GREMLIN Database
Q7LX43 - Dehydrogenase, putative
UniProt: Q7LX43 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 1000 (773)
Sequences: 2011 (1203)
Seq/√Len: 43.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
105_D108_N5.0641.00
339_N401_K5.0171.00
339_N402_V4.9051.00
148_I203_A4.8451.00
397_D429_T4.7321.00
101_N114_E4.5021.00
428_F433_V4.3311.00
102_V117_A4.3181.00
112_I202_K4.2831.00
103_T112_I4.1251.00
114_E202_K4.1091.00
111_A205_L3.9271.00
346_K392_N3.8531.00
18_E21_E3.8361.00
646_T829_E3.7021.00
168_S206_K3.6961.00
190_V198_G3.6191.00
171_E202_K3.5601.00
277_R280_L3.5501.00
387_Y425_G3.5351.00
628_Q657_K3.5091.00
222_N225_Q3.4341.00
699_T705_Y3.3841.00
825_V833_E3.3791.00
109_K131_L3.3761.00
17_D48_Y3.3591.00
440_R459_D3.3081.00
391_K426_K3.2931.00
763_I767_S3.2721.00
728_V736_K3.2641.00
131_L207_L3.2621.00
169_F181_R3.2581.00
795_M799_I3.2541.00
649_K832_A3.2161.00
110_M204_G3.1911.00
167_V191_C3.1661.00
6_E67_K3.0671.00
105_D110_M3.0361.00
58_I96_F3.0351.00
12_G54_S2.9811.00
55_V171_E2.9701.00
730_L828_I2.9661.00
61_V94_L2.8861.00
104_I125_Y2.8561.00
112_I204_G2.8361.00
795_M798_A2.8321.00
224_D228_H2.8091.00
746_N772_R2.7741.00
326_G340_L2.7091.00
647_A700_I2.6911.00
197_T442_Y2.6731.00
171_E179_L2.6641.00
6_E68_Y2.6151.00
171_E181_R2.6091.00
220_F229_A2.6051.00
218_I271_I2.6001.00
172_M198_G2.5971.00
50_A61_V2.5801.00
169_F204_G2.5411.00
482_F485_G2.5351.00
347_L392_N2.5241.00
174_N178_D2.5131.00
335_D402_V2.5001.00
275_S280_L2.4301.00
59_I179_L2.4061.00
278_S282_E2.3601.00
121_L124_I2.3431.00
62_V72_I2.3341.00
16_H21_E2.2811.00
65_G92_I2.2681.00
637_A644_A2.2681.00
259_K262_F2.2641.00
189_L442_Y2.2571.00
666_D704_D2.2491.00
332_R335_D2.2431.00
113_V144_V2.2391.00
102_V125_Y2.2391.00
224_D338_R2.1661.00
628_Q659_K2.1641.00
105_D204_G2.1571.00
800_G803_Y2.1501.00
51_Y98_K2.1291.00
59_I173_V2.1280.99
259_K263_E2.1220.99
123_D132_Q2.1120.99
236_E291_S2.0910.99
66_L449_E2.0720.99
15_F50_A2.0660.99
50_A92_I2.0600.99
667_S704_D2.0400.99
73_V91_G2.0250.99
109_K209_N2.0200.99
213_T216_M2.0100.99
587_P590_T2.0000.99
462_I466_A1.9960.99
425_G465_K1.9790.99
54_S99_M1.9710.99
193_A197_T1.9610.99
133_L163_I1.9550.99
746_N774_K1.9530.99
140_Y309_H1.9510.99
110_M168_S1.9310.99
63_R67_K1.9280.99
108_N204_G1.9270.99
566_I570_S1.9140.99
437_E440_R1.8860.99
71_P454_P1.8680.99
62_V452_F1.8580.99
228_H335_D1.8560.99
55_V179_L1.8530.99
94_L199_I1.8480.99
537_Y571_G1.8470.99
640_N643_V1.8420.99
117_A122_V1.8380.98
709_S732_L1.8350.98
381_V386_L1.8270.98
275_S281_V1.8170.98
387_Y465_K1.8060.98
228_H334_L1.7990.98
807_V830_F1.7910.98
283_P287_K1.7890.98
248_P266_K1.7890.98
43_N548_G1.7830.98
608_G793_D1.7700.98
648_L652_K1.7620.98
55_V201_A1.7510.98
103_T110_M1.7480.98
6_E10_L1.7420.98
730_L734_L1.7330.98
747_V830_F1.7250.98
55_V114_E1.7190.98
273_Y281_V1.7130.98
20_V545_F1.7110.98
120_K140_Y1.7080.98
380_P385_I1.7070.98
805_K825_V1.7030.98
103_T204_G1.7000.97
126_A207_L1.6900.97
182_L190_V1.6830.97
3_L7_L1.6780.97
4_E48_Y1.6780.97
335_D339_N1.6740.97
48_Y92_I1.6550.97
606_E610_E1.6510.97
347_L388_D1.6490.97
58_I94_L1.6290.97
241_W274_P1.6240.97
285_I288_I1.6190.97
173_V179_L1.6120.97
106_E109_K1.6090.96
189_L197_T1.6030.96
605_E610_E1.6010.96
735_L764_R1.5830.96
725_F729_P1.5820.96
152_A312_A1.5770.96
656_L737_S1.5750.96
286_Y290_Q1.5700.96
340_L344_L1.5420.95
5_E8_K1.5380.95
600_A604_P1.5380.95
282_E286_Y1.5260.95
481_R484_I1.5190.95
529_Y533_P1.5180.95
74_P96_F1.5130.95
127_Q210_F1.5020.95
212_P276_P1.5010.95
763_I775_K1.4920.95
391_K429_T1.4890.95
606_E609_V1.4870.95
125_Y128_Q1.4870.95
280_L284_K1.4820.94
749_L773_V1.4780.94
481_R485_G1.4750.94
289_A293_G1.4660.94
242_H305_W1.4660.94
684_M712_Y1.4580.94
391_K397_D1.4460.94
653_K832_A1.4440.94
642_A829_E1.4410.94
106_E110_M1.4350.93
436_Y440_R1.4270.93
671_D679_K1.4180.93
14_S57_D1.4100.93
96_F99_M1.4020.93
745_E833_E1.3940.92
566_I599_V1.3920.92
628_Q695_L1.3870.92
823_N829_E1.3830.92
366_E369_L1.3820.92
284_K287_K1.3800.92
104_I129_K1.3790.92
19_L22_R1.3700.92
570_S794_L1.3700.92
805_K830_F1.3690.92
712_Y720_G1.3600.91
605_E609_V1.3590.91
435_R438_V1.3570.91
367_V371_N1.3540.91
111_A122_V1.3530.91
468_L471_P1.3510.91
44_I418_K1.3500.91
440_R458_F1.3480.91
745_E805_K1.3450.91
461_K471_P1.3400.91
832_A835_L1.3390.91
4_E8_K1.3360.91
368_L371_N1.3360.91
590_T714_D1.3340.91
484_I830_F1.3310.90
461_K467_V1.3300.90
593_I677_G1.3260.90
124_I127_Q1.3200.90
58_I201_A1.3170.90
576_G587_P1.3170.90
687_N708_F1.3100.90
76_G143_T1.3070.90
120_K141_D1.2990.89
84_N424_M1.2870.89
747_V805_K1.2860.89
320_L368_L1.2730.88
450_E459_D1.2730.88
270_V304_W1.2710.88
573_H799_I1.2610.88
260_A263_E1.2540.88
681_L685_K1.2480.87
246_R251_S1.2440.87
126_A205_L1.2430.87
106_E129_K1.2430.87
96_F199_I1.2410.87
600_A605_E1.2400.87
685_K689_D1.2350.87
221_D225_Q1.2340.87
577_L581_V1.2320.87
199_I452_F1.2310.87
111_A126_A1.2240.86
58_I99_M1.2210.86
604_P610_E1.2200.86
12_G57_D1.2200.86
10_L64_L1.2190.86
601_K678_N1.2140.86
367_V372_A1.2140.86
13_D57_D1.2130.86
286_Y289_A1.2130.86
144_V148_I1.2110.86
72_I94_L1.2100.86
479_N484_I1.2080.86
612_S615_S1.2080.86
434_D437_E1.2070.86
595_L599_V1.2030.85
441_K444_E1.1990.85
647_A651_L1.1900.85
69_K449_E1.1880.85
656_L733_R1.1880.85
292_Y295_K1.1880.85
549_A564_S1.1840.84
148_I163_I1.1830.84
787_S791_R1.1790.84
61_V72_I1.1770.84
548_G551_A1.1720.84
605_E676_N1.1710.84
405_S430_E1.1710.84
554_E559_I1.1690.84
638_V664_S1.1650.83
341_E344_L1.1650.83
76_G96_F1.1650.83
480_F485_G1.1630.83
209_N276_P1.1620.83
10_L67_K1.1610.83
342_K346_K1.1580.83
56_E283_P1.1560.83
64_L68_Y1.1530.83
730_L831_L1.1530.83
117_A125_Y1.1520.83
796_A799_I1.1520.83
438_V441_K1.1520.83
747_V807_V1.1500.83
20_V24_S1.1490.83
77_R142_S1.1490.83
283_P286_Y1.1460.82
108_N112_I1.1450.82
747_V771_F1.1430.82
280_L283_P1.1410.82
444_E459_D1.1400.82
672_Y677_G1.1400.82
574_K592_L1.1400.82
21_E24_S1.1390.82
647_A730_L1.1380.82
56_E202_K1.1350.82
747_V773_V1.1310.82
748_N804_G1.1280.81
175_P451_I1.1260.81
479_N483_A1.1250.81
149_A193_A1.1240.81
70_I92_I1.1230.81
649_K653_K1.1220.81
683_K687_N1.1200.81
101_N764_R1.1190.81
652_K658_V1.1190.81
55_V99_M1.1170.81
418_K456_K1.1130.80
228_H338_R1.1110.80
697_I723_V1.1090.80
624_D627_S1.1080.80
55_V59_I1.1070.80
190_V200_I1.1060.80
169_F202_K1.1060.80
388_D392_N1.1000.80
603_L610_E1.0990.80
366_E371_N1.0980.80
705_Y727_V1.0910.79
701_T810_C1.0910.79
569_I592_L1.0870.79
96_F115_P1.0860.79
479_N482_F1.0850.79
213_T278_S1.0850.79
462_I465_K1.0840.79
597_S601_K1.0820.79
341_E353_D1.0810.79
630_I695_L1.0780.78
674_S787_S1.0750.78
627_S737_S1.0730.78
635_K704_D1.0730.78
349_E389_L1.0710.78
290_Q293_G1.0670.78
281_V285_I1.0650.77
344_L349_E1.0650.77
170_V191_C1.0620.77
795_M802_R1.0600.77
480_F483_A1.0540.77
100_T118_T1.0470.76
427_T436_Y1.0460.76
232_E235_R1.0400.76
111_A125_Y1.0390.76
6_E290_Q1.0380.76
397_D400_V1.0340.75
683_K686_Y1.0340.75
273_Y288_I1.0330.75
633_V661_I1.0320.75
513_S591_L1.0280.75
400_V429_T1.0260.75
474_Q482_F1.0210.74
597_S678_N1.0150.74
69_K451_I1.0100.74
749_L761_E1.0090.74
610_E613_L1.0070.73
300_E303_G1.0070.73
329_H332_R1.0040.73
63_R66_L1.0030.73
769_K831_L1.0020.73
633_V644_A1.0020.73
198_G452_F1.0000.73
172_M190_V1.0000.73
626_N657_K0.9990.73
125_Y129_K0.9980.73
631_L647_A0.9970.73
367_V370_V0.9960.73
557_G562_P0.9950.72
648_L660_V0.9950.72
406_L468_L0.9920.72
740_I743_S0.9900.72
366_E370_V0.9890.72
558_S562_P0.9880.72
113_V122_V0.9860.72
800_G820_V0.9840.72
21_E51_Y0.9840.72
701_T752_A0.9770.71
16_H51_Y0.9740.71
635_K666_D0.9730.71
823_N833_E0.9720.71
471_P474_Q0.9680.70
372_A382_D0.9640.70
588_I591_L0.9630.70
179_L201_A0.9620.70
659_K695_L0.9570.69
3_L65_G0.9550.69
579_D757_E0.9540.69
613_L616_D0.9540.69
817_F820_V0.9470.69
752_A810_C0.9450.68
629_F651_L0.9450.68
387_Y391_K0.9430.68
653_K835_L0.9420.68
7_L15_F0.9410.68
734_L765_R0.9410.68
635_K667_S0.9380.68
688_L692_N0.9380.68
62_V66_L0.9370.68
764_R767_S0.9340.68
224_D335_D0.9310.67
158_Y359_D0.9300.67
651_L698_I0.9270.67
332_R402_V0.9270.67
58_I199_I0.9260.67
349_E353_D0.9230.67
528_Q573_H0.9170.66
235_R291_S0.9160.66
600_A610_E0.9130.66
808_T815_A0.9130.66
6_E64_L0.9130.66
600_A606_E0.9120.66
119_W140_Y0.9120.66
687_N712_Y0.9110.66
729_P733_R0.9100.66
594_K598_L0.9100.66
432_G436_Y0.9080.65
171_E201_A0.9080.65
156_G160_Y0.9070.65
339_N342_K0.9070.65
648_L658_V0.9030.65
65_G72_I0.9020.65
602_K610_E0.9000.65
56_E59_I0.8990.65
772_R775_K0.8960.64
431_L439_I0.8920.64
342_K653_K0.8910.64
111_A207_L0.8900.64
155_I242_H0.8890.64
182_L188_A0.8890.64
133_L166_N0.8870.64
225_Q228_H0.8870.64
356_F413_A0.8860.63
461_K466_A0.8860.63
508_D511_D0.8830.63
459_D462_I0.8800.63
703_E810_C0.8780.63
560_D603_L0.8770.63
600_A603_L0.8770.63
427_T430_E0.8760.63
751_V756_S0.8760.63
287_K290_Q0.8750.62
595_L598_L0.8740.62
114_E171_E0.8730.62
441_K445_E0.8730.62
252_T255_A0.8720.62
647_A828_I0.8710.62
440_R460_P0.8710.62
299_G342_K0.8710.62
748_N806_V0.8650.62
294_G297_F0.8630.61
724_I727_V0.8620.61
340_L395_M0.8620.61
437_E441_K0.8600.61
3_L64_L0.8590.61
672_Y707_T0.8590.61
47_D91_G0.8560.61
159_E274_P0.8550.61
587_P591_L0.8540.61
170_V190_V0.8540.61
89_D92_I0.8520.60
102_V111_A0.8520.60
31_F517_I0.8510.60
168_S204_G0.8480.60
799_I802_R0.8440.60
381_V384_K0.8420.59
120_K139_S0.8420.59
74_P199_I0.8380.59
289_A292_Y0.8370.59
433_V437_E0.8350.59
634_G810_C0.8330.59
3_L15_F0.8310.58
560_D564_S0.8300.58
24_S534_Q0.8300.58
630_I690_A0.8280.58
631_L700_I0.8270.58
31_F442_Y0.8270.58
569_I588_I0.8270.58
806_V817_F0.8250.58
606_E611_L0.8230.58
104_I111_A0.8230.58
721_T725_F0.8230.58
368_L382_D0.8230.58
102_V121_L0.8220.58
407_L416_Y0.8210.58
726_E729_P0.8210.58
318_Q514_L0.8200.57
610_E614_F0.8200.57
565_V568_E0.8190.57
440_R444_E0.8190.57
49_V93_L0.8190.57
634_G701_T0.8180.57
136_F156_G0.8170.57
69_K739_V0.8160.57
248_P252_T0.8160.57
104_I126_A0.8160.57
64_L70_I0.8140.57
151_D164_S0.8140.57
81_R312_A0.8140.57
198_G201_A0.8130.57
315_L517_I0.8120.57
611_L614_F0.8120.57
392_N622_V0.8110.57
713_K721_T0.8110.57
728_V732_L0.8100.57
692_N722_E0.8090.56
62_V94_L0.8070.56
171_E240_A0.8040.56
662_G693_N0.8030.56
10_L60_N0.8030.56
784_L815_A0.8000.56
285_I297_F0.7980.55
289_A297_F0.7970.55
134_R166_N0.7940.55
234_Y240_A0.7940.55
106_E131_L0.7940.55
627_S656_L0.7940.55
112_I772_R0.7930.55
646_T832_A0.7900.55
381_V385_I0.7890.55
525_V575_C0.7890.55
93_L172_M0.7880.54
47_D73_V0.7880.54
293_G296_V0.7870.54
162_F361_A0.7860.54
542_M810_C0.7850.54
159_E241_W0.7840.54
467_V474_Q0.7840.54
396_M406_L0.7840.54
181_R202_K0.7840.54
716_S719_A0.7790.54
418_K461_K0.7790.54
119_W147_G0.7780.53
321_L419_N0.7770.53
316_R371_N0.7760.53
646_T649_K0.7760.53
321_L369_L0.7740.53
549_A595_L0.7740.53
593_I672_Y0.7740.53
240_A273_Y0.7720.53
384_K388_D0.7700.53
728_V733_R0.7680.53
343_A389_L0.7670.52
175_P452_F0.7670.52
791_R794_L0.7670.52
339_N346_K0.7660.52
631_L658_V0.7650.52
470_I474_Q0.7650.52
102_V152_A0.7630.52
534_Q537_Y0.7630.52
380_P384_K0.7630.52
3_L6_E0.7620.52
62_V199_I0.7620.52
296_V342_K0.7620.52
643_V829_E0.7600.52
549_A562_P0.7590.52
751_V761_E0.7580.52
339_N398_E0.7570.51
97_S143_T0.7560.51
602_K605_E0.7560.51
624_D657_K0.7560.51
528_Q542_M0.7540.51
67_K288_I0.7530.51
537_Y567_A0.7520.51
479_N485_G0.7500.51
328_I336_L0.7500.51
283_P653_K0.7470.51
279_P286_Y0.7460.50
356_F363_E0.7460.50
62_V173_V0.7430.50
285_I292_Y0.7410.50
3_L48_Y0.7410.50
124_I293_G0.7390.50
55_V173_V0.7390.50
167_V170_V0.7370.50
61_V64_L0.7360.49
705_Y807_V0.7360.49
766_L771_F0.7350.49
237_V240_A0.7350.49
721_T724_I0.7350.49
741_D834_K0.7340.49
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157_S790_K0.5040.29
308_N780_S0.5030.29
200_I203_A0.5030.29
24_S544_D0.5030.29
167_V205_L0.5020.29
22_R144_V0.5020.29
203_A352_S0.5020.29
290_Q623_N0.5020.29
690_A768_E0.5020.29
730_L738_I0.5010.29
817_F824_A0.5010.29
529_Y575_C0.5010.29
117_A650_I0.5010.29
441_K679_K0.5000.28
244_Q417_A0.5000.28
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1f0xA 1 0.415 100 0.732 Contact Map
3pm9A 5 0.434 100 0.733 Contact Map
2uuuA 2 0.42 100 0.737 Contact Map
4bbyA 2 0.436 100 0.75 Contact Map
2exrA 1 0.411 100 0.758 Contact Map
1wvfA 2 0.431 100 0.762 Contact Map
1w1oA 1 0.397 100 0.772 Contact Map
1e8gA 5 0.436 100 0.773 Contact Map
4o95A 1 0.39 100 0.776 Contact Map
4mlaA 1 0.404 100 0.782 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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