GREMLIN Database
Q7LX45 - Uncharacterized protein
UniProt: Q7LX45 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 101 (91)
Sequences: 139 (107)
Seq/√Len: 11.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
82_R89_E3.1000.96
12_I28_I2.6430.90
63_A74_S2.2220.80
15_L28_I2.1330.77
40_V98_I2.0690.74
67_S90_K2.0640.74
48_A81_S2.0120.72
25_A37_E2.0000.72
8_T43_H1.9270.69
17_F56_Y1.9250.69
45_E76_K1.9210.69
12_I47_L1.8450.65
51_S98_I1.7090.59
13_F47_L1.7000.59
26_R37_E1.6930.58
59_I89_E1.6450.56
32_L44_L1.5430.51
46_H50_S1.4970.49
51_S97_L1.4800.48
82_R87_K1.4510.47
66_K92_E1.4480.47
24_S92_E1.4400.46
25_A41_Y1.4290.46
28_I41_Y1.4160.45
51_S56_Y1.3730.43
17_F82_R1.3400.41
67_S88_S1.3300.41
30_R82_R1.3190.40
76_K81_S1.2980.39
34_V40_V1.2940.39
93_M96_F1.2610.38
38_K72_F1.2380.37
26_R93_M1.2290.36
60_I74_S1.2230.36
11_K48_A1.2020.35
74_S81_S1.1980.35
72_F76_K1.1610.33
64_K70_Y1.1470.33
29_M37_E1.1300.32
27_E40_V1.1280.32
25_A38_K1.1180.31
55_G63_A1.0670.29
7_T40_V1.0570.29
22_P46_H1.0520.29
32_L38_K1.0490.29
43_H78_K1.0470.29
15_L24_S1.0410.28
55_G58_L1.0380.28
25_A85_I1.0200.28
56_Y98_I1.0100.27
57_M61_I0.9900.26
43_H59_I0.9860.26
31_R58_L0.9850.26
16_L87_K0.9810.26
24_S63_A0.9740.26
75_D89_E0.9740.26
29_M33_D0.9680.26
22_P95_K0.9540.25
30_R49_R0.9530.25
15_L27_E0.9420.25
37_E43_H0.9130.24
9_R80_P0.9090.23
6_L92_E0.9070.23
8_T56_Y0.8980.23
24_S95_K0.8800.22
42_D94_P0.8750.22
45_E77_I0.8560.22
46_H80_P0.8510.21
8_T32_L0.8440.21
92_E95_K0.8410.21
28_I60_I0.8410.21
39_E43_H0.8390.21
80_P94_P0.8380.21
85_I95_K0.8120.20
28_I35_R0.7900.20
14_L51_S0.7840.19
6_L14_L0.7750.19
34_V92_E0.7730.19
33_D99_R0.7640.19
7_T63_A0.7600.19
39_E72_F0.7580.19
11_K67_S0.7520.18
51_S58_L0.7500.18
25_A42_D0.7490.18
16_L47_L0.7410.18
21_E49_R0.7350.18
74_S77_I0.7310.18
47_L50_S0.7170.17
24_S32_L0.7100.17
33_D52_K0.7070.17
60_I63_A0.7020.17
6_L34_V0.7020.17
60_I93_M0.6980.17
31_R79_K0.6970.17
27_E53_R0.6960.17
49_R99_R0.6920.17
27_E98_I0.6780.16
20_D70_Y0.6620.16
38_K71_V0.6610.16
39_E49_R0.6570.16
25_A43_H0.6530.16
10_E56_Y0.6530.16
44_L85_I0.6480.16
40_V85_I0.6360.15
9_R91_I0.6360.15
37_E77_I0.6340.15
34_V96_F0.6280.15
70_Y94_P0.6280.15
7_T77_I0.6260.15
35_R60_I0.6150.15
44_L90_K0.6080.15
59_I78_K0.6050.15
43_H67_S0.6000.14
53_R56_Y0.5950.14
26_R76_K0.5950.14
26_R29_M0.5950.14
24_S27_E0.5850.14
20_D47_L0.5770.14
33_D90_K0.5710.14
29_M32_L0.5580.13
72_F79_K0.5540.13
58_L87_K0.5500.13
10_E29_M0.5450.13
79_K91_I0.5390.13
25_A50_S0.5370.13
66_K81_S0.5360.13
9_R46_H0.5340.13
27_E91_I0.5300.13
9_R12_I0.5270.13
70_Y74_S0.5210.13
15_L77_I0.5160.13
48_A70_Y0.5150.12
29_M74_S0.5130.12
22_P50_S0.5040.12
32_L41_Y0.5010.12
23_L52_K0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2gmgA 1 0.9703 100 0.317 Contact Map
2o03A 2 0.8515 96.5 0.835 Contact Map
3mwmA 2 0.8515 96.1 0.843 Contact Map
2xigA 4 0.8911 95.8 0.847 Contact Map
4etsA 2 0.901 95.7 0.848 Contact Map
1qbjA 1 0.604 95.4 0.851 Contact Map
1qgpA 1 0.6733 95.4 0.851 Contact Map
3eyyA 2 0.802 95.1 0.853 Contact Map
4rayA 4 0.802 95.1 0.853 Contact Map
2fe3A 2 0.8812 95.1 0.853 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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