CARA - SULSO - GREMLIN Contacts

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CARA - Carbamoyl-phosphate synthase small chain

UniProt:	Q59968	Sequences: MKLENKKGYLYLEDGTFIEGYSFGAKGIKVGEVVFTTSMNGYVESLTDPSYKGQILIITHPLVGNYGVPEKKYEQGILTNFESERIQVEGLIVAEHTYPSKWNSALTLDEWLKSENVPGVFDVDTRMIVKKIRTYGTMMGIIASELEIDDPRKYLEKKYDEIDFTQFTSPKSPIFHPNTGDMIVVVDCGIKHGILYGLYKRGFSIVRVPCSFSASKIIEYNPKGIVFSNGPGNPNLLENQIKTFSELVEYKIPILGICLGHQIATLALGGKIKKMKFGHRAINKPVIESNSNKCYISTHNHGYGIISKNDIPPNTKIWFYNPDDYTIEGLIHEKLPIITTQFHPEARPGPWDTTWVFDKFRTMVTGK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	367 (350)
Sequences:	4059 (2002)
Seq/√Len:	107.0

ECOLI - CARA
BACSU - CARA CARX
HALSA - CARA
SULSO - CARA

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
201_R	358_D	4.112	1.00
244_F	263_I	4.105	1.00
182_M	204_S	4.060	1.00
106_L	114_S	4.010	1.00
184_V	208_V	3.671	1.00
33_V	140_G	3.599	1.00
55_I	92_I	3.241	1.00
58_I	91_L	3.103	1.00
316_K	331_I	3.012	1.00
183_I	364_V	2.966	1.00
235_N	271_K	2.911	1.00
169_S	210_C	2.802	1.00
272_I	305_I	2.732	1.00
265_T	305_I	2.654	1.00
25_A	116_N	2.499	1.00
182_M	206_V	2.481	1.00
99_P	104_S	2.466	1.00
13_E	139_M	2.395	1.00
316_K	333_E	2.373	1.00
36_T	51_Y	2.331	1.00
14_D	131_K	2.296	1.00
174_I	207_R	2.229	1.00
273_K	304_G	2.205	1.00
255_L	356_V	2.175	1.00
280_R	302_G	2.170	1.00
27_G	118_P	2.166	1.00
185_V	226_V	2.149	1.00
109_D	113_K	2.140	1.00
193_G	196_Y	2.136	1.00
38_S	282_I	2.108	1.00
175_F	204_S	2.045	1.00
213_S	216_K	2.044	1.00
308_K	320_Y	2.000	1.00
134_T	277_F	2.000	1.00
273_K	307_S	1.997	1.00
170_P	174_I	1.981	1.00
23_F	119_G	1.975	1.00
265_T	330_L	1.972	1.00
264_A	339_T	1.960	1.00
203_F	361_R	1.914	1.00
186_V	208_V	1.910	1.00
317_I	327_I	1.873	1.00
208_V	212_F	1.871	1.00
7_K	19_E	1.856	1.00
45_S	56_L	1.842	1.00
70_E	105_A	1.833	1.00
264_A	337_I	1.818	1.00
330_L	339_T	1.803	1.00
185_V	190_I	1.797	1.00
215_S	246_E	1.758	1.00
248_V	337_I	1.745	1.00
218_I	252_I	1.739	1.00
18_I	131_K	1.729	1.00
81_F	111_W	1.714	1.00
184_V	220_Y	1.713	1.00
28_I	152_R	1.710	1.00
188_C	240_Q	1.691	1.00
92_I	120_V	1.682	1.00
181_D	364_V	1.665	1.00
225_I	252_I	1.663	1.00
163_D	166_Q	1.663	1.00
332_H	336_P	1.662	1.00
186_V	243_T	1.660	1.00
214_A	218_I	1.654	1.00
123_V	128_I	1.642	1.00
16_T	131_K	1.642	1.00
314_N	334_K	1.640	1.00
314_N	333_E	1.631	1.00
86_I	115_E	1.629	1.00
21_Y	122_D	1.619	1.00
331_I	359_K	1.604	1.00
181_D	365_T	1.604	1.00
287_I	292_N	1.603	1.00
151_P	155_L	1.565	1.00
8_G	120_V	1.558	1.00
332_H	335_L	1.554	1.00
55_I	90_G	1.547	1.00
59_T	129_V	1.542	1.00
242_K	245_S	1.530	1.00
56_L	88_V	1.516	1.00
55_I	140_G	1.506	1.00
251_K	335_L	1.501	1.00
36_T	45_S	1.493	1.00
295_Y	355_W	1.481	1.00
208_V	220_Y	1.475	1.00
211_S	239_N	1.472	1.00
197_G	354_T	1.467	1.00
90_G	142_I	1.459	1.00
184_V	222_P	1.457	1.00
290_N	316_K	1.448	1.00
186_V	217_I	1.418	1.00
188_C	227_F	1.416	1.00
99_P	107_T	1.415	1.00
107_T	110_E	1.411	1.00
93_V	96_H	1.411	1.00
243_T	246_E	1.401	1.00
288_E	359_K	1.401	1.00
268_L	332_H	1.400	1.00
21_Y	121_F	1.382	1.00
52_K	87_Q	1.379	1.00
261_H	339_T	1.367	1.00
289_S	320_Y	1.365	1.00
212_F	216_K	1.363	1.00
225_I	247_L	1.350	1.00
268_L	315_T	1.327	0.99
203_F	364_V	1.324	0.99
241_I	266_L	1.319	0.99
185_V	195_L	1.318	0.99
185_V	205_I	1.310	0.99
214_A	246_E	1.303	0.99
46_L	88_V	1.296	0.99
165_T	259_L	1.288	0.99
271_K	307_S	1.287	0.99
106_L	110_E	1.286	0.99
16_T	127_M	1.269	0.99
295_Y	353_T	1.269	0.99
270_G	310_D	1.266	0.99
180_G	365_T	1.264	0.99
226_V	255_L	1.258	0.99
11_Y	153_K	1.252	0.99
315_T	332_H	1.243	0.99
186_V	212_F	1.238	0.99
8_G	22_S	1.235	0.99
183_I	203_F	1.229	0.99
290_N	331_I	1.229	0.99
248_V	268_L	1.220	0.99
11_Y	17_F	1.215	0.99
13_E	138_M	1.209	0.99
307_S	310_D	1.206	0.99
169_S	211_S	1.203	0.99
273_K	326_T	1.200	0.99
190_I	195_L	1.198	0.99
216_K	219_E	1.194	0.99
224_G	364_V	1.187	0.99
287_I	320_Y	1.177	0.99
26_K	113_K	1.177	0.99
199_Y	205_I	1.169	0.99
319_F	342_F	1.166	0.99
52_K	167_F	1.156	0.98
86_I	117_V	1.156	0.98
362_T	365_T	1.154	0.98
255_L	338_I	1.147	0.98
290_N	359_K	1.140	0.98
235_N	266_L	1.138	0.98
288_E	295_Y	1.136	0.98
46_L	91_L	1.132	0.98
227_F	244_F	1.129	0.98
308_K	317_I	1.129	0.98
235_N	272_I	1.128	0.98
315_T	330_L	1.123	0.98
182_M	220_Y	1.122	0.98
38_S	45_S	1.105	0.98
247_L	254_I	1.102	0.98
165_T	237_L	1.097	0.98
183_I	361_R	1.094	0.98
84_E	87_Q	1.086	0.98
70_E	106_L	1.082	0.98
151_P	154_Y	1.078	0.98
170_P	173_P	1.073	0.98
218_I	251_K	1.070	0.98
179_T	204_S	1.070	0.98
242_K	246_E	1.057	0.97
27_G	116_N	1.050	0.97
80_N	103_N	1.043	0.97
264_A	330_L	1.041	0.97
69_P	80_N	1.040	0.97
10_L	120_V	1.039	0.97
96_H	109_D	1.038	0.97
68_V	106_L	1.028	0.97
270_G	311_I	1.028	0.97
29_K	90_G	1.021	0.97
33_V	132_I	1.021	0.97
287_I	322_P	1.019	0.97
254_I	264_A	1.018	0.97
338_I	356_V	1.017	0.97
282_I	298_T	0.999	0.96
8_G	144_S	0.998	0.96
45_S	58_I	0.994	0.96
29_K	142_I	0.994	0.96
244_F	254_I	0.985	0.96
28_I	145_E	0.984	0.96
186_V	213_S	0.974	0.96
246_E	249_E	0.967	0.95
243_T	247_L	0.966	0.95
221_N	252_I	0.964	0.95
181_D	203_F	0.958	0.95
258_C	343_H	0.955	0.95
82_E	196_Y	0.954	0.95
127_M	131_K	0.952	0.95
132_I	140_G	0.945	0.95
214_A	243_T	0.942	0.95
197_G	200_K	0.939	0.95
237_L	240_Q	0.939	0.95
43_V	69_P	0.938	0.95
162_I	167_F	0.933	0.95
206_V	220_Y	0.926	0.94
190_I	226_V	0.925	0.94
270_G	315_T	0.918	0.94
23_F	93_V	0.912	0.94
193_G	197_G	0.912	0.94
288_E	293_K	0.908	0.94
286_V	328_E	0.905	0.94
110_E	113_K	0.900	0.93
170_P	207_R	0.897	0.93
181_D	361_R	0.896	0.93
198_L	203_F	0.896	0.93
143_A	148_I	0.895	0.93
314_N	332_H	0.892	0.93
320_Y	325_Y	0.891	0.93
93_V	121_F	0.886	0.93
71_K	103_N	0.883	0.93
62_L	95_E	0.882	0.93
175_F	206_V	0.879	0.93
342_F	353_T	0.877	0.92
50_S	258_C	0.874	0.92
163_D	240_Q	0.869	0.92
24_G	119_G	0.864	0.92
9_Y	19_E	0.863	0.92
361_R	364_V	0.863	0.92
159_Y	162_I	0.861	0.92
53_G	89_E	0.861	0.92
157_K	162_I	0.861	0.92
212_F	220_Y	0.858	0.92
14_D	135_Y	0.858	0.92
176_H	199_Y	0.856	0.92
92_I	123_V	0.854	0.91
359_K	362_T	0.853	0.91
163_D	239_N	0.851	0.91
139_M	159_Y	0.851	0.91
18_I	127_M	0.851	0.91
31_G	55_I	0.849	0.91
205_I	226_V	0.845	0.91
68_V	81_F	0.837	0.91
85_R	115_E	0.831	0.90
159_Y	303_Y	0.825	0.90
104_S	107_T	0.820	0.90
213_S	243_T	0.820	0.90
185_V	228_S	0.820	0.90
215_S	219_E	0.819	0.90
201_R	361_R	0.818	0.90
268_L	337_I	0.816	0.90
318_W	331_I	0.815	0.89
33_V	57_I	0.811	0.89
9_Y	146_L	0.811	0.89
248_V	264_A	0.807	0.89
229_N	258_C	0.806	0.89
22_S	144_S	0.803	0.89
183_I	198_L	0.803	0.89
259_L	266_L	0.803	0.89
188_C	263_I	0.799	0.89
284_K	323_D	0.790	0.88
112_L	117_V	0.788	0.88
166_Q	211_S	0.788	0.88
249_E	335_L	0.787	0.88
92_I	140_G	0.786	0.88
217_I	222_P	0.785	0.88
238_E	242_K	0.785	0.88
217_I	243_T	0.785	0.88
332_H	337_I	0.780	0.87
161_E	236_L	0.779	0.87
46_L	112_L	0.778	0.87
358_D	361_R	0.777	0.87
227_F	254_I	0.775	0.87
177_P	180_G	0.769	0.87
84_E	192_H	0.769	0.87
11_Y	143_A	0.769	0.87
29_K	89_E	0.767	0.86
159_Y	164_F	0.765	0.86
9_Y	17_F	0.764	0.86
197_G	201_R	0.762	0.86
57_I	129_V	0.762	0.86
46_L	108_L	0.761	0.86
280_R	284_K	0.757	0.86
145_E	148_I	0.756	0.86
156_E	159_Y	0.754	0.85
225_I	250_Y	0.753	0.85
308_K	327_I	0.749	0.85
12_L	128_I	0.749	0.85
295_Y	342_F	0.749	0.85
47_T	81_F	0.748	0.85
192_H	196_Y	0.747	0.85
342_F	355_W	0.747	0.85
282_I	321_N	0.747	0.85
53_G	167_F	0.744	0.85
210_C	239_N	0.743	0.85
288_E	291_S	0.743	0.85
254_I	337_I	0.734	0.84
203_F	224_G	0.733	0.84
183_I	224_G	0.732	0.84
212_F	217_I	0.731	0.84
24_G	109_D	0.730	0.84
319_F	355_W	0.725	0.83
109_D	119_G	0.724	0.83
173_P	208_V	0.724	0.83
161_E	303_Y	0.721	0.83
88_V	91_L	0.720	0.83
143_A	147_E	0.720	0.83
38_S	298_T	0.719	0.83
174_I	195_L	0.715	0.82
178_N	204_S	0.714	0.82
112_L	119_G	0.709	0.82
161_E	164_F	0.709	0.82
225_I	254_I	0.708	0.82
66_Y	323_D	0.708	0.82
111_W	115_E	0.708	0.82
52_K	85_R	0.706	0.82
132_I	137_T	0.706	0.82
200_K	354_T	0.706	0.82
268_L	335_L	0.705	0.81
118_P	142_I	0.699	0.81
83_S	87_Q	0.698	0.81
265_T	270_G	0.698	0.81
184_V	206_V	0.698	0.81
194_I	257_I	0.697	0.81
214_A	250_Y	0.696	0.81
218_I	246_E	0.695	0.80
194_I	346_A	0.694	0.80
36_T	58_I	0.694	0.80
49_P	345_E	0.692	0.80
66_Y	69_P	0.690	0.80
310_D	313_P	0.687	0.80
88_V	117_V	0.686	0.80
194_I	258_C	0.682	0.79
239_N	242_K	0.682	0.79
131_K	135_Y	0.682	0.79
240_Q	243_T	0.682	0.79
160_D	235_N	0.682	0.79
110_E	114_S	0.680	0.79
28_I	143_A	0.680	0.79
30_V	141_I	0.680	0.79
307_S	327_I	0.679	0.79
91_L	112_L	0.679	0.79
186_V	227_F	0.677	0.79
176_H	195_L	0.674	0.78
214_A	247_L	0.672	0.78
213_S	247_L	0.671	0.78
36_T	284_K	0.668	0.78
164_F	303_Y	0.666	0.78
242_K	249_E	0.663	0.77
153_K	157_K	0.662	0.77
299_H	328_E	0.660	0.77
45_S	51_Y	0.660	0.77
180_G	204_S	0.659	0.77
333_E	336_P	0.658	0.77
271_K	310_D	0.658	0.77
258_C	350_P	0.657	0.77
51_Y	54_Q	0.656	0.77
211_S	216_K	0.655	0.76
139_M	160_D	0.655	0.76
128_I	140_G	0.651	0.76
52_K	89_E	0.651	0.76
63_V	93_V	0.650	0.76
280_R	342_F	0.648	0.76
174_I	199_Y	0.647	0.76
26_K	118_P	0.646	0.75
239_N	243_T	0.646	0.75
43_V	80_N	0.646	0.75
245_S	249_E	0.645	0.75
10_L	123_V	0.645	0.75
275_M	304_G	0.645	0.75
224_G	360_F	0.642	0.75
39_M	66_Y	0.640	0.75
47_T	111_W	0.639	0.75
23_F	96_H	0.633	0.74
236_L	303_Y	0.631	0.74
258_C	277_F	0.630	0.74
139_M	158_K	0.630	0.74
217_I	225_I	0.629	0.74
27_G	144_S	0.628	0.73
201_R	354_T	0.628	0.73
13_E	135_Y	0.626	0.73
62_L	66_Y	0.626	0.73
266_L	271_K	0.625	0.73
57_I	92_I	0.619	0.72
195_L	207_R	0.617	0.72
218_I	247_L	0.616	0.72
195_L	226_V	0.614	0.72
30_V	153_K	0.612	0.71
165_T	188_C	0.611	0.71
157_K	161_E	0.611	0.71
182_M	223_K	0.610	0.71
238_E	241_I	0.610	0.71
129_V	321_N	0.609	0.71
241_I	245_S	0.609	0.71
258_C	278_G	0.608	0.71
120_V	123_V	0.605	0.71
215_S	218_I	0.603	0.70
50_S	343_H	0.602	0.70
181_D	202_G	0.602	0.70
336_P	363_M	0.602	0.70
36_T	194_I	0.602	0.70
184_V	217_I	0.600	0.70
137_T	303_Y	0.600	0.70
34_V	280_R	0.600	0.70
343_H	350_P	0.599	0.70
295_Y	319_F	0.599	0.70
186_V	240_Q	0.599	0.70
217_I	247_L	0.598	0.70
299_H	321_N	0.597	0.70
9_Y	149_D	0.597	0.70
270_G	330_L	0.597	0.70
246_E	250_Y	0.596	0.69
86_I	111_W	0.595	0.69
173_P	220_Y	0.594	0.69
52_K	164_F	0.594	0.69
280_R	328_E	0.594	0.69
7_K	145_E	0.593	0.69
134_T	276_K	0.593	0.69
71_K	105_A	0.593	0.69
224_G	255_L	0.591	0.69
347_R	351_W	0.591	0.69
33_V	92_I	0.590	0.69
153_K	156_E	0.590	0.69
45_S	284_K	0.589	0.69
268_L	312_P	0.589	0.69
52_K	168_T	0.587	0.68
93_V	119_G	0.584	0.68
58_I	63_V	0.584	0.68
43_V	319_F	0.581	0.68
198_L	205_I	0.580	0.67
233_N	272_I	0.580	0.67
25_A	113_K	0.579	0.67
313_P	333_E	0.579	0.67
96_H	121_F	0.578	0.67
237_L	259_L	0.578	0.67
147_E	152_R	0.575	0.67
321_N	328_E	0.574	0.67
193_G	354_T	0.573	0.66
287_I	325_Y	0.572	0.66
36_T	57_I	0.570	0.66
328_E	342_F	0.570	0.66
251_K	336_P	0.570	0.66
261_H	305_I	0.570	0.66
50_S	229_N	0.569	0.66
185_V	255_L	0.568	0.66
181_D	223_K	0.568	0.66
22_S	26_K	0.567	0.66
282_I	347_R	0.567	0.66
83_S	86_I	0.567	0.66
163_D	236_L	0.566	0.66
288_E	355_W	0.564	0.65
166_Q	239_N	0.561	0.65
110_E	116_N	0.561	0.65
80_N	102_W	0.557	0.64
226_V	339_T	0.557	0.64
10_L	33_V	0.556	0.64
57_I	132_I	0.555	0.64
211_S	240_Q	0.555	0.64
288_E	318_W	0.555	0.64
258_C	262_Q	0.553	0.64
288_E	319_F	0.552	0.64
305_I	330_L	0.551	0.63
24_G	118_P	0.551	0.63
229_N	343_H	0.550	0.63
280_R	323_D	0.550	0.63
22_S	119_G	0.550	0.63
153_K	159_Y	0.549	0.63
296_I	345_E	0.549	0.63
208_V	213_S	0.548	0.63
34_V	277_F	0.548	0.63
152_R	155_L	0.547	0.63
275_M	302_G	0.547	0.63
165_T	236_L	0.546	0.63
18_I	138_M	0.544	0.63
46_L	58_I	0.543	0.62
177_P	204_S	0.542	0.62
197_G	280_R	0.542	0.62
262_Q	343_H	0.542	0.62
139_M	157_K	0.541	0.62
304_G	327_I	0.538	0.62
226_V	338_I	0.537	0.62
80_N	83_S	0.537	0.62
38_S	280_R	0.537	0.62
23_F	121_F	0.537	0.62
176_H	207_R	0.537	0.62
57_I	60_H	0.537	0.62
53_G	162_I	0.537	0.62
69_P	319_F	0.536	0.61
51_Y	258_C	0.534	0.61
55_I	88_V	0.533	0.61
132_I	138_M	0.532	0.61
137_T	302_G	0.532	0.61
69_P	101_K	0.531	0.61
193_G	347_R	0.530	0.61
359_K	363_M	0.530	0.61
241_I	267_A	0.529	0.60
131_K	138_M	0.529	0.60
340_T	356_V	0.529	0.60
186_V	225_I	0.528	0.60
45_S	261_H	0.528	0.60
259_L	263_I	0.527	0.60
23_F	118_P	0.527	0.60
307_S	311_I	0.525	0.60
198_L	361_R	0.524	0.60
95_E	122_D	0.522	0.59
210_C	240_Q	0.522	0.59
66_Y	258_C	0.521	0.59
159_Y	302_G	0.520	0.59
192_H	195_L	0.520	0.59
280_R	297_S	0.520	0.59
81_F	115_E	0.519	0.59
34_V	276_K	0.517	0.59
358_D	362_T	0.517	0.59
171_K	245_S	0.516	0.58
284_K	348_P	0.516	0.58
31_G	56_L	0.515	0.58
62_L	328_E	0.515	0.58
240_Q	263_I	0.514	0.58
9_Y	143_A	0.513	0.58
218_I	250_Y	0.512	0.58
8_G	118_P	0.511	0.58
60_H	66_Y	0.511	0.58
82_E	193_G	0.509	0.57
265_T	268_L	0.509	0.57
26_K	116_N	0.507	0.57
262_Q	278_G	0.507	0.57
284_K	303_Y	0.504	0.57
9_Y	147_E	0.503	0.57
319_F	356_V	0.503	0.57
186_V	247_L	0.502	0.56
311_I	327_I	0.501	0.56
196_Y	227_F	0.501	0.56
48_D	278_G	0.500	0.56
229_N	340_T	0.500	0.56
222_P	225_I	0.500	0.56

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1a9xB	1	0.9646	100	0.208	Contact Map
1vcoA	4	0.9319	100	0.652	Contact Map
1s1mA	4	0.9373	100	0.67	Contact Map
3nvaA	2	0.9155	100	0.685	Contact Map
4zdjA	4	0.9237	100	0.711	Contact Map
2vxoA	2	0.4877	100	0.773	Contact Map
3tqiA	3	0.4632	100	0.783	Contact Map
2h2wA	2	0.6376	100	0.785	Contact Map
2vpiA	1	0.4687	100	0.786	Contact Map
1gpmA	3	0.5068	100	0.786	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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