DPOL2 - SULSO - GREMLIN Contacts

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DPOL2 - DNA polymerase 2

UniProt:	Q07635	Sequences: MGRTQPSYTMAVNRELEKLERIIERLHSPILSLLLERVKEKVRYTQSASYDELVDPYNLVYFALIWALAEECEKMEEYVLDAYPIKGGVKLFLSNFKEKTIRTTFPVYTITDNPDIVLQHPEVRYYEKEKWKTLDGKEVKVYRFEVESLDAYYYMRKRLNVVNETPTVLSQTLYRLGIKPFRRFRSSDDEFPKVTIARVVPLDWYGESLKGKVFEVKINNEVRRFYEKPEVEVDIAECLGEACNYVKSNVKIRIEKKRSPVSAKGLIEWSFISLTPIHEIAYATIGKVLTINEAWVAFKRRIIIPKVVPRVEKLRRLEDIMMVDKGGLILFPQPGCYDNVYQVDFSSMYPSLIVKHNISAETVEACDDIKTELHSICLKEKGIIPEALQWLIERKSELKKIDEERAEAIKWILVASFGYLGYRNSLFGKIEAYEMVTYLARKTLRRTMEIAEEMGLRVLHGIIDSLVVKGDNVDKFIEKVEKETGLRLDYKRYNWIIFTITRNNTPYPTRYIANMNGEMIAKGLIRENMPNIVKSFLEDVLREFSSAKTCSDVKKLRIRDLFEHYRKRAINGEPIDYVIWIKDVPYVRGIKGFYEARLGYMGRDVNYYINYLKRVYEDVEEVMSRC	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	626 (544)
Sequences:	1895 (1098)
Seq/√Len:	47.1

ECOLI - DPO2
HALSA - Q9HRV9 Q9HHJ8
SULSO - DPOL2 DPOL1 DPOL3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
333_Q	457_R	5.044	1.00
228_K	255_E	4.522	1.00
577_Y	580_W	4.420	1.00
583_D	586_Y	4.076	1.00
583_D	587_V	3.951	1.00
574_P	580_W	3.445	1.00
368_D	373_L	3.422	1.00
577_Y	587_V	3.401	1.00
381_K	389_Q	3.214	1.00
577_Y	583_D	3.204	1.00
123_V	126_Y	3.133	1.00
602_G	607_Y	3.122	1.00
577_Y	582_K	3.093	1.00
370_K	373_L	3.067	1.00
82_A	87_G	2.915	1.00
583_D	588_R	2.868	1.00
582_K	587_V	2.818	1.00
585_P	588_R	2.811	1.00
577_Y	586_Y	2.761	1.00
121_P	130_K	2.729	1.00
119_Q	130_K	2.715	1.00
73_E	76_E	2.670	1.00
134_L	142_Y	2.654	1.00
368_D	371_T	2.635	1.00
602_G	605_V	2.633	1.00
575_I	580_W	2.559	1.00
598_L	602_G	2.520	1.00
579_I	583_D	2.406	1.00
539_D	543_E	2.381	1.00
574_P	579_I	2.372	1.00
130_K	133_T	2.341	1.00
274_L	295_W	2.281	1.00
125_Y	129_E	2.276	1.00
448_M	452_E	2.270	1.00
605_V	608_Y	2.258	1.00
590_I	597_R	2.253	1.00
580_W	583_D	2.250	1.00
77_E	82_A	2.223	1.00
228_K	248_S	2.199	1.00
574_P	577_Y	2.183	1.00
290_T	426_L	2.162	1.00
549_T	552_D	2.125	1.00
591_K	595_E	2.123	1.00
104_T	108_Y	2.115	1.00
605_V	609_I	2.114	1.00
580_W	587_V	2.107	1.00
84_P	87_G	2.066	1.00
223_R	229_P	2.060	1.00
602_G	608_Y	2.056	1.00
296_V	299_K	2.043	1.00
584_V	588_R	2.029	0.99
566_R	570_I	2.010	0.99
582_K	586_Y	2.009	0.99
582_K	585_P	1.992	0.99
150_D	249_N	1.979	0.99
74_K	77_E	1.950	0.99
145_E	150_D	1.949	0.99
105_F	108_Y	1.948	0.99
602_G	609_I	1.946	0.99
138_E	199_V	1.943	0.99
493_Y	520_I	1.943	0.99
369_I	373_L	1.931	0.99
389_Q	393_E	1.926	0.99
589_G	597_R	1.923	0.99
598_L	605_V	1.916	0.99
300_R	386_E	1.908	0.99
603_R	607_Y	1.899	0.99
508_P	518_E	1.896	0.99
560_D	564_H	1.868	0.99
592_G	595_E	1.861	0.99
589_G	595_E	1.861	0.99
477_I	481_E	1.855	0.99
84_P	154_Y	1.847	0.99
597_R	602_G	1.846	0.99
542_R	546_S	1.844	0.99
124_R	157_K	1.838	0.99
590_I	602_G	1.803	0.99
538_E	542_R	1.802	0.99
296_V	390_W	1.793	0.99
248_S	251_K	1.781	0.99
589_G	596_A	1.770	0.99
600_Y	603_R	1.769	0.99
505_T	524_L	1.765	0.99
82_A	88_G	1.758	0.98
566_R	569_A	1.712	0.98
479_K	482_K	1.708	0.98
603_R	609_I	1.702	0.98
581_I	584_V	1.700	0.98
576_D	580_W	1.699	0.98
599_G	603_R	1.697	0.98
574_P	578_V	1.678	0.98
580_W	585_P	1.675	0.98
141_V	263_A	1.674	0.98
574_P	583_D	1.672	0.98
560_D	563_E	1.669	0.98
364_E	367_D	1.667	0.98
574_P	585_P	1.663	0.98
598_L	603_R	1.662	0.98
292_N	412_I	1.654	0.98
143_R	146_V	1.654	0.98
368_D	372_E	1.650	0.98
579_I	585_P	1.643	0.98
74_K	82_A	1.640	0.98
575_I	585_P	1.640	0.98
417_F	433_Y	1.636	0.98
478_E	482_K	1.634	0.98
580_W	586_Y	1.607	0.97
121_P	127_E	1.594	0.97
579_I	584_V	1.586	0.97
222_V	252_I	1.582	0.97
590_I	596_A	1.565	0.97
475_K	479_K	1.549	0.97
400_K	403_E	1.549	0.97
564_H	568_R	1.540	0.96
599_G	602_G	1.532	0.96
382_G	385_P	1.531	0.96
574_P	582_K	1.525	0.96
579_I	582_K	1.525	0.96
598_L	607_Y	1.520	0.96
156_R	159_L	1.515	0.96
539_D	542_R	1.510	0.96
357_N	362_T	1.507	0.96
357_N	382_G	1.490	0.96
84_P	88_G	1.484	0.96
582_K	588_R	1.481	0.96
603_R	608_Y	1.478	0.96
103_T	106_P	1.478	0.96
235_I	238_C	1.448	0.95
132_K	135_D	1.443	0.95
86_K	89_V	1.437	0.95
590_I	607_Y	1.436	0.95
369_I	372_E	1.433	0.95
215_E	220_N	1.433	0.95
471_D	475_K	1.419	0.94
591_K	596_A	1.414	0.94
230_E	249_N	1.414	0.94
72_C	75_M	1.401	0.94
145_E	205_Y	1.400	0.94
384_I	420_L	1.397	0.94
590_I	593_F	1.396	0.94
474_D	478_E	1.384	0.94
166_P	169_L	1.381	0.94
85_I	88_G	1.373	0.93
356_H	443_T	1.371	0.93
577_Y	581_I	1.370	0.93
494_N	517_G	1.368	0.93
574_P	581_I	1.366	0.93
558_I	563_E	1.363	0.93
589_G	593_F	1.360	0.93
91_L	105_F	1.358	0.93
578_V	583_D	1.357	0.93
374_H	435_M	1.351	0.93
578_V	581_I	1.334	0.92
342_Q	467_V	1.333	0.92
577_Y	585_P	1.331	0.92
83_Y	88_G	1.329	0.92
452_E	457_R	1.328	0.92
326_G	437_T	1.328	0.92
62_F	131_W	1.328	0.92
72_C	77_E	1.325	0.92
72_C	82_A	1.322	0.92
590_I	605_V	1.322	0.92
326_G	329_I	1.319	0.92
590_I	603_R	1.315	0.92
161_V	164_E	1.312	0.92
392_I	413_L	1.311	0.92
142_Y	228_K	1.305	0.91
543_E	556_L	1.300	0.91
145_E	149_L	1.300	0.91
602_G	610_N	1.297	0.91
219_N	229_P	1.297	0.91
446_R	449_E	1.295	0.91
590_I	598_L	1.292	0.91
567_K	570_I	1.283	0.91
346_S	489_D	1.281	0.91
589_G	592_G	1.273	0.90
297_A	361_E	1.261	0.90
584_V	587_V	1.260	0.90
457_R	469_K	1.257	0.90
603_R	606_N	1.251	0.90
83_Y	87_G	1.247	0.89
397_E	400_K	1.244	0.89
57_Y	61_Y	1.240	0.89
598_L	608_Y	1.240	0.89
585_P	589_G	1.230	0.89
578_V	585_P	1.229	0.89
249_N	437_T	1.224	0.89
167_T	170_S	1.224	0.89
577_Y	588_R	1.220	0.88
261_V	264_K	1.216	0.88
182_R	188_D	1.212	0.88
575_I	583_D	1.208	0.88
451_A	466_L	1.205	0.88
400_K	404_E	1.196	0.87
444_L	466_L	1.195	0.87
87_G	92_F	1.194	0.87
579_I	587_V	1.190	0.87
575_I	579_I	1.188	0.87
214_F	534_K	1.180	0.87
599_G	605_V	1.178	0.87
606_N	609_I	1.178	0.87
595_E	600_Y	1.175	0.86
462_I	502_R	1.173	0.86
480_V	488_L	1.170	0.86
296_V	387_A	1.161	0.86
77_E	87_G	1.159	0.86
592_G	596_A	1.156	0.86
266_L	277_I	1.155	0.86
590_I	609_I	1.151	0.85
73_E	77_E	1.149	0.85
82_A	86_K	1.142	0.85
580_W	584_V	1.137	0.85
88_G	91_L	1.135	0.84
251_K	255_E	1.126	0.84
575_I	578_V	1.126	0.84
356_H	486_L	1.125	0.84
589_G	594_Y	1.125	0.84
581_I	587_V	1.124	0.84
100_T	109_T	1.123	0.84
342_Q	506_P	1.120	0.84
536_F	540_V	1.120	0.84
221_E	256_K	1.118	0.84
104_T	107_V	1.116	0.83
166_P	170_S	1.108	0.83
101_I	105_F	1.101	0.83
105_F	109_T	1.101	0.83
82_A	90_K	1.099	0.83
129_E	133_T	1.099	0.83
231_V	244_N	1.098	0.82
596_A	603_R	1.095	0.82
609_I	612_L	1.092	0.82
340_V	469_K	1.088	0.82
391_L	409_I	1.086	0.82
443_T	447_T	1.083	0.82
394_R	397_E	1.082	0.82
461_G	465_S	1.081	0.81
450_I	483_E	1.079	0.81
106_P	109_T	1.078	0.81
268_E	403_E	1.074	0.81
497_I	505_T	1.072	0.81
226_Y	252_I	1.072	0.81
433_Y	440_A	1.071	0.81
101_I	104_T	1.069	0.81
501_T	504_N	1.068	0.81
138_E	274_L	1.065	0.80
269_W	408_A	1.065	0.80
443_T	486_L	1.064	0.80
213_V	221_E	1.063	0.80
535_S	576_D	1.057	0.80
82_A	85_I	1.057	0.80
579_I	586_Y	1.057	0.80
71_E	77_E	1.057	0.80
100_T	108_Y	1.052	0.80
103_T	107_V	1.051	0.80
101_I	106_P	1.050	0.80
300_R	383_I	1.042	0.79
568_R	572_G	1.039	0.79
419_Y	425_S	1.027	0.78
417_F	440_A	1.025	0.78
204_W	257_K	1.024	0.78
558_I	561_L	1.024	0.78
83_Y	86_K	1.024	0.78
203_D	326_G	1.018	0.77
507_Y	546_S	1.017	0.77
101_I	108_Y	1.013	0.77
242_A	272_I	1.013	0.77
65_I	68_L	1.009	0.77
87_G	90_K	1.009	0.77
73_E	78_Y	1.007	0.77
199_V	505_T	1.000	0.76
580_W	588_R	1.000	0.76
598_L	609_I	0.994	0.76
470_G	490_Y	0.992	0.76
576_D	583_D	0.991	0.75
96_F	100_T	0.987	0.75
345_F	351_S	0.983	0.75
74_K	87_G	0.979	0.75
230_E	252_I	0.977	0.74
569_A	577_Y	0.972	0.74
521_A	524_L	0.971	0.74
245_Y	249_N	0.964	0.73
149_L	249_N	0.964	0.73
72_C	76_E	0.963	0.73
249_N	326_G	0.959	0.73
268_E	271_F	0.957	0.73
531_N	534_K	0.956	0.73
89_V	93_L	0.953	0.73
395_K	406_A	0.952	0.72
451_A	476_F	0.951	0.72
75_M	78_Y	0.949	0.72
473_V	477_I	0.949	0.72
209_L	216_V	0.948	0.72
161_V	168_V	0.945	0.72
569_A	572_G	0.945	0.72
574_P	587_V	0.944	0.72
335_G	408_A	0.941	0.72
479_K	483_E	0.940	0.71
145_E	249_N	0.938	0.71
598_L	601_M	0.938	0.71
93_L	96_F	0.938	0.71
312_E	323_V	0.938	0.71
90_K	93_L	0.937	0.71
591_K	597_R	0.937	0.71
323_V	423_R	0.937	0.71
590_I	594_Y	0.935	0.71
482_K	576_D	0.934	0.71
206_G	209_L	0.934	0.71
144_F	256_K	0.933	0.71
446_R	450_I	0.933	0.71
132_K	158_R	0.933	0.71
398_L	409_I	0.931	0.71
65_I	245_Y	0.924	0.70
200_V	277_I	0.924	0.70
276_P	279_E	0.923	0.70
88_G	92_F	0.922	0.70
234_D	237_E	0.921	0.70
297_A	383_I	0.917	0.70
531_N	535_S	0.917	0.70
591_K	594_Y	0.915	0.69
91_L	101_I	0.913	0.69
76_E	82_A	0.912	0.69
102_R	106_P	0.912	0.69
346_S	385_P	0.911	0.69
155_M	159_L	0.909	0.69
63_A	150_D	0.907	0.69
141_V	162_V	0.905	0.69
450_I	480_V	0.904	0.68
218_I	249_N	0.904	0.68
558_I	562_F	0.902	0.68
294_A	304_I	0.901	0.68
140_K	199_V	0.900	0.68
272_I	409_I	0.899	0.68
110_I	113_N	0.897	0.68
102_R	105_F	0.896	0.68
578_V	587_V	0.896	0.68
382_G	386_E	0.895	0.68
204_W	253_R	0.894	0.68
352_L	443_T	0.893	0.68
605_V	610_N	0.893	0.68
98_E	106_P	0.893	0.68
230_E	245_Y	0.888	0.67
116_I	247_K	0.885	0.67
599_G	609_I	0.884	0.67
77_E	88_G	0.884	0.67
91_L	100_T	0.879	0.66
88_G	250_V	0.879	0.66
95_N	101_I	0.878	0.66
91_L	94_S	0.878	0.66
92_F	95_N	0.877	0.66
578_V	588_R	0.876	0.66
233_V	238_C	0.874	0.66
607_Y	610_N	0.870	0.66
339_N	469_K	0.868	0.65
153_Y	157_K	0.861	0.65
290_T	307_V	0.860	0.65
352_L	486_L	0.859	0.65
144_F	221_E	0.857	0.64
570_I	573_E	0.856	0.64
590_I	595_E	0.854	0.64
343_V	476_F	0.853	0.64
498_F	522_K	0.853	0.64
445_R	449_E	0.849	0.64
334_P	438_Y	0.849	0.64
447_T	466_L	0.849	0.64
77_E	86_K	0.848	0.63
410_K	418_G	0.847	0.63
101_I	109_T	0.847	0.63
574_P	588_R	0.845	0.63
71_E	74_K	0.843	0.63
362_T	382_G	0.843	0.63
569_A	573_E	0.841	0.63
93_L	97_K	0.840	0.63
200_V	294_A	0.839	0.63
149_L	205_Y	0.839	0.63
581_I	598_L	0.837	0.62
63_A	66_W	0.837	0.62
529_M	533_V	0.835	0.62
568_R	571_N	0.833	0.62
605_V	612_L	0.832	0.62
71_E	75_M	0.829	0.62
150_D	245_Y	0.829	0.62
592_G	603_R	0.828	0.62
454_M	479_K	0.828	0.62
93_L	108_Y	0.825	0.61
381_K	386_E	0.824	0.61
453_E	471_D	0.824	0.61
89_V	95_N	0.823	0.61
88_G	103_T	0.819	0.61
83_Y	90_K	0.818	0.61
220_N	442_K	0.816	0.60
334_P	500_I	0.812	0.60
87_G	91_L	0.810	0.60
521_A	525_I	0.804	0.59
579_I	588_R	0.803	0.59
96_F	104_T	0.802	0.59
331_F	354_V	0.802	0.59
355_K	485_G	0.800	0.59
341_Y	468_V	0.796	0.59
576_D	579_I	0.792	0.58
346_S	487_R	0.790	0.58
594_Y	597_R	0.790	0.58
150_D	230_E	0.788	0.58
467_V	506_P	0.788	0.58
359_S	374_H	0.788	0.58
97_K	101_I	0.788	0.58
608_Y	612_L	0.786	0.58
290_T	419_Y	0.783	0.57
147_E	201_P	0.783	0.57
95_N	104_T	0.783	0.57
536_F	565_Y	0.782	0.57
100_T	105_F	0.781	0.57
364_E	601_M	0.781	0.57
550_C	553_V	0.780	0.57
168_V	171_Q	0.778	0.57
97_K	102_R	0.776	0.57
286_G	428_G	0.776	0.57
65_I	249_N	0.775	0.57
607_Y	612_L	0.774	0.56
98_E	104_T	0.774	0.56
55_D	61_Y	0.774	0.56
93_L	101_I	0.773	0.56
107_V	110_I	0.773	0.56
358_I	486_L	0.772	0.56
93_L	106_P	0.771	0.56
576_D	581_I	0.770	0.56
601_M	604_D	0.769	0.56
340_V	459_L	0.767	0.56
340_V	496_I	0.765	0.56
596_A	609_I	0.765	0.56
346_S	411_W	0.764	0.55
106_P	110_I	0.764	0.55
442_K	446_R	0.763	0.55
405_R	413_L	0.757	0.55
146_V	201_P	0.757	0.55
268_E	405_R	0.755	0.55
95_N	105_F	0.754	0.54
534_K	538_E	0.753	0.54
555_K	559_R	0.751	0.54
305_P	335_G	0.750	0.54
470_G	473_V	0.750	0.54
226_Y	388_L	0.750	0.54
574_P	584_V	0.746	0.54
162_V	171_Q	0.743	0.53
233_V	237_E	0.741	0.53
339_N	494_N	0.741	0.53
196_I	262_S	0.739	0.53
207_E	262_S	0.738	0.53
590_I	599_G	0.736	0.53
99_K	103_T	0.734	0.52
93_L	100_T	0.734	0.52
348_M	440_A	0.733	0.52
419_Y	427_F	0.733	0.52
246_V	250_V	0.733	0.52
585_P	590_I	0.730	0.52
347_S	411_W	0.730	0.52
140_K	198_R	0.727	0.52
85_I	89_V	0.725	0.52
214_F	220_N	0.724	0.52
218_I	408_A	0.724	0.52
496_I	506_P	0.723	0.51
89_V	94_S	0.723	0.51
397_E	401_I	0.723	0.51
103_T	108_Y	0.722	0.51
141_V	373_L	0.721	0.51
124_R	127_E	0.721	0.51
61_Y	250_V	0.721	0.51
576_D	587_V	0.718	0.51
241_E	244_N	0.717	0.51
450_I	479_K	0.717	0.51
375_S	379_K	0.716	0.51
377_C	381_K	0.716	0.51
62_F	65_I	0.715	0.51
590_I	606_N	0.713	0.50
292_N	387_A	0.713	0.50
575_I	586_Y	0.713	0.50
574_P	586_Y	0.713	0.50
154_Y	259_S	0.713	0.50
411_W	424_N	0.710	0.50
96_F	99_K	0.710	0.50
575_I	588_R	0.710	0.50
342_Q	461_G	0.709	0.50
602_G	612_L	0.708	0.50
123_V	179_K	0.705	0.50
66_W	69_A	0.705	0.50
217_K	222_V	0.705	0.50
154_Y	164_E	0.703	0.49
247_K	488_L	0.702	0.49
586_Y	589_G	0.702	0.49
94_S	97_K	0.701	0.49
406_A	527_E	0.701	0.49
91_L	108_Y	0.701	0.49
601_M	605_V	0.700	0.49
90_K	94_S	0.700	0.49
96_F	108_Y	0.699	0.49
218_I	326_G	0.697	0.49
150_D	205_Y	0.696	0.49
71_E	78_Y	0.696	0.49
552_D	555_K	0.693	0.48
268_E	493_Y	0.692	0.48
84_P	89_V	0.692	0.48
476_F	481_E	0.690	0.48
556_L	560_D	0.688	0.48
583_D	590_I	0.687	0.48
591_K	598_L	0.686	0.48
69_A	74_K	0.686	0.48
583_D	589_G	0.685	0.48
476_F	488_L	0.685	0.48
202_L	207_E	0.685	0.48
96_F	109_T	0.684	0.48
203_D	415_A	0.682	0.47
150_D	437_T	0.681	0.47
199_V	274_L	0.680	0.47
185_R	188_D	0.680	0.47
596_A	602_G	0.680	0.47
388_L	436_V	0.678	0.47
123_V	154_Y	0.678	0.47
61_Y	65_I	0.677	0.47
346_S	503_N	0.677	0.47
208_S	211_G	0.676	0.47
69_A	76_E	0.676	0.47
334_P	337_Y	0.676	0.47
97_K	100_T	0.675	0.47
410_K	464_D	0.674	0.47
347_S	506_P	0.674	0.47
568_R	573_E	0.673	0.46
85_I	90_K	0.673	0.46
207_E	263_A	0.673	0.46
61_Y	253_R	0.672	0.46
578_V	584_V	0.672	0.46
122_E	126_Y	0.671	0.46
96_F	103_T	0.670	0.46
231_V	241_E	0.669	0.46
597_R	603_R	0.668	0.46
85_I	105_F	0.668	0.46
65_I	150_D	0.667	0.46
91_L	96_F	0.667	0.46
165_T	171_Q	0.667	0.46
145_E	222_V	0.666	0.46
95_N	102_R	0.666	0.46
413_L	527_E	0.665	0.46
117_V	136_G	0.663	0.45
595_E	602_G	0.662	0.45
306_K	426_L	0.662	0.45
161_V	171_Q	0.661	0.45
451_A	498_F	0.660	0.45
128_K	135_D	0.660	0.45
84_P	90_K	0.660	0.45
127_E	331_F	0.659	0.45
101_I	111_T	0.658	0.45
351_S	398_L	0.656	0.45
207_E	266_L	0.656	0.45
468_V	474_D	0.656	0.45
330_L	461_G	0.656	0.45
218_I	230_E	0.655	0.45
332_P	441_R	0.654	0.45
58_N	62_F	0.653	0.44
596_A	608_Y	0.653	0.44
93_L	98_E	0.652	0.44
593_F	596_A	0.652	0.44
144_F	204_W	0.651	0.44
149_L	245_Y	0.650	0.44
263_A	524_L	0.650	0.44
142_Y	196_I	0.649	0.44
269_W	288_V	0.649	0.44
497_I	538_E	0.646	0.44
203_D	440_A	0.646	0.44
74_K	78_Y	0.645	0.44
106_P	111_T	0.645	0.44
57_Y	62_F	0.644	0.44
245_Y	252_I	0.644	0.44
525_I	528_N	0.644	0.44
134_L	449_E	0.643	0.43
453_E	572_G	0.642	0.43
590_I	608_Y	0.642	0.43
70_E	75_M	0.642	0.43
101_I	107_V	0.639	0.43
117_V	453_E	0.638	0.43
279_E	287_K	0.638	0.43
460_H	467_V	0.637	0.43
62_F	151_A	0.636	0.43
421_G	433_Y	0.633	0.43
149_L	230_E	0.632	0.42
85_I	107_V	0.629	0.42
90_K	99_K	0.627	0.42
82_A	92_F	0.622	0.41
99_K	102_R	0.622	0.41
135_D	304_I	0.621	0.41
543_E	546_S	0.620	0.41
410_K	463_I	0.618	0.41
208_S	221_E	0.618	0.41
213_V	216_V	0.617	0.41
597_R	600_Y	0.617	0.41
575_I	587_V	0.617	0.41
198_R	503_N	0.616	0.41
505_T	541_L	0.613	0.41
350_P	523_G	0.612	0.40
327_G	346_S	0.611	0.40
418_G	464_D	0.611	0.40
89_V	97_K	0.610	0.40
601_M	608_Y	0.610	0.40
69_A	72_C	0.610	0.40
577_Y	584_V	0.609	0.40
167_T	171_Q	0.608	0.40
58_N	63_A	0.607	0.40
127_E	164_E	0.607	0.40
347_S	465_S	0.606	0.40
329_I	501_T	0.605	0.40
540_V	553_V	0.605	0.40
141_V	258_R	0.604	0.40
100_T	107_V	0.604	0.40
521_A	541_L	0.604	0.40
269_W	273_S	0.604	0.40
524_L	537_L	0.602	0.40
594_Y	599_G	0.602	0.40
323_V	542_R	0.601	0.39
100_T	103_T	0.601	0.39
298_F	301_R	0.600	0.39
599_G	607_Y	0.599	0.39
140_K	505_T	0.599	0.39
330_L	525_I	0.599	0.39
203_D	437_T	0.598	0.39
95_N	99_K	0.598	0.39
526_R	530_P	0.597	0.39
536_F	561_L	0.597	0.39
473_V	481_E	0.597	0.39
326_G	421_G	0.596	0.39
591_K	602_G	0.596	0.39
96_F	101_I	0.594	0.39
64_L	468_V	0.594	0.39
394_R	403_E	0.594	0.39
65_I	230_E	0.592	0.39
376_I	379_K	0.591	0.38
65_I	252_I	0.591	0.38
597_R	608_Y	0.589	0.38
237_E	241_E	0.589	0.38
89_V	103_T	0.588	0.38
414_V	433_Y	0.587	0.38
88_G	96_F	0.586	0.38
150_D	326_G	0.585	0.38
55_D	58_N	0.585	0.38
83_Y	92_F	0.585	0.38
284_T	422_Y	0.585	0.38
359_S	362_T	0.585	0.38
471_D	474_D	0.585	0.38
223_R	600_Y	0.583	0.38
284_T	428_G	0.582	0.38
596_A	606_N	0.582	0.38
428_G	481_E	0.581	0.38
385_P	413_L	0.580	0.37
232_E	238_C	0.579	0.37
535_S	539_D	0.579	0.37
91_L	103_T	0.578	0.37
123_V	128_K	0.578	0.37
102_R	107_V	0.578	0.37
270_S	388_L	0.578	0.37
74_K	86_K	0.578	0.37
131_W	244_N	0.576	0.37
462_I	501_T	0.576	0.37
346_S	426_L	0.576	0.37
256_K	260_P	0.576	0.37
90_K	95_N	0.576	0.37
586_Y	590_I	0.575	0.37
576_D	605_V	0.575	0.37
169_L	197_A	0.574	0.37
173_L	403_E	0.574	0.37
589_G	602_G	0.574	0.37
244_N	364_E	0.574	0.37
293_E	408_A	0.574	0.37
420_L	427_F	0.574	0.37
530_P	533_V	0.573	0.37
128_K	341_Y	0.571	0.37
160_N	450_I	0.571	0.37
288_V	359_S	0.570	0.37
127_E	321_M	0.570	0.37
77_E	85_I	0.570	0.37
592_G	602_G	0.568	0.36
273_S	496_I	0.568	0.36
105_F	110_I	0.567	0.36
105_F	111_T	0.567	0.36
288_V	530_P	0.566	0.36
565_Y	568_R	0.565	0.36
591_K	603_R	0.565	0.36
58_N	65_I	0.564	0.36
266_L	280_I	0.562	0.36
218_I	245_Y	0.562	0.36
55_D	66_W	0.561	0.36
76_E	87_G	0.561	0.36
166_P	171_Q	0.560	0.36
606_N	612_L	0.559	0.36
418_G	463_I	0.559	0.36
145_E	326_G	0.558	0.35
143_R	150_D	0.558	0.35
577_Y	590_I	0.556	0.35
297_A	420_L	0.556	0.35
560_D	568_R	0.555	0.35
220_N	223_R	0.555	0.35
547_A	553_V	0.554	0.35
345_F	429_K	0.554	0.35
327_G	437_T	0.554	0.35
293_E	402_D	0.554	0.35
63_A	245_Y	0.553	0.35
575_I	582_K	0.553	0.35
498_F	520_I	0.552	0.35
96_F	102_R	0.551	0.35
72_C	78_Y	0.551	0.35
415_A	437_T	0.551	0.35
284_T	451_A	0.551	0.35
304_I	347_S	0.550	0.35
149_L	326_G	0.549	0.35
187_S	516_N	0.547	0.34
185_R	189_D	0.547	0.34
82_A	89_V	0.546	0.34
425_S	527_E	0.545	0.34
235_I	239_L	0.545	0.34
367_D	373_L	0.545	0.34
332_P	362_T	0.545	0.34
413_L	419_Y	0.545	0.34
589_G	603_R	0.544	0.34
343_V	528_N	0.544	0.34
309_P	312_E	0.544	0.34
505_T	545_S	0.544	0.34
298_F	304_I	0.543	0.34
555_K	560_D	0.543	0.34
347_S	350_P	0.542	0.34
421_G	465_S	0.542	0.34
62_F	67_A	0.541	0.34
58_N	69_A	0.541	0.34
129_E	141_V	0.540	0.34
599_G	604_D	0.540	0.34
324_D	406_A	0.540	0.34
74_K	88_G	0.539	0.34
591_K	605_V	0.538	0.34
288_V	360_A	0.537	0.34
104_T	111_T	0.535	0.33
332_P	444_L	0.535	0.33
242_A	343_V	0.534	0.33
58_N	64_L	0.534	0.33
280_I	422_Y	0.533	0.33
163_N	166_P	0.533	0.33
88_G	93_L	0.532	0.33
581_I	586_Y	0.532	0.33
160_N	555_K	0.532	0.33
460_H	528_N	0.531	0.33
429_K	520_I	0.531	0.33
285_I	421_G	0.531	0.33
71_E	76_E	0.530	0.33
460_H	465_S	0.530	0.33
216_V	407_E	0.529	0.33
73_E	87_G	0.529	0.33
290_T	422_Y	0.529	0.33
355_K	481_E	0.529	0.33
332_P	460_H	0.528	0.33
323_V	340_V	0.527	0.33
199_V	458_V	0.527	0.33
243_C	246_V	0.526	0.33
358_I	439_L	0.526	0.33
567_K	573_E	0.526	0.33
606_N	611_Y	0.526	0.33
74_K	84_P	0.524	0.32
69_A	75_M	0.524	0.32
413_L	528_N	0.524	0.32
55_D	140_K	0.523	0.32
96_F	555_K	0.523	0.32
367_D	474_D	0.523	0.32
473_V	476_F	0.523	0.32
205_Y	217_K	0.523	0.32
499_T	537_L	0.523	0.32
90_K	102_R	0.522	0.32
72_C	87_G	0.521	0.32
93_L	99_K	0.521	0.32
203_D	218_I	0.518	0.32
461_G	468_V	0.518	0.32
354_V	419_Y	0.518	0.32
126_Y	551_S	0.517	0.32
327_G	432_A	0.517	0.32
432_A	444_L	0.517	0.32
473_V	492_R	0.516	0.32
144_F	213_V	0.516	0.32
273_S	408_A	0.516	0.32
135_D	168_V	0.515	0.32
604_D	610_N	0.514	0.32
434_E	439_L	0.514	0.32
356_H	444_L	0.514	0.32
154_Y	595_E	0.513	0.31
123_V	539_D	0.512	0.31
163_N	171_Q	0.512	0.31
249_N	252_I	0.511	0.31
420_L	533_V	0.511	0.31
252_I	408_A	0.510	0.31
159_L	482_K	0.509	0.31
410_K	462_I	0.509	0.31
82_A	91_L	0.509	0.31
96_F	105_F	0.508	0.31
99_K	104_T	0.508	0.31
470_G	474_D	0.507	0.31
576_D	582_K	0.507	0.31
122_E	125_Y	0.507	0.31
345_F	391_L	0.506	0.31
209_L	497_I	0.506	0.31
401_I	404_E	0.506	0.31
100_T	104_T	0.506	0.31
478_E	552_D	0.506	0.31
107_V	112_D	0.505	0.31
152_Y	156_R	0.505	0.31
284_T	486_L	0.504	0.31
598_L	612_L	0.504	0.31
141_V	552_D	0.504	0.31
278_H	282_Y	0.503	0.31
192_P	278_H	0.503	0.31
385_P	528_N	0.503	0.31
143_R	198_R	0.502	0.31
230_E	238_C	0.501	0.30
326_G	335_G	0.501	0.30
262_S	552_D	0.500	0.30
576_D	588_R	0.500	0.30
243_C	248_S	0.500	0.30

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3iayA	1	0.9521	100	0.267	Contact Map
2gv9A	1	0.9505	100	0.285	Contact Map
4qclA	1	0.9617	100	0.293	Contact Map
1qhtA	1	0.8818	100	0.311	Contact Map
4fvmA	1	0.9425	100	0.316	Contact Map
3k59A	1	0.9137	100	0.336	Contact Map
3qexA	1	0.9553	100	0.337	Contact Map
4m8oA	1	0.9521	100	0.348	Contact Map
1s5jA	1	0.8179	100	0.351	Contact Map
2py5A	2	0.7077	100	0.633	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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