GREMLIN Database
CARA - Carbamoyl-phosphate synthase small chain
UniProt: Q59968 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 367 (350)
Sequences: 4059 (2002)
Seq/√Len: 107.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
201_R358_D4.1121.00
244_F263_I4.1051.00
182_M204_S4.0601.00
106_L114_S4.0101.00
184_V208_V3.6711.00
33_V140_G3.5991.00
55_I92_I3.2411.00
58_I91_L3.1031.00
316_K331_I3.0121.00
183_I364_V2.9661.00
235_N271_K2.9111.00
169_S210_C2.8021.00
272_I305_I2.7321.00
265_T305_I2.6541.00
25_A116_N2.4991.00
182_M206_V2.4811.00
99_P104_S2.4661.00
13_E139_M2.3951.00
316_K333_E2.3731.00
36_T51_Y2.3311.00
14_D131_K2.2961.00
174_I207_R2.2291.00
273_K304_G2.2051.00
255_L356_V2.1751.00
280_R302_G2.1701.00
27_G118_P2.1661.00
185_V226_V2.1491.00
109_D113_K2.1401.00
193_G196_Y2.1361.00
38_S282_I2.1081.00
175_F204_S2.0451.00
213_S216_K2.0441.00
308_K320_Y2.0001.00
134_T277_F2.0001.00
273_K307_S1.9971.00
170_P174_I1.9811.00
23_F119_G1.9751.00
265_T330_L1.9721.00
264_A339_T1.9601.00
203_F361_R1.9141.00
186_V208_V1.9101.00
317_I327_I1.8731.00
208_V212_F1.8711.00
7_K19_E1.8561.00
45_S56_L1.8421.00
70_E105_A1.8331.00
264_A337_I1.8181.00
330_L339_T1.8031.00
185_V190_I1.7971.00
215_S246_E1.7581.00
248_V337_I1.7451.00
218_I252_I1.7391.00
18_I131_K1.7291.00
81_F111_W1.7141.00
184_V220_Y1.7131.00
28_I152_R1.7101.00
188_C240_Q1.6911.00
92_I120_V1.6821.00
181_D364_V1.6651.00
225_I252_I1.6631.00
163_D166_Q1.6631.00
332_H336_P1.6621.00
186_V243_T1.6601.00
214_A218_I1.6541.00
123_V128_I1.6421.00
16_T131_K1.6421.00
314_N334_K1.6401.00
314_N333_E1.6311.00
86_I115_E1.6291.00
21_Y122_D1.6191.00
331_I359_K1.6041.00
181_D365_T1.6041.00
287_I292_N1.6031.00
151_P155_L1.5651.00
8_G120_V1.5581.00
332_H335_L1.5541.00
55_I90_G1.5471.00
59_T129_V1.5421.00
242_K245_S1.5301.00
56_L88_V1.5161.00
55_I140_G1.5061.00
251_K335_L1.5011.00
36_T45_S1.4931.00
295_Y355_W1.4811.00
208_V220_Y1.4751.00
211_S239_N1.4721.00
197_G354_T1.4671.00
90_G142_I1.4591.00
184_V222_P1.4571.00
290_N316_K1.4481.00
186_V217_I1.4181.00
188_C227_F1.4161.00
99_P107_T1.4151.00
107_T110_E1.4111.00
93_V96_H1.4111.00
243_T246_E1.4011.00
288_E359_K1.4011.00
268_L332_H1.4001.00
21_Y121_F1.3821.00
52_K87_Q1.3791.00
261_H339_T1.3671.00
289_S320_Y1.3651.00
212_F216_K1.3631.00
225_I247_L1.3501.00
268_L315_T1.3270.99
203_F364_V1.3240.99
241_I266_L1.3190.99
185_V195_L1.3180.99
185_V205_I1.3100.99
214_A246_E1.3030.99
46_L88_V1.2960.99
165_T259_L1.2880.99
271_K307_S1.2870.99
106_L110_E1.2860.99
16_T127_M1.2690.99
295_Y353_T1.2690.99
270_G310_D1.2660.99
180_G365_T1.2640.99
226_V255_L1.2580.99
11_Y153_K1.2520.99
315_T332_H1.2430.99
186_V212_F1.2380.99
8_G22_S1.2350.99
183_I203_F1.2290.99
290_N331_I1.2290.99
248_V268_L1.2200.99
11_Y17_F1.2150.99
13_E138_M1.2090.99
307_S310_D1.2060.99
169_S211_S1.2030.99
273_K326_T1.2000.99
190_I195_L1.1980.99
216_K219_E1.1940.99
224_G364_V1.1870.99
287_I320_Y1.1770.99
26_K113_K1.1770.99
199_Y205_I1.1690.99
319_F342_F1.1660.99
52_K167_F1.1560.98
86_I117_V1.1560.98
362_T365_T1.1540.98
255_L338_I1.1470.98
290_N359_K1.1400.98
235_N266_L1.1380.98
288_E295_Y1.1360.98
46_L91_L1.1320.98
227_F244_F1.1290.98
308_K317_I1.1290.98
235_N272_I1.1280.98
315_T330_L1.1230.98
182_M220_Y1.1220.98
38_S45_S1.1050.98
247_L254_I1.1020.98
165_T237_L1.0970.98
183_I361_R1.0940.98
84_E87_Q1.0860.98
70_E106_L1.0820.98
151_P154_Y1.0780.98
170_P173_P1.0730.98
218_I251_K1.0700.98
179_T204_S1.0700.98
242_K246_E1.0570.97
27_G116_N1.0500.97
80_N103_N1.0430.97
264_A330_L1.0410.97
69_P80_N1.0400.97
10_L120_V1.0390.97
96_H109_D1.0380.97
68_V106_L1.0280.97
270_G311_I1.0280.97
29_K90_G1.0210.97
33_V132_I1.0210.97
287_I322_P1.0190.97
254_I264_A1.0180.97
338_I356_V1.0170.97
282_I298_T0.9990.96
8_G144_S0.9980.96
45_S58_I0.9940.96
29_K142_I0.9940.96
244_F254_I0.9850.96
28_I145_E0.9840.96
186_V213_S0.9740.96
246_E249_E0.9670.95
243_T247_L0.9660.95
221_N252_I0.9640.95
181_D203_F0.9580.95
258_C343_H0.9550.95
82_E196_Y0.9540.95
127_M131_K0.9520.95
132_I140_G0.9450.95
214_A243_T0.9420.95
197_G200_K0.9390.95
237_L240_Q0.9390.95
43_V69_P0.9380.95
162_I167_F0.9330.95
206_V220_Y0.9260.94
190_I226_V0.9250.94
270_G315_T0.9180.94
23_F93_V0.9120.94
193_G197_G0.9120.94
288_E293_K0.9080.94
286_V328_E0.9050.94
110_E113_K0.9000.93
170_P207_R0.8970.93
181_D361_R0.8960.93
198_L203_F0.8960.93
143_A148_I0.8950.93
314_N332_H0.8920.93
320_Y325_Y0.8910.93
93_V121_F0.8860.93
71_K103_N0.8830.93
62_L95_E0.8820.93
175_F206_V0.8790.93
342_F353_T0.8770.92
50_S258_C0.8740.92
163_D240_Q0.8690.92
24_G119_G0.8640.92
9_Y19_E0.8630.92
361_R364_V0.8630.92
159_Y162_I0.8610.92
53_G89_E0.8610.92
157_K162_I0.8610.92
212_F220_Y0.8580.92
14_D135_Y0.8580.92
176_H199_Y0.8560.92
92_I123_V0.8540.91
359_K362_T0.8530.91
163_D239_N0.8510.91
139_M159_Y0.8510.91
18_I127_M0.8510.91
31_G55_I0.8490.91
205_I226_V0.8450.91
68_V81_F0.8370.91
85_R115_E0.8310.90
159_Y303_Y0.8250.90
104_S107_T0.8200.90
213_S243_T0.8200.90
185_V228_S0.8200.90
215_S219_E0.8190.90
201_R361_R0.8180.90
268_L337_I0.8160.90
318_W331_I0.8150.89
33_V57_I0.8110.89
9_Y146_L0.8110.89
248_V264_A0.8070.89
229_N258_C0.8060.89
22_S144_S0.8030.89
183_I198_L0.8030.89
259_L266_L0.8030.89
188_C263_I0.7990.89
284_K323_D0.7900.88
112_L117_V0.7880.88
166_Q211_S0.7880.88
249_E335_L0.7870.88
92_I140_G0.7860.88
217_I222_P0.7850.88
238_E242_K0.7850.88
217_I243_T0.7850.88
332_H337_I0.7800.87
161_E236_L0.7790.87
46_L112_L0.7780.87
358_D361_R0.7770.87
227_F254_I0.7750.87
177_P180_G0.7690.87
84_E192_H0.7690.87
11_Y143_A0.7690.87
29_K89_E0.7670.86
159_Y164_F0.7650.86
9_Y17_F0.7640.86
197_G201_R0.7620.86
57_I129_V0.7620.86
46_L108_L0.7610.86
280_R284_K0.7570.86
145_E148_I0.7560.86
156_E159_Y0.7540.85
225_I250_Y0.7530.85
308_K327_I0.7490.85
12_L128_I0.7490.85
295_Y342_F0.7490.85
47_T81_F0.7480.85
192_H196_Y0.7470.85
342_F355_W0.7470.85
282_I321_N0.7470.85
53_G167_F0.7440.85
210_C239_N0.7430.85
288_E291_S0.7430.85
254_I337_I0.7340.84
203_F224_G0.7330.84
183_I224_G0.7320.84
212_F217_I0.7310.84
24_G109_D0.7300.84
319_F355_W0.7250.83
109_D119_G0.7240.83
173_P208_V0.7240.83
161_E303_Y0.7210.83
88_V91_L0.7200.83
143_A147_E0.7200.83
38_S298_T0.7190.83
174_I195_L0.7150.82
178_N204_S0.7140.82
112_L119_G0.7090.82
161_E164_F0.7090.82
225_I254_I0.7080.82
66_Y323_D0.7080.82
111_W115_E0.7080.82
52_K85_R0.7060.82
132_I137_T0.7060.82
200_K354_T0.7060.82
268_L335_L0.7050.81
118_P142_I0.6990.81
83_S87_Q0.6980.81
265_T270_G0.6980.81
184_V206_V0.6980.81
194_I257_I0.6970.81
214_A250_Y0.6960.81
218_I246_E0.6950.80
194_I346_A0.6940.80
36_T58_I0.6940.80
49_P345_E0.6920.80
66_Y69_P0.6900.80
310_D313_P0.6870.80
88_V117_V0.6860.80
194_I258_C0.6820.79
239_N242_K0.6820.79
131_K135_Y0.6820.79
240_Q243_T0.6820.79
160_D235_N0.6820.79
110_E114_S0.6800.79
28_I143_A0.6800.79
30_V141_I0.6800.79
307_S327_I0.6790.79
91_L112_L0.6790.79
186_V227_F0.6770.79
176_H195_L0.6740.78
214_A247_L0.6720.78
213_S247_L0.6710.78
36_T284_K0.6680.78
164_F303_Y0.6660.78
242_K249_E0.6630.77
153_K157_K0.6620.77
299_H328_E0.6600.77
45_S51_Y0.6600.77
180_G204_S0.6590.77
333_E336_P0.6580.77
271_K310_D0.6580.77
258_C350_P0.6570.77
51_Y54_Q0.6560.77
211_S216_K0.6550.76
139_M160_D0.6550.76
128_I140_G0.6510.76
52_K89_E0.6510.76
63_V93_V0.6500.76
280_R342_F0.6480.76
174_I199_Y0.6470.76
26_K118_P0.6460.75
239_N243_T0.6460.75
43_V80_N0.6460.75
245_S249_E0.6450.75
10_L123_V0.6450.75
275_M304_G0.6450.75
224_G360_F0.6420.75
39_M66_Y0.6400.75
47_T111_W0.6390.75
23_F96_H0.6330.74
236_L303_Y0.6310.74
258_C277_F0.6300.74
139_M158_K0.6300.74
217_I225_I0.6290.74
27_G144_S0.6280.73
201_R354_T0.6280.73
13_E135_Y0.6260.73
62_L66_Y0.6260.73
266_L271_K0.6250.73
57_I92_I0.6190.72
195_L207_R0.6170.72
218_I247_L0.6160.72
195_L226_V0.6140.72
30_V153_K0.6120.71
165_T188_C0.6110.71
157_K161_E0.6110.71
182_M223_K0.6100.71
238_E241_I0.6100.71
129_V321_N0.6090.71
241_I245_S0.6090.71
258_C278_G0.6080.71
120_V123_V0.6050.71
215_S218_I0.6030.70
50_S343_H0.6020.70
181_D202_G0.6020.70
336_P363_M0.6020.70
36_T194_I0.6020.70
184_V217_I0.6000.70
137_T303_Y0.6000.70
34_V280_R0.6000.70
343_H350_P0.5990.70
295_Y319_F0.5990.70
186_V240_Q0.5990.70
217_I247_L0.5980.70
299_H321_N0.5970.70
9_Y149_D0.5970.70
270_G330_L0.5970.70
246_E250_Y0.5960.69
86_I111_W0.5950.69
173_P220_Y0.5940.69
52_K164_F0.5940.69
280_R328_E0.5940.69
7_K145_E0.5930.69
134_T276_K0.5930.69
71_K105_A0.5930.69
224_G255_L0.5910.69
347_R351_W0.5910.69
33_V92_I0.5900.69
153_K156_E0.5900.69
45_S284_K0.5890.69
268_L312_P0.5890.69
52_K168_T0.5870.68
93_V119_G0.5840.68
58_I63_V0.5840.68
43_V319_F0.5810.68
198_L205_I0.5800.67
233_N272_I0.5800.67
25_A113_K0.5790.67
313_P333_E0.5790.67
96_H121_F0.5780.67
237_L259_L0.5780.67
147_E152_R0.5750.67
321_N328_E0.5740.67
193_G354_T0.5730.66
287_I325_Y0.5720.66
36_T57_I0.5700.66
328_E342_F0.5700.66
251_K336_P0.5700.66
261_H305_I0.5700.66
50_S229_N0.5690.66
185_V255_L0.5680.66
181_D223_K0.5680.66
22_S26_K0.5670.66
282_I347_R0.5670.66
83_S86_I0.5670.66
163_D236_L0.5660.66
288_E355_W0.5640.65
166_Q239_N0.5610.65
110_E116_N0.5610.65
80_N102_W0.5570.64
226_V339_T0.5570.64
10_L33_V0.5560.64
57_I132_I0.5550.64
211_S240_Q0.5550.64
288_E318_W0.5550.64
258_C262_Q0.5530.64
288_E319_F0.5520.64
305_I330_L0.5510.63
24_G118_P0.5510.63
229_N343_H0.5500.63
280_R323_D0.5500.63
22_S119_G0.5500.63
153_K159_Y0.5490.63
296_I345_E0.5490.63
208_V213_S0.5480.63
34_V277_F0.5480.63
152_R155_L0.5470.63
275_M302_G0.5470.63
165_T236_L0.5460.63
18_I138_M0.5440.63
46_L58_I0.5430.62
177_P204_S0.5420.62
197_G280_R0.5420.62
262_Q343_H0.5420.62
139_M157_K0.5410.62
304_G327_I0.5380.62
226_V338_I0.5370.62
80_N83_S0.5370.62
38_S280_R0.5370.62
23_F121_F0.5370.62
176_H207_R0.5370.62
57_I60_H0.5370.62
53_G162_I0.5370.62
69_P319_F0.5360.61
51_Y258_C0.5340.61
55_I88_V0.5330.61
132_I138_M0.5320.61
137_T302_G0.5320.61
69_P101_K0.5310.61
193_G347_R0.5300.61
359_K363_M0.5300.61
241_I267_A0.5290.60
131_K138_M0.5290.60
340_T356_V0.5290.60
186_V225_I0.5280.60
45_S261_H0.5280.60
259_L263_I0.5270.60
23_F118_P0.5270.60
307_S311_I0.5250.60
198_L361_R0.5240.60
95_E122_D0.5220.59
210_C240_Q0.5220.59
66_Y258_C0.5210.59
159_Y302_G0.5200.59
192_H195_L0.5200.59
280_R297_S0.5200.59
81_F115_E0.5190.59
34_V276_K0.5170.59
358_D362_T0.5170.59
171_K245_S0.5160.58
284_K348_P0.5160.58
31_G56_L0.5150.58
62_L328_E0.5150.58
240_Q263_I0.5140.58
9_Y143_A0.5130.58
218_I250_Y0.5120.58
8_G118_P0.5110.58
60_H66_Y0.5110.58
82_E193_G0.5090.57
265_T268_L0.5090.57
26_K116_N0.5070.57
262_Q278_G0.5070.57
284_K303_Y0.5040.57
9_Y147_E0.5030.57
319_F356_V0.5030.57
186_V247_L0.5020.56
311_I327_I0.5010.56
196_Y227_F0.5010.56
48_D278_G0.5000.56
229_N340_T0.5000.56
222_P225_I0.5000.56
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1a9xB 1 0.9646 100 0.208 Contact Map
1vcoA 4 0.9319 100 0.652 Contact Map
1s1mA 4 0.9373 100 0.67 Contact Map
3nvaA 2 0.9155 100 0.685 Contact Map
4zdjA 4 0.9237 100 0.711 Contact Map
2vxoA 2 0.4877 100 0.773 Contact Map
3tqiA 3 0.4632 100 0.783 Contact Map
2h2wA 2 0.6376 100 0.785 Contact Map
2vpiA 1 0.4687 100 0.786 Contact Map
1gpmA 3 0.5068 100 0.786 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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