Q7LX44 - SULSO - GREMLIN Contacts

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Q7LX44 - dTDP-4-dehydrorhamnose reductase (RfbD-3)

UniProt:	Q7LX44	Sequences: MKIAVTDEGEVAKAIAKFLGGKGNEIIVVDNPSKVIREKPDVIIHTFEIPIFESNANPPLAWSFNTWYAINIARAGSKAGSVNVFLSSFLIYDGKRGFYKEHNTPHPLNYYGLTKLVGESSIISLGNYLVLRVGALFSLSYRGFLFPFIKASTMGKVLKCNKNFYISIIDLNTLAKVIKLLIDKEARGVINVGSNRVSLFDICSYLSDIFGNEVIEIDNRQRDFSLDDWLLRAYNIKIDAKESILSLIEYRLLNN	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	255 (219)
Sequences:	53134 (35828)
Seq/√Len:	2421.0

ECOLI - GALE RMLB1 YBJS RMLB2 GM4D FCL RMLD HLDD YFCH YEEZ
BACSU - YTCB GALE SPSK YFNG RMLB YFHF YTBQ YWNB YHEG YHFK
HALSA - Q9HSV1 Q9HPF1 Q9HSU9 Q9HSE7 Q9HRD1 Q9HML4 Q9HS50 Q9HSQ3 Q9HNV3 Q9HR86
SULSO - Q7LX44 Q97VN5 Q7LXG5 Q97UM3 Q7LXE6 Q7LXE8 Q980W1 Q97XJ9 Q97XG1 Q97XF9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
7_D	28_V	3.532	1.00
177_V	192_V	3.110	1.00
18_F	176_K	2.945	1.00
63_S	67_W	2.559	1.00
57_N	60_L	2.467	1.00
86_L	178_I	2.421	1.00
82_V	127_N	2.358	1.00
42_V	182_I	2.326	1.00
6_T	45_H	2.268	1.00
18_F	22_K	2.240	1.00
45_H	85_F	2.236	1.00
22_K	183_D	2.167	1.00
44_I	182_I	2.126	1.00
5_V	16_A	2.113	1.00
200_F	204_S	2.113	1.00
133_V	178_I	2.104	1.00
18_F	179_K	2.083	1.00
150_K	154_M	2.053	1.00
176_K	180_L	2.002	1.00
4_A	40_P	1.994	1.00
100_K	103_N	1.968	1.00
27_I	40_P	1.929	1.00
122_I	128_Y	1.929	1.00
198_S	201_D	1.861	1.00
131_L	181_L	1.831	1.00
33_S	37_R	1.772	1.00
15_I	175_A	1.772	1.00
205_Y	208_D	1.745	1.00
11_V	136_L	1.730	1.00
157_V	217_I	1.699	1.00
205_Y	209_I	1.690	1.00
167_S	195_N	1.663	1.00
87_S	91_I	1.635	1.00
92_Y	191_N	1.634	1.00
76_G	81_S	1.634	1.00
70_I	74_R	1.632	1.00
15_I	44_I	1.629	1.00
111_Y	115_K	1.621	1.00
201_D	204_S	1.620	1.00
18_F	21_G	1.595	1.00
67_W	70_I	1.592	1.00
180_L	184_K	1.550	1.00
73_A	125_L	1.548	1.00
131_L	178_I	1.547	1.00
105_P	116_L	1.547	1.00
72_I	83_N	1.540	1.00
62_W	117_V	1.537	1.00
179_K	183_D	1.533	1.00
46_T	86_L	1.527	1.00
22_K	179_K	1.520	1.00
70_I	121_S	1.515	1.00
17_K	140_S	1.512	1.00
15_I	46_T	1.508	1.00
45_H	69_A	1.502	1.00
27_I	38_E	1.495	1.00
116_L	120_S	1.483	1.00
169_I	174_L	1.479	1.00
43_I	76_G	1.477	1.00
171_L	175_A	1.470	1.00
65_N	114_T	1.453	1.00
137_F	170_D	1.450	1.00
59_P	63_S	1.442	1.00
151_A	156_K	1.424	1.00
18_F	175_A	1.401	1.00
69_A	118_G	1.384	1.00
133_V	174_L	1.368	1.00
86_L	133_V	1.366	1.00
44_I	178_I	1.363	1.00
74_R	77_S	1.362	1.00
200_F	218_D	1.343	1.00
19_L	179_K	1.331	1.00
64_F	68_Y	1.321	1.00
170_D	173_T	1.311	1.00
24_N	183_D	1.307	1.00
82_V	129_L	1.297	1.00
165_Y	196_R	1.290	1.00
76_G	83_N	1.286	1.00
120_S	123_I	1.281	1.00
10_E	138_S	1.274	1.00
132_R	189_V	1.271	1.00
16_A	28_V	1.269	1.00
113_L	117_V	1.266	1.00
123_I	189_V	1.259	1.00
159_K	217_I	1.244	1.00
13_K	140_S	1.242	1.00
33_S	36_I	1.221	1.00
8_E	30_D	1.212	1.00
75_A	79_A	1.190	1.00
18_F	172_N	1.189	1.00
7_D	16_A	1.189	1.00
85_F	118_G	1.181	1.00
3_I	24_N	1.161	1.00
74_R	78_K	1.151	1.00
123_I	130_V	1.150	1.00
14_A	172_N	1.140	1.00
123_I	128_Y	1.133	1.00
173_T	194_S	1.126	1.00
46_T	178_I	1.124	1.00
132_R	191_N	1.121	1.00
73_A	83_N	1.116	1.00
207_S	213_E	1.111	1.00
4_A	29_V	1.102	1.00
119_E	132_R	1.087	1.00
99_Y	103_N	1.083	1.00
85_F	122_I	1.081	1.00
49_I	64_F	1.062	1.00
87_S	119_E	1.047	1.00
85_F	130_V	1.044	1.00
6_T	47_F	1.040	1.00
83_N	122_I	1.034	1.00
35_V	40_P	1.033	1.00
144_F	148_F	1.029	1.00
157_V	215_I	1.025	1.00
17_K	21_G	1.024	1.00
165_Y	198_S	1.020	1.00
3_I	19_L	1.020	1.00
10_E	171_L	1.016	1.00
121_S	124_S	1.012	1.00
84_V	131_L	1.004	1.00
89_F	134_G	0.999	1.00
15_I	19_L	0.999	1.00
74_R	125_L	0.995	1.00
73_A	122_I	0.995	1.00
53_E	57_N	0.991	1.00
73_A	121_S	0.988	1.00
14_A	171_L	0.987	1.00
36_I	78_K	0.978	1.00
27_I	39_K	0.971	1.00
139_L	170_D	0.960	1.00
136_L	169_I	0.958	1.00
136_L	174_L	0.952	1.00
67_W	71_N	0.950	1.00
82_V	185_E	0.950	1.00
3_I	42_V	0.947	1.00
130_V	189_V	0.941	1.00
62_W	66_T	0.937	1.00
197_V	201_D	0.935	1.00
134_G	193_G	0.934	1.00
36_I	79_A	0.921	1.00
197_V	202_I	0.919	1.00
180_L	183_D	0.918	1.00
204_S	207_S	0.916	1.00
101_E	191_N	0.915	1.00
62_W	114_T	0.915	1.00
20_G	26_I	0.894	1.00
71_N	74_R	0.891	1.00
143_G	146_F	0.886	1.00
61_A	114_T	0.879	1.00
24_N	41_D	0.875	1.00
14_A	17_K	0.874	1.00
71_N	75_A	0.868	1.00
68_Y	71_N	0.868	1.00
131_L	192_V	0.862	1.00
129_L	181_L	0.861	1.00
75_A	78_K	0.857	1.00
27_I	30_D	0.853	1.00
117_V	120_S	0.848	1.00
91_I	119_E	0.837	1.00
152_S	207_S	0.835	1.00
95_K	99_Y	0.826	1.00
77_S	126_G	0.824	1.00
77_S	125_L	0.824	1.00
6_T	72_I	0.824	1.00
149_I	206_L	0.816	1.00
69_A	73_A	0.814	1.00
207_S	214_V	0.813	1.00
3_I	182_I	0.810	1.00
118_G	122_I	0.809	1.00
49_I	60_L	0.807	1.00
3_I	44_I	0.804	1.00
176_K	179_K	0.799	1.00
135_A	166_I	0.796	1.00
66_T	117_V	0.795	1.00
214_V	218_D	0.795	1.00
60_L	64_F	0.794	1.00
60_L	63_S	0.793	1.00
62_W	67_W	0.788	1.00
14_A	175_A	0.784	1.00
218_D	221_Q	0.772	1.00
19_L	182_I	0.767	1.00
11_V	174_L	0.767	1.00
58_P	113_L	0.764	1.00
107_P	112_G	0.764	1.00
150_K	153_T	0.762	1.00
69_A	122_I	0.761	1.00
49_I	61_A	0.761	1.00
207_S	212_N	0.758	1.00
54_S	61_A	0.749	1.00
149_I	153_T	0.749	1.00
131_L	177_V	0.747	1.00
204_S	208_D	0.744	1.00
159_K	219_N	0.742	1.00
26_I	30_D	0.741	1.00
16_A	26_I	0.737	1.00
147_P	150_K	0.736	1.00
91_I	105_P	0.736	1.00
113_L	124_S	0.734	1.00
96_R	103_N	0.732	1.00
164_F	199_L	0.723	1.00
147_P	151_A	0.721	1.00
93_D	106_H	0.714	1.00
45_H	72_I	0.713	1.00
15_I	178_I	0.705	1.00
120_S	124_S	0.705	1.00
167_S	194_S	0.704	1.00
14_A	140_S	0.701	1.00
128_Y	187_R	0.700	1.00
117_V	121_S	0.700	1.00
43_I	72_I	0.699	1.00
14_A	18_F	0.699	1.00
42_V	82_V	0.699	1.00
35_V	79_A	0.698	1.00
27_I	31_N	0.698	1.00
34_K	38_E	0.696	1.00
55_N	110_Y	0.694	1.00
137_F	194_S	0.684	1.00
113_L	120_S	0.683	1.00
34_K	37_R	0.680	1.00
13_K	17_K	0.677	1.00
4_A	43_I	0.677	1.00
109_N	112_G	0.672	1.00
121_S	125_L	0.671	1.00
62_W	113_L	0.670	1.00
155_G	212_N	0.668	1.00
175_A	179_K	0.666	1.00
84_V	181_L	0.664	1.00
114_T	118_G	0.657	1.00
28_V	31_N	0.654	1.00
166_I	199_L	0.653	1.00
58_P	110_Y	0.651	1.00
201_D	205_Y	0.651	1.00
167_S	196_R	0.651	1.00
129_L	188_G	0.650	1.00
22_K	176_K	0.647	1.00
110_Y	113_L	0.646	1.00
107_P	116_L	0.646	1.00
90_L	112_G	0.645	1.00
139_L	172_N	0.642	1.00
216_E	219_N	0.639	1.00
203_C	207_S	0.638	1.00
35_V	75_A	0.633	1.00
110_Y	114_T	0.632	1.00
151_A	159_K	0.632	1.00
152_S	158_L	0.629	1.00
149_I	210_F	0.626	1.00
35_V	38_E	0.626	1.00
134_G	167_S	0.625	1.00
49_I	65_N	0.624	1.00
35_V	43_I	0.624	1.00
69_A	85_F	0.622	1.00
152_S	206_L	0.621	1.00
14_A	139_L	0.619	1.00
24_N	42_V	0.617	1.00
160_C	163_N	0.613	1.00
42_V	84_V	0.612	1.00
43_I	83_N	0.608	1.00
142_R	146_F	0.606	1.00
22_K	180_L	0.604	1.00
94_G	108_L	0.603	1.00
65_N	111_Y	0.600	1.00
19_L	24_N	0.600	1.00
17_K	172_N	0.598	1.00
88_S	91_I	0.597	1.00
215_I	218_D	0.595	1.00
46_T	133_V	0.595	1.00
10_E	14_A	0.595	1.00
87_S	132_R	0.593	1.00
122_I	130_V	0.593	1.00
50_P	143_G	0.591	1.00
86_L	131_L	0.591	1.00
173_T	176_K	0.590	1.00
84_V	182_I	0.588	1.00
174_L	192_V	0.586	1.00
163_N	218_D	0.584	1.00
184_K	190_I	0.582	1.00
158_L	216_E	0.582	1.00
35_V	39_K	0.580	1.00
23_G	26_I	0.577	1.00
129_L	190_I	0.575	1.00
70_I	125_L	0.571	1.00
97_G	103_N	0.570	1.00
197_V	205_Y	0.570	1.00
129_L	187_R	0.570	1.00
138_S	171_L	0.570	1.00
141_Y	146_F	0.569	1.00
73_A	77_S	0.568	1.00
151_A	155_G	0.567	1.00
72_I	76_G	0.567	1.00
91_I	132_R	0.562	1.00
48_E	65_N	0.562	1.00
84_V	178_I	0.557	1.00
145_L	202_I	0.557	1.00
8_E	28_V	0.556	1.00
215_I	221_Q	0.551	1.00
88_S	115_K	0.548	1.00
15_I	179_K	0.547	1.00
179_K	182_I	0.547	1.00
217_I	220_R	0.544	1.00
105_P	120_S	0.543	1.00
29_V	34_K	0.541	1.00
20_G	23_G	0.539	1.00
66_T	114_T	0.534	1.00
35_V	76_G	0.533	1.00
16_A	20_G	0.532	1.00
207_S	216_E	0.530	1.00
125_L	128_Y	0.530	1.00
148_F	158_L	0.526	1.00
39_K	79_A	0.525	1.00
16_A	23_G	0.524	1.00
76_G	79_A	0.522	1.00
160_C	203_C	0.522	1.00
105_P	189_V	0.520	1.00
145_L	148_F	0.520	1.00
152_S	210_F	0.519	1.00
168_I	199_L	0.516	1.00
34_K	40_P	0.514	1.00
159_K	162_K	0.514	1.00
26_I	31_N	0.514	1.00
87_S	130_V	0.511	1.00
43_I	81_S	0.508	1.00
214_V	217_I	0.506	1.00
207_S	210_F	0.506	1.00
5_V	19_L	0.504	1.00
133_V	136_L	0.503	1.00
83_N	128_Y	0.503	1.00
127_N	185_E	0.501	1.00
86_L	89_F	0.500	1.00
19_L	44_I	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3m2pA	2	0.9882	100	0.275	Contact Map
3sc6A	3	0.9961	100	0.276	Contact Map
1rkxA	3	0.9843	100	0.277	Contact Map
1vl0A	3	0.9922	100	0.281	Contact Map
3sxpA	3	0.9843	100	0.281	Contact Map
2pzmA	2	0.9882	100	0.283	Contact Map
2yy7A	2	0.9961	100	0.284	Contact Map
1sb8A	2	1	100	0.286	Contact Map
1n2sA	2	0.9922	100	0.289	Contact Map
1orrA	3	1	100	0.29	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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