GREMLIN Database
Q7LX46 - 2-haloalkanoic acid dehalogenase
UniProt: Q7LX46 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 222 (194)
Sequences: 27834 (22090)
Seq/√Len: 1586.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
148_I152_H2.9481.00
129_E134_K2.8931.00
181_A188_A2.7541.00
171_G177_D2.7361.00
105_E136_Y2.5851.00
101_I105_E2.4551.00
115_V139_G2.4541.00
3_T162_I2.4531.00
113_K138_D2.3651.00
158_Y161_E2.3641.00
117_V155_I2.2391.00
122_R145_D2.2121.00
182_K202_E2.1591.00
206_S210_E2.1291.00
160_M167_G2.1281.00
148_I154_K2.1221.00
118_S125_Y2.0691.00
178_V188_A2.0031.00
6_V114_L1.9931.00
106_E110_L1.9661.00
179_I183_R1.9261.00
187_E202_E1.9211.00
163_A166_D1.9051.00
108_K138_D1.8411.00
160_M186_L1.8211.00
108_K136_Y1.8121.00
5_F169_H1.7971.00
4_I112_F1.7901.00
81_I85_N1.7711.00
106_E212_L1.7651.00
168_I189_I1.7431.00
169_H181_A1.7291.00
100_S208_L1.7111.00
35_D38_R1.7021.00
114_L137_F1.6851.00
162_I167_G1.6301.00
160_M164_K1.6071.00
5_F117_V1.5831.00
5_F159_A1.5731.00
192_D206_S1.5391.00
4_I170_I1.5211.00
4_I107_A1.5081.00
82_T86_S1.4971.00
189_I205_V1.4561.00
97_Y193_R1.4471.00
80_L83_R1.4191.00
207_N210_E1.4021.00
103_F208_L1.3871.00
189_I203_N1.3761.00
11_T170_I1.3721.00
192_D204_K1.3571.00
78_E82_T1.3551.00
106_E109_G1.3481.00
99_D102_T1.3321.00
103_F212_L1.3181.00
8_L13_V1.3111.00
12_L100_S1.2831.00
8_L116_L1.2771.00
70_Y73_N1.2641.00
96_L133_I1.2391.00
153_P157_S1.2071.00
5_F167_G1.2061.00
141_V159_A1.1951.00
29_E80_L1.1951.00
122_R142_A1.1941.00
102_T209_L1.1771.00
80_L84_L1.1711.00
167_G186_L1.1521.00
26_A30_I1.1491.00
157_S161_E1.1471.00
25_Y29_E1.1451.00
125_Y142_A1.1411.00
156_F169_H1.1381.00
9_G15_F1.1331.00
43_V47_L1.1141.00
117_V159_A1.1131.00
78_E85_N1.1081.00
78_E81_I1.1031.00
63_F66_R1.1021.00
156_F180_G1.1001.00
105_E109_G1.0901.00
82_T85_N1.0861.00
73_N76_P1.0811.00
8_L120_A1.0791.00
162_I166_D1.0791.00
81_I84_L1.0711.00
132_G135_K1.0681.00
156_F186_L1.0611.00
21_E25_Y1.0601.00
3_T113_K1.0541.00
42_A45_K1.0521.00
182_K188_A1.0471.00
154_K158_Y1.0451.00
89_L92_G1.0441.00
108_K114_L1.0411.00
79_Q83_R1.0371.00
24_A28_K1.0341.00
116_L137_F1.0321.00
21_E24_A1.0311.00
8_L125_Y1.0281.00
25_Y28_K1.0181.00
9_G120_A1.0121.00
104_L137_F1.0081.00
101_I136_Y1.0021.00
44_A47_L0.9971.00
21_E93_E0.9951.00
169_H186_L0.9911.00
187_E203_N0.9891.00
122_R144_C0.9851.00
115_V159_A0.9631.00
168_I187_E0.9591.00
44_A48_G0.9561.00
156_F171_G0.9521.00
126_K130_D0.9511.00
105_E135_K0.9501.00
24_A36_E0.9481.00
40_F43_V0.9461.00
157_S184_A0.9451.00
102_T105_E0.9421.00
67_E70_Y0.9391.00
99_D207_N0.9391.00
147_N154_K0.9351.00
157_S164_K0.9351.00
170_I189_I0.9211.00
182_K200_I0.9191.00
96_L101_I0.9141.00
27_L32_Y0.9131.00
3_T167_G0.9101.00
62_A66_R0.9101.00
141_V158_Y0.9051.00
63_F67_E0.9051.00
164_K186_L0.8991.00
69_F72_L0.8961.00
176_I179_I0.8951.00
107_A112_F0.8931.00
118_S142_A0.8921.00
190_L204_K0.8841.00
205_V211_A0.8831.00
80_L85_N0.8811.00
154_K157_S0.8771.00
66_R70_Y0.8731.00
5_F186_L0.8721.00
126_K129_E0.8711.00
114_L136_Y0.8641.00
146_L158_Y0.8551.00
104_L136_Y0.8501.00
142_A145_D0.8501.00
38_R41_K0.8381.00
37_R41_K0.8371.00
4_I168_I0.8281.00
3_T115_V0.8231.00
8_L127_I0.8221.00
180_G184_A0.8181.00
9_G118_S0.8181.00
178_V190_L0.8141.00
38_R42_A0.8141.00
97_Y191_L0.8061.00
155_I159_A0.7971.00
178_V201_R0.7971.00
173_I176_I0.7941.00
107_A114_L0.7911.00
29_E83_R0.7891.00
97_Y100_S0.7841.00
9_G172_D0.7841.00
36_E40_F0.7811.00
99_D209_L0.7811.00
5_F115_V0.7761.00
13_V131_L0.7741.00
22_N26_A0.7731.00
120_A125_Y0.7721.00
83_R86_S0.7691.00
139_G159_A0.7621.00
188_A202_E0.7611.00
40_F44_A0.7581.00
79_Q82_T0.7561.00
119_N149_M0.7551.00
101_I135_K0.7521.00
20_H24_A0.7501.00
193_R208_L0.7501.00
189_I211_A0.7481.00
13_V127_I0.7471.00
141_V155_I0.7381.00
169_H177_D0.7371.00
19_Y23_I0.7311.00
101_I132_G0.7251.00
164_K167_G0.7221.00
67_E71_E0.7221.00
28_K33_N0.7221.00
10_E16_K0.7151.00
17_P95_E0.7101.00
179_I182_K0.7071.00
114_L138_D0.7031.00
64_D68_L0.6961.00
191_L208_L0.6931.00
128_V134_K0.6921.00
96_L131_L0.6871.00
30_I80_L0.6851.00
14_H17_P0.6851.00
102_T106_E0.6801.00
73_N77_D0.6801.00
91_S126_K0.6791.00
155_I180_G0.6781.00
146_L155_I0.6761.00
125_Y140_I0.6721.00
170_I211_A0.6701.00
43_V46_I0.6691.00
205_V212_L0.6691.00
156_F177_D0.6641.00
209_L212_L0.6631.00
34_V39_V0.6601.00
25_Y89_L0.6591.00
13_V94_Y0.6581.00
19_Y120_A0.6571.00
205_V208_L0.6571.00
190_L201_R0.6521.00
208_L212_L0.6521.00
153_P183_R0.6521.00
117_V169_H0.6521.00
77_D80_L0.6501.00
88_N92_G0.6491.00
119_N176_I0.6491.00
198_P206_S0.6481.00
129_E135_K0.6441.00
42_A46_I0.6431.00
14_H95_E0.6391.00
169_H180_G0.6391.00
34_V38_R0.6351.00
9_G127_I0.6341.00
20_H39_V0.6281.00
99_D103_F0.6281.00
23_I27_L0.6271.00
103_F170_I0.6251.00
18_R94_Y0.6231.00
17_P21_E0.6231.00
108_K135_K0.6191.00
11_T191_L0.6141.00
160_M184_A0.6121.00
20_H36_E0.6071.00
11_T177_D0.6051.00
40_F47_L0.6031.00
119_N151_P0.6021.00
192_D197_Y0.6001.00
70_Y74_I0.6001.00
98_D207_N0.5981.00
105_E108_K0.5971.00
120_A171_G0.5941.00
98_D209_L0.5921.00
113_K162_I0.5911.00
99_D193_R0.5881.00
117_V141_V0.5831.00
176_I180_G0.5751.00
65_F68_L0.5741.00
69_F74_I0.5741.00
143_S155_I0.5681.00
6_V103_F0.5681.00
137_F140_I0.5661.00
37_R40_F0.5611.00
68_L72_L0.5591.00
103_F107_A0.5581.00
100_S104_L0.5571.00
39_V42_A0.5551.00
29_E84_L0.5531.00
70_Y77_D0.5531.00
100_S103_F0.5521.00
78_E86_S0.5521.00
5_F156_F0.5511.00
120_A177_D0.5501.00
157_S160_M0.5471.00
41_K45_K0.5471.00
156_F181_A0.5431.00
25_Y84_L0.5411.00
21_E89_L0.5381.00
96_L100_S0.5361.00
17_P36_E0.5331.00
14_H97_Y0.5291.00
108_K111_G0.5281.00
128_V133_I0.5261.00
115_V138_D0.5251.00
19_Y22_N0.5241.00
39_V43_V0.5221.00
180_G183_R0.5191.00
192_D196_F0.5181.00
64_D67_E0.5161.00
15_F120_A0.5151.00
4_I114_L0.5121.00
69_F73_N0.5121.00
103_F205_V0.5091.00
179_I199_E0.5091.00
12_L116_L0.5021.00
123_S126_K0.5011.00
40_F46_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2zg6A 2 0.9054 100 0.299 Contact Map
4uw9A 1 0.8964 100 0.3 Contact Map
3k1zA 1 0.9955 100 0.323 Contact Map
3ed5A 1 0.982 100 0.34 Contact Map
3iruA 4 0.9775 100 0.341 Contact Map
3smvA 1 0.973 100 0.344 Contact Map
1swvA 2 0.9685 100 0.345 Contact Map
3nasA 2 0.8829 100 0.349 Contact Map
3dv9A 1 0.9189 100 0.351 Contact Map
2no4A 4 0.9595 100 0.355 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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