GREMLIN Database
Q7LX47 - Uncharacterized protein
UniProt: Q7LX47 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 127 (120)
Sequences: 373 (283)
Seq/√Len: 25.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
11_V24_L4.5241.00
2_E8_L3.8331.00
78_R118_D3.4011.00
59_T62_S3.2321.00
103_P111_R3.0061.00
101_L104_Y2.8991.00
85_A122_F2.7080.99
47_V72_K2.5660.99
2_E24_L2.5520.99
74_N77_S2.3300.98
14_M115_F2.1010.97
15_K24_L2.0340.96
73_S78_R1.8780.93
2_E50_R1.8200.92
48_V52_I1.7820.92
38_T68_Y1.7700.91
8_L27_A1.7110.90
57_L71_H1.6610.88
2_E31_Q1.6320.87
48_V107_W1.5830.86
66_V121_F1.5170.83
48_V72_K1.4850.82
13_N22_I1.4490.80
92_T120_Y1.4210.79
101_L109_M1.4130.78
8_L26_N1.4100.78
54_I80_I1.3820.77
70_I77_S1.3800.77
8_L24_L1.3750.77
14_M72_K1.3510.75
57_L60_A1.3440.75
2_E11_V1.3100.73
81_I120_Y1.2760.71
93_E121_F1.2740.71
39_V57_L1.2540.70
29_A56_F1.2400.69
77_S118_D1.2270.68
29_A40_I1.2270.68
11_V21_D1.2190.67
110_R113_H1.2140.67
28_D31_Q1.1940.66
61_F90_F1.1810.65
5_M103_P1.1650.64
73_S118_D1.1640.64
3_I13_N1.1460.62
29_A63_I1.1450.62
74_N118_D1.1410.62
69_S122_F1.1280.61
39_V64_S1.1250.61
10_T25_I1.0980.59
48_V54_I1.0760.57
41_Q69_S1.0700.57
21_D40_I1.0490.56
6_E38_T1.0420.55
4_D56_F1.0410.55
98_R114_E1.0200.53
63_I67_V1.0150.53
73_S117_V1.0140.53
30_T59_T0.9980.52
49_N61_F0.9830.51
47_V74_N0.9790.50
72_K77_S0.9730.50
58_Q84_M0.9700.50
52_I58_Q0.9560.49
46_G53_D0.9420.48
25_I96_S0.9400.47
90_F93_E0.9380.47
29_A32_F0.9360.47
84_M87_D0.9150.46
11_V15_K0.9070.45
94_I121_F0.8990.44
68_Y121_F0.8910.44
101_L115_F0.8850.43
5_M26_N0.8830.43
78_R117_V0.8810.43
42_N45_F0.8780.43
12_K22_I0.8770.43
80_I88_Y0.8290.39
96_S110_R0.8200.39
34_S86_K0.8200.39
47_V69_S0.8130.38
109_M119_I0.8120.38
19_D62_S0.8050.38
70_I119_I0.7960.37
8_L22_I0.7940.37
18_L65_D0.7910.37
73_S94_I0.7870.37
61_F67_V0.7860.36
5_M16_S0.7840.36
9_D102_K0.7840.36
7_S104_Y0.7820.36
11_V57_L0.7780.36
44_P53_D0.7720.36
42_N53_D0.7720.36
45_F53_D0.7720.36
60_A83_T0.7700.35
80_I116_L0.7690.35
16_S19_D0.7680.35
8_L11_V0.7510.34
72_K95_L0.7510.34
96_S116_L0.7500.34
88_Y102_K0.7490.34
11_V99_F0.7390.33
5_M63_I0.7340.33
73_S96_S0.7330.33
23_E88_Y0.7270.33
107_W121_F0.7230.32
100_R114_E0.7180.32
86_K101_L0.7110.32
82_I105_Y0.7100.31
13_N26_N0.7050.31
72_K118_D0.6950.31
116_L119_I0.6910.30
3_I28_D0.6880.30
2_E66_V0.6880.30
5_M12_K0.6870.30
72_K94_I0.6840.30
6_E12_K0.6800.30
19_D78_R0.6740.29
79_E123_S0.6740.29
27_A113_H0.6650.29
78_R119_I0.6640.29
28_D123_S0.6600.28
14_M118_D0.6590.28
11_V66_V0.6500.28
11_V18_L0.6500.28
84_M119_I0.6400.27
106_P109_M0.6320.27
7_S12_K0.6320.27
107_W113_H0.6270.26
57_L69_S0.6220.26
14_M41_Q0.6220.26
100_R118_D0.6200.26
26_N51_G0.6170.26
7_S37_D0.6130.26
94_I119_I0.6130.26
66_V88_Y0.6110.26
2_E85_A0.6110.26
112_V115_F0.6080.25
78_R101_L0.6060.25
52_I55_K0.6000.25
94_I99_F0.5990.25
40_I91_S0.5940.25
12_K31_Q0.5900.24
105_Y113_H0.5840.24
118_D122_F0.5820.24
37_D109_M0.5810.24
38_T64_S0.5790.24
2_E30_T0.5760.24
9_D59_T0.5650.23
64_S85_A0.5610.23
37_D69_S0.5600.23
49_N52_I0.5600.23
37_D74_N0.5560.23
82_I116_L0.5530.22
57_L85_A0.5530.22
41_Q104_Y0.5530.22
39_V63_I0.5500.22
36_F69_S0.5460.22
18_L35_K0.5430.22
25_I110_R0.5420.22
14_M70_I0.5400.22
72_K122_F0.5400.22
40_I116_L0.5400.22
54_I72_K0.5390.22
23_E32_F0.5350.22
79_E82_I0.5350.22
77_S119_I0.5300.21
90_F122_F0.5280.21
14_M51_G0.5260.21
25_I102_K0.5260.21
13_N16_S0.5230.21
69_S73_S0.5190.21
47_V77_S0.5180.21
50_R109_M0.5150.21
24_L86_K0.5140.20
25_I121_F0.5080.20
8_L12_K0.5060.20
11_V80_I0.5040.20
68_Y94_I0.5000.20
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1wy7A 1 0.9843 99.7 0.643 Contact Map
1ne2A 2 0.9528 99.5 0.688 Contact Map
3tm4A 1 0.7717 98.9 0.769 Contact Map
3tmaA 2 0.811 98.7 0.784 Contact Map
2oyrA 1 0.7874 98.7 0.786 Contact Map
3vseA 1 0.9921 98.7 0.786 Contact Map
3lkdA 1 0.937 98.6 0.791 Contact Map
3lduA 1 0.8346 98.5 0.795 Contact Map
3khkA 1 0.937 98.5 0.796 Contact Map
2f8lA 1 0.9134 98.5 0.797 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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