GREMLIN Database
DPOL2 - DNA polymerase 2
UniProt: Q07635 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 626 (544)
Sequences: 1895 (1098)
Seq/√Len: 47.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
333_Q457_R5.0441.00
228_K255_E4.5221.00
577_Y580_W4.4201.00
583_D586_Y4.0761.00
583_D587_V3.9511.00
574_P580_W3.4451.00
368_D373_L3.4221.00
577_Y587_V3.4011.00
381_K389_Q3.2141.00
577_Y583_D3.2041.00
123_V126_Y3.1331.00
602_G607_Y3.1221.00
577_Y582_K3.0931.00
370_K373_L3.0671.00
82_A87_G2.9151.00
583_D588_R2.8681.00
582_K587_V2.8181.00
585_P588_R2.8111.00
577_Y586_Y2.7611.00
121_P130_K2.7291.00
119_Q130_K2.7151.00
73_E76_E2.6701.00
134_L142_Y2.6541.00
368_D371_T2.6351.00
602_G605_V2.6331.00
575_I580_W2.5591.00
598_L602_G2.5201.00
579_I583_D2.4061.00
539_D543_E2.3811.00
574_P579_I2.3721.00
130_K133_T2.3411.00
274_L295_W2.2811.00
125_Y129_E2.2761.00
448_M452_E2.2701.00
605_V608_Y2.2581.00
590_I597_R2.2531.00
580_W583_D2.2501.00
77_E82_A2.2231.00
228_K248_S2.1991.00
574_P577_Y2.1831.00
290_T426_L2.1621.00
549_T552_D2.1251.00
591_K595_E2.1231.00
104_T108_Y2.1151.00
605_V609_I2.1141.00
580_W587_V2.1071.00
84_P87_G2.0661.00
223_R229_P2.0601.00
602_G608_Y2.0561.00
296_V299_K2.0431.00
584_V588_R2.0290.99
566_R570_I2.0100.99
582_K586_Y2.0090.99
582_K585_P1.9920.99
150_D249_N1.9790.99
74_K77_E1.9500.99
145_E150_D1.9490.99
105_F108_Y1.9480.99
602_G609_I1.9460.99
138_E199_V1.9430.99
493_Y520_I1.9430.99
369_I373_L1.9310.99
389_Q393_E1.9260.99
589_G597_R1.9230.99
598_L605_V1.9160.99
300_R386_E1.9080.99
603_R607_Y1.8990.99
508_P518_E1.8960.99
560_D564_H1.8680.99
592_G595_E1.8610.99
589_G595_E1.8610.99
477_I481_E1.8550.99
84_P154_Y1.8470.99
597_R602_G1.8460.99
542_R546_S1.8440.99
124_R157_K1.8380.99
590_I602_G1.8030.99
538_E542_R1.8020.99
296_V390_W1.7930.99
248_S251_K1.7810.99
589_G596_A1.7700.99
600_Y603_R1.7690.99
505_T524_L1.7650.99
82_A88_G1.7580.98
566_R569_A1.7120.98
479_K482_K1.7080.98
603_R609_I1.7020.98
581_I584_V1.7000.98
576_D580_W1.6990.98
599_G603_R1.6970.98
574_P578_V1.6780.98
580_W585_P1.6750.98
141_V263_A1.6740.98
574_P583_D1.6720.98
560_D563_E1.6690.98
364_E367_D1.6670.98
574_P585_P1.6630.98
598_L603_R1.6620.98
292_N412_I1.6540.98
143_R146_V1.6540.98
368_D372_E1.6500.98
579_I585_P1.6430.98
74_K82_A1.6400.98
575_I585_P1.6400.98
417_F433_Y1.6360.98
478_E482_K1.6340.98
580_W586_Y1.6070.97
121_P127_E1.5940.97
579_I584_V1.5860.97
222_V252_I1.5820.97
590_I596_A1.5650.97
475_K479_K1.5490.97
400_K403_E1.5490.97
564_H568_R1.5400.96
599_G602_G1.5320.96
382_G385_P1.5310.96
574_P582_K1.5250.96
579_I582_K1.5250.96
598_L607_Y1.5200.96
156_R159_L1.5150.96
539_D542_R1.5100.96
357_N362_T1.5070.96
357_N382_G1.4900.96
84_P88_G1.4840.96
582_K588_R1.4810.96
603_R608_Y1.4780.96
103_T106_P1.4780.96
235_I238_C1.4480.95
132_K135_D1.4430.95
86_K89_V1.4370.95
590_I607_Y1.4360.95
369_I372_E1.4330.95
215_E220_N1.4330.95
471_D475_K1.4190.94
591_K596_A1.4140.94
230_E249_N1.4140.94
72_C75_M1.4010.94
145_E205_Y1.4000.94
384_I420_L1.3970.94
590_I593_F1.3960.94
474_D478_E1.3840.94
166_P169_L1.3810.94
85_I88_G1.3730.93
356_H443_T1.3710.93
577_Y581_I1.3700.93
494_N517_G1.3680.93
574_P581_I1.3660.93
558_I563_E1.3630.93
589_G593_F1.3600.93
91_L105_F1.3580.93
578_V583_D1.3570.93
374_H435_M1.3510.93
578_V581_I1.3340.92
342_Q467_V1.3330.92
577_Y585_P1.3310.92
83_Y88_G1.3290.92
452_E457_R1.3280.92
326_G437_T1.3280.92
62_F131_W1.3280.92
72_C77_E1.3250.92
72_C82_A1.3220.92
590_I605_V1.3220.92
326_G329_I1.3190.92
590_I603_R1.3150.92
161_V164_E1.3120.92
392_I413_L1.3110.92
142_Y228_K1.3050.91
543_E556_L1.3000.91
145_E149_L1.3000.91
602_G610_N1.2970.91
219_N229_P1.2970.91
446_R449_E1.2950.91
590_I598_L1.2920.91
567_K570_I1.2830.91
346_S489_D1.2810.91
589_G592_G1.2730.90
297_A361_E1.2610.90
584_V587_V1.2600.90
457_R469_K1.2570.90
603_R606_N1.2510.90
83_Y87_G1.2470.89
397_E400_K1.2440.89
57_Y61_Y1.2400.89
598_L608_Y1.2400.89
585_P589_G1.2300.89
578_V585_P1.2290.89
249_N437_T1.2240.89
167_T170_S1.2240.89
577_Y588_R1.2200.88
261_V264_K1.2160.88
182_R188_D1.2120.88
575_I583_D1.2080.88
451_A466_L1.2050.88
400_K404_E1.1960.87
444_L466_L1.1950.87
87_G92_F1.1940.87
579_I587_V1.1900.87
575_I579_I1.1880.87
214_F534_K1.1800.87
599_G605_V1.1780.87
606_N609_I1.1780.87
595_E600_Y1.1750.86
462_I502_R1.1730.86
480_V488_L1.1700.86
296_V387_A1.1610.86
77_E87_G1.1590.86
592_G596_A1.1560.86
266_L277_I1.1550.86
590_I609_I1.1510.85
73_E77_E1.1490.85
82_A86_K1.1420.85
580_W584_V1.1370.85
88_G91_L1.1350.84
251_K255_E1.1260.84
575_I578_V1.1260.84
356_H486_L1.1250.84
589_G594_Y1.1250.84
581_I587_V1.1240.84
100_T109_T1.1230.84
342_Q506_P1.1200.84
536_F540_V1.1200.84
221_E256_K1.1180.84
104_T107_V1.1160.83
166_P170_S1.1080.83
101_I105_F1.1010.83
105_F109_T1.1010.83
82_A90_K1.0990.83
129_E133_T1.0990.83
231_V244_N1.0980.82
596_A603_R1.0950.82
609_I612_L1.0920.82
340_V469_K1.0880.82
391_L409_I1.0860.82
443_T447_T1.0830.82
394_R397_E1.0820.82
461_G465_S1.0810.81
450_I483_E1.0790.81
106_P109_T1.0780.81
268_E403_E1.0740.81
497_I505_T1.0720.81
226_Y252_I1.0720.81
433_Y440_A1.0710.81
101_I104_T1.0690.81
501_T504_N1.0680.81
138_E274_L1.0650.80
269_W408_A1.0650.80
443_T486_L1.0640.80
213_V221_E1.0630.80
535_S576_D1.0570.80
82_A85_I1.0570.80
579_I586_Y1.0570.80
71_E77_E1.0570.80
100_T108_Y1.0520.80
103_T107_V1.0510.80
101_I106_P1.0500.80
300_R383_I1.0420.79
568_R572_G1.0390.79
419_Y425_S1.0270.78
417_F440_A1.0250.78
204_W257_K1.0240.78
558_I561_L1.0240.78
83_Y86_K1.0240.78
203_D326_G1.0180.77
507_Y546_S1.0170.77
101_I108_Y1.0130.77
242_A272_I1.0130.77
65_I68_L1.0090.77
87_G90_K1.0090.77
73_E78_Y1.0070.77
199_V505_T1.0000.76
580_W588_R1.0000.76
598_L609_I0.9940.76
470_G490_Y0.9920.76
576_D583_D0.9910.75
96_F100_T0.9870.75
345_F351_S0.9830.75
74_K87_G0.9790.75
230_E252_I0.9770.74
569_A577_Y0.9720.74
521_A524_L0.9710.74
245_Y249_N0.9640.73
149_L249_N0.9640.73
72_C76_E0.9630.73
249_N326_G0.9590.73
268_E271_F0.9570.73
531_N534_K0.9560.73
89_V93_L0.9530.73
395_K406_A0.9520.72
451_A476_F0.9510.72
75_M78_Y0.9490.72
473_V477_I0.9490.72
209_L216_V0.9480.72
161_V168_V0.9450.72
569_A572_G0.9450.72
574_P587_V0.9440.72
335_G408_A0.9410.72
479_K483_E0.9400.71
145_E249_N0.9380.71
598_L601_M0.9380.71
93_L96_F0.9380.71
312_E323_V0.9380.71
90_K93_L0.9370.71
591_K597_R0.9370.71
323_V423_R0.9370.71
590_I594_Y0.9350.71
482_K576_D0.9340.71
206_G209_L0.9340.71
144_F256_K0.9330.71
446_R450_I0.9330.71
132_K158_R0.9330.71
398_L409_I0.9310.71
65_I245_Y0.9240.70
200_V277_I0.9240.70
276_P279_E0.9230.70
88_G92_F0.9220.70
234_D237_E0.9210.70
297_A383_I0.9170.70
531_N535_S0.9170.70
591_K594_Y0.9150.69
91_L101_I0.9130.69
76_E82_A0.9120.69
102_R106_P0.9120.69
346_S385_P0.9110.69
155_M159_L0.9090.69
63_A150_D0.9070.69
141_V162_V0.9050.69
450_I480_V0.9040.68
218_I249_N0.9040.68
558_I562_F0.9020.68
294_A304_I0.9010.68
140_K199_V0.9000.68
272_I409_I0.8990.68
110_I113_N0.8970.68
102_R105_F0.8960.68
578_V587_V0.8960.68
382_G386_E0.8950.68
204_W253_R0.8940.68
352_L443_T0.8930.68
605_V610_N0.8930.68
98_E106_P0.8930.68
230_E245_Y0.8880.67
116_I247_K0.8850.67
599_G609_I0.8840.67
77_E88_G0.8840.67
91_L100_T0.8790.66
88_G250_V0.8790.66
95_N101_I0.8780.66
91_L94_S0.8780.66
92_F95_N0.8770.66
578_V588_R0.8760.66
233_V238_C0.8740.66
607_Y610_N0.8700.66
339_N469_K0.8680.65
153_Y157_K0.8610.65
290_T307_V0.8600.65
352_L486_L0.8590.65
144_F221_E0.8570.64
570_I573_E0.8560.64
590_I595_E0.8540.64
343_V476_F0.8530.64
498_F522_K0.8530.64
445_R449_E0.8490.64
334_P438_Y0.8490.64
447_T466_L0.8490.64
77_E86_K0.8480.63
410_K418_G0.8470.63
101_I109_T0.8470.63
574_P588_R0.8450.63
71_E74_K0.8430.63
362_T382_G0.8430.63
569_A573_E0.8410.63
93_L97_K0.8400.63
200_V294_A0.8390.63
149_L205_Y0.8390.63
581_I598_L0.8370.62
63_A66_W0.8370.62
529_M533_V0.8350.62
568_R571_N0.8330.62
605_V612_L0.8320.62
71_E75_M0.8290.62
150_D245_Y0.8290.62
592_G603_R0.8280.62
454_M479_K0.8280.62
93_L108_Y0.8250.61
381_K386_E0.8240.61
453_E471_D0.8240.61
89_V95_N0.8230.61
88_G103_T0.8190.61
83_Y90_K0.8180.61
220_N442_K0.8160.60
334_P500_I0.8120.60
87_G91_L0.8100.60
521_A525_I0.8040.59
579_I588_R0.8030.59
96_F104_T0.8020.59
331_F354_V0.8020.59
355_K485_G0.8000.59
341_Y468_V0.7960.59
576_D579_I0.7920.58
346_S487_R0.7900.58
594_Y597_R0.7900.58
150_D230_E0.7880.58
467_V506_P0.7880.58
359_S374_H0.7880.58
97_K101_I0.7880.58
608_Y612_L0.7860.58
290_T419_Y0.7830.57
147_E201_P0.7830.57
95_N104_T0.7830.57
536_F565_Y0.7820.57
100_T105_F0.7810.57
364_E601_M0.7810.57
550_C553_V0.7800.57
168_V171_Q0.7780.57
97_K102_R0.7760.57
286_G428_G0.7760.57
65_I249_N0.7750.57
607_Y612_L0.7740.56
98_E104_T0.7740.56
55_D61_Y0.7740.56
93_L101_I0.7730.56
107_V110_I0.7730.56
358_I486_L0.7720.56
93_L106_P0.7710.56
576_D581_I0.7700.56
601_M604_D0.7690.56
340_V459_L0.7670.56
340_V496_I0.7650.56
596_A609_I0.7650.56
346_S411_W0.7640.55
106_P110_I0.7640.55
442_K446_R0.7630.55
405_R413_L0.7570.55
146_V201_P0.7570.55
268_E405_R0.7550.55
95_N105_F0.7540.54
534_K538_E0.7530.54
555_K559_R0.7510.54
305_P335_G0.7500.54
470_G473_V0.7500.54
226_Y388_L0.7500.54
574_P584_V0.7460.54
162_V171_Q0.7430.53
233_V237_E0.7410.53
339_N494_N0.7410.53
196_I262_S0.7390.53
207_E262_S0.7380.53
590_I599_G0.7360.53
99_K103_T0.7340.52
93_L100_T0.7340.52
348_M440_A0.7330.52
419_Y427_F0.7330.52
246_V250_V0.7330.52
585_P590_I0.7300.52
347_S411_W0.7300.52
140_K198_R0.7270.52
85_I89_V0.7250.52
214_F220_N0.7240.52
218_I408_A0.7240.52
496_I506_P0.7230.51
89_V94_S0.7230.51
397_E401_I0.7230.51
103_T108_Y0.7220.51
141_V373_L0.7210.51
124_R127_E0.7210.51
61_Y250_V0.7210.51
576_D587_V0.7180.51
241_E244_N0.7170.51
450_I479_K0.7170.51
375_S379_K0.7160.51
377_C381_K0.7160.51
62_F65_I0.7150.51
590_I606_N0.7130.50
292_N387_A0.7130.50
575_I586_Y0.7130.50
574_P586_Y0.7130.50
154_Y259_S0.7130.50
411_W424_N0.7100.50
96_F99_K0.7100.50
575_I588_R0.7100.50
342_Q461_G0.7090.50
602_G612_L0.7080.50
123_V179_K0.7050.50
66_W69_A0.7050.50
217_K222_V0.7050.50
154_Y164_E0.7030.49
247_K488_L0.7020.49
586_Y589_G0.7020.49
94_S97_K0.7010.49
406_A527_E0.7010.49
91_L108_Y0.7010.49
601_M605_V0.7000.49
90_K94_S0.7000.49
96_F108_Y0.6990.49
218_I326_G0.6970.49
150_D205_Y0.6960.49
71_E78_Y0.6960.49
552_D555_K0.6930.48
268_E493_Y0.6920.48
84_P89_V0.6920.48
476_F481_E0.6900.48
556_L560_D0.6880.48
583_D590_I0.6870.48
591_K598_L0.6860.48
69_A74_K0.6860.48
583_D589_G0.6850.48
476_F488_L0.6850.48
202_L207_E0.6850.48
96_F109_T0.6840.48
203_D415_A0.6820.47
150_D437_T0.6810.47
199_V274_L0.6800.47
185_R188_D0.6800.47
596_A602_G0.6800.47
388_L436_V0.6780.47
123_V154_Y0.6780.47
61_Y65_I0.6770.47
346_S503_N0.6770.47
208_S211_G0.6760.47
69_A76_E0.6760.47
334_P337_Y0.6760.47
97_K100_T0.6750.47
410_K464_D0.6740.47
347_S506_P0.6740.47
568_R573_E0.6730.46
85_I90_K0.6730.46
207_E263_A0.6730.46
61_Y253_R0.6720.46
578_V584_V0.6720.46
122_E126_Y0.6710.46
96_F103_T0.6700.46
231_V241_E0.6690.46
597_R603_R0.6680.46
85_I105_F0.6680.46
65_I150_D0.6670.46
91_L96_F0.6670.46
165_T171_Q0.6670.46
145_E222_V0.6660.46
95_N102_R0.6660.46
413_L527_E0.6650.46
117_V136_G0.6630.45
595_E602_G0.6620.45
306_K426_L0.6620.45
161_V171_Q0.6610.45
451_A498_F0.6600.45
128_K135_D0.6600.45
84_P90_K0.6600.45
127_E331_F0.6590.45
101_I111_T0.6580.45
351_S398_L0.6560.45
207_E266_L0.6560.45
468_V474_D0.6560.45
330_L461_G0.6560.45
218_I230_E0.6550.45
332_P441_R0.6540.45
58_N62_F0.6530.44
596_A608_Y0.6530.44
93_L98_E0.6520.44
593_F596_A0.6520.44
144_F204_W0.6510.44
149_L245_Y0.6500.44
263_A524_L0.6500.44
142_Y196_I0.6490.44
269_W288_V0.6490.44
497_I538_E0.6460.44
203_D440_A0.6460.44
74_K78_Y0.6450.44
106_P111_T0.6450.44
57_Y62_F0.6440.44
245_Y252_I0.6440.44
525_I528_N0.6440.44
134_L449_E0.6430.43
453_E572_G0.6420.43
590_I608_Y0.6420.43
70_E75_M0.6420.43
101_I107_V0.6390.43
117_V453_E0.6380.43
279_E287_K0.6380.43
460_H467_V0.6370.43
62_F151_A0.6360.43
421_G433_Y0.6330.43
149_L230_E0.6320.42
85_I107_V0.6290.42
90_K99_K0.6270.42
82_A92_F0.6220.41
99_K102_R0.6220.41
135_D304_I0.6210.41
543_E546_S0.6200.41
410_K463_I0.6180.41
208_S221_E0.6180.41
213_V216_V0.6170.41
597_R600_Y0.6170.41
575_I587_V0.6170.41
198_R503_N0.6160.41
505_T541_L0.6130.41
350_P523_G0.6120.40
327_G346_S0.6110.40
418_G464_D0.6110.40
89_V97_K0.6100.40
601_M608_Y0.6100.40
69_A72_C0.6100.40
577_Y584_V0.6090.40
167_T171_Q0.6080.40
58_N63_A0.6070.40
127_E164_E0.6070.40
347_S465_S0.6060.40
329_I501_T0.6050.40
540_V553_V0.6050.40
141_V258_R0.6040.40
100_T107_V0.6040.40
521_A541_L0.6040.40
269_W273_S0.6040.40
524_L537_L0.6020.40
594_Y599_G0.6020.40
323_V542_R0.6010.39
100_T103_T0.6010.39
298_F301_R0.6000.39
599_G607_Y0.5990.39
140_K505_T0.5990.39
330_L525_I0.5990.39
203_D437_T0.5980.39
95_N99_K0.5980.39
526_R530_P0.5970.39
536_F561_L0.5970.39
473_V481_E0.5970.39
326_G421_G0.5960.39
591_K602_G0.5960.39
96_F101_I0.5940.39
64_L468_V0.5940.39
394_R403_E0.5940.39
65_I230_E0.5920.39
376_I379_K0.5910.38
65_I252_I0.5910.38
597_R608_Y0.5890.38
237_E241_E0.5890.38
89_V103_T0.5880.38
414_V433_Y0.5870.38
88_G96_F0.5860.38
150_D326_G0.5850.38
55_D58_N0.5850.38
83_Y92_F0.5850.38
284_T422_Y0.5850.38
359_S362_T0.5850.38
471_D474_D0.5850.38
223_R600_Y0.5830.38
284_T428_G0.5820.38
596_A606_N0.5820.38
428_G481_E0.5810.38
385_P413_L0.5800.37
232_E238_C0.5790.37
535_S539_D0.5790.37
91_L103_T0.5780.37
123_V128_K0.5780.37
102_R107_V0.5780.37
270_S388_L0.5780.37
74_K86_K0.5780.37
131_W244_N0.5760.37
462_I501_T0.5760.37
346_S426_L0.5760.37
256_K260_P0.5760.37
90_K95_N0.5760.37
586_Y590_I0.5750.37
576_D605_V0.5750.37
169_L197_A0.5740.37
173_L403_E0.5740.37
589_G602_G0.5740.37
244_N364_E0.5740.37
293_E408_A0.5740.37
420_L427_F0.5740.37
530_P533_V0.5730.37
128_K341_Y0.5710.37
160_N450_I0.5710.37
288_V359_S0.5700.37
127_E321_M0.5700.37
77_E85_I0.5700.37
592_G602_G0.5680.36
273_S496_I0.5680.36
105_F110_I0.5670.36
105_F111_T0.5670.36
288_V530_P0.5660.36
565_Y568_R0.5650.36
591_K603_R0.5650.36
58_N65_I0.5640.36
266_L280_I0.5620.36
218_I245_Y0.5620.36
55_D66_W0.5610.36
76_E87_G0.5610.36
166_P171_Q0.5600.36
606_N612_L0.5590.36
418_G463_I0.5590.36
145_E326_G0.5580.35
143_R150_D0.5580.35
577_Y590_I0.5560.35
297_A420_L0.5560.35
560_D568_R0.5550.35
220_N223_R0.5550.35
547_A553_V0.5540.35
345_F429_K0.5540.35
327_G437_T0.5540.35
293_E402_D0.5540.35
63_A245_Y0.5530.35
575_I582_K0.5530.35
498_F520_I0.5520.35
96_F102_R0.5510.35
72_C78_Y0.5510.35
415_A437_T0.5510.35
284_T451_A0.5510.35
304_I347_S0.5500.35
149_L326_G0.5490.35
187_S516_N0.5470.34
185_R189_D0.5470.34
82_A89_V0.5460.34
425_S527_E0.5450.34
235_I239_L0.5450.34
367_D373_L0.5450.34
332_P362_T0.5450.34
413_L419_Y0.5450.34
589_G603_R0.5440.34
343_V528_N0.5440.34
309_P312_E0.5440.34
505_T545_S0.5440.34
298_F304_I0.5430.34
555_K560_D0.5430.34
347_S350_P0.5420.34
421_G465_S0.5420.34
62_F67_A0.5410.34
58_N69_A0.5410.34
129_E141_V0.5400.34
599_G604_D0.5400.34
324_D406_A0.5400.34
74_K88_G0.5390.34
591_K605_V0.5380.34
288_V360_A0.5370.34
104_T111_T0.5350.33
332_P444_L0.5350.33
242_A343_V0.5340.33
58_N64_L0.5340.33
280_I422_Y0.5330.33
163_N166_P0.5330.33
88_G93_L0.5320.33
581_I586_Y0.5320.33
160_N555_K0.5320.33
460_H528_N0.5310.33
429_K520_I0.5310.33
285_I421_G0.5310.33
71_E76_E0.5300.33
460_H465_S0.5300.33
216_V407_E0.5290.33
73_E87_G0.5290.33
290_T422_Y0.5290.33
355_K481_E0.5290.33
332_P460_H0.5280.33
323_V340_V0.5270.33
199_V458_V0.5270.33
243_C246_V0.5260.33
358_I439_L0.5260.33
567_K573_E0.5260.33
606_N611_Y0.5260.33
74_K84_P0.5240.32
69_A75_M0.5240.32
413_L528_N0.5240.32
55_D140_K0.5230.32
96_F555_K0.5230.32
367_D474_D0.5230.32
473_V476_F0.5230.32
205_Y217_K0.5230.32
499_T537_L0.5230.32
90_K102_R0.5220.32
72_C87_G0.5210.32
93_L99_K0.5210.32
203_D218_I0.5180.32
461_G468_V0.5180.32
354_V419_Y0.5180.32
126_Y551_S0.5170.32
327_G432_A0.5170.32
432_A444_L0.5170.32
473_V492_R0.5160.32
144_F213_V0.5160.32
273_S408_A0.5160.32
135_D168_V0.5150.32
604_D610_N0.5140.32
434_E439_L0.5140.32
356_H444_L0.5140.32
154_Y595_E0.5130.31
123_V539_D0.5120.31
163_N171_Q0.5120.31
249_N252_I0.5110.31
420_L533_V0.5110.31
252_I408_A0.5100.31
159_L482_K0.5090.31
410_K462_I0.5090.31
82_A91_L0.5090.31
96_F105_F0.5080.31
99_K104_T0.5080.31
470_G474_D0.5070.31
576_D582_K0.5070.31
122_E125_Y0.5070.31
345_F391_L0.5060.31
209_L497_I0.5060.31
401_I404_E0.5060.31
100_T104_T0.5060.31
478_E552_D0.5060.31
107_V112_D0.5050.31
152_Y156_R0.5050.31
284_T486_L0.5040.31
598_L612_L0.5040.31
141_V552_D0.5040.31
278_H282_Y0.5030.31
192_P278_H0.5030.31
385_P528_N0.5030.31
143_R198_R0.5020.31
230_E238_C0.5010.30
326_G335_G0.5010.30
262_S552_D0.5000.30
576_D588_R0.5000.30
243_C248_S0.5000.30
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3iayA 1 0.9521 100 0.267 Contact Map
2gv9A 1 0.9505 100 0.285 Contact Map
4qclA 1 0.9617 100 0.293 Contact Map
1qhtA 1 0.8818 100 0.311 Contact Map
4fvmA 1 0.9425 100 0.316 Contact Map
3k59A 1 0.9137 100 0.336 Contact Map
3qexA 1 0.9553 100 0.337 Contact Map
4m8oA 1 0.9521 100 0.348 Contact Map
1s5jA 1 0.8179 100 0.351 Contact Map
2py5A 2 0.7077 100 0.633 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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