TRPC - SULSO - GREMLIN Contacts

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TRPC - Indole-3-glycerol phosphate synthase

UniProt:	Q06121	Sequences: MPRYLKGWLKDVVQLSLRRPSFRASRQRPIISLNERILEFNKRNITAIIAEYKRKSPSGLDVERDPIEYSKFMERYAVGLSILTEEKYFNGSYETLRKIASSVSIPILMKDFIVKESQIDDAYNLGADTVLLIVKILTERELESLLEYARSYGMEPLIEINDENDLDIALRIGARFIGINSRDLETLEINKENQRKLISMIPSNVVKVAESGISERNEIEELRKLGVNAFLIGSSLMRNPEKIKEFIL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	248 (243)
Sequences:	3751 (2490)
Seq/√Len:	159.7

ECOLI - TRPC
BACSU - TRPC
HALSA - TRPC
SULSO - TRPC

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
139_E	168_I	4.058	1.00
93_Y	125_L	3.375	1.00
5_L	136_I	3.213	1.00
7_G	88_Y	3.126	1.00
138_T	141_E	3.085	1.00
163_E	196_K	2.780	1.00
195_R	221_E	2.726	1.00
208_V	229_A	2.452	1.00
65_D	68_E	2.447	1.00
120_D	148_Y	2.421	1.00
55_K	90_N	2.412	1.00
16_S	115_K	2.378	1.00
116_E	144_S	2.333	1.00
163_E	200_M	2.290	1.00
241_E	244_K	2.284	1.00
73_M	104_S	2.257	1.00
7_G	87_K	2.257	1.00
100_A	128_D	2.184	1.00
216_R	220_E	2.177	1.00
194_Q	227_V	2.066	1.00
146_L	156_P	2.037	1.00
179_I	207_K	2.000	1.00
119_I	130_V	1.969	1.00
150_R	175_R	1.923	1.00
149_A	156_P	1.865	1.00
19_R	27_Q	1.862	1.00
219_I	230_F	1.852	1.00
32_S	35_E	1.847	1.00
192_E	195_R	1.846	1.00
192_E	196_K	1.846	1.00
141_E	144_S	1.811	1.00
160_I	166_L	1.795	1.00
32_S	155_E	1.786	1.00
94_E	97_R	1.734	1.00
135_K	165_D	1.726	1.00
139_E	171_R	1.711	1.00
166_L	201_I	1.708	1.00
20_P	117_S	1.648	1.00
61_D	90_N	1.644	1.00
198_I	207_K	1.610	1.00
96_L	107_I	1.572	1.00
8_W	11_D	1.558	1.00
146_L	150_R	1.555	1.00
201_I	207_K	1.544	1.00
54_R	95_T	1.540	1.00
214_S	235_S	1.536	1.00
38_L	175_R	1.525	1.00
120_D	152_Y	1.520	1.00
67_I	99_I	1.516	1.00
209_A	222_L	1.510	1.00
194_Q	209_A	1.500	1.00
221_E	225_L	1.491	1.00
109_M	121_D	1.488	1.00
33_L	37_I	1.478	1.00
195_R	225_L	1.473	1.00
134_V	169_A	1.472	1.00
15_L	121_D	1.461	1.00
183_D	188_E	1.448	1.00
7_G	10_K	1.439	1.00
183_D	186_T	1.429	1.00
119_I	145_L	1.423	1.00
11_D	85_E	1.416	1.00
143_E	147_E	1.401	1.00
116_E	148_Y	1.399	1.00
167_D	200_M	1.384	1.00
15_L	117_S	1.383	1.00
59_G	234_S	1.382	1.00
46_T	230_F	1.376	1.00
79_G	129_T	1.375	1.00
132_L	137_L	1.367	1.00
93_Y	109_M	1.360	1.00
80_L	103_V	1.356	1.00
239_N	245_E	1.354	1.00
74_E	243_I	1.337	1.00
146_L	174_A	1.333	1.00
134_V	142_L	1.329	1.00
149_A	154_M	1.305	1.00
148_Y	151_S	1.279	1.00
100_A	107_I	1.278	1.00
73_M	105_I	1.258	1.00
97_R	125_L	1.255	1.00
155_E	176_F	1.245	1.00
130_V	149_A	1.245	1.00
234_S	238_R	1.241	1.00
23_R	27_Q	1.224	1.00
22_F	25_S	1.219	1.00
52_Y	99_I	1.218	1.00
147_E	151_S	1.216	1.00
146_L	172_I	1.209	1.00
157_L	208_V	1.194	1.00
75_R	243_I	1.191	1.00
64_R	95_T	1.179	1.00
109_M	122_A	1.175	1.00
190_N	196_K	1.167	1.00
67_I	98_K	1.163	1.00
9_L	141_E	1.158	1.00
164_N	167_D	1.149	1.00
25_S	120_D	1.147	1.00
46_T	219_I	1.146	1.00
66_P	99_I	1.145	1.00
220_E	224_K	1.144	1.00
8_W	85_E	1.144	1.00
92_S	95_T	1.141	1.00
20_P	23_R	1.140	1.00
73_M	103_V	1.138	1.00
213_I	219_I	1.135	1.00
71_K	74_E	1.112	1.00
14_Q	18_R	1.098	1.00
23_R	26_R	1.094	1.00
166_L	200_M	1.090	0.99
146_L	173_G	1.079	0.99
5_L	9_L	1.061	0.99
94_E	98_K	1.055	0.99
71_K	102_S	1.053	0.99
135_K	185_E	1.051	0.99
50_A	77_A	1.049	0.99
166_L	197_L	1.048	0.99
148_Y	152_Y	1.043	0.99
54_R	90_N	1.029	0.99
5_L	114_V	1.027	0.99
14_Q	17_L	1.015	0.99
134_V	168_I	1.014	0.99
19_R	24_A	1.012	0.99
33_L	36_R	0.990	0.99
216_R	223_R	0.988	0.99
215_E	218_E	0.988	0.99
15_L	93_Y	0.987	0.99
37_I	40_F	0.986	0.99
198_I	227_V	0.982	0.99
62_V	237_M	0.979	0.99
10_K	13_V	0.978	0.99
21_S	25_S	0.977	0.99
37_I	41_N	0.971	0.99
162_D	185_E	0.971	0.99
158_I	174_A	0.971	0.99
86_E	92_S	0.963	0.99
192_E	221_E	0.963	0.99
54_R	64_R	0.960	0.99
67_I	102_S	0.960	0.99
6_K	9_L	0.957	0.99
66_P	70_S	0.955	0.99
150_R	156_P	0.950	0.99
219_I	232_I	0.948	0.99
93_Y	121_D	0.939	0.98
187_L	234_S	0.933	0.98
70_S	103_V	0.925	0.98
217_N	220_E	0.922	0.98
21_S	120_D	0.922	0.98
116_E	141_E	0.921	0.98
54_R	61_D	0.918	0.98
181_S	194_Q	0.916	0.98
222_L	227_V	0.904	0.98
64_R	69_Y	0.902	0.98
11_D	86_E	0.900	0.98
113_I	145_L	0.899	0.98
214_S	218_E	0.893	0.98
170_L	205_V	0.893	0.98
24_A	120_D	0.890	0.98
174_A	177_I	0.890	0.98
183_D	193_N	0.888	0.98
2_P	6_K	0.887	0.98
59_G	238_R	0.877	0.98
193_N	196_K	0.874	0.98
181_S	209_A	0.873	0.98
4_Y	8_W	0.870	0.97
213_I	232_I	0.868	0.97
95_T	98_K	0.867	0.97
3_R	7_G	0.865	0.97
119_I	148_Y	0.864	0.97
169_A	174_A	0.863	0.97
157_L	178_G	0.861	0.97
140_R	144_S	0.861	0.97
7_G	11_D	0.859	0.97
31_I	36_R	0.858	0.97
218_E	221_E	0.851	0.97
52_Y	64_R	0.851	0.97
58_S	83_L	0.850	0.97
61_D	64_R	0.846	0.97
150_R	155_E	0.846	0.97
176_F	206_V	0.845	0.97
3_R	87_K	0.841	0.97
195_R	227_V	0.838	0.97
178_G	210_E	0.828	0.97
145_L	148_Y	0.823	0.96
9_L	114_V	0.821	0.96
40_F	45_I	0.821	0.96
48_I	230_F	0.820	0.96
49_I	208_V	0.816	0.96
69_Y	237_M	0.813	0.96
118_Q	145_L	0.807	0.96
213_I	222_L	0.803	0.96
67_I	71_K	0.802	0.96
209_A	227_V	0.800	0.96
144_S	148_Y	0.789	0.96
3_R	88_Y	0.789	0.96
134_V	158_I	0.783	0.95
235_S	245_E	0.782	0.95
194_Q	207_K	0.779	0.95
181_S	222_L	0.775	0.95
206_V	229_A	0.773	0.95
110_K	211_S	0.768	0.95
34_N	38_L	0.760	0.95
82_I	107_I	0.758	0.94
62_V	238_R	0.755	0.94
72_F	76_Y	0.754	0.94
12_V	15_L	0.752	0.94
16_S	117_S	0.748	0.94
12_V	114_V	0.747	0.94
181_S	193_N	0.746	0.94
11_D	87_K	0.744	0.94
36_R	41_N	0.743	0.94
119_I	154_M	0.742	0.94
8_W	86_E	0.741	0.94
30_I	123_Y	0.737	0.94
170_L	201_I	0.737	0.94
95_T	99_I	0.736	0.94
33_L	41_N	0.736	0.94
113_I	119_I	0.736	0.94
123_Y	154_M	0.729	0.93
161_N	210_E	0.728	0.93
64_R	90_N	0.723	0.93
222_L	230_F	0.722	0.93
99_I	103_V	0.720	0.93
69_Y	242_K	0.718	0.93
162_D	165_D	0.714	0.93
122_A	125_L	0.713	0.92
143_E	171_R	0.708	0.92
36_R	155_E	0.706	0.92
97_R	101_S	0.706	0.92
13_V	16_S	0.704	0.92
167_D	170_L	0.700	0.92
79_G	176_F	0.699	0.92
174_A	205_V	0.698	0.92
99_I	107_I	0.697	0.92
163_E	167_D	0.695	0.91
144_S	147_E	0.690	0.91
6_K	10_K	0.690	0.91
47_A	78_V	0.689	0.91
201_I	205_V	0.684	0.91
135_K	161_N	0.683	0.91
189_I	212_G	0.682	0.91
221_E	224_K	0.681	0.91
170_L	202_P	0.680	0.91
177_I	205_V	0.676	0.90
31_I	35_E	0.672	0.90
122_A	130_V	0.669	0.90
85_E	88_Y	0.668	0.90
11_D	15_L	0.667	0.90
34_N	175_R	0.661	0.89
173_G	205_V	0.660	0.89
112_F	211_S	0.657	0.89
28_R	31_I	0.657	0.89
29_P	33_L	0.656	0.89
129_T	156_P	0.656	0.89
52_Y	70_S	0.656	0.89
48_I	242_K	0.655	0.89
86_E	93_Y	0.655	0.89
113_I	118_Q	0.654	0.89
41_N	229_A	0.651	0.89
211_S	231_L	0.649	0.88
70_S	99_I	0.647	0.88
65_D	98_K	0.644	0.88
30_I	36_R	0.643	0.88
167_D	171_R	0.642	0.88
43_R	78_V	0.638	0.88
189_I	209_A	0.637	0.88
8_W	12_V	0.637	0.88
139_E	143_E	0.633	0.87
179_I	194_Q	0.629	0.87
3_R	6_K	0.628	0.87
116_E	145_L	0.627	0.87
84_T	109_M	0.624	0.86
36_R	40_F	0.624	0.86
59_G	214_S	0.624	0.86
197_L	201_I	0.623	0.86
80_L	99_I	0.622	0.86
158_I	169_A	0.621	0.86
132_L	142_L	0.616	0.86
100_A	122_A	0.616	0.86
150_R	173_G	0.615	0.86
110_K	131_L	0.611	0.85
76_Y	105_I	0.611	0.85
166_L	207_K	0.610	0.85
35_E	38_L	0.609	0.85
181_S	191_K	0.609	0.85
55_K	61_D	0.609	0.85
52_Y	69_Y	0.606	0.85
137_L	141_E	0.605	0.85
64_R	237_M	0.603	0.85
10_K	14_Q	0.599	0.84
35_E	155_E	0.598	0.84
113_I	132_L	0.598	0.84
85_E	187_L	0.597	0.84
82_I	99_I	0.595	0.84
131_L	231_L	0.593	0.84
25_S	151_S	0.593	0.84
58_S	178_G	0.591	0.83
37_I	229_A	0.591	0.83
165_D	168_I	0.590	0.83
134_V	165_D	0.587	0.83
38_L	42_K	0.586	0.83
83_L	231_L	0.584	0.83
129_T	155_E	0.582	0.82
132_L	145_L	0.581	0.82
33_L	79_G	0.580	0.82
207_K	227_V	0.578	0.82
35_E	41_N	0.577	0.82
30_I	33_L	0.575	0.82
142_L	158_I	0.575	0.82
79_G	155_E	0.575	0.82
196_K	200_M	0.574	0.82
235_S	239_N	0.567	0.81
164_N	168_I	0.566	0.81
29_P	32_S	0.566	0.81
24_A	27_Q	0.565	0.81
114_V	136_I	0.565	0.81
16_S	21_S	0.562	0.80
37_I	79_G	0.561	0.80
84_T	96_L	0.559	0.80
191_K	213_I	0.558	0.80
175_R	204_N	0.557	0.80
32_S	36_R	0.555	0.79
99_I	102_S	0.554	0.79
160_I	193_N	0.554	0.79
19_R	124_N	0.550	0.79
2_P	5_L	0.547	0.78
77_A	80_L	0.546	0.78
141_E	145_L	0.545	0.78
19_R	117_S	0.542	0.78
12_V	85_E	0.542	0.78
26_R	147_E	0.540	0.78
8_W	114_V	0.538	0.77
110_K	159_E	0.536	0.77
70_S	102_S	0.535	0.77
83_L	211_S	0.535	0.77
15_L	19_R	0.534	0.77
186_T	189_I	0.534	0.77
47_A	229_A	0.532	0.76
140_R	143_E	0.532	0.76
85_E	90_N	0.532	0.76
168_I	171_R	0.531	0.76
170_L	177_I	0.528	0.76
77_A	105_I	0.526	0.76
131_L	211_S	0.526	0.76
113_I	130_V	0.526	0.76
197_L	200_M	0.523	0.75
82_I	96_L	0.522	0.75
34_N	155_E	0.521	0.75
232_I	235_S	0.521	0.75
191_K	194_Q	0.519	0.75
21_S	24_A	0.518	0.75
215_E	235_S	0.516	0.74
70_S	80_L	0.516	0.74
46_T	223_R	0.514	0.74
242_K	245_E	0.509	0.73
31_I	34_N	0.507	0.73
66_P	95_T	0.505	0.73
112_F	131_L	0.504	0.73
73_M	76_Y	0.504	0.73
133_I	184_L	0.504	0.73
19_R	23_R	0.503	0.72
162_D	197_L	0.500	0.72
160_I	169_A	0.500	0.72
56_S	133_I	0.500	0.72

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1piiA	1	0.9879	100	0.31	Contact Map
4a29A	1	0.996	100	0.353	Contact Map
1i4nA	1	0.9677	100	0.358	Contact Map
3tsmA	2	1	100	0.36	Contact Map
3qjaA	1	0.9556	100	0.384	Contact Map
1vc4A	2	0.9718	100	0.396	Contact Map
1hg3A	3	0.8024	100	0.651	Contact Map
1w0mA	3	0.7863	99.9	0.684	Contact Map
2yzrA	5	0.8105	99.9	0.703	Contact Map
1jvnA	1	0.9274	99.9	0.716	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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