GREMLIN Database
Q7LX44 - dTDP-4-dehydrorhamnose reductase (RfbD-3)
UniProt: Q7LX44 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 255 (219)
Sequences: 53134 (35828)
Seq/√Len: 2421.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
7_D28_V3.5321.00
177_V192_V3.1101.00
18_F176_K2.9451.00
63_S67_W2.5591.00
57_N60_L2.4671.00
86_L178_I2.4211.00
82_V127_N2.3581.00
42_V182_I2.3261.00
6_T45_H2.2681.00
18_F22_K2.2401.00
45_H85_F2.2361.00
22_K183_D2.1671.00
44_I182_I2.1261.00
5_V16_A2.1131.00
200_F204_S2.1131.00
133_V178_I2.1041.00
18_F179_K2.0831.00
150_K154_M2.0531.00
176_K180_L2.0021.00
4_A40_P1.9941.00
100_K103_N1.9681.00
27_I40_P1.9291.00
122_I128_Y1.9291.00
198_S201_D1.8611.00
131_L181_L1.8311.00
33_S37_R1.7721.00
15_I175_A1.7721.00
205_Y208_D1.7451.00
11_V136_L1.7301.00
157_V217_I1.6991.00
205_Y209_I1.6901.00
167_S195_N1.6631.00
87_S91_I1.6351.00
92_Y191_N1.6341.00
76_G81_S1.6341.00
70_I74_R1.6321.00
15_I44_I1.6291.00
111_Y115_K1.6211.00
201_D204_S1.6201.00
18_F21_G1.5951.00
67_W70_I1.5921.00
180_L184_K1.5501.00
73_A125_L1.5481.00
131_L178_I1.5471.00
105_P116_L1.5471.00
72_I83_N1.5401.00
62_W117_V1.5371.00
179_K183_D1.5331.00
46_T86_L1.5271.00
22_K179_K1.5201.00
70_I121_S1.5151.00
17_K140_S1.5121.00
15_I46_T1.5081.00
45_H69_A1.5021.00
27_I38_E1.4951.00
116_L120_S1.4831.00
169_I174_L1.4791.00
43_I76_G1.4771.00
171_L175_A1.4701.00
65_N114_T1.4531.00
137_F170_D1.4501.00
59_P63_S1.4421.00
151_A156_K1.4241.00
18_F175_A1.4011.00
69_A118_G1.3841.00
133_V174_L1.3681.00
86_L133_V1.3661.00
44_I178_I1.3631.00
74_R77_S1.3621.00
200_F218_D1.3431.00
19_L179_K1.3311.00
64_F68_Y1.3211.00
170_D173_T1.3111.00
24_N183_D1.3071.00
82_V129_L1.2971.00
165_Y196_R1.2901.00
76_G83_N1.2861.00
120_S123_I1.2811.00
10_E138_S1.2741.00
132_R189_V1.2711.00
16_A28_V1.2691.00
113_L117_V1.2661.00
123_I189_V1.2591.00
159_K217_I1.2441.00
13_K140_S1.2421.00
33_S36_I1.2211.00
8_E30_D1.2121.00
75_A79_A1.1901.00
18_F172_N1.1891.00
7_D16_A1.1891.00
85_F118_G1.1811.00
3_I24_N1.1611.00
74_R78_K1.1511.00
123_I130_V1.1501.00
14_A172_N1.1401.00
123_I128_Y1.1331.00
173_T194_S1.1261.00
46_T178_I1.1241.00
132_R191_N1.1211.00
73_A83_N1.1161.00
207_S213_E1.1111.00
4_A29_V1.1021.00
119_E132_R1.0871.00
99_Y103_N1.0831.00
85_F122_I1.0811.00
49_I64_F1.0621.00
87_S119_E1.0471.00
85_F130_V1.0441.00
6_T47_F1.0401.00
83_N122_I1.0341.00
35_V40_P1.0331.00
144_F148_F1.0291.00
157_V215_I1.0251.00
17_K21_G1.0241.00
165_Y198_S1.0201.00
3_I19_L1.0201.00
10_E171_L1.0161.00
121_S124_S1.0121.00
84_V131_L1.0041.00
89_F134_G0.9991.00
15_I19_L0.9991.00
74_R125_L0.9951.00
73_A122_I0.9951.00
53_E57_N0.9911.00
73_A121_S0.9881.00
14_A171_L0.9871.00
36_I78_K0.9781.00
27_I39_K0.9711.00
139_L170_D0.9601.00
136_L169_I0.9581.00
136_L174_L0.9521.00
67_W71_N0.9501.00
82_V185_E0.9501.00
3_I42_V0.9471.00
130_V189_V0.9411.00
62_W66_T0.9371.00
197_V201_D0.9351.00
134_G193_G0.9341.00
36_I79_A0.9211.00
197_V202_I0.9191.00
180_L183_D0.9181.00
204_S207_S0.9161.00
101_E191_N0.9151.00
62_W114_T0.9151.00
20_G26_I0.8941.00
71_N74_R0.8911.00
143_G146_F0.8861.00
61_A114_T0.8791.00
24_N41_D0.8751.00
14_A17_K0.8741.00
71_N75_A0.8681.00
68_Y71_N0.8681.00
131_L192_V0.8621.00
129_L181_L0.8611.00
75_A78_K0.8571.00
27_I30_D0.8531.00
117_V120_S0.8481.00
91_I119_E0.8371.00
152_S207_S0.8351.00
95_K99_Y0.8261.00
77_S126_G0.8241.00
77_S125_L0.8241.00
6_T72_I0.8241.00
149_I206_L0.8161.00
69_A73_A0.8141.00
207_S214_V0.8131.00
3_I182_I0.8101.00
118_G122_I0.8091.00
49_I60_L0.8071.00
3_I44_I0.8041.00
176_K179_K0.7991.00
135_A166_I0.7961.00
66_T117_V0.7951.00
214_V218_D0.7951.00
60_L64_F0.7941.00
60_L63_S0.7931.00
62_W67_W0.7881.00
14_A175_A0.7841.00
218_D221_Q0.7721.00
19_L182_I0.7671.00
11_V174_L0.7671.00
58_P113_L0.7641.00
107_P112_G0.7641.00
150_K153_T0.7621.00
69_A122_I0.7611.00
49_I61_A0.7611.00
207_S212_N0.7581.00
54_S61_A0.7491.00
149_I153_T0.7491.00
131_L177_V0.7471.00
204_S208_D0.7441.00
159_K219_N0.7421.00
26_I30_D0.7411.00
16_A26_I0.7371.00
147_P150_K0.7361.00
91_I105_P0.7361.00
113_L124_S0.7341.00
96_R103_N0.7321.00
164_F199_L0.7231.00
147_P151_A0.7211.00
93_D106_H0.7141.00
45_H72_I0.7131.00
15_I178_I0.7051.00
120_S124_S0.7051.00
167_S194_S0.7041.00
14_A140_S0.7011.00
128_Y187_R0.7001.00
117_V121_S0.7001.00
43_I72_I0.6991.00
14_A18_F0.6991.00
42_V82_V0.6991.00
35_V79_A0.6981.00
27_I31_N0.6981.00
34_K38_E0.6961.00
55_N110_Y0.6941.00
137_F194_S0.6841.00
113_L120_S0.6831.00
34_K37_R0.6801.00
13_K17_K0.6771.00
4_A43_I0.6771.00
109_N112_G0.6721.00
121_S125_L0.6711.00
62_W113_L0.6701.00
155_G212_N0.6681.00
175_A179_K0.6661.00
84_V181_L0.6641.00
114_T118_G0.6571.00
28_V31_N0.6541.00
166_I199_L0.6531.00
58_P110_Y0.6511.00
201_D205_Y0.6511.00
167_S196_R0.6511.00
129_L188_G0.6501.00
22_K176_K0.6471.00
110_Y113_L0.6461.00
107_P116_L0.6461.00
90_L112_G0.6451.00
139_L172_N0.6421.00
216_E219_N0.6391.00
203_C207_S0.6381.00
35_V75_A0.6331.00
110_Y114_T0.6321.00
151_A159_K0.6321.00
152_S158_L0.6291.00
149_I210_F0.6261.00
35_V38_E0.6261.00
134_G167_S0.6251.00
49_I65_N0.6241.00
35_V43_I0.6241.00
69_A85_F0.6221.00
152_S206_L0.6211.00
14_A139_L0.6191.00
24_N42_V0.6171.00
160_C163_N0.6131.00
42_V84_V0.6121.00
43_I83_N0.6081.00
142_R146_F0.6061.00
22_K180_L0.6041.00
94_G108_L0.6031.00
65_N111_Y0.6001.00
19_L24_N0.6001.00
17_K172_N0.5981.00
88_S91_I0.5971.00
215_I218_D0.5951.00
46_T133_V0.5951.00
10_E14_A0.5951.00
87_S132_R0.5931.00
122_I130_V0.5931.00
50_P143_G0.5911.00
86_L131_L0.5911.00
173_T176_K0.5901.00
84_V182_I0.5881.00
174_L192_V0.5861.00
163_N218_D0.5841.00
184_K190_I0.5821.00
158_L216_E0.5821.00
35_V39_K0.5801.00
23_G26_I0.5771.00
129_L190_I0.5751.00
70_I125_L0.5711.00
97_G103_N0.5701.00
197_V205_Y0.5701.00
129_L187_R0.5701.00
138_S171_L0.5701.00
141_Y146_F0.5691.00
73_A77_S0.5681.00
151_A155_G0.5671.00
72_I76_G0.5671.00
91_I132_R0.5621.00
48_E65_N0.5621.00
84_V178_I0.5571.00
145_L202_I0.5571.00
8_E28_V0.5561.00
215_I221_Q0.5511.00
88_S115_K0.5481.00
15_I179_K0.5471.00
179_K182_I0.5471.00
217_I220_R0.5441.00
105_P120_S0.5431.00
29_V34_K0.5411.00
20_G23_G0.5391.00
66_T114_T0.5341.00
35_V76_G0.5331.00
16_A20_G0.5321.00
207_S216_E0.5301.00
125_L128_Y0.5301.00
148_F158_L0.5261.00
39_K79_A0.5251.00
16_A23_G0.5241.00
76_G79_A0.5221.00
160_C203_C0.5221.00
105_P189_V0.5201.00
145_L148_F0.5201.00
152_S210_F0.5191.00
168_I199_L0.5161.00
34_K40_P0.5141.00
159_K162_K0.5141.00
26_I31_N0.5141.00
87_S130_V0.5111.00
43_I81_S0.5081.00
214_V217_I0.5061.00
207_S210_F0.5061.00
5_V19_L0.5041.00
133_V136_L0.5031.00
83_N128_Y0.5031.00
127_N185_E0.5011.00
86_L89_F0.5001.00
19_L44_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3m2pA 2 0.9882 100 0.275 Contact Map
3sc6A 3 0.9961 100 0.276 Contact Map
1rkxA 3 0.9843 100 0.277 Contact Map
1vl0A 3 0.9922 100 0.281 Contact Map
3sxpA 3 0.9843 100 0.281 Contact Map
2pzmA 2 0.9882 100 0.283 Contact Map
2yy7A 2 0.9961 100 0.284 Contact Map
1sb8A 2 1 100 0.286 Contact Map
1n2sA 2 0.9922 100 0.289 Contact Map
1orrA 3 1 100 0.29 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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