GREMLIN Database
Q7LX34 - Transposase ISC1058
UniProt: Q7LX34 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 299 (281)
Sequences: 319 (192)
Seq/√Len: 11.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
191_D219_R3.0170.95
17_V20_R2.8910.94
284_V288_N2.8400.93
251_S255_R2.8060.93
170_T195_V2.5060.88
17_V21_Y2.4890.87
257_F276_K2.4810.87
272_E281_A2.4510.87
10_W13_Y2.4010.85
241_G244_W2.2860.82
51_P54_F2.2670.82
71_E89_Y2.2120.80
240_Y247_E2.2080.80
12_K35_D2.1880.79
16_N287_A2.1270.77
142_K166_S2.1140.77
28_Y33_W2.1110.77
253_V261_V2.1040.77
39_E42_R2.0950.76
121_T139_K2.0760.76
208_K211_S2.0490.75
219_R234_W2.0370.74
14_D89_Y1.9960.73
284_V287_A1.9760.72
145_I250_F1.9750.72
154_V280_Y1.9450.71
60_F279_A1.9120.69
65_L193_N1.8980.69
244_W250_F1.8820.68
159_V253_V1.8520.67
24_M206_P1.8510.67
130_A135_T1.8250.65
42_R46_T1.8040.64
240_Y243_R1.7550.62
140_F144_E1.7500.62
247_E272_E1.7390.61
242_V289_S1.7340.61
124_G241_G1.7060.60
112_V155_I1.6920.59
125_G181_V1.6770.59
243_R247_E1.6750.58
94_K160_T1.6550.58
88_D91_T1.6500.57
159_V273_A1.6370.57
116_A166_S1.6350.57
156_N200_V1.6350.57
13_Y20_R1.6260.56
147_M246_V1.6140.56
52_K55_D1.6010.55
92_I185_Y1.5970.55
33_W57_F1.5960.55
111_E250_F1.5950.55
119_I159_V1.5900.54
156_N173_D1.5550.53
191_D234_W1.5470.52
249_L252_A1.5450.52
216_H220_R1.5420.52
15_E19_T1.5200.51
55_D95_R1.5150.51
266_F270_V1.5090.50
42_R47_K1.4940.50
113_I149_N1.4900.49
134_K260_S1.4870.49
69_A160_T1.4760.49
34_W57_F1.4740.49
185_Y203_V1.4640.48
159_V270_V1.4620.48
213_K241_G1.4480.47
192_A195_V1.4330.47
146_V150_N1.4310.47
202_V222_A1.4260.46
284_V289_S1.4200.46
90_S233_R1.4150.46
206_P210_A1.3660.43
88_D202_V1.3620.43
122_N139_K1.3540.43
252_A280_Y1.3510.43
169_K172_K1.3430.42
51_P59_A1.3390.42
152_F249_L1.3380.42
31_E40_E1.3350.42
76_A127_Y1.3340.42
13_Y17_V1.3330.42
123_T126_Q1.3300.42
114_A174_L1.3200.41
166_S281_A1.3200.41
95_R234_W1.3110.41
191_D207_K1.3010.40
265_S268_G1.3000.40
81_K143_I1.3000.40
273_A284_V1.2940.40
63_I83_I1.2870.40
67_Y80_L1.2820.39
29_V202_V1.2820.39
95_R191_D1.2810.39
161_S246_V1.2790.39
11_S29_V1.2730.39
34_W41_N1.2700.39
102_T236_E1.2660.39
195_V213_K1.2590.38
212_T223_V1.2530.38
6_Y14_D1.2470.38
52_K145_I1.2460.38
259_E276_K1.2440.38
188_K207_K1.2400.38
128_I235_R1.2370.37
29_V33_W1.2290.37
264_T289_S1.2270.37
119_I273_A1.2250.37
151_E241_G1.2220.37
76_A95_R1.2130.36
65_L149_N1.2090.36
52_K95_R1.2050.36
232_D235_R1.1990.36
114_A139_K1.1930.35
8_R33_W1.1880.35
148_D189_T1.1870.35
33_W40_E1.1860.35
50_A108_D1.1770.35
111_E149_N1.1660.34
58_L74_L1.1640.34
74_L155_I1.1580.34
19_T25_F1.1560.34
39_E47_K1.1520.34
124_G242_V1.1480.33
6_Y155_I1.1430.33
24_M50_A1.1420.33
6_Y16_N1.1410.33
162_N224_R1.1380.33
73_V210_A1.1320.33
19_T90_S1.1070.32
45_R54_F1.1040.31
129_V135_T1.1000.31
83_I117_T1.0950.31
112_V150_N1.0950.31
144_E160_T1.0930.31
139_K162_N1.0920.31
57_F261_V1.0890.31
247_E281_A1.0890.31
127_Y144_E1.0870.31
43_N184_F1.0870.31
124_G128_I1.0830.31
28_Y31_E1.0800.30
16_N288_N1.0720.30
269_Q281_A1.0720.30
229_L233_R1.0710.30
24_M60_F1.0610.30
205_P269_Q1.0600.30
56_E96_V1.0480.29
9_D21_Y1.0470.29
95_R219_R1.0450.29
243_R254_K1.0430.29
107_S164_V1.0430.29
204_V207_K1.0410.29
48_Y242_V1.0370.29
245_R249_L1.0340.29
36_L49_K1.0260.28
270_V279_A1.0240.28
18_I71_E1.0230.28
33_W36_L1.0220.28
90_S209_N1.0220.28
128_I135_T1.0220.28
247_E254_K1.0190.28
225_E229_L1.0160.28
159_V225_E1.0150.28
16_N284_V0.9970.27
185_Y285_H0.9810.27
114_A161_S0.9800.26
6_Y104_P0.9790.26
43_N46_T0.9790.26
11_S39_E0.9770.26
274_K277_F0.9760.26
152_F252_A0.9740.26
86_S141_L0.9730.26
24_M143_I0.9720.26
165_E168_V0.9670.26
30_F47_K0.9660.26
118_G142_K0.9630.26
16_N117_T0.9620.26
75_R208_K0.9610.26
23_L31_E0.9600.26
137_D219_R0.9530.25
148_D207_K0.9520.25
19_T22_K0.9490.25
248_S251_S0.9490.25
116_A173_D0.9390.25
140_F205_P0.9380.25
184_F195_V0.9340.25
114_A285_H0.9330.25
29_V38_A0.9160.24
132_W140_F0.9140.24
7_K226_F0.9100.24
29_V34_W0.9040.24
184_F200_V0.9030.24
25_F90_S0.8960.23
49_K154_V0.8950.23
114_A170_T0.8920.23
12_K38_A0.8920.23
111_E289_S0.8820.23
89_Y143_I0.8740.23
174_L263_A0.8740.23
128_I245_R0.8720.23
11_S229_L0.8710.23
111_E124_G0.8640.22
232_D236_E0.8630.22
29_V40_E0.8610.22
199_G221_K0.8540.22
280_Y283_M0.8530.22
152_F257_F0.8510.22
123_T154_V0.8490.22
73_V97_R0.8440.22
14_D90_S0.8380.21
31_E261_V0.8330.21
71_E75_R0.8240.21
23_L73_V0.8240.21
13_Y115_D0.8240.21
184_F202_V0.8230.21
107_S246_V0.8200.21
274_K284_V0.8200.21
144_E166_S0.8190.21
16_N62_H0.8180.21
62_H202_V0.8180.21
273_A287_A0.8170.21
15_E91_T0.8170.21
9_D17_V0.8150.21
127_Y140_F0.8140.21
90_S214_R0.8070.20
273_A285_H0.8070.20
118_G140_F0.8030.20
8_R18_I0.7960.20
39_E197_K0.7950.20
172_K208_K0.7830.20
181_V268_G0.7810.20
175_Q180_K0.7810.20
119_I261_V0.7790.20
90_S219_R0.7790.20
70_I227_R0.7750.19
8_R58_L0.7750.19
269_Q272_E0.7740.19
143_I206_P0.7730.19
248_S289_S0.7730.19
109_E245_R0.7570.19
18_I35_D0.7530.19
97_R265_S0.7520.19
120_S132_W0.7510.19
24_M33_W0.7490.19
25_F58_L0.7480.19
119_I252_A0.7450.19
86_S165_E0.7410.18
228_K265_S0.7390.18
72_G95_R0.7360.18
152_F248_S0.7340.18
35_D38_A0.7320.18
25_F83_I0.7300.18
167_A229_L0.7260.18
241_G253_V0.7260.18
214_R267_A0.7240.18
203_V285_H0.7190.18
207_K245_R0.7170.18
97_R267_A0.7150.18
72_G206_P0.7150.18
31_E83_I0.7130.18
20_R219_R0.7120.18
72_G126_Q0.7100.18
243_R258_G0.7080.17
195_V241_G0.7060.17
80_L286_L0.7060.17
280_Y284_V0.7060.17
50_A121_T0.7050.17
206_P226_F0.7040.17
66_P69_A0.7020.17
242_V248_S0.7010.17
81_K256_T0.6960.17
240_Y254_K0.6960.17
58_L249_L0.6960.17
263_A275_L0.6940.17
104_P216_H0.6930.17
280_Y289_S0.6920.17
245_R248_S0.6890.17
252_A261_V0.6860.17
42_R266_F0.6840.17
100_K117_T0.6820.17
253_V257_F0.6810.17
271_V274_K0.6800.17
91_T148_D0.6780.17
99_M172_K0.6770.17
15_E200_V0.6760.17
72_G127_Y0.6740.17
160_T266_F0.6730.16
51_P55_D0.6710.16
134_K233_R0.6710.16
163_E226_F0.6690.16
57_F259_E0.6650.16
74_L262_R0.6630.16
248_S266_F0.6630.16
186_G238_K0.6630.16
136_R241_G0.6610.16
7_K34_W0.6570.16
92_I246_V0.6570.16
128_I134_K0.6560.16
92_I175_Q0.6560.16
49_K172_K0.6550.16
16_N286_L0.6550.16
123_T132_W0.6540.16
32_H35_D0.6520.16
278_W282_W0.6510.16
83_I154_V0.6480.16
106_A204_V0.6470.16
21_Y234_W0.6470.16
109_E160_T0.6470.16
86_S133_G0.6460.16
100_K163_E0.6440.16
199_G225_E0.6400.16
181_V257_F0.6400.16
122_N136_R0.6400.16
8_R134_K0.6390.16
22_K25_F0.6390.16
107_S190_Y0.6380.16
243_R272_E0.6370.16
30_F34_W0.6360.16
41_N61_L0.6330.15
82_I92_I0.6330.15
189_T250_F0.6310.15
262_R275_L0.6280.15
120_S126_Q0.6250.15
141_L252_A0.6240.15
153_N158_E0.6230.15
133_G188_K0.6220.15
130_A136_R0.6220.15
253_V276_K0.6220.15
146_V238_K0.6210.15
74_L83_I0.6190.15
167_A263_A0.6150.15
39_E48_Y0.6120.15
132_W195_V0.6100.15
165_E244_W0.6080.15
125_G207_K0.6080.15
11_S232_D0.6060.15
56_E104_P0.6050.15
107_S223_V0.6050.15
92_I109_E0.6030.15
115_D118_G0.5990.15
50_A191_D0.5960.15
159_V261_V0.5950.14
120_S140_F0.5940.14
123_T141_L0.5910.14
265_S285_H0.5900.14
51_P181_V0.5880.14
261_V273_A0.5870.14
218_A262_R0.5870.14
18_I75_R0.5870.14
20_R234_W0.5840.14
44_A70_I0.5830.14
10_W20_R0.5820.14
50_A57_F0.5810.14
72_G76_A0.5790.14
119_I253_V0.5780.14
80_L276_K0.5760.14
100_K202_V0.5760.14
115_D131_K0.5760.14
279_A283_M0.5760.14
98_N228_K0.5730.14
262_R277_F0.5730.14
128_I185_Y0.5710.14
7_K114_A0.5710.14
115_D190_Y0.5680.14
241_G276_K0.5680.14
147_M286_L0.5670.14
235_R253_V0.5670.14
62_H145_I0.5650.14
50_A268_G0.5610.14
240_Y272_E0.5600.14
133_G141_L0.5590.14
12_K100_K0.5590.14
22_K51_P0.5580.14
161_S164_V0.5530.13
28_Y157_A0.5520.13
126_Q287_A0.5520.13
72_G125_G0.5510.13
9_D20_R0.5510.13
145_I152_F0.5510.13
229_L237_E0.5480.13
18_I25_F0.5450.13
186_G228_K0.5450.13
137_D191_D0.5410.13
29_V32_H0.5360.13
70_I186_G0.5360.13
89_Y94_K0.5360.13
83_I236_E0.5360.13
206_P219_R0.5350.13
115_D187_D0.5340.13
72_G77_L0.5330.13
109_E180_K0.5310.13
145_I183_K0.5290.13
65_L210_A0.5280.13
188_K191_D0.5270.13
80_L93_W0.5270.13
68_R259_E0.5270.13
90_S164_V0.5270.13
61_L167_A0.5260.13
269_Q280_Y0.5260.13
9_D13_Y0.5250.13
64_F250_F0.5250.13
98_N225_E0.5240.13
140_F173_D0.5240.13
153_N165_E0.5230.13
123_T252_A0.5230.13
212_T215_G0.5200.13
41_N154_V0.5200.13
93_W145_I0.5190.13
61_L136_R0.5170.13
213_K217_L0.5150.13
117_T191_D0.5150.13
58_L92_I0.5140.13
59_A96_V0.5130.13
164_V277_F0.5130.13
274_K282_W0.5080.12
121_T226_F0.5030.12
80_L124_G0.5020.12
73_V265_S0.5010.12
16_N36_L0.5000.12
61_L275_L0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1musA 2 0.8629 96.9 0.931 Contact Map
4fcyA 4 0.8528 86.8 0.953 Contact Map
4fw1A 2 0.5117 53.8 0.964 Contact Map
1cxqA 2 0.4448 40 0.967 Contact Map
4u7bA 2 0.8763 37.4 0.967 Contact Map
4mq3A 1 0.4181 30.6 0.969 Contact Map
1bcoA 1 0.5686 23.5 0.97 Contact Map
3l3uA 2 0.4682 19.3 0.972 Contact Map
1c6vA 4 0.4548 17.7 0.972 Contact Map
1k6yA 4 0.592 12.7 0.974 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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