GREMLIN Database
Q7LX51 - Transposase ISC1217
UniProt: Q7LX51 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 354 (299)
Sequences: 1058 (821)
Seq/√Len: 47.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
189_F205_G4.5971.00
145_I178_S3.5091.00
36_L303_F3.3171.00
89_I172_L3.2591.00
287_L307_K3.1691.00
91_D192_W2.8391.00
166_K174_E2.8251.00
90_D274_R2.7561.00
90_D278_E2.6371.00
143_H178_S2.5661.00
89_I187_R2.4941.00
204_V271_W2.4551.00
128_V281_I2.3961.00
88_I132_K2.3251.00
142_I182_L2.2981.00
222_V228_G2.2951.00
127_L193_Y2.2731.00
150_R154_E2.2281.00
274_R278_E2.1751.00
143_H175_F2.1371.00
130_G139_I2.0651.00
239_I242_L2.0371.00
91_D168_K2.0250.99
145_I174_E2.0220.99
222_V226_P1.9880.99
278_E285_K1.9800.99
152_V155_E1.9260.99
91_D193_Y1.9150.99
22_I30_K1.8840.99
220_V223_S1.8720.99
224_E228_G1.8670.99
293_S299_R1.8580.99
240_K244_I1.8480.99
26_T30_K1.8260.99
275_W278_E1.8130.99
90_D285_K1.7610.99
294_F299_R1.7520.98
231_L234_Y1.7490.98
62_N65_D1.7480.98
32_V59_T1.7410.98
36_L40_A1.7300.98
193_Y274_R1.6980.98
147_Y165_F1.6760.98
228_G232_V1.6540.98
224_E230_Y1.6280.98
70_A74_E1.6180.97
130_G281_I1.6010.97
167_T170_D1.5920.97
91_D275_W1.5900.97
243_V246_D1.5720.97
145_I301_S1.5690.97
85_V131_V1.5680.97
95_H117_H1.5650.97
93_H121_E1.5530.97
168_K193_Y1.5480.97
221_P228_G1.5390.97
170_D173_L1.5340.96
86_L270_T1.5340.96
115_R192_W1.5060.96
22_I25_M1.4960.96
226_P229_E1.4950.96
211_A256_F1.4890.96
63_N292_G1.4820.96
220_V229_E1.4730.96
296_T307_K1.4730.96
129_I175_F1.4620.95
93_H114_C1.4620.95
64_L306_L1.4620.95
90_D275_W1.4380.95
203_T258_T1.4290.95
274_R285_K1.4250.95
194_V205_G1.4180.95
158_R298_V1.4100.94
89_I129_I1.4020.94
275_W285_K1.3790.94
45_N50_A1.3650.93
260_L264_A1.3630.93
206_E253_R1.3560.93
303_F310_S1.3350.93
77_K179_L1.3140.92
108_G288_G1.3100.92
193_Y285_K1.3000.91
279_V283_E1.2870.91
114_C121_E1.2770.91
109_A122_P1.2750.91
260_L265_E1.2690.90
202_N258_T1.2660.90
297_W301_S1.2600.90
18_V34_K1.2570.90
37_L309_L1.2550.90
240_K245_D1.2530.90
295_L303_F1.2460.90
92_T278_E1.2450.90
260_L263_T1.2370.89
152_V160_G1.2240.89
48_E51_Q1.2210.89
186_A270_T1.2160.88
108_G148_I1.2100.88
39_G49_I1.2090.88
211_A254_Y1.2040.88
102_M124_I1.2040.88
69_Q302_G1.2030.88
21_V25_M1.2000.88
240_K243_V1.1980.88
22_I29_R1.1940.88
239_I243_V1.1910.87
19_N23_L1.1910.87
188_V270_T1.1890.87
292_G300_N1.1840.87
154_E162_E1.1820.87
130_G280_L1.1820.87
242_L267_I1.1720.87
220_V232_V1.1680.86
20_E25_M1.1630.86
262_D265_E1.1600.86
276_D311_L1.1560.86
200_Q214_V1.1530.86
58_E62_N1.1480.85
168_K192_W1.1420.85
205_G256_F1.1350.85
86_L188_V1.1320.85
93_H112_F1.1290.84
43_G46_A1.1290.84
145_I171_A1.1280.84
204_V257_S1.1190.84
190_D278_E1.1080.83
242_L246_D1.1010.83
222_V227_Q1.0960.83
304_V307_K1.0920.82
201_G258_T1.0910.82
274_R281_I1.0900.82
21_V24_S1.0890.82
90_D277_I1.0890.82
228_G231_L1.0860.82
57_Y61_L1.0830.82
96_K109_A1.0770.81
139_I276_D1.0760.81
92_T275_W1.0760.81
222_V225_F1.0760.81
242_L252_R1.0750.81
141_V280_L1.0740.81
195_N210_S1.0730.81
147_Y168_K1.0700.81
275_W314_V1.0620.81
94_D126_L1.0600.80
34_K38_L1.0590.80
230_Y233_E1.0540.80
221_P226_P1.0540.80
114_C117_H1.0510.80
127_L168_K1.0490.80
221_P227_Q1.0460.80
29_R67_A1.0370.79
46_A293_S1.0300.78
127_L172_L1.0300.78
139_I280_L1.0280.78
112_F115_R1.0240.78
114_C125_Q1.0210.78
125_Q168_K1.0130.77
90_D193_Y1.0120.77
285_K314_V1.0090.77
167_T177_S1.0030.77
28_T33_A1.0030.77
225_F228_G1.0010.76
88_I188_V0.9990.76
225_F230_Y0.9980.76
38_L41_V0.9960.76
222_V229_E0.9960.76
102_M242_L0.9940.76
227_Q231_L0.9930.76
63_N67_A0.9900.76
216_G219_S0.9880.76
224_E229_E0.9870.75
128_V141_V0.9860.75
220_V225_F0.9850.75
207_L256_F0.9840.75
63_N69_Q0.9800.75
153_E156_L0.9730.74
73_I77_K0.9730.74
126_L300_N0.9700.74
255_F271_W0.9660.74
141_V311_L0.9630.74
124_I300_N0.9580.73
77_K200_Q0.9550.73
249_G257_S0.9510.73
158_R318_K0.9490.73
141_V312_L0.9490.73
124_I148_I0.9460.72
171_A175_F0.9410.72
97_L102_M0.9350.71
226_P234_Y0.9330.71
75_V80_V0.9320.71
277_I285_K0.9310.71
26_T29_R0.9280.71
25_M29_R0.9250.71
224_E227_Q0.9240.71
24_S71_K0.9210.70
243_V247_Y0.9200.70
193_Y275_W0.9190.70
115_R121_E0.9170.70
129_I176_L0.9100.69
281_I285_K0.9080.69
189_F194_V0.9070.69
152_V159_R0.9040.69
153_E162_E0.9040.69
36_L293_S0.9030.69
284_L289_L0.8990.68
227_Q230_Y0.8980.68
112_F124_I0.8970.68
126_L304_V0.8950.68
82_D136_N0.8950.68
127_L171_A0.8940.68
160_G163_V0.8940.68
306_L310_S0.8940.68
33_A37_L0.8930.68
222_V230_Y0.8880.67
92_T285_K0.8850.67
110_Q151_K0.8800.67
91_D277_I0.8800.67
150_R187_R0.8720.66
112_F121_E0.8700.66
263_T266_D0.8660.65
199_L205_G0.8660.65
127_L145_I0.8660.65
212_R236_G0.8620.65
181_G214_V0.8610.65
90_D168_K0.8600.65
21_V34_K0.8600.65
238_P242_L0.8600.65
91_D281_I0.8530.64
101_A292_G0.8510.64
111_I122_P0.8450.64
261_N264_A0.8440.63
48_E293_S0.8440.63
281_I284_L0.8420.63
220_V228_G0.8410.63
172_L187_R0.8410.63
125_Q149_P0.8390.63
94_D304_V0.8380.63
27_G31_D0.8380.63
98_Y109_A0.8340.63
94_D128_V0.8340.63
207_L278_E0.8330.62
58_E72_L0.8290.62
116_A290_E0.8290.62
117_H121_E0.8290.62
32_V35_R0.8260.62
191_S207_L0.8260.62
229_E232_V0.8130.61
23_L30_K0.8100.60
92_T274_R0.8090.60
190_D274_R0.8080.60
192_W275_W0.8060.60
271_W274_R0.8040.60
98_Y295_L0.8040.60
129_I187_R0.8000.59
299_R303_F0.7950.59
112_F149_P0.7930.59
114_C275_W0.7900.58
214_V219_S0.7870.58
150_R217_G0.7870.58
189_F192_W0.7790.57
18_V37_L0.7750.57
234_Y318_K0.7740.57
89_I176_L0.7720.57
214_V218_R0.7710.56
20_E24_S0.7710.56
45_N118_K0.7680.56
21_V33_A0.7650.56
72_L75_V0.7520.55
93_H120_F0.7520.55
278_E281_I0.7490.54
199_L256_F0.7490.54
193_Y278_E0.7460.54
148_I159_R0.7460.54
241_L244_I0.7340.53
166_K177_S0.7330.53
44_R291_G0.7310.53
86_L272_E0.7300.52
25_M28_T0.7280.52
18_V21_V0.7260.52
39_G60_V0.7250.52
129_I179_L0.7220.52
98_Y101_A0.7210.52
152_V157_K0.7210.52
21_V27_G0.7180.51
90_D190_D0.7160.51
115_R120_F0.7130.51
278_E314_V0.7100.50
32_V63_N0.7100.50
92_T289_L0.7090.50
148_I152_V0.7050.50
17_A20_E0.7040.50
54_E218_R0.6970.49
194_V198_T0.6940.49
221_P224_E0.6920.49
156_L162_E0.6890.48
17_A313_V0.6860.48
277_I287_L0.6850.48
60_V63_N0.6840.48
127_L147_Y0.6780.47
25_M30_K0.6780.47
62_N67_A0.6770.47
222_V233_E0.6770.47
275_W281_I0.6730.47
127_L274_R0.6710.47
172_L194_V0.6640.46
210_S250_Y0.6630.46
228_G233_E0.6610.46
93_H125_Q0.6600.45
68_A302_G0.6590.45
191_S208_K0.6590.45
153_E159_R0.6540.45
288_G291_G0.6520.45
26_T32_V0.6500.44
188_V273_N0.6500.44
122_P149_P0.6500.44
168_K172_L0.6480.44
44_R50_A0.6380.43
195_N205_G0.6380.43
114_C120_F0.6370.43
97_L121_E0.6370.43
40_A306_L0.6360.43
39_G288_G0.6360.43
225_F229_E0.6350.43
257_S293_S0.6340.43
112_F125_Q0.6330.43
228_G234_Y0.6320.43
69_Q305_A0.6310.43
119_R200_Q0.6300.42
124_I303_F0.6300.42
94_D101_A0.6290.42
239_I244_I0.6250.42
111_I121_E0.6240.42
223_S228_G0.6230.42
95_H121_E0.6220.42
102_M297_W0.6210.42
166_K207_L0.6160.41
264_A273_N0.6140.41
94_D303_F0.6140.41
289_L304_V0.6130.41
92_T304_V0.6130.41
279_V282_R0.6110.41
60_V142_I0.6110.41
102_M300_N0.6100.41
132_K273_N0.6080.40
127_L289_L0.6070.40
123_A271_W0.6050.40
131_V189_F0.6050.40
192_W278_E0.6020.40
34_K176_L0.6010.40
87_L144_I0.6010.40
43_G49_I0.6000.40
241_L254_Y0.5970.39
245_D248_K0.5950.39
17_A31_D0.5920.39
153_E161_E0.5910.39
29_R296_T0.5900.39
299_R306_L0.5890.39
220_V226_P0.5880.38
21_V213_V0.5880.38
32_V62_N0.5880.38
80_V166_K0.5870.38
93_H115_R0.5870.38
197_R251_G0.5870.38
65_D299_R0.5860.38
89_I233_E0.5850.38
156_L163_V0.5840.38
292_G303_F0.5800.38
203_T268_I0.5800.38
33_A36_L0.5790.38
45_N305_A0.5780.37
83_H233_E0.5760.37
68_A84_P0.5740.37
88_I276_D0.5730.37
114_C290_E0.5720.37
46_A113_Y0.5720.37
207_L211_A0.5710.37
47_T299_R0.5700.37
83_H156_L0.5690.37
26_T33_A0.5690.37
276_D280_L0.5680.37
184_V201_G0.5680.37
296_T311_L0.5650.36
120_F308_A0.5650.36
101_A256_F0.5640.36
29_R68_A0.5630.36
45_N288_G0.5630.36
190_D281_I0.5620.36
18_V33_A0.5590.36
114_C123_A0.5590.36
20_E26_T0.5580.36
44_R98_Y0.5580.36
168_K171_A0.5580.36
45_N311_L0.5570.36
99_A109_A0.5520.35
39_G108_G0.5510.35
31_D68_A0.5500.35
316_Y322_G0.5500.35
64_L302_G0.5500.35
158_R163_V0.5490.35
28_T31_D0.5460.35
84_P232_V0.5460.35
19_N22_I0.5450.34
95_H114_C0.5450.34
75_V79_L0.5450.34
136_N268_I0.5440.34
101_A128_V0.5420.34
189_F208_K0.5410.34
21_V182_L0.5380.34
129_I199_L0.5370.34
252_R309_L0.5370.34
76_V79_L0.5350.34
42_V286_A0.5340.33
261_N265_E0.5340.33
36_L85_V0.5340.33
76_V223_S0.5330.33
111_I120_F0.5310.33
275_W282_R0.5300.33
298_V302_G0.5290.33
300_N304_V0.5280.33
90_D130_G0.5260.33
45_N291_G0.5250.33
217_G243_V0.5250.33
23_L188_V0.5240.33
87_L179_L0.5240.33
19_N34_K0.5220.32
159_R163_V0.5210.32
241_L251_G0.5210.32
296_T308_A0.5200.32
222_V232_V0.5150.32
302_G305_A0.5150.32
43_G142_I0.5140.32
192_W208_K0.5140.32
46_A195_N0.5130.32
22_I176_L0.5110.31
114_C141_V0.5100.31
51_Q187_R0.5100.31
123_A203_T0.5090.31
29_R33_A0.5080.31
111_I253_R0.5080.31
36_L39_G0.5070.31
274_R287_L0.5060.31
24_S33_A0.5050.31
17_A21_V0.5030.31
88_I130_G0.5030.31
40_A284_L0.5030.31
91_D191_S0.5010.31
282_R285_K0.5000.31
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1musA 2 0.9237 99.9 0.716 Contact Map
2kkoA 2 0.3023 12.4 0.968 Contact Map
2j49A 1 0.2288 9.1 0.97 Contact Map
3owqA 1 0.226 8.2 0.971 Contact Map
3qfiA 1 0.2571 7.2 0.971 Contact Map
3mzyA 1 0.2119 7.1 0.971 Contact Map
3rqiA 2 0.1667 6.1 0.972 Contact Map
3hdeA 2 0.2797 5.9 0.972 Contact Map
1xjtA 1 0.2881 5.6 0.973 Contact Map
1xjuA 2 0.2881 5.3 0.973 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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