GREMLIN Database
TRPC - Indole-3-glycerol phosphate synthase
UniProt: Q06121 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 248 (243)
Sequences: 3751 (2490)
Seq/√Len: 159.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
139_E168_I4.0581.00
93_Y125_L3.3751.00
5_L136_I3.2131.00
7_G88_Y3.1261.00
138_T141_E3.0851.00
163_E196_K2.7801.00
195_R221_E2.7261.00
208_V229_A2.4521.00
65_D68_E2.4471.00
120_D148_Y2.4211.00
55_K90_N2.4121.00
16_S115_K2.3781.00
116_E144_S2.3331.00
163_E200_M2.2901.00
241_E244_K2.2841.00
73_M104_S2.2571.00
7_G87_K2.2571.00
100_A128_D2.1841.00
216_R220_E2.1771.00
194_Q227_V2.0661.00
146_L156_P2.0371.00
179_I207_K2.0001.00
119_I130_V1.9691.00
150_R175_R1.9231.00
149_A156_P1.8651.00
19_R27_Q1.8621.00
219_I230_F1.8521.00
32_S35_E1.8471.00
192_E195_R1.8461.00
192_E196_K1.8461.00
141_E144_S1.8111.00
160_I166_L1.7951.00
32_S155_E1.7861.00
94_E97_R1.7341.00
135_K165_D1.7261.00
139_E171_R1.7111.00
166_L201_I1.7081.00
20_P117_S1.6481.00
61_D90_N1.6441.00
198_I207_K1.6101.00
96_L107_I1.5721.00
8_W11_D1.5581.00
146_L150_R1.5551.00
201_I207_K1.5441.00
54_R95_T1.5401.00
214_S235_S1.5361.00
38_L175_R1.5251.00
120_D152_Y1.5201.00
67_I99_I1.5161.00
209_A222_L1.5101.00
194_Q209_A1.5001.00
221_E225_L1.4911.00
109_M121_D1.4881.00
33_L37_I1.4781.00
195_R225_L1.4731.00
134_V169_A1.4721.00
15_L121_D1.4611.00
183_D188_E1.4481.00
7_G10_K1.4391.00
183_D186_T1.4291.00
119_I145_L1.4231.00
11_D85_E1.4161.00
143_E147_E1.4011.00
116_E148_Y1.3991.00
167_D200_M1.3841.00
15_L117_S1.3831.00
59_G234_S1.3821.00
46_T230_F1.3761.00
79_G129_T1.3751.00
132_L137_L1.3671.00
93_Y109_M1.3601.00
80_L103_V1.3561.00
239_N245_E1.3541.00
74_E243_I1.3371.00
146_L174_A1.3331.00
134_V142_L1.3291.00
149_A154_M1.3051.00
148_Y151_S1.2791.00
100_A107_I1.2781.00
73_M105_I1.2581.00
97_R125_L1.2551.00
155_E176_F1.2451.00
130_V149_A1.2451.00
234_S238_R1.2411.00
23_R27_Q1.2241.00
22_F25_S1.2191.00
52_Y99_I1.2181.00
147_E151_S1.2161.00
146_L172_I1.2091.00
157_L208_V1.1941.00
75_R243_I1.1911.00
64_R95_T1.1791.00
109_M122_A1.1751.00
190_N196_K1.1671.00
67_I98_K1.1631.00
9_L141_E1.1581.00
164_N167_D1.1491.00
25_S120_D1.1471.00
46_T219_I1.1461.00
66_P99_I1.1451.00
220_E224_K1.1441.00
8_W85_E1.1441.00
92_S95_T1.1411.00
20_P23_R1.1401.00
73_M103_V1.1381.00
213_I219_I1.1351.00
71_K74_E1.1121.00
14_Q18_R1.0981.00
23_R26_R1.0941.00
166_L200_M1.0900.99
146_L173_G1.0790.99
5_L9_L1.0610.99
94_E98_K1.0550.99
71_K102_S1.0530.99
135_K185_E1.0510.99
50_A77_A1.0490.99
166_L197_L1.0480.99
148_Y152_Y1.0430.99
54_R90_N1.0290.99
5_L114_V1.0270.99
14_Q17_L1.0150.99
134_V168_I1.0140.99
19_R24_A1.0120.99
33_L36_R0.9900.99
216_R223_R0.9880.99
215_E218_E0.9880.99
15_L93_Y0.9870.99
37_I40_F0.9860.99
198_I227_V0.9820.99
62_V237_M0.9790.99
10_K13_V0.9780.99
21_S25_S0.9770.99
37_I41_N0.9710.99
162_D185_E0.9710.99
158_I174_A0.9710.99
86_E92_S0.9630.99
192_E221_E0.9630.99
54_R64_R0.9600.99
67_I102_S0.9600.99
6_K9_L0.9570.99
66_P70_S0.9550.99
150_R156_P0.9500.99
219_I232_I0.9480.99
93_Y121_D0.9390.98
187_L234_S0.9330.98
70_S103_V0.9250.98
217_N220_E0.9220.98
21_S120_D0.9220.98
116_E141_E0.9210.98
54_R61_D0.9180.98
181_S194_Q0.9160.98
222_L227_V0.9040.98
64_R69_Y0.9020.98
11_D86_E0.9000.98
113_I145_L0.8990.98
214_S218_E0.8930.98
170_L205_V0.8930.98
24_A120_D0.8900.98
174_A177_I0.8900.98
183_D193_N0.8880.98
2_P6_K0.8870.98
59_G238_R0.8770.98
193_N196_K0.8740.98
181_S209_A0.8730.98
4_Y8_W0.8700.97
213_I232_I0.8680.97
95_T98_K0.8670.97
3_R7_G0.8650.97
119_I148_Y0.8640.97
169_A174_A0.8630.97
157_L178_G0.8610.97
140_R144_S0.8610.97
7_G11_D0.8590.97
31_I36_R0.8580.97
218_E221_E0.8510.97
52_Y64_R0.8510.97
58_S83_L0.8500.97
61_D64_R0.8460.97
150_R155_E0.8460.97
176_F206_V0.8450.97
3_R87_K0.8410.97
195_R227_V0.8380.97
178_G210_E0.8280.97
145_L148_Y0.8230.96
9_L114_V0.8210.96
40_F45_I0.8210.96
48_I230_F0.8200.96
49_I208_V0.8160.96
69_Y237_M0.8130.96
118_Q145_L0.8070.96
213_I222_L0.8030.96
67_I71_K0.8020.96
209_A227_V0.8000.96
144_S148_Y0.7890.96
3_R88_Y0.7890.96
134_V158_I0.7830.95
235_S245_E0.7820.95
194_Q207_K0.7790.95
181_S222_L0.7750.95
206_V229_A0.7730.95
110_K211_S0.7680.95
34_N38_L0.7600.95
82_I107_I0.7580.94
62_V238_R0.7550.94
72_F76_Y0.7540.94
12_V15_L0.7520.94
16_S117_S0.7480.94
12_V114_V0.7470.94
181_S193_N0.7460.94
11_D87_K0.7440.94
36_R41_N0.7430.94
119_I154_M0.7420.94
8_W86_E0.7410.94
30_I123_Y0.7370.94
170_L201_I0.7370.94
95_T99_I0.7360.94
33_L41_N0.7360.94
113_I119_I0.7360.94
123_Y154_M0.7290.93
161_N210_E0.7280.93
64_R90_N0.7230.93
222_L230_F0.7220.93
99_I103_V0.7200.93
69_Y242_K0.7180.93
162_D165_D0.7140.93
122_A125_L0.7130.92
143_E171_R0.7080.92
36_R155_E0.7060.92
97_R101_S0.7060.92
13_V16_S0.7040.92
167_D170_L0.7000.92
79_G176_F0.6990.92
174_A205_V0.6980.92
99_I107_I0.6970.92
163_E167_D0.6950.91
144_S147_E0.6900.91
6_K10_K0.6900.91
47_A78_V0.6890.91
201_I205_V0.6840.91
135_K161_N0.6830.91
189_I212_G0.6820.91
221_E224_K0.6810.91
170_L202_P0.6800.91
177_I205_V0.6760.90
31_I35_E0.6720.90
122_A130_V0.6690.90
85_E88_Y0.6680.90
11_D15_L0.6670.90
34_N175_R0.6610.89
173_G205_V0.6600.89
112_F211_S0.6570.89
28_R31_I0.6570.89
29_P33_L0.6560.89
129_T156_P0.6560.89
52_Y70_S0.6560.89
48_I242_K0.6550.89
86_E93_Y0.6550.89
113_I118_Q0.6540.89
41_N229_A0.6510.89
211_S231_L0.6490.88
70_S99_I0.6470.88
65_D98_K0.6440.88
30_I36_R0.6430.88
167_D171_R0.6420.88
43_R78_V0.6380.88
189_I209_A0.6370.88
8_W12_V0.6370.88
139_E143_E0.6330.87
179_I194_Q0.6290.87
3_R6_K0.6280.87
116_E145_L0.6270.87
84_T109_M0.6240.86
36_R40_F0.6240.86
59_G214_S0.6240.86
197_L201_I0.6230.86
80_L99_I0.6220.86
158_I169_A0.6210.86
132_L142_L0.6160.86
100_A122_A0.6160.86
150_R173_G0.6150.86
110_K131_L0.6110.85
76_Y105_I0.6110.85
166_L207_K0.6100.85
35_E38_L0.6090.85
181_S191_K0.6090.85
55_K61_D0.6090.85
52_Y69_Y0.6060.85
137_L141_E0.6050.85
64_R237_M0.6030.85
10_K14_Q0.5990.84
35_E155_E0.5980.84
113_I132_L0.5980.84
85_E187_L0.5970.84
82_I99_I0.5950.84
131_L231_L0.5930.84
25_S151_S0.5930.84
58_S178_G0.5910.83
37_I229_A0.5910.83
165_D168_I0.5900.83
134_V165_D0.5870.83
38_L42_K0.5860.83
83_L231_L0.5840.83
129_T155_E0.5820.82
132_L145_L0.5810.82
33_L79_G0.5800.82
207_K227_V0.5780.82
35_E41_N0.5770.82
30_I33_L0.5750.82
142_L158_I0.5750.82
79_G155_E0.5750.82
196_K200_M0.5740.82
235_S239_N0.5670.81
164_N168_I0.5660.81
29_P32_S0.5660.81
24_A27_Q0.5650.81
114_V136_I0.5650.81
16_S21_S0.5620.80
37_I79_G0.5610.80
84_T96_L0.5590.80
191_K213_I0.5580.80
175_R204_N0.5570.80
32_S36_R0.5550.79
99_I102_S0.5540.79
160_I193_N0.5540.79
19_R124_N0.5500.79
2_P5_L0.5470.78
77_A80_L0.5460.78
141_E145_L0.5450.78
19_R117_S0.5420.78
12_V85_E0.5420.78
26_R147_E0.5400.78
8_W114_V0.5380.77
110_K159_E0.5360.77
70_S102_S0.5350.77
83_L211_S0.5350.77
15_L19_R0.5340.77
186_T189_I0.5340.77
47_A229_A0.5320.76
140_R143_E0.5320.76
85_E90_N0.5320.76
168_I171_R0.5310.76
170_L177_I0.5280.76
77_A105_I0.5260.76
131_L211_S0.5260.76
113_I130_V0.5260.76
197_L200_M0.5230.75
82_I96_L0.5220.75
34_N155_E0.5210.75
232_I235_S0.5210.75
191_K194_Q0.5190.75
21_S24_A0.5180.75
215_E235_S0.5160.74
70_S80_L0.5160.74
46_T223_R0.5140.74
242_K245_E0.5090.73
31_I34_N0.5070.73
66_P95_T0.5050.73
112_F131_L0.5040.73
73_M76_Y0.5040.73
133_I184_L0.5040.73
19_R23_R0.5030.72
162_D197_L0.5000.72
160_I169_A0.5000.72
56_S133_I0.5000.72
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1piiA 1 0.9879 100 0.31 Contact Map
4a29A 1 0.996 100 0.353 Contact Map
1i4nA 1 0.9677 100 0.358 Contact Map
3tsmA 2 1 100 0.36 Contact Map
3qjaA 1 0.9556 100 0.384 Contact Map
1vc4A 2 0.9718 100 0.396 Contact Map
1hg3A 3 0.8024 100 0.651 Contact Map
1w0mA 3 0.7863 99.9 0.684 Contact Map
2yzrA 5 0.8105 99.9 0.703 Contact Map
1jvnA 1 0.9274 99.9 0.716 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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