GREMLIN Database
Q7LX49 - Endonuclease IV related protein
UniProt: Q7LX49 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 283 (251)
Sequences: 2339 (1526)
Seq/√Len: 96.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
221_V232_I4.2021.00
131_K174_E4.1591.00
196_D199_K3.3801.00
223_R238_A3.0521.00
155_T187_T2.9101.00
62_Q66_E2.8871.00
219_S235_D2.8041.00
169_I173_K2.7711.00
118_Y122_T2.7651.00
85_E88_K2.7251.00
90_E94_Q2.7111.00
34_V39_L2.5431.00
202_D206_K2.5101.00
182_I187_T2.4851.00
123_P167_E2.4561.00
104_E148_N2.3751.00
267_D270_K2.3691.00
89_I133_G2.3571.00
124_E170_S2.3231.00
197_Y250_K2.3051.00
127_Y170_S2.2561.00
188_F238_A2.1371.00
103_A108_A2.1171.00
215_S257_L2.0701.00
35_K67_L2.0671.00
267_D271_M2.0641.00
31_I63_V2.0541.00
170_S174_E2.0231.00
166_D207_E2.0161.00
222_Y228_V1.8911.00
203_R207_E1.8871.00
128_Q174_E1.8831.00
203_R206_K1.8441.00
81_L133_G1.8341.00
72_S258_I1.8281.00
166_D203_R1.8241.00
89_I129_N1.7631.00
244_L247_E1.7531.00
204_L213_I1.7481.00
28_V56_T1.7391.00
239_P243_P1.7381.00
82_C126_C1.7081.00
165_L200_I1.6991.00
93_K136_E1.6831.00
83_S88_K1.6641.00
97_L140_K1.6491.00
242_E245_A1.6471.00
34_V42_M1.6101.00
232_I236_A1.5951.00
122_T125_E1.5951.00
61_G107_G1.5931.00
32_R63_V1.5931.00
180_P204_L1.5901.00
58_E62_Q1.5561.00
172_S178_V1.5181.00
56_T59_E1.5181.00
198_G202_D1.4771.00
43_E258_I1.4741.00
87_E91_A1.4741.00
189_A222_Y1.4621.00
72_S214_N1.4481.00
201_I253_I1.4421.00
61_G65_R1.4151.00
54_K105_L1.4010.99
172_S212_H1.3880.99
127_Y162_F1.3820.99
197_Y201_I1.3650.99
117_F160_T1.3440.99
89_I93_K1.3400.99
175_L178_V1.3390.99
199_K203_R1.3340.99
135_E175_L1.3260.99
164_T167_E1.2980.99
52_M57_A1.2910.99
41_A258_I1.2760.99
73_V103_A1.2700.99
94_Q98_D1.2690.99
15_P70_R1.2630.99
96_I113_I1.2620.99
153_V168_V1.2540.99
188_F224_R1.2490.99
168_V180_P1.2490.99
117_F161_A1.2460.99
251_R254_S1.2430.99
22_A44_V1.2380.99
197_Y246_K1.2370.99
28_V59_E1.2360.99
29_E33_T1.2270.99
118_Y123_P1.2230.99
33_T36_E1.2180.98
128_Q132_E1.2090.98
170_S173_K1.2040.98
63_V66_E1.1980.98
172_S180_P1.1920.98
178_V212_H1.1910.98
129_N132_E1.1690.98
103_A111_I1.1690.98
73_V108_A1.1600.98
31_I42_M1.1570.98
118_Y126_C1.1490.98
54_K58_E1.1490.98
31_I35_K1.1390.98
128_Q170_S1.1330.98
86_K90_E1.1200.97
89_I132_E1.1170.97
112_A181_Y1.1150.97
96_I137_V1.1140.97
125_E128_Q1.1070.97
28_V63_V1.0960.97
25_K32_R1.0930.97
122_T126_C1.0900.97
165_L204_L1.0800.97
60_T64_A1.0740.97
93_K133_G1.0730.97
110_A152_G1.0670.96
35_K63_V1.0540.96
125_E129_N1.0380.96
16_A248_L1.0350.96
253_I257_L1.0270.96
219_S237_N1.0210.95
72_S112_A1.0170.95
164_T203_R1.0170.95
50_V53_S1.0110.95
62_Q65_R1.0100.95
59_E62_Q1.0080.95
220_L238_A1.0070.95
59_E63_V0.9980.95
64_A71_L0.9910.95
100_A111_I0.9820.94
226_K238_A0.9810.94
41_A70_R0.9730.94
98_D101_D0.9710.94
32_R36_E0.9680.94
187_T194_E0.9550.94
15_P40_N0.9540.94
188_F195_I0.9520.93
223_R226_K0.9490.93
110_A150_K0.9480.93
152_G179_I0.9470.93
47_V78_F0.9420.93
75_A113_I0.9420.93
166_D169_I0.9370.93
134_L151_F0.9260.92
58_E65_R0.9240.92
266_R271_M0.9240.92
269_L272_K0.9200.92
33_T37_L0.9190.92
57_A105_L0.9140.92
180_P208_L0.9130.92
97_L101_D0.9120.92
63_V67_L0.9110.92
266_R270_K0.8960.91
233_P263_E0.8920.91
127_Y174_E0.8890.91
118_Y160_T0.8880.91
241_F245_A0.8870.91
188_F239_P0.8850.91
195_I238_A0.8810.90
219_S240_P0.8810.90
28_V32_R0.8790.90
196_D200_I0.8750.90
42_M64_A0.8750.90
195_I224_R0.8700.90
47_V91_A0.8680.90
144_M177_G0.8670.90
233_P236_A0.8650.90
44_V106_M0.8620.90
268_A272_K0.8590.89
130_V171_I0.8560.89
75_A96_I0.8560.89
136_E139_D0.8480.89
100_A149_V0.8450.89
169_I207_E0.8440.89
84_E119_G0.8380.88
213_I253_I0.8350.88
86_K129_N0.8340.88
27_T106_M0.8320.88
201_I250_K0.8300.88
99_T111_I0.8270.88
234_I248_L0.8220.87
134_L178_V0.8220.87
88_K91_A0.8170.87
81_L96_I0.8130.87
104_E149_V0.8120.87
75_A111_I0.8050.86
152_G214_N0.7980.86
57_A61_G0.7960.85
82_C130_V0.7960.85
197_Y243_P0.7960.85
79_I95_R0.7950.85
214_N258_I0.7890.85
46_F49_G0.7880.85
55_E59_E0.7870.85
46_F76_P0.7810.84
236_A269_L0.7790.84
205_I208_L0.7760.84
247_E253_I0.7580.83
183_D231_H0.7510.82
244_L257_L0.7480.82
123_P164_T0.7470.82
29_E32_R0.7420.81
151_F178_V0.7420.81
25_K33_T0.7390.81
89_I136_E0.7350.81
31_I64_A0.7340.80
20_H30_G0.7310.80
126_C162_F0.7270.80
43_E72_S0.7260.80
50_V56_T0.7250.80
124_E128_Q0.7220.79
129_N133_G0.7180.79
126_C129_N0.7170.79
215_S247_E0.7150.79
113_I151_F0.7150.79
197_Y253_I0.7140.79
74_H154_E0.7140.79
110_A179_I0.7120.78
198_G250_K0.7090.78
82_C129_N0.7060.78
139_D144_M0.7050.78
84_E121_M0.7040.78
268_A271_M0.7040.78
132_E136_E0.7030.78
27_T44_V0.7030.78
165_L192_G0.6990.77
134_L138_I0.6950.77
100_A151_F0.6940.77
231_H260_E0.6930.77
217_F248_L0.6910.76
27_T30_G0.6910.76
138_I151_F0.6880.76
76_P95_R0.6850.76
245_A249_L0.6830.76
222_Y238_A0.6810.75
202_D252_D0.6810.75
101_D104_E0.6790.75
217_F244_L0.6790.75
233_P262_P0.6750.75
188_F226_K0.6700.74
21_S33_T0.6690.74
204_L209_G0.6680.74
156_M161_A0.6680.74
101_D144_M0.6670.74
97_L137_V0.6670.74
81_L92_S0.6630.73
234_I244_L0.6620.73
20_H37_L0.6620.73
127_Y171_I0.6620.73
53_S56_T0.6580.73
70_R109_D0.6580.73
114_H186_H0.6580.73
167_E208_L0.6570.73
158_K161_A0.6570.73
204_L208_L0.6560.73
74_H186_H0.6540.72
140_K177_G0.6540.72
154_E186_H0.6530.72
15_P69_V0.6490.72
18_V37_L0.6480.72
78_F92_S0.6450.71
39_L233_P0.6420.71
183_D260_E0.6410.71
165_L207_E0.6380.70
168_V172_S0.6380.70
243_P246_K0.6370.70
75_A79_I0.6370.70
82_C233_P0.6330.70
182_I253_I0.6330.70
188_F244_L0.6280.69
191_Q194_E0.6240.69
43_E152_G0.6220.69
195_I246_K0.6190.68
210_L213_I0.6180.68
173_K207_E0.6180.68
232_I262_P0.6180.68
83_S129_N0.6150.68
31_I71_L0.6150.68
121_M129_N0.6150.68
109_D150_K0.6150.68
74_H114_H0.6130.67
182_I215_S0.6100.67
210_L215_S0.6070.67
265_E268_A0.6070.67
45_E49_G0.6050.66
136_E140_K0.6050.66
150_K179_I0.6040.66
266_R269_L0.6040.66
31_I60_T0.6040.66
85_E121_M0.6030.66
114_H154_E0.6020.66
88_K129_N0.6020.66
22_A30_G0.5970.65
135_E176_K0.5960.65
94_Q101_D0.5900.65
98_D102_R0.5820.63
46_F50_V0.5820.63
183_D216_H0.5820.63
217_F247_E0.5810.63
196_D224_R0.5790.63
263_E267_D0.5790.63
112_A214_N0.5780.63
20_H34_V0.5700.62
194_E197_Y0.5690.62
127_Y167_E0.5680.62
198_G246_K0.5640.61
62_Q211_T0.5630.61
233_P266_R0.5610.61
60_T63_V0.5610.61
187_T190_R0.5610.61
216_H231_H0.5570.60
138_I177_G0.5520.59
157_A230_E0.5520.59
195_I243_P0.5520.59
245_A248_L0.5510.59
182_I200_I0.5500.59
172_S208_L0.5500.59
115_I156_M0.5500.59
23_K29_E0.5490.59
193_G196_D0.5480.59
190_R225_G0.5470.59
184_W218_E0.5460.59
234_I243_P0.5450.58
111_I149_V0.5440.58
47_V50_V0.5430.58
219_S239_P0.5420.58
204_L207_E0.5400.58
215_S252_D0.5390.58
76_P158_K0.5380.57
79_I92_S0.5380.57
89_I121_M0.5380.57
66_E206_K0.5360.57
72_S152_G0.5360.57
123_P170_S0.5360.57
235_D240_P0.5350.57
166_D200_I0.5340.57
123_P160_T0.5340.57
46_F95_R0.5330.57
163_G168_V0.5330.57
88_K96_I0.5330.57
158_K227_Y0.5330.57
188_F243_P0.5330.57
40_N158_K0.5260.56
159_E227_Y0.5260.56
123_P162_F0.5260.56
130_V156_M0.5250.56
104_E150_K0.5240.56
35_K69_V0.5230.55
195_I200_I0.5220.55
97_L144_M0.5220.55
116_A130_V0.5190.55
72_S110_A0.5190.55
201_I215_S0.5170.55
64_A67_L0.5170.55
41_A256_T0.5150.54
222_Y226_K0.5140.54
158_K228_V0.5110.54
131_K170_S0.5100.54
218_E229_D0.5100.54
104_E144_M0.5100.54
165_L187_T0.5100.54
65_R199_K0.5080.53
78_F91_A0.5080.53
16_A19_P0.5080.53
189_A224_R0.5070.53
202_D205_I0.5060.53
130_V162_F0.5060.53
80_N231_H0.5050.53
169_I208_L0.5050.53
38_G68_G0.5050.53
93_K140_K0.5050.53
221_V230_E0.5040.53
155_T208_L0.5030.53
158_K189_A0.5020.52
35_K40_N0.5020.52
106_M163_G0.5020.52
168_V187_T0.5000.52
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tc3A 1 0.9046 100 0.536 Contact Map
3aalA 1 0.9364 100 0.553 Contact Map
4hnoA 1 0.9364 100 0.558 Contact Map
1qtwA 1 0.9329 100 0.561 Contact Map
3aamA 1 0.9011 100 0.579 Contact Map
3wqoA 2 0.9187 100 0.596 Contact Map
3ayvA 2 0.8304 100 0.612 Contact Map
3tvaA 1 0.9011 100 0.621 Contact Map
2j6vA 1 0.8551 100 0.626 Contact Map
1i60A 1 0.9117 100 0.627 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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