GREMLIN Database
TRPG - Anthranilate synthase component 2
UniProt: Q06129 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 195 (173)
Sequences: 11881 (6279)
Seq/√Len: 477.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
91_G140_V3.0921.00
99_R141_D2.8021.00
90_I169_I2.7001.00
97_K141_D2.3711.00
24_L189_Y2.3081.00
127_A183_L2.2981.00
59_E92_Y2.2361.00
3_L27_Y2.2241.00
21_V50_I2.2211.00
152_I163_H2.2121.00
91_G162_I2.2021.00
5_L31_I2.1991.00
164_H167_Y2.1561.00
150_D163_H2.1371.00
23_E185_Y2.1261.00
37_S40_G2.0951.00
150_D165_E2.0271.00
151_A159_I1.9861.00
183_L186_K1.8541.00
20_I185_Y1.8351.00
6_I18_A1.8041.00
68_L93_A1.7991.00
153_S161_A1.7681.00
131_K182_S1.7261.00
9_N51_I1.7121.00
164_H168_P1.7101.00
71_I89_A1.6711.00
69_D72_K1.6591.00
42_E73_Y1.6541.00
87_H171_G1.6241.00
31_I36_I1.6201.00
99_R139_V1.5821.00
130_F183_L1.5791.00
3_L29_I1.5351.00
29_I44_I1.5261.00
186_K189_Y1.4941.00
163_H170_Y1.4911.00
40_G43_R1.4891.00
189_Y193_N1.4821.00
68_L72_K1.4591.00
148_I166_E1.4521.00
109_I133_T1.4391.00
102_R158_E1.4241.00
106_H137_S1.4021.00
140_V162_I1.4011.00
42_E77_R1.3731.00
68_L92_Y1.3651.00
69_D73_Y1.3481.00
17_I83_V1.3431.00
162_I171_G1.3151.00
133_T180_G1.3131.00
51_I67_S1.3021.00
6_I50_I1.2951.00
90_I171_G1.2921.00
4_T48_R1.2921.00
126_I130_F1.2881.00
94_F169_I1.2751.00
10_Y34_D1.2681.00
26_S192_L1.2511.00
59_E97_K1.2501.00
111_N131_K1.2461.00
139_V158_E1.2301.00
111_N129_E1.2201.00
64_I89_A1.2181.00
149_V162_I1.2051.00
48_R191_F1.2021.00
36_I40_G1.1851.00
91_G96_A1.1731.00
50_I81_L1.1701.00
112_I132_A1.1611.00
123_Y161_A1.1581.00
148_I165_E1.1551.00
49_I70_V1.1431.00
87_H140_V1.1341.00
38_I42_E1.0981.00
109_I131_K1.0901.00
59_E63_D1.0831.00
24_L188_L1.0671.00
98_I140_V1.0611.00
130_F187_I1.0601.00
17_I188_L1.0581.00
29_I46_P1.0481.00
16_N19_Q1.0421.00
64_I68_L1.0421.00
20_I23_E1.0281.00
39_K43_R1.0261.00
56_G63_D1.0251.00
96_A146_P1.0181.00
77_R167_Y1.0161.00
165_E168_P1.0071.00
110_S129_E1.0061.00
36_I44_I0.9711.00
72_K93_A0.9711.00
39_K42_E0.9711.00
101_A139_V0.9601.00
149_V164_H0.9561.00
4_T26_S0.9481.00
148_I164_H0.9441.00
97_K142_E0.9421.00
5_L44_I0.9411.00
121_S163_H0.9391.00
9_N67_S0.9351.00
132_A181_T0.9321.00
5_L41_I0.9221.00
84_C175_H0.9191.00
51_I80_I0.9151.00
18_A22_G0.9121.00
49_I78_T0.9111.00
76_K167_Y0.9111.00
94_F149_V0.9051.00
127_A182_S0.9051.00
81_L172_V0.8961.00
6_I13_F0.8911.00
24_L185_Y0.8911.00
87_H162_I0.8901.00
100_R104_V0.8871.00
70_V73_Y0.8861.00
48_R192_L0.8851.00
36_I41_I0.8821.00
123_Y190_N0.8821.00
38_I73_Y0.8801.00
22_G28_P0.8781.00
3_L44_I0.8731.00
153_S174_F0.8711.00
39_K73_Y0.8711.00
126_I183_L0.8701.00
7_I31_I0.8651.00
121_S170_Y0.8561.00
19_Q22_G0.8551.00
83_V172_V0.8481.00
91_G146_P0.8411.00
64_I67_S0.8371.00
152_I170_Y0.8301.00
33_N65_G0.8241.00
142_E151_A0.8181.00
10_Y32_R0.8181.00
67_S89_A0.8151.00
57_T63_D0.8111.00
145_R151_A0.8061.00
172_V176_P0.8061.00
5_L46_P0.8051.00
9_N33_N0.8041.00
7_I70_V0.8041.00
24_L192_L0.8011.00
103_K156_D0.8011.00
57_T138_L0.8011.00
174_F187_I0.7951.00
125_G190_N0.7941.00
152_I161_A0.7901.00
163_H190_N0.7891.00
127_A130_F0.7771.00
42_E78_T0.7761.00
145_R159_I0.7741.00
130_F184_G0.7711.00
41_I46_P0.7621.00
126_I186_K0.7611.00
21_V188_L0.7591.00
84_C88_Q0.7591.00
121_S124_Y0.7561.00
154_A158_E0.7541.00
71_I90_I0.7531.00
94_F164_H0.7511.00
4_T21_V0.7511.00
21_V192_L0.7511.00
154_A157_N0.7431.00
123_Y174_F0.7411.00
31_I40_G0.7371.00
6_I21_V0.7371.00
94_F167_Y0.7371.00
71_I80_I0.7321.00
170_Y191_F0.7311.00
13_F18_A0.7311.00
21_V26_S0.7231.00
122_L170_Y0.7201.00
110_S155_E0.7191.00
14_V30_V0.7171.00
134_R160_M0.7171.00
15_Y18_A0.7101.00
57_T100_R0.7061.00
68_L89_A0.7051.00
7_I41_I0.7021.00
31_I44_I0.7021.00
130_F186_K0.7011.00
185_Y189_Y0.6941.00
73_Y77_R0.6941.00
59_E98_I0.6931.00
3_L47_D0.6921.00
26_S48_R0.6891.00
65_G93_A0.6791.00
104_V137_S0.6691.00
18_A30_V0.6681.00
19_Q23_E0.6681.00
25_G28_P0.6641.00
92_Y97_K0.6611.00
66_V71_I0.6601.00
123_Y163_H0.6571.00
98_I138_L0.6541.00
50_I191_F0.6531.00
57_T92_Y0.6521.00
164_H169_I0.6521.00
16_N20_I0.6461.00
46_P78_T0.6381.00
66_V89_A0.6371.00
6_I52_S0.6341.00
8_D14_V0.6331.00
66_V69_D0.6271.00
7_I36_I0.6240.99
56_G59_E0.6240.99
66_V70_V0.6170.99
40_G44_I0.6160.99
6_I14_V0.6140.99
133_T178_S0.6130.99
38_I69_D0.6130.99
108_K133_T0.6070.99
110_S131_K0.6010.99
121_S190_N0.5980.99
14_V52_S0.5970.99
174_F184_G0.5970.99
81_L187_I0.5940.99
96_A140_V0.5940.99
133_T182_S0.5920.99
49_I80_I0.5920.99
125_G186_K0.5910.99
20_I188_L0.5900.99
68_L71_I0.5900.99
123_Y153_S0.5820.99
57_T98_I0.5780.99
172_V187_I0.5740.99
59_E68_L0.5730.99
48_R81_L0.5670.99
45_D78_T0.5660.99
133_T181_T0.5660.99
84_C136_H0.5640.99
51_I71_I0.5620.99
139_V156_D0.5620.99
6_I28_P0.5610.99
5_L29_I0.5610.99
106_H135_Y0.5550.99
9_N89_A0.5500.99
80_I90_I0.5500.99
71_I93_A0.5460.99
88_Q173_Q0.5450.99
101_A158_E0.5370.98
112_I129_E0.5320.98
33_N66_V0.5300.98
142_E145_R0.5280.98
53_P84_C0.5280.98
65_G68_L0.5270.98
126_I187_I0.5260.98
112_I153_S0.5250.98
5_L36_I0.5170.98
65_G92_Y0.5150.98
76_K80_I0.5120.98
90_I162_I0.5120.98
101_A104_V0.5060.98
67_S71_I0.5050.98
81_L170_Y0.5040.98
48_R79_P0.5040.98
121_S152_I0.5010.98
105_F110_S0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tqiA 3 0.8821 100 0.23 Contact Map
2vxoA 2 0.9385 100 0.237 Contact Map
1gpmA 3 0.9538 100 0.243 Contact Map
2ywbA 4 0.9179 100 0.249 Contact Map
3uowA 2 0.9692 100 0.281 Contact Map
1a9xB 1 0.9231 100 0.315 Contact Map
1qdlB 2 0.9692 100 0.318 Contact Map
2vpiA 1 0.9077 100 0.325 Contact Map
1i1qB 1 0.9231 100 0.337 Contact Map
3r75A 2 0.9436 100 0.352 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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