GREMLIN Database
SYA - Alanine--tRNA ligase
UniProt: P96041 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 900 (865)
Sequences: 250 (188)
Seq/√Len: 6.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
21_K32_T6.0851.00
94_L102_V5.4380.99
609_V719_I5.3210.99
467_N476_H5.3040.99
660_I722_V4.9920.99
149_A242_V4.9690.99
468_F476_H4.8060.98
467_N475_R4.6970.98
468_F473_A4.5410.97
468_F472_V4.4920.97
467_N472_V4.3030.96
560_E576_K4.2110.96
684_I697_L4.1620.96
603_H741_A4.1420.96
467_N473_A4.1380.96
469_Y473_A4.0620.95
72_F173_E3.9780.94
468_F475_R3.8890.94
473_A476_H3.8430.93
70_L80_R3.8130.93
469_Y476_H3.7760.93
66_R147_E3.7550.92
94_L98_I3.6020.91
472_V476_H3.5990.91
545_G564_T3.5070.90
656_A722_V3.4340.88
469_Y472_V3.3350.87
663_R715_N3.2840.86
391_F508_Y3.2380.85
529_L550_I3.2050.85
150_A188_F3.1330.83
167_T236_V2.9410.79
26_C45_C2.8710.77
638_I737_L2.8630.77
614_A638_I2.8610.77
123_S147_E2.8570.77
644_L737_L2.8380.76
66_R123_S2.8370.76
134_N138_T2.8350.76
472_V475_R2.8330.76
150_A242_V2.8240.76
375_R378_E2.7740.74
663_R717_S2.7160.73
621_H640_H2.7150.73
505_E533_K2.7060.72
37_K46_T2.7040.72
67_E80_R2.6910.72
643_A735_I2.6570.71
172_T188_F2.6290.70
76_R173_E2.5970.69
508_Y709_G2.5660.68
98_I102_V2.5630.68
467_N470_A2.5600.68
465_P468_F2.5530.68
71_S74_E2.5520.68
610_I614_A2.5430.67
39_Y46_T2.5410.67
650_K754_A2.5380.67
143_L255_A2.5350.67
138_T141_R2.5330.67
83_P260_Y2.4900.66
642_K648_E2.4780.65
465_P472_V2.4460.64
469_Y475_R2.4210.63
166_E170_Y2.4050.63
465_P476_H2.3990.63
784_K788_I2.3770.62
571_I841_I2.3770.62
777_I781_V2.3750.62
121_V150_A2.3510.61
359_V709_G2.3400.61
470_A473_A2.3190.60
501_L530_I2.2780.58
127_I340_M2.2500.57
24_K38_E2.2490.57
256_F880_N2.2280.57
66_R70_L2.1810.55
161_V280_L2.1260.53
561_V575_L2.1160.53
251_K256_F2.1080.52
33_K172_T2.1010.52
98_I126_S2.0830.51
340_M345_L2.0820.51
605_T666_V2.0820.51
465_P469_Y2.0400.50
614_A737_L2.0370.50
470_A476_H1.9940.48
219_Q230_P1.9800.48
22_I29_P1.9620.47
517_F590_G1.9600.47
96_L214_T1.9590.47
773_R777_I1.9530.47
645_T648_E1.9410.46
544_L628_E1.9290.46
94_L97_T1.9190.45
91_R105_Q1.9020.45
214_T240_Y1.9010.45
776_R782_E1.9000.45
106_P116_P1.8670.44
96_L109_T1.8480.43
883_L892_I1.8380.42
267_F330_I1.8240.42
505_E510_K1.8230.42
130_E359_V1.8180.42
719_I823_E1.8090.41
149_A192_W1.8080.41
467_N471_L1.8040.41
686_E707_S1.7960.41
96_L355_L1.7850.41
677_E685_Y1.7790.40
330_I363_A1.7720.40
107_H234_K1.7710.40
506_K571_I1.7630.40
151_H238_T1.7620.40
272_G585_G1.7510.39
888_S891_E1.7350.39
611_L636_L1.7320.39
235_I571_I1.7240.38
228_Y254_S1.7200.38
70_L121_V1.7180.38
81_I663_R1.7100.38
73_F78_H1.7070.38
34_D37_K1.7060.38
72_F76_R1.6970.38
96_L127_I1.6910.37
138_T206_T1.6900.37
684_I739_Y1.6900.37
83_P691_N1.6860.37
22_I27_Q1.6790.37
192_W220_Y1.6690.37
536_F561_V1.6680.37
617_V652_I1.6550.36
109_T125_P1.6490.36
777_I782_E1.6380.36
340_M356_G1.6320.35
10_L13_F1.6310.35
530_I666_V1.6270.35
67_E71_S1.6250.35
21_K34_D1.6170.35
74_E80_R1.6080.35
257_H260_Y1.6040.34
727_V737_L1.5970.34
75_K651_L1.5970.34
651_L654_N1.5910.34
514_M535_T1.5850.34
201_P219_Q1.5770.34
465_P473_A1.5760.33
467_N474_K1.5730.33
691_N707_S1.5690.33
539_E545_G1.5670.33
571_I755_K1.5640.33
96_L340_M1.5610.33
539_E565_Q1.5600.33
673_R685_Y1.5560.33
214_T355_L1.5520.33
289_G292_D1.5480.33
141_R152_H1.5450.32
407_L411_R1.5360.32
536_F590_G1.5360.32
545_G565_Q1.5310.32
343_D543_Q1.5290.32
67_E74_E1.5270.32
121_V149_A1.5240.32
630_T634_G1.5240.32
259_I821_D1.5070.31
126_S449_D1.5060.31
96_L125_P1.5000.31
95_Y627_A1.4900.31
151_H355_L1.4850.31
503_P569_D1.4810.30
213_A240_Y1.4810.30
37_K41_S1.4790.30
192_W690_P1.4790.30
765_T777_I1.4750.30
656_A685_Y1.4740.30
92_E695_I1.4700.30
129_L355_L1.4680.30
214_T356_G1.4670.30
129_L143_L1.4610.30
634_G739_Y1.4580.30
453_E471_L1.4540.30
362_R627_A1.4530.30
345_L359_V1.4520.30
456_K666_V1.4500.30
843_I847_R1.4500.30
335_K391_F1.4280.29
170_Y768_D1.4250.29
673_R677_E1.4170.29
535_T590_G1.4170.29
518_E530_I1.4140.28
94_L738_E1.4120.28
648_E651_L1.4110.28
215_L238_T1.4030.28
106_P115_P1.4010.28
97_T126_S1.3980.28
547_T596_R1.3960.28
857_R860_K1.3940.28
399_D405_V1.3930.28
102_V248_V1.3930.28
759_A770_L1.3930.28
501_L523_G1.3860.28
151_H214_T1.3830.28
132_I359_V1.3830.28
185_E208_G1.3820.27
65_A249_T1.3720.27
195_G198_N1.3690.27
530_I861_I1.3680.27
656_A660_I1.3680.27
20_R126_S1.3490.27
212_L437_L1.3460.26
70_L123_S1.3450.26
252_T784_K1.3440.26
462_F593_N1.3440.26
115_P118_N1.3410.26
158_D161_V1.3400.26
869_G888_S1.3370.26
345_L356_G1.3330.26
192_W231_L1.3320.26
463_E636_L1.3320.26
174_F179_L1.3300.26
734_I852_T1.3270.26
153_A443_S1.3190.26
171_A238_T1.3180.26
509_Y709_G1.3170.26
609_V659_V1.3170.26
889_K893_I1.3130.26
611_L706_E1.3120.25
127_I215_L1.3080.25
457_K485_Y1.3050.25
294_D330_I1.3030.25
18_F636_L1.3020.25
887_K894_D1.3010.25
192_W219_Q1.2940.25
166_E169_A1.2930.25
807_E812_K1.2910.25
256_F387_W1.2870.25
181_I700_I1.2840.25
84_K103_D1.2820.25
96_L163_W1.2780.25
210_L603_H1.2720.24
181_I566_K1.2700.24
267_F331_L1.2640.24
70_L74_E1.2640.24
412_F447_P1.2600.24
107_H203_L1.2590.24
273_V857_R1.2580.24
141_R206_T1.2560.24
214_T346_V1.2550.24
150_A219_Q1.2540.24
532_D840_A1.2510.24
619_G676_A1.2490.24
94_L248_V1.2480.24
125_P355_L1.2470.24
109_T129_L1.2370.23
638_I702_D1.2250.23
72_F170_Y1.2250.23
93_D105_Q1.2250.23
13_F170_Y1.2240.23
517_F535_T1.2220.23
140_G209_G1.2220.23
582_I586_D1.2180.23
765_T778_L1.2140.23
122_V152_H1.2120.23
782_E791_Y1.2100.23
94_L126_S1.2080.23
10_L164_K1.2070.23
199_A214_T1.2010.23
251_K829_L1.1940.22
177_K449_D1.1920.22
432_I436_D1.1900.22
129_L352_E1.1880.22
127_I355_L1.1880.22
109_T355_L1.1850.22
90_W140_G1.1810.22
121_V188_F1.1790.22
338_M835_T1.1780.22
96_L240_Y1.1720.22
765_T773_R1.1700.22
78_H217_F1.1690.22
871_K882_I1.1690.22
96_L129_L1.1650.22
96_L356_G1.1650.22
214_T340_M1.1650.22
42_D98_I1.1630.22
351_G446_V1.1610.22
213_A355_L1.1560.21
149_A219_Q1.1560.21
217_F238_T1.1540.21
41_S51_F1.1540.21
109_T143_L1.1530.21
151_H240_Y1.1490.21
778_L781_V1.1490.21
507_L533_K1.1470.21
830_R878_F1.1460.21
97_T102_V1.1450.21
205_V213_A1.1420.21
90_W93_D1.1390.21
566_K702_D1.1390.21
523_G584_V1.1380.21
100_S163_W1.1360.21
385_G460_V1.1330.21
157_P385_G1.1320.21
123_S149_A1.1310.21
610_I737_L1.1300.21
465_P470_A1.1290.21
340_M401_I1.1260.21
794_I871_K1.1230.21
299_I306_V1.1220.21
637_D736_R1.1190.20
209_G247_W1.1170.20
138_T152_H1.1160.20
685_Y707_S1.1150.20
70_L73_F1.1120.20
889_K892_I1.1120.20
130_E260_Y1.1110.20
109_T127_I1.1100.20
575_L592_I1.1090.20
630_T663_R1.1080.20
719_I808_I1.1050.20
67_E70_L1.1000.20
307_S660_I1.1000.20
340_M355_L1.0990.20
617_V656_A1.0950.20
125_P163_W1.0920.20
641_H692_S1.0920.20
362_R629_K1.0880.20
205_V214_T1.0870.20
152_H206_T1.0860.20
338_M383_Q1.0850.20
302_H305_M1.0810.20
718_E871_K1.0780.20
127_I345_L1.0770.20
107_H690_P1.0770.20
215_L240_Y1.0740.19
707_S732_D1.0720.19
558_R589_R1.0680.19
586_D650_K1.0670.19
841_I889_K1.0660.19
199_A240_Y1.0650.19
215_L365_K1.0630.19
103_D123_S1.0620.19
39_Y850_I1.0620.19
435_E617_V1.0600.19
778_L782_E1.0600.19
459_R680_Y1.0580.19
96_L143_L1.0570.19
353_G531_L1.0560.19
38_E381_K1.0550.19
19_K32_T1.0510.19
242_V745_L1.0510.19
13_F169_A1.0470.19
305_M726_N1.0470.19
81_I636_L1.0460.19
291_I296_P1.0460.19
141_R676_A1.0440.19
468_F474_K1.0440.19
619_G640_H1.0430.19
308_K645_T1.0420.19
184_E569_D1.0400.19
212_L248_V1.0390.19
20_R563_D1.0340.19
151_H167_T1.0330.19
549_L558_R1.0310.18
181_I737_L1.0310.18
91_R681_G1.0310.18
149_A188_F1.0300.18
434_T438_I1.0300.18
109_T214_T1.0290.18
741_A744_A1.0270.18
638_I644_L1.0260.18
536_F709_G1.0190.18
18_F701_K1.0180.18
343_D347_P1.0180.18
733_G736_R1.0180.18
344_G729_R1.0170.18
265_Y719_I1.0160.18
428_R485_Y1.0160.18
188_F234_K1.0140.18
51_F251_K1.0130.18
96_L199_A1.0120.18
98_I634_G1.0120.18
88_A685_Y1.0110.18
409_Q636_L1.0110.18
776_R781_V1.0110.18
463_E864_E1.0110.18
66_R149_A1.0090.18
199_A213_A1.0090.18
609_V722_V1.0090.18
389_E698_L1.0070.18
95_Y98_I1.0050.18
582_I588_V1.0050.18
60_L249_T1.0040.18
315_K622_I1.0030.18
645_T818_G1.0010.18
227_D508_Y1.0000.18
87_L615_K0.9970.18
256_F881_V0.9970.18
90_W105_Q0.9960.18
238_T355_L0.9960.18
442_D606_V0.9960.18
23_C40_C0.9940.18
18_F49_Y0.9930.18
121_V242_V0.9930.18
446_V719_I0.9910.18
569_D651_L0.9900.18
350_S727_V0.9890.18
79_T435_E0.9880.18
118_N240_Y0.9860.17
647_E651_L0.9860.17
446_V451_L0.9850.17
328_F707_S0.9850.17
553_E669_L0.9850.17
646_E670_E0.9840.17
667_K699_E0.9840.17
87_L706_E0.9830.17
656_A673_R0.9820.17
202_C648_E0.9810.17
218_M621_H0.9810.17
773_R776_R0.9810.17
256_F335_K0.9790.17
341_L500_T0.9780.17
81_I165_D0.9780.17
96_L151_H0.9770.17
215_L340_M0.9760.17
240_Y355_L0.9760.17
190_E195_G0.9740.17
435_E867_K0.9740.17
109_T116_P0.9720.17
309_E410_Q0.9710.17
520_K587_N0.9710.17
97_T634_G0.9670.17
25_S39_Y0.9670.17
69_F121_V0.9660.17
787_L790_Q0.9660.17
84_K629_K0.9620.17
818_G847_R0.9620.17
80_R150_A0.9620.17
601_M865_L0.9610.17
201_P365_K0.9610.17
644_L727_V0.9590.17
786_N789_I0.9570.17
260_Y335_K0.9530.17
845_D886_K0.9530.17
288_A291_I0.9520.17
841_I846_N0.9520.17
885_S888_S0.9500.17
210_L248_V0.9450.17
205_V240_Y0.9450.17
576_K810_G0.9440.17
41_S187_N0.9440.17
118_N214_T0.9440.17
151_H213_A0.9440.17
557_K581_T0.9440.17
621_H641_H0.9440.17
66_R238_T0.9430.17
782_E825_N0.9420.17
453_E722_V0.9420.17
88_A95_Y0.9420.17
163_W355_L0.9420.17
107_H188_F0.9400.17
451_L462_F0.9400.17
576_K803_L0.9400.17
811_N838_T0.9390.17
212_L684_I0.9380.17
113_V203_L0.9340.16
446_V838_T0.9320.16
566_K569_D0.9320.16
215_L355_L0.9310.16
842_S845_D0.9290.16
220_Y690_P0.9260.16
293_P777_I0.9240.16
293_P298_T0.9230.16
644_L735_I0.9230.16
435_E458_K0.9220.16
606_V713_V0.9200.16
557_K588_V0.9190.16
859_D885_S0.9180.16
102_V246_A0.9180.16
587_N591_E0.9150.16
111_G621_H0.9120.16
93_D140_G0.9110.16
666_V713_V0.9110.16
179_L636_L0.9080.16
246_A249_T0.9040.16
263_L331_L0.9040.16
151_H215_L0.9030.16
138_T187_N0.9020.16
261_G690_P0.9020.16
759_A777_I0.9010.16
340_M346_V0.9000.16
545_G563_D0.8990.16
129_L508_Y0.8980.16
120_L247_W0.8950.16
260_Y447_P0.8940.16
425_T705_I0.8940.16
11_N166_E0.8930.16
624_Q637_D0.8930.16
272_G418_K0.8930.16
655_Y734_I0.8920.16
773_R781_V0.8920.16
230_P234_K0.8920.16
199_A355_L0.8910.16
780_E785_N0.8910.16
188_F242_V0.8890.16
49_Y818_G0.8890.16
567_V864_E0.8870.16
174_F177_K0.8860.15
138_T366_V0.8840.15
143_L259_I0.8830.15
108_V213_A0.8830.15
119_P163_W0.8830.15
126_S346_V0.8810.15
528_Y723_K0.8810.15
74_E644_L0.8800.15
592_I769_Q0.8780.15
706_E820_N0.8730.15
105_Q140_G0.8730.15
201_P657_N0.8720.15
68_K174_F0.8720.15
353_G676_A0.8710.15
817_E890_E0.8700.15
130_E335_K0.8680.15
543_Q711_T0.8680.15
78_H162_Y0.8670.15
424_S818_G0.8660.15
313_D737_L0.8650.15
610_I779_N0.8650.15
105_Q188_F0.8640.15
596_R600_L0.8630.15
544_L634_G0.8630.15
636_L639_T0.8620.15
127_I238_T0.8620.15
81_I368_R0.8610.15
223_T229_I0.8600.15
556_S862_V0.8590.15
315_K378_E0.8570.15
725_I748_Y0.8570.15
73_F164_K0.8570.15
105_Q209_G0.8550.15
645_T812_K0.8550.15
221_K698_L0.8520.15
246_A250_Q0.8490.15
28_T294_D0.8490.15
380_V832_L0.8480.15
524_I649_V0.8470.15
510_K823_E0.8470.15
352_E383_Q0.8430.15
812_K831_K0.8420.15
771_P777_I0.8390.15
641_H666_V0.8380.15
221_K229_I0.8370.15
455_L462_F0.8370.15
685_Y732_D0.8370.15
311_G737_L0.8350.15
32_T149_A0.8340.15
109_T340_M0.8320.14
256_F331_L0.8290.14
208_G690_P0.8290.14
306_V638_I0.8280.14
212_L246_A0.8260.14
353_G540_G0.8260.14
659_V782_E0.8260.14
22_I36_K0.8250.14
225_N524_I0.8250.14
415_I692_S0.8250.14
351_G644_L0.8240.14
188_F203_L0.8240.14
622_I638_I0.8240.14
645_T810_G0.8240.14
378_E862_V0.8220.14
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42_D138_T0.5390.10
198_N213_A0.5390.10
65_A218_M0.5390.10
348_S353_G0.5380.10
777_I780_E0.5380.10
218_M353_G0.5380.10
169_A173_E0.5370.10
155_N214_T0.5370.10
621_H626_G0.5370.10
96_L728_E0.5370.10
107_H242_V0.5360.10
39_Y650_K0.5350.10
485_Y714_S0.5350.10
96_L100_S0.5350.10
844_S847_R0.5350.10
847_R883_L0.5350.10
264_V603_H0.5350.10
64_E379_L0.5340.10
870_G883_L0.5340.10
441_Y603_H0.5340.10
15_K747_D0.5340.10
450_L600_L0.5340.10
771_P778_L0.5340.10
221_K582_I0.5340.10
124_Q128_R0.5340.10
124_Q131_D0.5340.10
124_Q136_G0.5340.10
124_Q142_H0.5340.10
128_R131_D0.5340.10
128_R136_G0.5340.10
128_R142_H0.5340.10
131_D136_G0.5340.10
131_D142_H0.5340.10
136_G142_H0.5340.10
419_V444_N0.5330.10
171_A215_L0.5320.10
600_L631_P0.5320.10
619_G736_R0.5320.10
179_L651_L0.5320.10
384_I856_M0.5310.10
125_P198_N0.5300.10
190_E253_P0.5300.10
682_V707_S0.5300.10
263_L639_T0.5290.10
117_A517_F0.5290.10
240_Y346_V0.5290.10
815_I819_L0.5280.10
759_A879_A0.5280.10
822_E842_S0.5280.10
127_I163_W0.5270.10
864_E888_S0.5270.10
249_T252_T0.5260.10
424_S505_E0.5260.10
763_I773_R0.5260.10
74_E161_V0.5250.10
109_T151_H0.5250.10
861_I892_I0.5250.10
16_N147_E0.5230.10
129_L359_V0.5230.10
566_K638_I0.5230.10
793_R891_E0.5230.10
10_L16_N0.5230.10
622_I806_Y0.5220.10
174_F405_V0.5220.10
135_V440_V0.5220.10
214_T358_L0.5220.10
238_T365_K0.5210.10
617_V648_E0.5210.10
321_L698_L0.5200.10
852_T869_G0.5200.10
94_L634_G0.5200.10
116_P603_H0.5200.10
657_N873_G0.5200.10
29_P38_E0.5200.10
75_K225_N0.5200.10
90_W195_G0.5200.10
273_V427_A0.5200.10
22_I25_S0.5190.10
303_R325_A0.5180.10
647_E746_V0.5180.10
247_W704_D0.5180.10
411_R723_K0.5170.10
848_L851_A0.5170.10
849_Q852_T0.5170.10
231_L246_A0.5170.10
65_A231_L0.5160.10
410_Q842_S0.5160.10
592_I618_L0.5160.10
165_D438_I0.5150.10
652_I656_A0.5150.10
759_A838_T0.5150.10
210_L814_Y0.5150.10
861_I894_D0.5150.10
303_R307_S0.5150.10
425_T845_D0.5150.10
624_Q733_G0.5140.10
109_T213_A0.5140.10
517_F596_R0.5140.10
54_N391_F0.5140.10
352_E732_D0.5130.10
119_P140_G0.5130.10
152_H685_Y0.5130.10
256_F263_L0.5130.10
143_L503_P0.5120.10
568_N593_N0.5120.10
288_A303_R0.5120.10
108_V199_A0.5120.10
86_V119_P0.5120.10
609_V847_R0.5120.10
194_E383_Q0.5120.10
83_P393_Q0.5120.10
60_L341_L0.5110.10
779_N803_L0.5110.10
807_E886_K0.5110.10
213_A365_K0.5110.10
190_E199_A0.5110.10
449_D878_F0.5110.10
127_I590_G0.5100.10
670_E694_T0.5100.10
437_L451_L0.5100.10
600_L634_G0.5100.10
533_K553_E0.5100.10
98_I129_L0.5090.10
70_L238_T0.5090.10
421_S851_A0.5090.10
125_P731_Q0.5080.10
318_E770_L0.5080.10
808_I813_I0.5080.10
18_F97_T0.5080.10
107_H260_Y0.5070.10
622_I763_I0.5060.09
601_M871_K0.5060.09
31_W73_F0.5060.09
58_Q672_N0.5050.09
268_F298_T0.5050.09
145_T208_G0.5040.09
174_F352_E0.5040.09
59_P250_Q0.5040.09
80_R147_E0.5030.09
153_A167_T0.5030.09
137_V508_Y0.5030.09
260_Y511_D0.5030.09
506_K566_K0.5030.09
79_T533_K0.5020.09
73_F167_T0.5020.09
267_F329_Q0.5010.09
442_D476_H0.5010.09
212_L394_V0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3wqyA 2 0.9756 100 0.199 Contact Map
2zzeA 1 0.7589 100 0.291 Contact Map
2ztgA 1 0.8044 100 0.301 Contact Map
1yfsA 1 0.4378 100 0.593 Contact Map
3hy0A 1 0.4144 100 0.606 Contact Map
3kewA 1 0.25 100 0.822 Contact Map
2e1bA 1 0.2378 100 0.827 Contact Map
1nyrA 2 0.4033 100 0.91 Contact Map
1v4pA 2 0.1678 100 0.911 Contact Map
1tkeA 1 0.2311 100 0.913 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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