GREMLIN Database
TRPE - Anthranilate synthase component 1
UniProt: Q06128 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 421 (392)
Sequences: 6071 (3961)
Seq/√Len: 200.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
285_C313_G4.5941.00
286_V314_T3.6571.00
63_N320_N3.5591.00
334_V358_A3.4201.00
157_K161_E3.2991.00
244_R259_E3.2141.00
293_P312_I3.1111.00
234_I312_I3.0731.00
286_V317_K3.0491.00
170_Y175_Y2.9971.00
294_E297_Y2.9841.00
341_M344_N2.9281.00
399_N402_S2.8991.00
186_R385_L2.7561.00
243_T304_V2.5991.00
156_N159_S2.5351.00
170_Y348_T2.5181.00
161_E401_E2.4411.00
176_I179_V2.4311.00
291_K312_I2.4211.00
300_K305_Q2.4211.00
160_Y392_A2.4041.00
157_K401_E2.3371.00
246_R253_D2.3331.00
27_G45_A2.3231.00
362_G372_F2.3191.00
316_K319_Y2.2771.00
57_D60_N2.2681.00
258_L262_N2.2591.00
219_L356_P2.2481.00
254_L258_L2.2461.00
169_E173_S2.2031.00
257_E300_K2.1991.00
319_Y323_N2.1751.00
186_R387_R2.1661.00
176_I342_A2.1591.00
237_T277_A2.1451.00
193_P218_Y2.1441.00
331_A374_I2.1381.00
210_F361_V2.0601.00
57_D326_S2.0511.00
155_L163_I2.0501.00
167_S179_V2.0231.00
188_I385_L2.0161.00
247_G252_E2.0131.00
233_N314_T2.0121.00
88_Y343_M1.9411.00
263_S266_D1.9171.00
162_R165_S1.9111.00
226_L371_E1.8551.00
234_I314_T1.8301.00
254_L257_E1.8121.00
284_V327_A1.8121.00
238_Y299_E1.8011.00
252_E255_K1.7881.00
381_L386_L1.7711.00
40_R122_D1.7491.00
16_F26_A1.7411.00
345_I349_L1.7301.00
27_G83_I1.7291.00
43_V120_I1.7191.00
213_K218_Y1.7101.00
405_F409_H1.7071.00
281_L285_C1.7001.00
167_S181_L1.6991.00
178_Q393_G1.6981.00
298_V307_I1.6871.00
82_M114_T1.6801.00
165_S168_L1.6761.00
250_Q254_L1.6731.00
154_S352_Y1.6611.00
164_V400_P1.6591.00
169_E172_R1.6531.00
170_Y345_I1.6531.00
247_G256_L1.6491.00
157_K404_Y1.6431.00
286_V316_K1.6221.00
86_I90_A1.6211.00
210_F221_G1.6171.00
187_Y386_L1.6081.00
192_D195_R1.5891.00
261_M307_I1.5591.00
179_V346_I1.5341.00
165_S400_P1.5331.00
133_D143_I1.5311.00
248_A252_E1.5261.00
183_R407_T1.5221.00
271_L296_M1.5171.00
240_I308_V1.5161.00
231_Q369_N1.5111.00
256_L259_E1.5011.00
220_I381_L1.4951.00
184_F387_R1.4871.00
257_E298_V1.4761.00
151_Y187_Y1.4671.00
166_E169_E1.4541.00
170_Y341_M1.4501.00
282_G288_G1.4251.00
299_E308_V1.4241.00
249_D252_E1.4171.00
401_E405_F1.4101.00
379_A386_L1.4091.00
189_F381_L1.4051.00
161_E400_P1.4051.00
159_S162_R1.4041.00
255_K259_E1.4021.00
159_S351_E1.4001.00
175_Y341_M1.3871.00
236_E310_K1.3861.00
404_Y408_E1.3581.00
221_G373_A1.3461.00
157_K405_F1.3431.00
89_D347_E1.3371.00
356_P375_A1.3241.00
236_E312_I1.3171.00
252_E256_L1.3111.00
17_K198_Y1.3051.00
211_Y218_Y1.2991.00
193_P381_L1.2981.00
166_E348_T1.2901.00
244_R256_L1.2811.00
392_A407_T1.2591.00
281_L313_G1.2511.00
230_V315_L1.2491.00
166_E170_Y1.2441.00
176_I345_I1.2381.00
161_E165_S1.2371.00
315_L324_V1.2271.00
168_L396_Y1.2241.00
89_D353_K1.2231.00
361_V375_A1.2151.00
58_P110_A1.2151.00
405_F408_E1.2111.00
365_S369_N1.2031.00
208_Y226_L1.2031.00
402_S405_F1.2001.00
244_R266_D1.1881.00
230_V235_V1.1871.00
390_A411_L1.1831.00
233_N317_K1.1771.00
159_S163_I1.1741.00
168_L172_R1.1721.00
112_F372_F1.1711.00
182_S389_H1.1691.00
152_D188_I1.1691.00
251_E255_K1.1681.00
193_P211_Y1.1621.00
158_N162_R1.1531.00
196_I381_L1.1511.00
255_K258_L1.1511.00
86_I325_L1.1411.00
95_E340_P1.1381.00
325_L372_F1.1371.00
25_V51_Y1.1341.00
63_N67_K1.1341.00
30_E201_R1.1191.00
100_L347_E1.1181.00
197_Y201_R1.1101.00
267_K296_M1.1051.00
97_I344_N1.1021.00
181_L392_A1.0991.00
210_F219_L1.0931.00
230_V324_V1.0901.00
42_S123_H1.0901.00
230_V233_N1.0891.00
78_F81_G1.0831.00
86_I110_A1.0831.00
293_P310_K1.0801.00
261_M298_V1.0791.00
235_V281_L1.0791.00
103_A106_D1.0781.00
194_L211_Y1.0761.00
196_I379_A1.0741.00
180_V391_G1.0721.00
238_Y294_E1.0701.00
172_R396_Y1.0701.00
196_I220_I1.0661.00
271_L295_L1.0651.00
257_E305_Q1.0641.00
379_A414_L1.0641.00
61_I64_G1.0621.00
183_R408_E1.0601.00
258_L261_M1.0581.00
235_V324_V1.0561.00
78_F83_I1.0541.00
153_E183_R1.0541.00
320_N323_N1.0531.00
325_L364_I1.0531.00
164_V394_I1.0481.00
294_E310_K1.0451.00
49_N116_D1.0421.00
92_R347_E1.0371.00
204_N222_S1.0341.00
111_E214_F1.0331.00
164_V168_L1.0271.00
85_Y356_P1.0251.00
162_R166_E1.0191.00
189_F386_L1.0151.00
121_Y128_V1.0111.00
188_I384_E1.0071.00
154_S186_R1.0021.00
388_I411_L1.0021.00
238_Y310_K1.0021.00
181_L394_I0.9901.00
341_M348_T0.9891.00
274_V295_L0.9861.00
179_V345_I0.9851.00
103_A353_K0.9841.00
235_V285_C0.9831.00
48_T115_P0.9821.00
58_P93_F0.9811.00
155_L181_L0.9761.00
221_G361_V0.9751.00
230_V321_A0.9710.99
165_S169_E0.9710.99
60_N64_G0.9700.99
107_W380_F0.9670.99
229_R236_E0.9650.99
261_M267_K0.9620.99
163_I351_E0.9560.99
45_A83_I0.9520.99
363_F371_E0.9510.99
266_D402_S0.9490.99
286_V289_T0.9480.99
245_P256_L0.9470.99
53_K111_E0.9470.99
276_L332_G0.9430.99
185_Y390_A0.9410.99
60_N63_N0.9310.99
57_D93_F0.9310.99
50_G65_Y0.9310.99
114_T366_A0.9300.99
227_L328_T0.9290.99
322_L364_I0.9290.99
23_F47_S0.9260.99
152_D186_R0.9240.99
63_N326_S0.9190.99
204_N303_H0.9190.99
388_I415_K0.9150.99
360_A372_F0.9130.99
155_L351_E0.9110.99
241_A333_T0.9100.99
120_I131_N0.9080.99
263_S402_S0.9050.99
268_A397_D0.9050.99
218_Y381_L0.9030.99
206_S209_M0.8990.99
227_L237_T0.8990.99
164_V181_L0.8980.99
356_P380_F0.8960.99
49_N114_T0.8950.99
183_R404_Y0.8940.99
107_W217_K0.8930.99
347_E353_K0.8880.99
86_I112_F0.8880.99
171_I396_Y0.8870.99
341_M345_I0.8770.99
241_A270_H0.8770.99
167_S176_I0.8770.99
291_K314_T0.8730.99
412_K416_T0.8690.99
163_I167_S0.8650.99
297_Y310_K0.8640.99
228_F370_A0.8610.99
184_F352_Y0.8610.99
209_M222_S0.8550.99
168_L400_P0.8540.99
90_A110_A0.8490.99
273_L333_T0.8410.99
233_N286_V0.8410.99
217_K382_N0.8400.99
30_E197_Y0.8320.98
210_F373_A0.8310.98
345_I348_T0.8280.98
90_A93_F0.8250.98
87_S109_Y0.8240.98
63_N323_N0.8230.98
91_V343_M0.8220.98
81_G366_A0.8200.98
86_I364_I0.8170.98
43_V118_I0.8150.98
94_W329_F0.8120.98
379_A388_I0.8120.98
245_P409_H0.8110.98
189_F196_I0.8110.98
119_I128_V0.8000.98
228_F328_T0.8000.98
281_L328_T0.7960.98
105_E387_R0.7960.98
212_L361_V0.7950.98
117_N132_A0.7920.98
74_I77_L0.7910.98
104_A352_Y0.7890.98
98_R344_N0.7890.98
182_S407_T0.7880.98
108_P217_K0.7860.98
241_A273_L0.7850.98
282_G287_P0.7840.98
180_V358_A0.7840.98
167_S349_L0.7840.98
151_Y415_K0.7820.98
167_S394_I0.7790.98
334_V376_I0.7780.98
84_G112_F0.7780.98
226_L236_E0.7770.98
64_G67_K0.7770.98
277_A331_A0.7760.98
158_N161_E0.7730.97
179_V342_A0.7730.97
51_Y111_E0.7720.97
161_E399_N0.7700.97
244_R409_H0.7700.97
101_K347_E0.7690.97
67_K320_N0.7680.97
149_S188_I0.7660.97
246_R300_K0.7640.97
200_L222_S0.7630.97
165_S172_R0.7630.97
27_G115_P0.7620.97
203_I416_T0.7620.97
235_V315_L0.7610.97
294_E299_E0.7580.97
180_V334_V0.7580.97
216_E382_N0.7500.97
180_V335_S0.7480.97
59_V90_A0.7440.97
257_E261_M0.7440.97
91_V347_E0.7400.97
161_E164_V0.7400.97
163_I181_L0.7390.97
89_D92_R0.7380.97
298_V305_Q0.7370.97
301_Y308_V0.7370.97
230_V370_A0.7350.97
259_E262_N0.7350.97
32_I35_P0.7350.97
92_R109_Y0.7310.96
270_H273_L0.7300.96
364_I370_A0.7270.96
118_I131_N0.7220.96
16_F211_Y0.7220.96
154_S184_F0.7210.96
331_A373_A0.7180.96
155_L183_R0.7170.96
232_D369_N0.7150.96
47_S117_N0.7150.96
237_T328_T0.7130.96
185_Y415_K0.7130.96
245_P402_S0.7110.96
197_Y220_I0.7100.96
321_A370_A0.7080.96
226_L238_Y0.7070.96
54_I110_A0.7010.95
52_L61_I0.7010.95
93_F109_Y0.6990.95
95_E283_K0.6970.95
219_L361_V0.6950.95
194_L198_Y0.6940.95
323_N327_A0.6940.95
23_F213_K0.6930.95
153_E185_Y0.6880.95
184_F389_H0.6880.95
302_S413_A0.6870.95
65_Y68_D0.6840.95
267_K271_L0.6820.95
266_D395_V0.6820.95
41_Y120_I0.6810.95
111_E217_K0.6790.95
171_I176_I0.6770.95
392_A402_S0.6710.94
227_L241_A0.6710.94
177_F279_N0.6690.94
247_G253_D0.6680.94
394_I402_S0.6680.94
69_L366_A0.6680.94
103_A382_N0.6670.94
227_L270_H0.6650.94
235_V313_G0.6650.94
247_G250_Q0.6650.94
91_V94_W0.6650.94
23_F46_W0.6630.94
19_I44_I0.6620.94
215_D218_Y0.6610.94
50_G114_T0.6570.94
340_P344_N0.6570.94
40_R124_N0.6560.94
251_E254_L0.6550.94
206_S303_H0.6530.93
46_W117_N0.6530.93
163_I349_L0.6520.93
155_L159_S0.6490.93
352_Y389_H0.6470.93
259_E263_S0.6450.93
175_Y345_I0.6450.93
270_H358_A0.6420.93
153_E407_T0.6410.93
185_Y408_E0.6400.93
62_L112_F0.6380.93
381_L384_E0.6370.93
268_A278_R0.6360.93
43_V83_I0.6350.92
229_R371_E0.6350.92
233_N315_L0.6350.92
86_I372_F0.6340.92
99_D353_K0.6330.92
147_K190_S0.6310.92
67_K70_K0.6310.92
115_P118_I0.6300.92
278_R337_A0.6300.92
227_L277_A0.6290.92
219_L378_T0.6290.92
404_Y407_T0.6290.92
204_N413_A0.6290.92
293_P311_V0.6290.92
270_H277_A0.6280.92
340_P343_M0.6260.92
92_R99_D0.6230.92
380_F387_R0.6220.92
83_I212_L0.6210.92
267_K295_L0.6210.92
275_D280_D0.6210.92
86_I362_G0.6210.92
270_H333_T0.6210.92
161_E404_Y0.6180.91
334_V374_I0.6170.91
22_D213_K0.6150.91
228_F324_V0.6130.91
190_S384_E0.6120.91
262_N267_K0.6120.91
182_S391_G0.6090.91
296_M307_I0.6080.91
94_W326_S0.6070.91
303_H413_A0.6070.91
185_Y411_L0.6070.91
196_I386_L0.6060.91
253_D305_Q0.6030.90
56_D60_N0.6020.90
30_E209_M0.6020.90
87_S90_A0.6000.90
21_R213_K0.6000.90
292_V295_L0.6000.90
16_F44_I0.5990.90
180_V346_I0.5990.90
238_Y297_Y0.5980.90
17_K21_R0.5970.90
95_E343_M0.5960.90
106_D382_N0.5960.90
231_Q234_I0.5950.90
249_D255_K0.5950.90
64_G68_D0.5940.90
167_S346_I0.5910.90
162_R169_E0.5910.90
323_N326_S0.5910.90
26_A213_K0.5900.89
99_D347_E0.5900.89
275_D278_R0.5900.89
284_V324_V0.5890.89
285_C290_V0.5850.89
71_L74_I0.5850.89
388_I413_A0.5820.89
335_S343_M0.5820.89
78_F118_I0.5810.89
122_D127_K0.5800.89
279_N283_K0.5800.89
270_H274_V0.5780.88
270_H305_Q0.5770.88
105_E353_K0.5750.88
229_R369_N0.5750.88
365_S368_G0.5740.88
57_D61_I0.5730.88
325_L370_A0.5730.88
214_F217_K0.5720.88
245_P405_F0.5720.88
270_H309_S0.5690.88
238_Y301_Y0.5690.88
191_G196_I0.5680.88
49_N69_L0.5680.88
174_G278_R0.5660.87
270_H296_M0.5660.87
16_F19_I0.5650.87
61_I65_Y0.5630.87
331_A358_A0.5630.87
241_A392_A0.5620.87
117_N130_V0.5610.87
408_E412_K0.5600.87
221_G375_A0.5590.87
63_N322_L0.5580.87
261_M264_E0.5580.87
282_G285_C0.5580.87
48_T51_Y0.5570.87
237_T311_V0.5560.87
272_M278_R0.5560.87
304_V409_H0.5540.86
210_F378_T0.5530.86
170_Y344_N0.5530.86
333_T392_A0.5520.86
193_P220_I0.5520.86
59_V62_L0.5510.86
362_G370_A0.5510.86
170_Y349_L0.5500.86
52_L65_Y0.5480.86
151_Y418_I0.5480.86
177_F278_R0.5480.86
49_N366_A0.5460.86
207_P301_Y0.5460.86
65_Y69_L0.5460.86
264_E267_K0.5460.86
315_L319_Y0.5460.86
283_K340_P0.5440.85
177_F335_S0.5440.85
234_I293_P0.5430.85
234_I291_K0.5430.85
227_L273_L0.5420.85
244_R305_Q0.5420.85
119_I130_V0.5410.85
217_K380_F0.5410.85
105_E355_G0.5400.85
268_A272_M0.5400.85
166_E349_L0.5390.85
56_D64_G0.5380.85
18_C21_R0.5370.85
233_N318_K0.5370.85
328_T372_F0.5360.84
411_L415_K0.5360.84
154_S183_R0.5360.84
303_H416_T0.5350.84
409_H412_K0.5350.84
55_H61_I0.5350.84
180_V373_A0.5350.84
153_E404_Y0.5330.84
167_S180_V0.5320.84
205_P302_S0.5320.84
246_R305_Q0.5320.84
358_A373_A0.5310.84
52_L55_H0.5300.84
219_L375_A0.5300.84
237_T301_Y0.5300.84
58_P62_L0.5290.84
195_R198_Y0.5280.84
392_A398_S0.5270.84
272_M279_N0.5270.84
279_N337_A0.5260.83
145_E191_G0.5260.83
40_R125_E0.5260.83
267_K307_I0.5240.83
160_Y407_T0.5240.83
103_A184_F0.5230.83
101_K353_K0.5220.83
220_I379_A0.5220.83
256_L305_Q0.5210.83
171_I400_P0.5200.83
382_N385_L0.5200.83
275_D337_A0.5190.83
249_D256_L0.5190.83
23_F26_A0.5170.82
88_Y335_S0.5170.82
49_N82_M0.5160.82
251_E317_K0.5160.82
277_A358_A0.5150.82
85_Y217_K0.5140.82
73_D76_G0.5140.82
162_R190_S0.5130.82
112_F362_G0.5130.82
272_M275_D0.5120.82
178_Q395_V0.5120.82
111_E114_T0.5090.81
168_L397_D0.5090.81
92_R98_R0.5080.81
195_R199_N0.5080.81
240_I376_I0.5070.81
188_I383_K0.5070.81
79_K367_D0.5070.81
85_Y112_F0.5060.81
226_L331_A0.5060.81
331_A334_V0.5060.81
334_V375_A0.5040.81
272_M280_D0.5040.81
153_E408_E0.5040.81
54_I58_P0.5030.81
85_Y107_W0.5030.81
241_A395_V0.5030.81
168_L399_N0.5020.80
49_N52_L0.5010.80
150_F188_I0.5010.80
157_K408_E0.5010.80
279_N339_K0.5000.80
280_D337_A0.5000.80
277_A333_T0.5000.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1qdlA 1 0.9834 100 0.095 Contact Map
1k0eA 1 0.9596 100 0.112 Contact Map
1i1qA 2 0.9929 100 0.119 Contact Map
4grhA 1 0.9311 100 0.126 Contact Map
3h9mA 1 0.9097 100 0.164 Contact Map
3logA 1 0.962 100 0.171 Contact Map
2fn0A 2 0.9287 100 0.216 Contact Map
3gseA 1 0.8884 100 0.265 Contact Map
3os6A 3 0.8717 100 0.278 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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