Q7LX49 - SULSO - GREMLIN Contacts

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Q7LX49 - Endonuclease IV related protein

UniProt:	Q7LX49	Sequences: MYNKFKLMAKIYLGPAGVPHSAKKKNTVEGIRTVKELGLNAMEVEFVQGVRMSKETAEETGQVARELGVRLSVHAPYFINLCSEEKEKIEASKQRILDTADRAELMGADAIAIHIAFYGKMTPEECYQNVKEGLEEVIDKAREMGIRNVKFGVETMAKETAFGTLDEVISISKELKGVIPYIDWAHTFARQGGEIDYGKIIDRLIKELGLTHINSHFESLVYRRGKYVDEHIPIDANAPPFEPLAKELLKRDISITLICESPELERDALKMKEVLERLGYRLE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	283 (251)
Sequences:	2339 (1526)
Seq/√Len:	96.3

ECOLI - END4
BACSU - END4
HALSA - END4
SULSO - Q7LX49

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
221_V	232_I	4.202	1.00
131_K	174_E	4.159	1.00
196_D	199_K	3.380	1.00
223_R	238_A	3.052	1.00
155_T	187_T	2.910	1.00
62_Q	66_E	2.887	1.00
219_S	235_D	2.804	1.00
169_I	173_K	2.771	1.00
118_Y	122_T	2.765	1.00
85_E	88_K	2.725	1.00
90_E	94_Q	2.711	1.00
34_V	39_L	2.543	1.00
202_D	206_K	2.510	1.00
182_I	187_T	2.485	1.00
123_P	167_E	2.456	1.00
104_E	148_N	2.375	1.00
267_D	270_K	2.369	1.00
89_I	133_G	2.357	1.00
124_E	170_S	2.323	1.00
197_Y	250_K	2.305	1.00
127_Y	170_S	2.256	1.00
188_F	238_A	2.137	1.00
103_A	108_A	2.117	1.00
215_S	257_L	2.070	1.00
35_K	67_L	2.067	1.00
267_D	271_M	2.064	1.00
31_I	63_V	2.054	1.00
170_S	174_E	2.023	1.00
166_D	207_E	2.016	1.00
222_Y	228_V	1.891	1.00
203_R	207_E	1.887	1.00
128_Q	174_E	1.883	1.00
203_R	206_K	1.844	1.00
81_L	133_G	1.834	1.00
72_S	258_I	1.828	1.00
166_D	203_R	1.824	1.00
89_I	129_N	1.763	1.00
244_L	247_E	1.753	1.00
204_L	213_I	1.748	1.00
28_V	56_T	1.739	1.00
239_P	243_P	1.738	1.00
82_C	126_C	1.708	1.00
165_L	200_I	1.699	1.00
93_K	136_E	1.683	1.00
83_S	88_K	1.664	1.00
97_L	140_K	1.649	1.00
242_E	245_A	1.647	1.00
34_V	42_M	1.610	1.00
232_I	236_A	1.595	1.00
122_T	125_E	1.595	1.00
61_G	107_G	1.593	1.00
32_R	63_V	1.593	1.00
180_P	204_L	1.590	1.00
58_E	62_Q	1.556	1.00
172_S	178_V	1.518	1.00
56_T	59_E	1.518	1.00
198_G	202_D	1.477	1.00
43_E	258_I	1.474	1.00
87_E	91_A	1.474	1.00
189_A	222_Y	1.462	1.00
72_S	214_N	1.448	1.00
201_I	253_I	1.442	1.00
61_G	65_R	1.415	1.00
54_K	105_L	1.401	0.99
172_S	212_H	1.388	0.99
127_Y	162_F	1.382	0.99
197_Y	201_I	1.365	0.99
117_F	160_T	1.344	0.99
89_I	93_K	1.340	0.99
175_L	178_V	1.339	0.99
199_K	203_R	1.334	0.99
135_E	175_L	1.326	0.99
164_T	167_E	1.298	0.99
52_M	57_A	1.291	0.99
41_A	258_I	1.276	0.99
73_V	103_A	1.270	0.99
94_Q	98_D	1.269	0.99
15_P	70_R	1.263	0.99
96_I	113_I	1.262	0.99
153_V	168_V	1.254	0.99
188_F	224_R	1.249	0.99
168_V	180_P	1.249	0.99
117_F	161_A	1.246	0.99
251_R	254_S	1.243	0.99
22_A	44_V	1.238	0.99
197_Y	246_K	1.237	0.99
28_V	59_E	1.236	0.99
29_E	33_T	1.227	0.99
118_Y	123_P	1.223	0.99
33_T	36_E	1.218	0.98
128_Q	132_E	1.209	0.98
170_S	173_K	1.204	0.98
63_V	66_E	1.198	0.98
172_S	180_P	1.192	0.98
178_V	212_H	1.191	0.98
129_N	132_E	1.169	0.98
103_A	111_I	1.169	0.98
73_V	108_A	1.160	0.98
31_I	42_M	1.157	0.98
118_Y	126_C	1.149	0.98
54_K	58_E	1.149	0.98
31_I	35_K	1.139	0.98
128_Q	170_S	1.133	0.98
86_K	90_E	1.120	0.97
89_I	132_E	1.117	0.97
112_A	181_Y	1.115	0.97
96_I	137_V	1.114	0.97
125_E	128_Q	1.107	0.97
28_V	63_V	1.096	0.97
25_K	32_R	1.093	0.97
122_T	126_C	1.090	0.97
165_L	204_L	1.080	0.97
60_T	64_A	1.074	0.97
93_K	133_G	1.073	0.97
110_A	152_G	1.067	0.96
35_K	63_V	1.054	0.96
125_E	129_N	1.038	0.96
16_A	248_L	1.035	0.96
253_I	257_L	1.027	0.96
219_S	237_N	1.021	0.95
72_S	112_A	1.017	0.95
164_T	203_R	1.017	0.95
50_V	53_S	1.011	0.95
62_Q	65_R	1.010	0.95
59_E	62_Q	1.008	0.95
220_L	238_A	1.007	0.95
59_E	63_V	0.998	0.95
64_A	71_L	0.991	0.95
100_A	111_I	0.982	0.94
226_K	238_A	0.981	0.94
41_A	70_R	0.973	0.94
98_D	101_D	0.971	0.94
32_R	36_E	0.968	0.94
187_T	194_E	0.955	0.94
15_P	40_N	0.954	0.94
188_F	195_I	0.952	0.93
223_R	226_K	0.949	0.93
110_A	150_K	0.948	0.93
152_G	179_I	0.947	0.93
47_V	78_F	0.942	0.93
75_A	113_I	0.942	0.93
166_D	169_I	0.937	0.93
134_L	151_F	0.926	0.92
58_E	65_R	0.924	0.92
266_R	271_M	0.924	0.92
269_L	272_K	0.920	0.92
33_T	37_L	0.919	0.92
57_A	105_L	0.914	0.92
180_P	208_L	0.913	0.92
97_L	101_D	0.912	0.92
63_V	67_L	0.911	0.92
266_R	270_K	0.896	0.91
233_P	263_E	0.892	0.91
127_Y	174_E	0.889	0.91
118_Y	160_T	0.888	0.91
241_F	245_A	0.887	0.91
188_F	239_P	0.885	0.91
195_I	238_A	0.881	0.90
219_S	240_P	0.881	0.90
28_V	32_R	0.879	0.90
196_D	200_I	0.875	0.90
42_M	64_A	0.875	0.90
195_I	224_R	0.870	0.90
47_V	91_A	0.868	0.90
144_M	177_G	0.867	0.90
233_P	236_A	0.865	0.90
44_V	106_M	0.862	0.90
268_A	272_K	0.859	0.89
130_V	171_I	0.856	0.89
75_A	96_I	0.856	0.89
136_E	139_D	0.848	0.89
100_A	149_V	0.845	0.89
169_I	207_E	0.844	0.89
84_E	119_G	0.838	0.88
213_I	253_I	0.835	0.88
86_K	129_N	0.834	0.88
27_T	106_M	0.832	0.88
201_I	250_K	0.830	0.88
99_T	111_I	0.827	0.88
234_I	248_L	0.822	0.87
134_L	178_V	0.822	0.87
88_K	91_A	0.817	0.87
81_L	96_I	0.813	0.87
104_E	149_V	0.812	0.87
75_A	111_I	0.805	0.86
152_G	214_N	0.798	0.86
57_A	61_G	0.796	0.85
82_C	130_V	0.796	0.85
197_Y	243_P	0.796	0.85
79_I	95_R	0.795	0.85
214_N	258_I	0.789	0.85
46_F	49_G	0.788	0.85
55_E	59_E	0.787	0.85
46_F	76_P	0.781	0.84
236_A	269_L	0.779	0.84
205_I	208_L	0.776	0.84
247_E	253_I	0.758	0.83
183_D	231_H	0.751	0.82
244_L	257_L	0.748	0.82
123_P	164_T	0.747	0.82
29_E	32_R	0.742	0.81
151_F	178_V	0.742	0.81
25_K	33_T	0.739	0.81
89_I	136_E	0.735	0.81
31_I	64_A	0.734	0.80
20_H	30_G	0.731	0.80
126_C	162_F	0.727	0.80
43_E	72_S	0.726	0.80
50_V	56_T	0.725	0.80
124_E	128_Q	0.722	0.79
129_N	133_G	0.718	0.79
126_C	129_N	0.717	0.79
215_S	247_E	0.715	0.79
113_I	151_F	0.715	0.79
197_Y	253_I	0.714	0.79
74_H	154_E	0.714	0.79
110_A	179_I	0.712	0.78
198_G	250_K	0.709	0.78
82_C	129_N	0.706	0.78
139_D	144_M	0.705	0.78
84_E	121_M	0.704	0.78
268_A	271_M	0.704	0.78
132_E	136_E	0.703	0.78
27_T	44_V	0.703	0.78
165_L	192_G	0.699	0.77
134_L	138_I	0.695	0.77
100_A	151_F	0.694	0.77
231_H	260_E	0.693	0.77
217_F	248_L	0.691	0.76
27_T	30_G	0.691	0.76
138_I	151_F	0.688	0.76
76_P	95_R	0.685	0.76
245_A	249_L	0.683	0.76
222_Y	238_A	0.681	0.75
202_D	252_D	0.681	0.75
101_D	104_E	0.679	0.75
217_F	244_L	0.679	0.75
233_P	262_P	0.675	0.75
188_F	226_K	0.670	0.74
21_S	33_T	0.669	0.74
204_L	209_G	0.668	0.74
156_M	161_A	0.668	0.74
101_D	144_M	0.667	0.74
97_L	137_V	0.667	0.74
81_L	92_S	0.663	0.73
234_I	244_L	0.662	0.73
20_H	37_L	0.662	0.73
127_Y	171_I	0.662	0.73
53_S	56_T	0.658	0.73
70_R	109_D	0.658	0.73
114_H	186_H	0.658	0.73
167_E	208_L	0.657	0.73
158_K	161_A	0.657	0.73
204_L	208_L	0.656	0.73
74_H	186_H	0.654	0.72
140_K	177_G	0.654	0.72
154_E	186_H	0.653	0.72
15_P	69_V	0.649	0.72
18_V	37_L	0.648	0.72
78_F	92_S	0.645	0.71
39_L	233_P	0.642	0.71
183_D	260_E	0.641	0.71
165_L	207_E	0.638	0.70
168_V	172_S	0.638	0.70
243_P	246_K	0.637	0.70
75_A	79_I	0.637	0.70
82_C	233_P	0.633	0.70
182_I	253_I	0.633	0.70
188_F	244_L	0.628	0.69
191_Q	194_E	0.624	0.69
43_E	152_G	0.622	0.69
195_I	246_K	0.619	0.68
210_L	213_I	0.618	0.68
173_K	207_E	0.618	0.68
232_I	262_P	0.618	0.68
83_S	129_N	0.615	0.68
31_I	71_L	0.615	0.68
121_M	129_N	0.615	0.68
109_D	150_K	0.615	0.68
74_H	114_H	0.613	0.67
182_I	215_S	0.610	0.67
210_L	215_S	0.607	0.67
265_E	268_A	0.607	0.67
45_E	49_G	0.605	0.66
136_E	140_K	0.605	0.66
150_K	179_I	0.604	0.66
266_R	269_L	0.604	0.66
31_I	60_T	0.604	0.66
85_E	121_M	0.603	0.66
114_H	154_E	0.602	0.66
88_K	129_N	0.602	0.66
22_A	30_G	0.597	0.65
135_E	176_K	0.596	0.65
94_Q	101_D	0.590	0.65
98_D	102_R	0.582	0.63
46_F	50_V	0.582	0.63
183_D	216_H	0.582	0.63
217_F	247_E	0.581	0.63
196_D	224_R	0.579	0.63
263_E	267_D	0.579	0.63
112_A	214_N	0.578	0.63
20_H	34_V	0.570	0.62
194_E	197_Y	0.569	0.62
127_Y	167_E	0.568	0.62
198_G	246_K	0.564	0.61
62_Q	211_T	0.563	0.61
233_P	266_R	0.561	0.61
60_T	63_V	0.561	0.61
187_T	190_R	0.561	0.61
216_H	231_H	0.557	0.60
138_I	177_G	0.552	0.59
157_A	230_E	0.552	0.59
195_I	243_P	0.552	0.59
245_A	248_L	0.551	0.59
182_I	200_I	0.550	0.59
172_S	208_L	0.550	0.59
115_I	156_M	0.550	0.59
23_K	29_E	0.549	0.59
193_G	196_D	0.548	0.59
190_R	225_G	0.547	0.59
184_W	218_E	0.546	0.59
234_I	243_P	0.545	0.58
111_I	149_V	0.544	0.58
47_V	50_V	0.543	0.58
219_S	239_P	0.542	0.58
204_L	207_E	0.540	0.58
215_S	252_D	0.539	0.58
76_P	158_K	0.538	0.57
79_I	92_S	0.538	0.57
89_I	121_M	0.538	0.57
66_E	206_K	0.536	0.57
72_S	152_G	0.536	0.57
123_P	170_S	0.536	0.57
235_D	240_P	0.535	0.57
166_D	200_I	0.534	0.57
123_P	160_T	0.534	0.57
46_F	95_R	0.533	0.57
163_G	168_V	0.533	0.57
88_K	96_I	0.533	0.57
158_K	227_Y	0.533	0.57
188_F	243_P	0.533	0.57
40_N	158_K	0.526	0.56
159_E	227_Y	0.526	0.56
123_P	162_F	0.526	0.56
130_V	156_M	0.525	0.56
104_E	150_K	0.524	0.56
35_K	69_V	0.523	0.55
195_I	200_I	0.522	0.55
97_L	144_M	0.522	0.55
116_A	130_V	0.519	0.55
72_S	110_A	0.519	0.55
201_I	215_S	0.517	0.55
64_A	67_L	0.517	0.55
41_A	256_T	0.515	0.54
222_Y	226_K	0.514	0.54
158_K	228_V	0.511	0.54
131_K	170_S	0.510	0.54
218_E	229_D	0.510	0.54
104_E	144_M	0.510	0.54
165_L	187_T	0.510	0.54
65_R	199_K	0.508	0.53
78_F	91_A	0.508	0.53
16_A	19_P	0.508	0.53
189_A	224_R	0.507	0.53
202_D	205_I	0.506	0.53
130_V	162_F	0.506	0.53
80_N	231_H	0.505	0.53
169_I	208_L	0.505	0.53
38_G	68_G	0.505	0.53
93_K	140_K	0.505	0.53
221_V	230_E	0.504	0.53
155_T	208_L	0.503	0.53
158_K	189_A	0.502	0.52
35_K	40_N	0.502	0.52
106_M	163_G	0.502	0.52
168_V	187_T	0.500	0.52

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3tc3A	1	0.9046	100	0.536	Contact Map
3aalA	1	0.9364	100	0.553	Contact Map
4hnoA	1	0.9364	100	0.558	Contact Map
1qtwA	1	0.9329	100	0.561	Contact Map
3aamA	1	0.9011	100	0.579	Contact Map
3wqoA	2	0.9187	100	0.596	Contact Map
3ayvA	2	0.8304	100	0.612	Contact Map
3tvaA	1	0.9011	100	0.621	Contact Map
2j6vA	1	0.8551	100	0.626	Contact Map
1i60A	1	0.9117	100	0.627	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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