CARB - SULSO - GREMLIN Contacts

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CARB - Carbamoyl-phosphate synthase large chain

UniProt:	Q59969	Sequences: MRETPKKVLVIGSGPIKIAEAAEFDYSGSQALKALKEEGIETVLVNSNVATVQTSKKFADKLYMLPVVWWAVEKVIEKERPDGIMIGFGGQTALNVGVDLHKKGVLQKYNVKVLGTQIDGIEKALSREKFRETMIENNLPVPPSLSARSEEEAIKNAKIVGYPVMVRVSFNLGGRGSMVAWTEEDLKKNIRRALSQSYIGEVLLEKYLYHWIELEYEVMRDKKGNSAVIACIENLDPMGVHTGESTVVAPCQTLDNLEYQNMRTYTIEVARSINLIGECNVQFALNPRGYEYYIIETNPRMSRSSALASKATGYPLAYVSAKLALGYELHEVINKVSGRTCACFEPSLDYIVTKIPRWDLSKFENVDQSLATEMMSVGEVMSIGRSFEESLQKAIRMLDIGEPGVVGGKVYESNMSKEEALKYLKERRPYWFLYAAKAFKEGATINEVYEVTGINEFFLNKIKGLVDFYETLRKLKEIDKETLKLAKKLGFSDEQISKALNKSTEYVRKIRYETNTIPVVKLIDTLAGEWPAVTNYMYLTYNGTEDDIEFSQGNKLLIIGAGGFRIGVSVEFDWSVVSLMEAGSKYFDEVAVLNYNPETVSTDWDIARKLYFDEISVERVLDLIKKEKFRYVATFSGGQIGNSIAKELEENGVRLLGTSGSSVDIAENREKFSKLLDKLGISQPDWISATSLGEIKKFANEVGFPVLVRPSYVLSGSSMKIAYSEEELYEYVRRATEISPKYPVVISKYIENAIEAEIDGVSDGNKVLGITLEHIEEAGVHSGDATMSIPFRKLSENNVNRMRENVLNIARELNIKGPFNVQFVVKENTPYIIELNLRASRSMPFSSKAKGINLINESMKAIFDGLDFSEDYYEPPSKYWAVKSAQFSWSQLRGAYPFLGPEMKSTGEAASFGVTFYDALLKSWLSSMPNRIPNKNGIALVYGNKNLDYLKDTADNLTRFGLTVYSISELPLQDIETIDKMKAEELVRAKKVEIIVTDGYLKKFDYNIRRTAVDYNIPIILNGRLGYEVSKAFLNYDSLTFFEISEYGGGI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	1051 (1029)
Sequences:	2853 (1170)
Seq/√Len:	36.5

ECOLI - CARB
BACSU - CARB CARY
HALSA - CARB
SULSO - CARB

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
353_T	390_S	6.972	1.00
463_K	467_D	5.543	1.00
224_G	271_R	4.725	1.00
7_K	41_E	4.581	1.00
7_K	43_V	4.556	1.00
286_N	289_G	4.461	1.00
557_L	593_L	4.389	1.00
700_N	725_E	4.366	1.00
102_K	122_E	4.268	1.00
80_R	109_Y	4.248	1.00
678_K	812_E	4.237	1.00
67_V	96_V	4.226	1.00
661_S	671_K	4.085	1.00
860_K	865_G	4.067	1.00
940_L	954_A	3.843	1.00
554_N	630_R	3.664	1.00
153_A	190_I	3.640	1.00
190_I	202_V	3.606	1.00
617_V	621_L	3.556	1.00
437_K	441_E	3.504	1.00
136_E	272_S	3.383	1.00
396_R	619_R	3.362	1.00
216_Y	231_C	3.360	1.00
286_N	291_E	3.358	1.00
913_G	918_D	3.352	1.00
8_V	40_I	3.327	1.00
546_D	626_K	3.261	1.00
937_G	963_T	3.201	1.00
804_E	808_N	3.179	1.00
792_R	880_W	3.172	1.00
73_E	108_K	3.128	1.00
765_N	866_L	3.104	1.00
262_M	292_Y	3.081	1.00
235_L	462_I	3.045	1.00
956_N	1034_L	3.030	1.00
435_A	448_V	3.029	1.00
231_C	251_C	3.028	1.00
77_E	109_Y	3.009	1.00
76_I	109_Y	2.995	1.00
439_F	459_L	2.981	1.00
143_P	206_K	2.955	1.00
866_L	869_S	2.908	1.00
706_V	746_I	2.894	1.00
593_L	623_L	2.889	1.00
40_I	325_L	2.888	1.00
468_F	489_L	2.879	1.00
512_Y	625_K	2.856	1.00
73_E	77_E	2.824	1.00
158_K	183_E	2.823	1.00
154_I	187_K	2.808	1.00
696_K	729_Y	2.781	1.00
796_E	800_N	2.766	1.00
865_G	869_S	2.749	1.00
41_E	61_K	2.740	1.00
761_V	861_A	2.728	1.00
73_E	109_Y	2.696	1.00
760_G	806_V	2.669	1.00
446_N	456_E	2.656	1.00
128_E	132_E	2.582	1.00
439_F	445_I	2.571	1.00
8_V	325_L	2.568	1.00
557_L	624_I	2.561	1.00
391_L	432_F	2.530	1.00
183_E	187_K	2.530	1.00
147_A	156_N	2.525	1.00
421_L	447_E	2.523	1.00
687_I	701_E	2.518	1.00
704_F	725_E	2.490	1.00
884_S	923_S	2.470	1.00
480_K	484_K	2.459	1.00
388_E	461_K	2.447	1.00
149_S	152_E	2.420	1.00
944_N	947_L	2.389	1.00
72_V	96_V	2.375	1.00
157_A	162_Y	2.372	1.00
384_G	389_E	2.360	1.00
682_S	805_N	2.357	1.00
45_V	75_V	2.333	1.00
866_L	870_E	2.333	1.00
484_K	488_K	2.325	1.00
585_K	856_N	2.317	0.99
624_I	653_V	2.312	0.99
807_L	811_R	2.297	0.99
69_W	99_D	2.282	0.99
687_I	698_F	2.274	0.99
73_E	103_K	2.271	0.99
724_S	727_E	2.267	0.99
957_L	1030_S	2.266	0.99
139_L	268_E	2.255	0.99
416_S	419_E	2.247	0.99
471_T	485_L	2.247	0.99
799_V	876_P	2.238	0.99
857_E	870_E	2.229	0.99
270_A	281_V	2.212	0.99
216_Y	251_C	2.203	0.99
553_G	589_E	2.196	0.99
206_K	291_E	2.171	0.99
37_E	322_K	2.157	0.99
503_S	506_Y	2.155	0.99
662_S	814_N	2.148	0.99
996_V	1026_G	2.148	0.99
140_P	291_E	2.145	0.99
937_G	965_Y	2.129	0.99
443_A	447_E	2.125	0.99
735_A	739_S	2.123	0.99
392_Q	491_F	2.122	0.99
162_Y	183_E	2.105	0.99
482_T	486_A	2.103	0.99
551_S	589_E	2.102	0.99
801_R	804_E	2.101	0.99
508_R	621_L	2.086	0.99
148_R	201_E	2.079	0.99
557_L	623_L	2.069	0.99
505_E	650_E	2.061	0.99
368_Q	429_P	2.050	0.99
439_F	448_V	2.048	0.99
417_K	441_E	2.041	0.99
139_L	265_Y	2.039	0.99
145_L	159_I	2.038	0.99
769_G	854_L	2.031	0.99
696_K	725_E	2.030	0.99
373_E	891_Q	2.022	0.99
74_K	77_E	2.018	0.99
681_I	805_N	2.018	0.99
649_E	661_S	2.012	0.99
69_W	103_K	2.002	0.98
98_V	118_I	2.001	0.98
756_A	794_L	1.992	0.98
388_E	464_G	1.985	0.98
725_E	729_Y	1.966	0.98
766_K	868_F	1.965	0.98
285_L	292_Y	1.963	0.98
445_I	459_L	1.960	0.98
664_D	712_Y	1.959	0.98
269_V	294_I	1.956	0.98
162_Y	182_T	1.955	0.98
240_V	427_R	1.945	0.98
958_T	971_P	1.945	0.98
435_A	454_I	1.926	0.98
646_K	650_E	1.923	0.98
611_Y	627_E	1.921	0.98
797_N	828_N	1.912	0.98
685_D	701_E	1.908	0.98
664_D	671_K	1.907	0.98
512_Y	517_I	1.906	0.98
38_E	322_K	1.893	0.98
157_A	164_V	1.893	0.98
691_S	694_E	1.890	0.98
73_E	105_V	1.888	0.98
148_R	152_E	1.886	0.98
510_I	514_T	1.878	0.98
76_I	111_V	1.877	0.98
169_S	201_E	1.871	0.98
182_T	185_D	1.868	0.98
64_M	910_A	1.855	0.97
586_Y	860_K	1.850	0.97
180_A	189_N	1.849	0.97
77_E	108_K	1.848	0.97
735_A	744_V	1.848	0.97
974_D	977_T	1.845	0.97
946_N	998_D	1.841	0.97
762_S	811_R	1.825	0.97
145_L	156_N	1.819	0.97
758_I	806_V	1.811	0.97
493_D	511_R	1.808	0.97
981_M	985_E	1.804	0.97
697_K	701_E	1.803	0.97
45_V	72_V	1.801	0.97
517_I	625_K	1.798	0.97
585_K	860_K	1.797	0.97
682_S	829_T	1.797	0.97
101_H	118_I	1.797	0.97
251_C	259_Y	1.795	0.97
149_S	200_G	1.790	0.97
970_L	977_T	1.785	0.97
444_T	447_E	1.778	0.97
449_Y	459_L	1.769	0.97
470_E	473_R	1.769	0.97
995_I	1012_A	1.767	0.97
7_K	61_K	1.759	0.97
730_E	734_R	1.750	0.96
475_L	479_D	1.737	0.96
675_L	809_I	1.722	0.96
689_A	698_F	1.721	0.96
439_F	462_I	1.716	0.96
736_T	744_V	1.706	0.96
122_E	129_K	1.703	0.96
194_L	200_G	1.700	0.96
756_A	825_V	1.698	0.96
133_T	272_S	1.688	0.96
386_S	542_N	1.685	0.96
166_V	202_V	1.674	0.95
756_A	802_M	1.671	0.95
556_L	656_L	1.670	0.95
380_V	397_M	1.664	0.95
801_R	805_N	1.654	0.95
166_V	204_L	1.651	0.95
436_A	440_K	1.646	0.95
795_S	798_N	1.642	0.95
101_H	107_Q	1.638	0.95
1010_R	1014_D	1.629	0.95
735_A	738_I	1.628	0.95
509_K	513_E	1.621	0.94
181_W	185_D	1.619	0.94
617_V	647_E	1.618	0.94
403_P	498_K	1.618	0.94
436_A	462_I	1.613	0.94
131_R	135_I	1.601	0.94
795_S	828_N	1.595	0.94
718_S	735_A	1.590	0.94
685_D	748_K	1.584	0.94
760_G	819_F	1.583	0.94
424_L	438_A	1.579	0.94
532_A	535_N	1.571	0.93
675_L	812_E	1.567	0.93
222_K	328_E	1.562	0.93
123_K	272_S	1.562	0.93
387_F	457_F	1.561	0.93
583_G	590_V	1.559	0.93
586_Y	863_F	1.556	0.93
69_W	72_V	1.553	0.93
465_L	491_F	1.547	0.93
273_I	297_T	1.545	0.93
479_D	482_T	1.542	0.93
464_G	489_L	1.542	0.93
483_L	510_I	1.539	0.93
682_S	801_R	1.533	0.93
162_Y	186_L	1.529	0.93
84_I	111_V	1.529	0.93
975_I	986_L	1.527	0.92
554_N	588_D	1.525	0.92
504_T	508_R	1.522	0.92
791_F	799_V	1.516	0.92
223_K	328_E	1.512	0.92
510_I	513_E	1.508	0.92
166_V	186_L	1.507	0.92
617_V	651_N	1.505	0.92
673_S	683_Q	1.504	0.92
825_V	830_P	1.502	0.92
947_L	969_E	1.499	0.92
216_Y	266_T	1.496	0.92
915_T	918_D	1.492	0.92
801_R	830_P	1.486	0.91
496_I	500_L	1.479	0.91
258_E	290_Y	1.479	0.91
69_W	96_V	1.478	0.91
71_A	75_V	1.475	0.91
963_T	973_Q	1.475	0.91
798_N	830_P	1.474	0.91
630_R	654_R	1.469	0.91
235_L	246_T	1.469	0.91
756_A	830_P	1.467	0.91
965_Y	992_V	1.461	0.91
583_G	863_F	1.458	0.91
105_V	109_Y	1.455	0.90
761_V	854_L	1.455	0.90
522_L	537_M	1.455	0.90
391_L	405_V	1.451	0.90
987_V	1017_I	1.450	0.90
507_V	510_I	1.450	0.90
147_A	153_A	1.441	0.90
798_N	825_V	1.439	0.90
786_T	884_S	1.438	0.90
319_V	335_K	1.435	0.90
633_A	859_M	1.434	0.90
443_A	448_V	1.433	0.90
512_Y	622_D	1.428	0.90
671_K	712_Y	1.426	0.90
449_Y	453_G	1.420	0.89
798_N	828_N	1.417	0.89
417_K	447_E	1.413	0.89
147_A	152_E	1.411	0.89
421_L	443_A	1.410	0.89
4_T	112_K	1.408	0.89
556_L	863_F	1.408	0.89
805_N	830_P	1.407	0.89
468_F	486_A	1.400	0.89
865_G	870_E	1.395	0.89
800_N	803_R	1.394	0.88
99_D	102_K	1.391	0.88
142_P	293_Y	1.390	0.88
662_S	665_I	1.390	0.88
472_L	486_A	1.388	0.88
665_I	812_E	1.377	0.88
439_F	463_K	1.373	0.88
859_M	863_F	1.372	0.88
86_I	97_G	1.369	0.88
942_Y	950_L	1.369	0.88
132_E	136_E	1.367	0.87
421_L	451_V	1.358	0.87
235_L	435_A	1.357	0.87
521_K	545_E	1.345	0.87
395_I	432_F	1.344	0.87
551_S	555_K	1.340	0.86
150_E	186_L	1.339	0.86
67_V	72_V	1.338	0.86
440_K	469_Y	1.338	0.86
494_E	504_T	1.336	0.86
801_R	829_T	1.333	0.86
632_V	653_V	1.332	0.86
480_K	514_T	1.322	0.86
676_L	832_I	1.318	0.85
962_L	1033_F	1.318	0.85
339_R	533_V	1.317	0.85
699_A	704_F	1.316	0.85
681_I	830_P	1.314	0.85
762_S	767_V	1.313	0.85
255_D	258_E	1.311	0.85
478_I	483_L	1.302	0.85
806_V	823_F	1.298	0.85
68_V	71_A	1.293	0.84
465_L	489_L	1.292	0.84
517_I	622_D	1.289	0.84
956_N	1030_S	1.284	0.84
403_P	494_E	1.271	0.83
555_K	589_E	1.270	0.83
674_K	678_K	1.269	0.83
556_L	583_G	1.269	0.83
9_L	84_I	1.265	0.83
261_N	285_L	1.263	0.83
468_F	482_T	1.261	0.83
502_K	506_Y	1.260	0.83
38_E	327_Y	1.258	0.83
979_D	982_K	1.256	0.83
155_K	158_K	1.256	0.83
461_K	464_G	1.254	0.82
590_V	863_F	1.252	0.82
157_A	186_L	1.250	0.82
621_L	653_V	1.250	0.82
472_L	499_A	1.248	0.82
673_S	686_W	1.248	0.82
502_K	507_V	1.246	0.82
633_A	862_I	1.241	0.82
809_I	821_V	1.236	0.82
420_A	448_V	1.236	0.82
235_L	248_V	1.235	0.82
443_A	451_V	1.235	0.82
123_K	136_E	1.230	0.81
392_Q	465_L	1.227	0.81
150_E	154_I	1.218	0.81
548_I	626_K	1.215	0.80
219_M	319_V	1.213	0.80
475_L	482_T	1.208	0.80
124_A	281_V	1.205	0.80
732_V	736_T	1.204	0.80
799_V	803_R	1.203	0.80
98_V	129_K	1.202	0.80
767_V	811_R	1.197	0.79
472_L	496_I	1.196	0.79
547_D	550_F	1.194	0.79
955_D	959_R	1.193	0.79
457_F	461_K	1.189	0.79
402_E	433_L	1.187	0.79
968_S	974_D	1.184	0.79
954_A	964_V	1.181	0.78
546_D	550_F	1.180	0.78
609_K	627_E	1.177	0.78
1031_K	1034_L	1.177	0.78
736_T	739_S	1.176	0.78
1006_Y	1010_R	1.174	0.78
123_K	133_T	1.172	0.78
586_Y	865_G	1.172	0.78
144_S	205_E	1.167	0.78
129_K	132_E	1.163	0.77
265_Y	292_Y	1.158	0.77
436_A	466_V	1.150	0.77
168_V	177_S	1.149	0.77
771_T	799_V	1.147	0.76
84_I	106_L	1.147	0.76
417_K	421_L	1.146	0.76
45_V	100_L	1.146	0.76
803_R	874_E	1.146	0.76
449_Y	456_E	1.145	0.76
581_E	606_I	1.143	0.76
192_R	196_Q	1.141	0.76
32_L	58_F	1.140	0.76
621_L	651_N	1.139	0.76
980_K	985_E	1.138	0.76
976_E	982_K	1.135	0.76
861_A	870_E	1.134	0.76
518_P	541_Y	1.129	0.75
771_T	803_R	1.127	0.75
122_E	170_F	1.126	0.75
999_G	1005_D	1.124	0.75
391_L	462_I	1.124	0.75
977_T	1004_F	1.123	0.75
248_V	353_T	1.122	0.75
338_G	533_V	1.120	0.75
478_I	500_L	1.119	0.75
388_E	489_L	1.118	0.75
98_V	122_E	1.117	0.74
619_R	622_D	1.116	0.74
256_N	260_Q	1.114	0.74
206_K	293_Y	1.112	0.74
788_S	916_F	1.111	0.74
805_N	823_F	1.111	0.74
508_R	651_N	1.109	0.74
550_F	609_K	1.108	0.74
327_Y	332_V	1.108	0.74
153_A	204_L	1.106	0.74
423_Y	434_Y	1.105	0.74
186_L	204_L	1.102	0.73
11_I	67_V	1.097	0.73
69_W	105_V	1.095	0.73
423_Y	428_R	1.095	0.73
319_V	332_V	1.093	0.73
386_S	390_S	1.092	0.73
69_W	73_E	1.092	0.73
975_I	978_I	1.089	0.73
448_V	462_I	1.087	0.72
135_I	141_V	1.085	0.72
471_T	482_T	1.084	0.72
97_G	113_V	1.083	0.72
392_Q	404_G	1.079	0.72
182_T	980_K	1.076	0.72
845_F	910_A	1.076	0.72
131_R	205_E	1.075	0.72
424_L	452_T	1.074	0.71
386_S	489_L	1.073	0.71
260_Q	263_R	1.072	0.71
212_I	455_N	1.069	0.71
777_E	1024_R	1.066	0.71
615_I	644_I	1.064	0.71
216_Y	226_S	1.063	0.71
722_A	744_V	1.059	0.70
219_M	270_A	1.059	0.70
225_N	343_C	1.059	0.70
860_K	870_E	1.059	0.70
938_I	996_V	1.058	0.70
99_D	103_K	1.056	0.70
380_V	394_A	1.056	0.70
732_V	735_A	1.055	0.70
124_A	718_S	1.053	0.70
580_M	607_A	1.050	0.70
17_K	175_R	1.050	0.70
226_S	267_I	1.049	0.70
119_D	129_K	1.046	0.69
264_T	268_E	1.045	0.69
140_P	206_K	1.044	0.69
218_V	228_V	1.042	0.69
437_K	440_K	1.041	0.69
139_L	294_I	1.041	0.69
622_D	625_K	1.040	0.69
681_I	801_R	1.039	0.69
11_I	93_A	1.037	0.69
223_K	330_H	1.035	0.69
483_L	516_T	1.035	0.69
994_I	1020_I	1.035	0.69
996_V	1023_G	1.035	0.69
977_T	981_M	1.034	0.69
881_A	912_F	1.032	0.68
718_S	736_T	1.031	0.68
226_S	271_R	1.030	0.68
750_I	826_K	1.028	0.68
190_I	204_L	1.028	0.68
153_A	166_V	1.027	0.68
448_V	459_L	1.026	0.68
11_I	72_V	1.024	0.68
334_N	337_S	1.022	0.68
438_A	443_A	1.021	0.68
205_E	208_L	1.021	0.68
987_V	1011_T	1.020	0.67
257_L	290_Y	1.018	0.67
225_N	328_E	1.017	0.67
806_V	821_V	1.012	0.67
445_I	463_K	1.011	0.67
417_K	443_A	1.009	0.67
811_R	814_N	1.008	0.67
187_K	191_R	1.005	0.66
226_S	270_A	1.002	0.66
809_I	832_I	1.001	0.66
83_G	86_I	0.998	0.66
729_Y	733_R	0.997	0.66
559_I	620_V	0.994	0.65
248_V	387_F	0.993	0.65
521_K	542_N	0.991	0.65
917_Y	1031_K	0.990	0.65
36_K	58_F	0.989	0.65
189_N	193_A	0.989	0.65
934_N	1033_F	0.987	0.65
967_I	1008_I	0.987	0.65
420_A	441_E	0.986	0.65
105_V	108_K	0.980	0.64
816_K	861_A	0.979	0.64
580_M	590_V	0.979	0.64
791_F	794_L	0.977	0.64
445_I	460_N	0.976	0.64
162_Y	187_K	0.973	0.64
933_P	936_N	0.973	0.64
288_R	453_G	0.973	0.64
385_R	542_N	0.972	0.64
260_Q	530_W	0.969	0.63
995_I	1008_I	0.966	0.63
276_I	323_L	0.965	0.63
786_T	885_A	0.964	0.63
789_I	846_S	0.964	0.63
676_L	680_G	0.962	0.63
232_I	247_V	0.961	0.63
260_Q	529_E	0.960	0.63
712_Y	742_Y	0.960	0.63
480_K	516_T	0.960	0.63
879_Y	912_F	0.959	0.63
965_Y	973_Q	0.959	0.63
119_D	123_K	0.956	0.62
157_A	190_I	0.955	0.62
460_N	463_K	0.955	0.62
497_S	503_S	0.954	0.62
987_V	1008_I	0.954	0.62
468_F	485_L	0.953	0.62
216_Y	259_Y	0.953	0.62
849_A	881_A	0.952	0.62
33_K	605_D	0.952	0.62
355_I	358_W	0.951	0.62
518_P	622_D	0.951	0.62
139_L	281_V	0.949	0.62
385_R	521_K	0.948	0.62
690_T	694_E	0.948	0.62
34_A	332_V	0.947	0.62
497_S	507_V	0.946	0.62
335_K	604_W	0.945	0.61
22_A	564_F	0.942	0.61
142_P	208_L	0.941	0.61
424_L	434_Y	0.941	0.61
154_I	183_E	0.939	0.61
695_I	732_V	0.938	0.61
269_V	629_F	0.937	0.61
449_Y	454_I	0.936	0.61
462_I	466_V	0.935	0.61
6_K	41_E	0.935	0.61
506_Y	509_K	0.931	0.60
251_C	348_L	0.929	0.60
732_V	739_S	0.927	0.60
166_V	190_I	0.927	0.60
1004_F	1008_I	0.926	0.60
983_A	1008_I	0.925	0.60
636_S	858_S	0.924	0.60
1020_I	1029_V	0.923	0.60
738_I	744_V	0.923	0.60
646_K	649_E	0.922	0.60
773_E	793_K	0.921	0.59
211_W	293_Y	0.916	0.59
516_T	541_Y	0.916	0.59
406_V	498_K	0.913	0.59
447_E	450_E	0.912	0.59
938_I	954_A	0.910	0.59
256_N	530_W	0.909	0.58
152_E	155_K	0.907	0.58
266_T	283_F	0.907	0.58
579_L	633_A	0.906	0.58
589_E	609_K	0.905	0.58
1000_Y	1003_K	0.904	0.58
546_D	549_E	0.904	0.58
377_V	564_F	0.904	0.58
692_L	729_Y	0.903	0.58
355_I	394_A	0.903	0.58
464_G	468_F	0.902	0.58
340_T	344_F	0.901	0.58
736_T	742_Y	0.899	0.58
803_R	873_Y	0.898	0.58
976_E	981_M	0.896	0.57
164_V	186_L	0.896	0.57
246_T	432_F	0.895	0.57
43_V	75_V	0.894	0.57
965_Y	986_L	0.894	0.57
767_V	807_L	0.893	0.57
351_I	390_S	0.890	0.57
178_M	189_N	0.888	0.57
732_V	744_V	0.888	0.57
948_D	952_D	0.887	0.57
9_L	76_I	0.886	0.56
940_L	950_L	0.885	0.56
131_R	146_S	0.885	0.56
762_S	819_F	0.883	0.56
182_T	989_A	0.883	0.56
344_F	529_E	0.882	0.56
260_Q	344_F	0.879	0.56
997_T	1008_I	0.879	0.56
617_V	644_I	0.878	0.56
850_K	871_D	0.876	0.56
468_F	471_T	0.876	0.56
151_E	155_K	0.874	0.55
219_M	227_A	0.873	0.55
284_A	293_Y	0.872	0.55
937_G	993_E	0.872	0.55
165_M	179_V	0.871	0.55
162_Y	629_F	0.870	0.55
825_V	828_N	0.868	0.55
45_V	67_V	0.867	0.55
802_M	806_V	0.867	0.55
224_G	228_V	0.867	0.55
265_Y	269_V	0.867	0.55
941_V	967_I	0.867	0.55
182_T	988_R	0.865	0.55
318_Y	335_K	0.865	0.55
450_E	453_G	0.864	0.55
967_I	1004_F	0.864	0.55
216_Y	252_Q	0.861	0.54
392_Q	495_Q	0.858	0.54
400_I	433_L	0.857	0.54
3_E	40_I	0.857	0.54
143_P	291_E	0.856	0.54
263_R	344_F	0.856	0.54
377_V	595_Y	0.854	0.54
483_L	507_V	0.854	0.54
982_K	985_E	0.854	0.54
1029_V	1033_F	0.854	0.54
72_V	75_V	0.853	0.54
150_E	153_A	0.853	0.54
519_V	542_N	0.853	0.54
389_E	490_G	0.853	0.54
381_M	612_F	0.852	0.54
263_R	345_E	0.851	0.53
652_G	764_G	0.849	0.53
154_I	157_A	0.847	0.53
369_S	426_E	0.846	0.53
240_V	426_E	0.846	0.53
483_L	511_R	0.845	0.53
577_V	1006_Y	0.844	0.53
279_C	297_T	0.838	0.52
758_I	802_M	0.838	0.52
232_I	297_T	0.838	0.52
987_V	1015_Y	0.836	0.52
155_K	159_I	0.836	0.52
166_V	189_N	0.836	0.52
205_E	615_I	0.836	0.52
1022_N	1025_L	0.834	0.52
344_F	534_T	0.834	0.52
714_L	845_F	0.833	0.52
164_V	204_L	0.832	0.52
630_R	656_L	0.832	0.52
117_Q	222_K	0.830	0.52
551_S	609_K	0.830	0.52
352_V	383_I	0.830	0.52
367_D	429_P	0.830	0.52
505_E	651_N	0.829	0.52
765_N	811_R	0.829	0.52
154_I	162_Y	0.829	0.52
126_S	201_E	0.828	0.51
693_G	697_K	0.827	0.51
934_N	962_L	0.825	0.51
581_E	585_K	0.825	0.51
401_G	404_G	0.825	0.51
175_R	891_Q	0.823	0.51
564_F	595_Y	0.823	0.51
77_E	80_R	0.822	0.51
143_P	159_I	0.822	0.51
56_K	851_G	0.820	0.51
244_E	370_L	0.820	0.51
334_N	524_D	0.818	0.51
392_Q	457_F	0.818	0.51
978_I	984_E	0.818	0.51
684_P	714_L	0.817	0.50
942_Y	954_A	0.816	0.50
726_E	729_Y	0.816	0.50
232_I	292_Y	0.816	0.50
802_M	825_V	0.816	0.50
556_L	588_D	0.814	0.50
673_S	707_L	0.812	0.50
216_Y	270_A	0.810	0.50
526_L	530_W	0.810	0.50
953_T	1030_S	0.809	0.50
943_G	946_N	0.809	0.50
683_Q	718_S	0.808	0.50
211_W	605_D	0.806	0.50
972_L	977_T	0.806	0.50
471_T	476_K	0.806	0.50
260_Q	526_L	0.805	0.49
483_L	514_T	0.805	0.49
208_L	238_M	0.805	0.49
675_L	813_L	0.803	0.49
397_M	614_E	0.801	0.49
648_L	653_V	0.801	0.49
577_V	581_E	0.801	0.49
228_V	336_V	0.800	0.49
775_I	788_S	0.800	0.49
670_E	688_S	0.799	0.49
100_L	106_L	0.799	0.49
808_N	812_E	0.797	0.49
139_L	292_Y	0.797	0.49
665_I	675_L	0.796	0.49
131_R	203_L	0.796	0.49
92_T	172_L	0.793	0.48
83_G	114_L	0.793	0.48
590_V	859_M	0.793	0.48
973_Q	977_T	0.793	0.48
232_I	377_V	0.791	0.48
941_V	1008_I	0.791	0.48
8_V	855_I	0.791	0.48
154_I	166_V	0.790	0.48
809_I	819_F	0.790	0.48
697_K	700_N	0.788	0.48
690_T	736_T	0.786	0.48
344_F	530_W	0.786	0.48
446_N	450_E	0.785	0.48
757_E	769_G	0.785	0.48
620_V	644_I	0.784	0.48
537_M	548_I	0.782	0.47
495_Q	499_A	0.782	0.47
29_S	58_F	0.779	0.47
3_E	8_V	0.779	0.47
731_Y	736_T	0.778	0.47
947_L	997_T	0.776	0.47
939_A	967_I	0.776	0.47
799_V	806_V	0.776	0.47
582_A	856_N	0.775	0.47
175_R	373_E	0.775	0.47
937_G	986_L	0.774	0.47
575_S	855_I	0.774	0.47
147_A	833_I	0.771	0.46
227_A	595_Y	0.771	0.46
231_C	259_Y	0.769	0.46
739_S	744_V	0.769	0.46
263_R	524_D	0.768	0.46
150_E	157_A	0.768	0.46
256_N	263_R	0.768	0.46
204_L	262_M	0.767	0.46
847_S	854_L	0.766	0.46
247_V	297_T	0.765	0.46
966_S	972_L	0.765	0.46
670_E	690_T	0.765	0.46
147_A	202_V	0.765	0.46
786_T	924_W	0.765	0.46
384_G	490_G	0.764	0.46
833_I	1006_Y	0.764	0.46
334_N	534_T	0.763	0.46
164_V	190_I	0.762	0.46
424_L	923_S	0.760	0.45
175_R	913_G	0.759	0.45
884_S	924_W	0.759	0.45
852_I	857_E	0.757	0.45
153_A	203_L	0.756	0.45
495_Q	498_K	0.755	0.45
802_M	830_P	0.755	0.45
500_L	507_V	0.754	0.45
940_L	964_V	0.754	0.45
58_F	62_L	0.754	0.45
247_V	292_Y	0.753	0.45
833_I	1002_K	0.752	0.45
773_E	792_R	0.752	0.45
88_F	208_L	0.752	0.45
53_Q	244_E	0.752	0.45
219_M	321_A	0.749	0.45
216_Y	227_A	0.749	0.45
122_E	397_M	0.748	0.44
947_L	967_I	0.748	0.44
797_N	801_R	0.747	0.44
865_G	868_F	0.747	0.44
984_E	1011_T	0.747	0.44
333_I	341_C	0.746	0.44
232_I	564_F	0.745	0.44
960_F	1034_L	0.745	0.44
45_V	105_V	0.745	0.44
288_R	456_E	0.745	0.44
559_I	615_I	0.744	0.44
337_S	534_T	0.743	0.44
339_R	532_A	0.743	0.44
132_E	135_I	0.743	0.44
166_V	193_A	0.742	0.44
421_L	448_V	0.742	0.44
531_P	535_N	0.741	0.44
337_S	524_D	0.741	0.44
344_F	524_D	0.740	0.44
5_P	1028_E	0.740	0.44
439_F	443_A	0.739	0.44
55_S	574_W	0.739	0.44
885_A	923_S	0.738	0.44
275_L	559_I	0.738	0.44
420_A	438_A	0.737	0.44
708_V	806_V	0.736	0.43
269_V	281_V	0.735	0.43
10_V	42_T	0.735	0.43
943_G	1005_D	0.733	0.43
947_L	966_S	0.733	0.43
387_F	461_K	0.732	0.43
345_E	524_D	0.732	0.43
4_T	40_I	0.732	0.43
231_C	252_Q	0.732	0.43
359_D	377_V	0.731	0.43
181_W	209_Y	0.731	0.43
1010_R	1013_V	0.731	0.43
17_K	240_V	0.731	0.43
29_S	53_Q	0.731	0.43
199_I	532_A	0.730	0.43
717_S	736_T	0.730	0.43
981_M	1004_F	0.730	0.43
478_I	507_V	0.729	0.43
986_L	991_K	0.729	0.43
150_E	190_I	0.729	0.43
389_E	540_T	0.728	0.43
559_I	634_T	0.727	0.43
724_S	746_I	0.726	0.43
508_R	622_D	0.726	0.43
6_K	82_D	0.725	0.42
937_G	973_Q	0.725	0.42
682_S	830_P	0.725	0.42
256_N	345_E	0.725	0.42
420_A	434_Y	0.725	0.42
139_L	297_T	0.724	0.42
588_D	630_R	0.724	0.42
754_I	798_N	0.724	0.42
406_V	436_A	0.723	0.42
723_Y	945_K	0.723	0.42
722_A	735_A	0.722	0.42
219_M	229_I	0.722	0.42
659_S	814_N	0.722	0.42
677_D	683_Q	0.722	0.42
402_E	406_V	0.721	0.42
487_K	618_E	0.720	0.42
718_S	738_I	0.720	0.42
756_A	887_F	0.719	0.42
754_I	793_K	0.719	0.42
693_G	729_Y	0.719	0.42
819_F	835_L	0.718	0.42
493_D	508_R	0.715	0.42
158_K	162_Y	0.715	0.42
942_Y	946_N	0.715	0.42
447_E	451_V	0.714	0.42
151_E	184_E	0.713	0.41
186_L	198_Y	0.713	0.41
178_M	193_A	0.713	0.41
160_V	165_M	0.712	0.41
75_V	323_L	0.712	0.41
815_I	819_F	0.712	0.41
259_Y	344_F	0.712	0.41
415_M	419_E	0.710	0.41
826_K	829_T	0.709	0.41
552_Q	555_K	0.708	0.41
343_C	579_L	0.708	0.41
872_Y	875_P	0.707	0.41
973_Q	991_K	0.707	0.41
211_W	291_E	0.707	0.41
762_S	765_N	0.707	0.41
1000_Y	1005_D	0.705	0.41
695_I	735_A	0.704	0.41
520_V	539_L	0.704	0.41
402_E	408_G	0.704	0.41
355_I	432_F	0.703	0.41
5_P	9_L	0.703	0.41
256_N	337_S	0.702	0.41
128_E	146_S	0.702	0.41
334_N	345_E	0.701	0.40
358_W	400_I	0.700	0.40
497_S	502_K	0.700	0.40
977_T	982_K	0.699	0.40
824_V	888_S	0.699	0.40
579_L	859_M	0.698	0.40
757_E	888_S	0.698	0.40
692_L	732_V	0.698	0.40
885_A	888_S	0.698	0.40
168_V	171_N	0.697	0.40
550_F	626_K	0.696	0.40
756_A	771_T	0.695	0.40
335_K	605_D	0.695	0.40
674_K	680_G	0.695	0.40
286_N	293_Y	0.695	0.40
750_I	810_A	0.693	0.40
644_I	771_T	0.693	0.40
970_L	975_I	0.691	0.40
689_A	739_S	0.691	0.40
515_N	869_S	0.691	0.40
477_E	500_L	0.691	0.40
175_R	196_Q	0.690	0.40
447_E	528_G	0.690	0.40
240_V	369_S	0.690	0.40
256_N	334_N	0.689	0.39
487_K	541_Y	0.689	0.39
969_E	997_T	0.687	0.39
247_V	564_F	0.686	0.39
229_I	251_C	0.686	0.39
297_T	377_V	0.685	0.39
160_V	962_L	0.684	0.39
417_K	437_K	0.684	0.39
22_A	377_V	0.684	0.39
71_A	925_L	0.683	0.39
732_V	738_I	0.683	0.39
336_V	604_W	0.683	0.39
634_T	655_L	0.683	0.39
877_S	881_A	0.682	0.39
247_V	279_C	0.682	0.39
861_A	866_L	0.681	0.39
958_T	964_V	0.680	0.39
365_N	904_K	0.680	0.39
5_P	609_K	0.679	0.39
809_I	813_L	0.679	0.39
229_I	587_F	0.679	0.39
529_E	534_T	0.677	0.38
150_E	179_V	0.676	0.38
564_F	892_L	0.676	0.38
263_R	529_E	0.675	0.38
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775_I	950_L	0.674	0.38
232_I	323_L	0.674	0.38
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40_I	83_G	0.673	0.38
649_E	660_G	0.673	0.38
557_L	630_R	0.671	0.38
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558_I	583_G	0.671	0.38
64_M	570_V	0.671	0.38
558_I	590_V	0.670	0.38
558_I	912_F	0.670	0.38
917_Y	1035_N	0.670	0.38
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247_V	377_V	0.669	0.38
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799_V	830_P	0.666	0.38
804_E	807_L	0.666	0.38
511_R	541_Y	0.665	0.37
969_E	1004_F	0.665	0.37
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591_A	609_K	0.664	0.37
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591_A	611_Y	0.662	0.37
265_Y	268_E	0.661	0.37
557_L	629_F	0.661	0.37
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623_L	626_K	0.655	0.37
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383_I	523_I	0.649	0.36
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276_I	320_S	0.646	0.36
537_M	595_Y	0.646	0.36
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938_I	957_L	0.640	0.35
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849_A	854_L	0.634	0.35
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580_M	685_D	0.634	0.35
665_I	678_K	0.634	0.35
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1019_I	1022_N	0.632	0.35
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974_D	978_I	0.630	0.35
385_R	545_E	0.630	0.35
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415_M	423_Y	0.630	0.35
321_A	616_S	0.630	0.35
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583_G	633_A	0.629	0.35
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635_F	833_I	0.617	0.34
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563_G	595_Y	0.616	0.34
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482_T	516_T	0.615	0.33
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3_E	548_I	0.537	0.28
644_I	791_F	0.537	0.28
576_V	605_D	0.537	0.28
952_D	955_D	0.537	0.28
392_Q	561_A	0.537	0.28
532_A	881_A	0.536	0.28
927_S	932_I	0.536	0.28
578_S	947_L	0.536	0.28
983_A	997_T	0.535	0.28
540_T	771_T	0.535	0.28
852_I	874_E	0.534	0.27
202_V	209_Y	0.534	0.27
110_N	255_D	0.534	0.27
739_S	743_P	0.534	0.27
492_S	516_T	0.534	0.27
949_Y	1023_G	0.534	0.27
256_N	534_T	0.533	0.27
452_T	830_P	0.533	0.27
229_I	970_L	0.533	0.27
749_Y	1024_R	0.533	0.27
666_A	684_P	0.532	0.27
5_P	485_L	0.532	0.27
444_T	460_N	0.532	0.27
968_S	976_E	0.532	0.27
465_L	1020_I	0.532	0.27
373_E	923_S	0.532	0.27
71_A	926_S	0.531	0.27
312_T	778_A	0.531	0.27
604_W	898_F	0.531	0.27
7_K	81_P	0.531	0.27
765_N	868_F	0.531	0.27
17_K	885_A	0.530	0.27
741_K	744_V	0.530	0.27
422_K	444_T	0.530	0.27
456_E	459_L	0.529	0.27
150_E	194_L	0.529	0.27
634_T	663_V	0.529	0.27
65_L	76_I	0.529	0.27
953_T	960_F	0.528	0.27
77_E	956_N	0.528	0.27
524_D	529_E	0.528	0.27
292_Y	377_V	0.527	0.27
256_N	526_L	0.527	0.27
355_I	380_V	0.526	0.27
415_M	420_A	0.526	0.27
447_E	964_V	0.526	0.27
140_P	143_P	0.526	0.27
771_T	802_M	0.526	0.27
225_N	345_E	0.526	0.27
740_P	823_F	0.526	0.27
114_L	616_S	0.526	0.27
118_I	327_Y	0.525	0.27
327_Y	331_E	0.525	0.27
609_K	1013_V	0.525	0.27
289_G	292_Y	0.525	0.27
259_Y	348_L	0.525	0.27
445_I	448_V	0.525	0.27
359_D	885_A	0.525	0.27
957_L	1026_G	0.525	0.27
524_D	532_A	0.525	0.27
808_N	839_A	0.525	0.27
55_S	65_L	0.525	0.27
749_Y	752_N	0.525	0.27
252_Q	433_L	0.525	0.27
501_N	668_N	0.525	0.27
62_L	275_L	0.525	0.27
3_E	960_F	0.524	0.27
227_A	485_L	0.524	0.27
467_D	470_E	0.524	0.27
496_I	507_V	0.524	0.27
232_I	359_D	0.524	0.27
526_L	529_E	0.523	0.27
70_W	99_D	0.523	0.27
256_N	344_F	0.523	0.27
340_T	345_E	0.523	0.27
164_V	595_Y	0.523	0.27
833_I	917_Y	0.523	0.27
169_S	177_S	0.522	0.27
259_Y	529_E	0.522	0.27
407_G	410_V	0.522	0.27
674_K	833_I	0.522	0.27
797_N	806_V	0.522	0.27
290_Y	592_V	0.521	0.27
88_F	537_M	0.521	0.27
366_V	895_A	0.521	0.27
580_M	584_S	0.521	0.27
486_A	516_T	0.521	0.27
192_R	830_P	0.521	0.27
692_L	741_K	0.521	0.27
165_M	780_V	0.521	0.27
771_T	791_F	0.520	0.26
683_Q	686_W	0.520	0.26
526_L	535_N	0.519	0.26
276_I	279_C	0.519	0.26
93_A	576_V	0.518	0.26
240_V	980_K	0.518	0.26
833_I	859_M	0.518	0.26
537_M	788_S	0.518	0.26
359_D	577_V	0.518	0.26
720_K	997_T	0.518	0.26
947_L	1005_D	0.518	0.26
788_S	1020_I	0.518	0.26
757_E	849_A	0.518	0.26
187_K	680_G	0.518	0.26
592_V	641_G	0.517	0.26
439_F	449_Y	0.517	0.26
22_A	595_Y	0.517	0.26
141_V	675_L	0.517	0.26
564_F	686_W	0.516	0.26
933_P	994_I	0.516	0.26
336_V	534_T	0.516	0.26
519_V	544_T	0.516	0.26
466_V	470_E	0.516	0.26
882_V	919_A	0.515	0.26
983_A	986_L	0.515	0.26
896_Y	1009_R	0.515	0.26
696_K	700_N	0.515	0.26
108_K	935_K	0.515	0.26
139_L	361_S	0.515	0.26
981_M	989_A	0.514	0.26
390_S	394_A	0.513	0.26
219_M	228_V	0.513	0.26
786_T	920_L	0.513	0.26
141_V	281_V	0.513	0.26
337_S	529_E	0.513	0.26
977_T	980_K	0.513	0.26
856_N	860_K	0.512	0.26
189_N	942_Y	0.512	0.26
569_S	715_S	0.512	0.26
96_V	706_V	0.512	0.26
582_A	585_K	0.512	0.26
936_N	962_L	0.512	0.26
757_E	1022_N	0.511	0.26
208_L	294_I	0.511	0.26
141_V	923_S	0.511	0.26
484_K	701_E	0.511	0.26
267_I	1016_N	0.511	0.26
391_L	472_L	0.510	0.26
266_T	727_E	0.510	0.26
460_N	467_D	0.510	0.26
762_S	853_N	0.510	0.26
223_K	801_R	0.510	0.26
722_A	913_G	0.509	0.26
440_K	495_Q	0.509	0.26
680_G	959_R	0.508	0.26
833_I	1025_L	0.508	0.26
376_S	769_G	0.508	0.26
246_T	435_A	0.508	0.26
116_T	231_C	0.508	0.26
139_L	247_V	0.507	0.26
744_V	884_S	0.507	0.26
225_N	528_G	0.507	0.26
983_A	1007_N	0.507	0.26
735_A	909_A	0.506	0.26
10_V	204_L	0.506	0.26
102_K	257_L	0.506	0.26
33_K	211_W	0.506	0.26
147_A	425_K	0.506	0.26
343_C	1019_I	0.505	0.25
41_E	252_Q	0.505	0.25
292_Y	359_D	0.505	0.25
212_I	525_T	0.505	0.25
101_H	119_D	0.504	0.25
621_L	632_V	0.504	0.25
113_V	131_R	0.504	0.25
155_K	552_Q	0.504	0.25
65_L	79_E	0.504	0.25
624_I	632_V	0.504	0.25
140_P	368_Q	0.504	0.25
923_S	926_S	0.504	0.25
261_N	290_Y	0.503	0.25
177_S	373_E	0.503	0.25
81_P	833_I	0.502	0.25
13_S	999_G	0.502	0.25
139_L	279_C	0.502	0.25
473_R	591_A	0.502	0.25
718_S	929_P	0.502	0.25
55_S	360_L	0.501	0.25
88_F	523_I	0.501	0.25
481_E	814_N	0.501	0.25
319_V	338_G	0.501	0.25
260_Q	334_N	0.501	0.25
1002_K	1005_D	0.501	0.25
633_A	761_V	0.501	0.25
151_E	187_K	0.501	0.25
238_M	1025_L	0.500	0.25
825_V	833_I	0.500	0.25
256_N	524_D	0.500	0.25
678_K	765_N	0.500	0.25

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1a9xA	3	0.981	100	0.416	Contact Map
3jrxA	1	0.3873	100	0.893	Contact Map
3glkA	1	0.3739	100	0.894	Contact Map
3orqA	2	0.3416	100	0.898	Contact Map
2vpqA	2	0.3939	100	0.9	Contact Map
1ulzA	2	0.3996	100	0.901	Contact Map
2dzdA	2	0.393	100	0.904	Contact Map
3q2oA	2	0.3435	100	0.904	Contact Map
1w96A	1	0.393	100	0.904	Contact Map
2dwcA	4	0.353	100	0.908	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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