_G728_L0.9830.98
184_V191_L0.9820.98
651_D655_N0.9790.98
66_G83_D0.9780.98
374_L394_L0.9760.98
30_G250_R0.9750.98
465_T469_Q0.9730.98
367_I425_L0.9710.98
227_A459_H0.9690.98
453_I485_I0.9680.97
516_R520_D0.9680.97
474_E515_A0.9670.97
185_Y245_S0.9660.97
418_G604_N0.9660.97
124_E165_K0.9620.97
93_A112_V0.9620.97
51_V110_I0.9570.97
269_R346_E0.9540.97
173_P230_A0.9530.97
32_L248_Y0.9490.97
306_V326_A0.9480.97
172_Y648_I0.9480.97
356_D370_R0.9470.97
127_L293_I0.9460.97
532_S536_E0.9450.97
184_V245_S0.9430.97
420_R602_V0.9420.97
44_A112_V0.9410.97
127_L329_V0.9410.97
540_K545_I0.9370.97
64_I247_Q0.9370.97
93_A110_I0.9330.97
293_I329_V0.9300.97
536_E547_P0.9220.97
49_I110_I0.9220.97
647_E727_D0.9200.97
660_N663_D0.9200.97
43_H119_A0.9200.97
63_V93_A0.9200.97
95_I107_A0.9200.97
212_N246_L0.9180.97
629_E679_Y0.9180.97
596_H702_T0.9180.97
151_P289_I0.9170.97
162_L277_F0.9160.96
60_V106_A0.9160.96
166_F354_I0.9150.96
474_E519_K0.9150.96
405_R409_K0.9140.96
151_P321_D0.9140.96
197_Q227_A0.9130.96
259_S659_G0.9110.96
538_Q546_N0.9110.96
6_R629_E0.9100.96
519_K539_Y0.9100.96
276_K323_R0.9050.96
64_I96_L0.9020.96
367_I397_L0.9020.96
120_V126_A0.9010.96
421_V611_L0.8980.96
525_L562_N0.8970.96
218_R490_A0.8960.96
271_Q309_A0.8950.96
203_R214_V0.8920.96
543_K554_S0.8920.96
629_E633_I0.8920.96
34_L244_A0.8900.96
317_Y370_R0.8840.96
232_L499_Y0.8820.96
241_T254_W0.8810.96
438_E507_A0.8770.96
151_P287_A0.8730.95
190_L246_L0.8720.95
14_K464_E0.8720.95
317_Y352_E0.8710.95
462_G627_L0.8710.95
651_D657_L0.8690.95
166_F357_I0.8680.95
599_L612_D0.8670.95
471_V482_V0.8670.95
442_V518_V0.8670.95
456_A503_S0.8670.95
615_A636_V0.8660.95
217_I242_V0.8650.95
461_Q498_T0.8620.95
381_V387_K0.8600.95
456_A463_A0.8590.95
409_K412_N0.8590.95
469_Q625_P0.8570.95
49_I92_I0.8560.95
275_V350_V0.8560.95
81_A85_I0.8560.95
407_F599_L0.8550.95
36_I91_P0.8530.95
64_I243_Y0.8520.95
150_D321_D0.8510.95
38_R264_G0.8500.95
212_N216_D0.8490.95
412_N416_K0.8470.95
41_V85_I0.8470.95
33_Y253_K0.8470.95
395_K398_E0.8460.95
37_V93_A0.8450.95
279_A354_I0.8430.94
154_A286_T0.8430.94
427_F595_S0.8420.94
46_I114_Y0.8420.94
544_V558_V0.8410.94
419_R604_N0.8400.94
711_E717_R0.8400.94
397_L427_F0.8400.94
353_R707_I0.8390.94
451_Q483_E0.8390.94
139_N143_K0.8390.94
161_V278_G0.8390.94
15_L22_Y0.8370.94
656_L659_G0.8340.94
639_G699_T0.8330.94
51_V54_A0.8320.94
648_I656_L0.8310.94
23_I26_I0.8300.94
103_A107_A0.8300.94
44_A85_I0.8300.94
289_I325_N0.8270.94
531_K536_E0.8250.94
158_S287_A0.8180.94
443_R453_I0.8180.94
444_I555_L0.8150.93
194_A202_M0.8120.93
256_A261_D0.8120.93
55_L67_L0.8110.93
271_Q294_I0.8100.93
470_I623_V0.8060.93
14_K223_D0.8050.93
288_I319_V0.8040.93
466_G627_L0.8040.93
166_F719_T0.8030.93
273_H290_D0.8020.93
513_L516_R0.8020.93
619_I628_A0.8010.93
442_V471_V0.8010.93
54_A60_V0.8000.93
553_M558_V0.8000.93
42_A119_A0.8000.93
33_Y100_K0.7990.93
179_R261_D0.7990.93
450_V518_V0.7990.93
369_V372_R0.7990.93
123_P272_I0.7980.93
404_Y409_K0.7970.93
37_V112_V0.7960.93
203_R489_T0.7960.93
139_N142_Y0.7950.93
619_I694_I0.7950.93
178_T255_V0.7920.92
349_F353_R0.7920.92
122_N272_I0.7910.92
163_E289_I0.7910.92
555_L559_A0.7900.92
104_A257_L0.7890.92
218_R489_T0.7890.92
68_T247_Q0.7890.92
687_A691_A0.7890.92
357_I717_R0.7890.92
618_D683_G0.7890.92
432_N590_T0.7880.92
351_Y354_I0.7880.92
148_S322_L0.7880.92
723_S728_L0.7880.92
545_I552_T0.7870.92
51_V65_T0.7860.92
547_P550_G0.7850.92
41_V92_I0.7850.92
600_A608_V0.7830.92
410_R599_L0.7810.92
478_S542_G0.7810.92
368_Y405_R0.7810.92
151_P323_R0.7790.92
613_Y675_I0.7790.92
397_L425_L0.7790.92
154_A158_S0.7780.92
67_L82_K0.7780.92
286_T321_D0.7770.92
520_D534_V0.7760.92
7_V468_A0.7750.92
126_A131_V0.7740.91
199_A489_T0.7740.91
661_L666_I0.7740.91
154_A157_N0.7730.91
374_L427_F0.7720.91
155_L158_S0.7710.91
166_F353_R0.7710.91
86_L299_A0.7700.91
442_V514_A0.7690.91
444_I522_V0.7690.91
425_L597_V0.7690.91
121_I654_G0.7690.91
444_I450_V0.7660.91
392_N680_M0.7660.91
398_E401_E0.7650.91
55_L68_T0.7650.91
522_V544_V0.7650.91
452_V511_A0.7630.91
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563_M566_L0.5320.69
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500_G635_G0.5310.68
224_V457_S0.5310.68
440_A514_A0.5300.68
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32_L62_G0.5200.67
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553_M556_K0.5120.66
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613_Y640_F0.5100.65
517_R580_A0.5100.65
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202_M219_V0.5090.65
174_S262_I0.5090.65
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4_G469_Q0.5080.65
107_A111_Q0.5080.65
559_A567_G0.5080.65
577_G580_A0.5070.65
704_P707_I0.5070.65
576_P579_E0.5070.65
404_Y425_L0.5060.65
305_L338_Q0.5060.65
415_R420_R0.5060.65
56_K111_Q0.5050.65
173_P267_H0.5050.65
5_Q469_Q0.5050.65
7_V469_Q0.5040.64
283_G369_V0.5040.64
37_V54_A0.5040.64
359_A364_L0.5040.64
120_V125_K0.5040.64
408_E425_L0.5040.64
40_N88_V0.5030.64
464_E486_W0.5030.64
7_V465_T0.5030.64
154_A320_R0.5030.64
353_R708_R0.5020.64
439_S493_G0.5020.64
183_S190_L0.5010.64
475_L522_V0.5000.64
432_N505_T0.5000.64
269_R336_L0.5000.64
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1t3qB 2 0.9959 100 0.112 Contact Map
1rm6A 2 0.9918 100 0.113 Contact Map
1ffvB 2 0.9931 100 0.119 Contact Map
1n62B 2 0.9959 100 0.122 Contact Map
2w3sB 2 0.9877 100 0.134 Contact Map
3uncA 2 0.9602 100 0.15 Contact Map
4usaA 2 0.9602 100 0.154 Contact Map
1dgjA 1 0.9588 100 0.156 Contact Map
3zyvA 3 0.9616 100 0.161 Contact Map
3nvzC 2 0.9657 100 0.161 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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