GREMLIN Database
Q7LX53 - Uncharacterized protein
UniProt: Q7LX53 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 113 (95)
Sequences: 10182 (7442)
Seq/√Len: 763.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
41_P45_E3.0741.00
71_E98_Y3.0491.00
34_M70_K2.3131.00
44_Y48_H2.2871.00
20_P23_M2.1791.00
19_L23_M2.1581.00
47_H108_M2.1351.00
106_L110_L2.1241.00
23_M27_L2.1181.00
21_P106_L1.9581.00
41_P54_L1.9071.00
24_V35_I1.7591.00
27_L30_S1.7351.00
62_H65_E1.6981.00
71_E96_R1.6861.00
21_P110_L1.6811.00
74_V89_M1.6181.00
43_E81_R1.5521.00
19_L98_Y1.3981.00
86_T97_A1.3851.00
27_L71_E1.3671.00
102_G106_L1.3661.00
82_A99_Y1.3531.00
63_L67_F1.3211.00
24_V100_M1.3201.00
67_F70_K1.2931.00
68_E94_K1.2751.00
27_L33_I1.2631.00
75_V104_M1.2621.00
24_V73_A1.2591.00
21_P100_M1.2421.00
38_I85_A1.2411.00
21_P25_R1.2371.00
18_D101_I1.2331.00
34_M53_I1.2201.00
19_L24_V1.2091.00
36_L66_L1.1991.00
104_M108_M1.1851.00
33_I73_A1.1761.00
86_T99_Y1.1621.00
20_P101_I1.1361.00
35_I75_V1.1181.00
55_A64_T1.0951.00
74_V86_T1.0921.00
62_H67_F1.0921.00
48_H75_V1.0811.00
76_C79_G1.0631.00
49_I75_V1.0561.00
86_T90_P1.0091.00
43_E77_E1.0071.00
40_T43_E1.0041.00
74_V97_A0.9921.00
49_I52_A0.9701.00
89_M97_A0.9681.00
39_R77_E0.9591.00
76_C82_A0.9541.00
73_A100_M0.9531.00
74_V85_A0.9501.00
25_R28_W0.9461.00
72_V89_M0.9431.00
100_M106_L0.9421.00
105_A109_C0.9361.00
39_R104_M0.9321.00
105_A108_M0.9181.00
100_M103_G0.9171.00
90_P95_K0.9131.00
38_I74_V0.9091.00
35_I49_I0.8931.00
52_A75_V0.8931.00
61_E65_E0.8841.00
19_L73_A0.8791.00
77_E105_A0.8591.00
25_R29_K0.8561.00
78_H105_A0.8331.00
24_V28_W0.8311.00
88_G92_L0.8291.00
50_P107_W0.8211.00
87_Y91_H0.8151.00
90_P97_A0.8101.00
100_M107_W0.8041.00
22_S110_L0.8031.00
76_C81_R0.7981.00
22_S26_K0.7901.00
47_H104_M0.7731.00
23_M26_K0.7661.00
33_I71_E0.7651.00
89_M94_K0.7641.00
24_V27_L0.7621.00
42_Q45_E0.7521.00
34_M72_V0.7521.00
17_I98_Y0.7471.00
34_M67_F0.7451.00
17_I90_P0.7271.00
18_D99_Y0.7221.00
44_Y52_A0.7171.00
43_E46_E0.7091.00
17_I86_T0.7031.00
44_Y54_L0.7031.00
63_L66_L0.6911.00
83_R99_Y0.6891.00
66_L72_V0.6761.00
106_L109_C0.6611.00
59_Y63_L0.6581.00
56_P59_Y0.6531.00
48_H54_L0.6481.00
24_V33_I0.6461.00
26_K30_S0.6441.00
27_L31_G0.6381.00
30_S33_I0.6351.00
19_L33_I0.6311.00
72_V94_K0.6191.00
55_A60_L0.6171.00
27_L73_A0.6151.00
78_H81_R0.6071.00
60_L85_A0.6021.00
62_H66_L0.5991.00
64_T67_F0.5921.00
41_P59_Y0.5871.00
29_K51_G0.5861.00
90_P96_R0.5831.00
77_E81_R0.5801.00
36_L53_I0.5801.00
40_T58_D0.5681.00
57_L88_G0.5611.00
43_E78_H0.5561.00
78_H82_A0.5531.00
21_P28_W0.5461.00
39_R54_L0.5431.00
87_Y90_P0.5411.00
29_K32_K0.5411.00
72_V97_A0.5381.00
28_W51_G0.5311.00
88_G91_H0.5301.00
19_L27_L0.5261.00
39_R43_E0.5221.00
57_L84_Y0.5211.00
28_W31_G0.5121.00
41_P56_P0.5071.00
38_I57_L0.5051.00
55_A85_A0.5041.00
49_I107_W0.5041.00
93_Y96_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4jgtA 1 1 99.9 0.244 Contact Map
1rhsA 1 1 99.9 0.251 Contact Map
1urhA 1 0.9381 99.9 0.256 Contact Map
1yt8A 1 1 99.9 0.262 Contact Map
2hhgA 2 1 99.9 0.265 Contact Map
3utnX 1 1 99.9 0.266 Contact Map
3d1pA 1 0.885 99.9 0.266 Contact Map
3ilmA 2 0.8407 99.9 0.268 Contact Map
1e0cA 1 1 99.9 0.268 Contact Map
1qxnA 2 1 99.9 0.269 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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