GREMLIN Database
RL12 - 50S ribosomal protein L12
UniProt: P96040 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 106 (106)
Sequences: 188 (140)
Seq/√Len: 13.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
18_S21_A5.3251.00
33_V38_L2.8430.96
57_A61_P2.5860.93
16_E35_E2.4130.90
49_N89_K2.3210.88
13_A31_I2.2350.86
26_L37_R2.1940.85
26_L29_A2.1920.85
81_K85_K2.0910.82
23_K27_T2.0480.81
49_N52_E2.0380.81
6_A44_A1.7720.70
12_S34_D1.7320.68
24_N27_T1.6990.67
93_S96_E1.6560.65
7_S41_V1.6150.63
9_L25_V1.6150.63
8_L12_S1.5330.59
36_V44_A1.5030.57
99_S103_S1.3780.50
37_R40_A1.3750.50
23_K38_L1.3750.50
23_K34_D1.3480.49
49_N55_K1.3060.47
14_K96_E1.2900.46
80_K85_K1.2870.46
66_A71_T1.2750.45
17_I43_A1.2690.45
35_E76_A1.2680.45
36_V97_I1.2560.44
54_L90_K1.2440.43
1_M5_Y1.2300.43
6_A28_A1.2290.43
22_L53_V1.2190.42
42_V57_A1.2180.42
47_E56_N1.2150.42
37_R102_A1.1960.41
79_E83_E1.1870.40
51_D98_A1.1830.40
91_G102_A1.1600.39
9_L57_A1.1310.37
6_A18_S1.1050.36
70_A73_A1.1030.36
41_V99_S1.0940.36
14_K92_P1.0890.35
41_V103_S1.0850.35
48_V97_I1.0790.35
11_H51_D1.0780.35
36_V99_S1.0750.35
46_K103_S1.0430.33
100_G106_G1.0340.33
94_E103_S1.0230.32
4_I42_V1.0180.32
54_L99_S1.0130.32
4_I49_N1.0050.31
77_A81_K1.0050.31
2_E5_Y1.0010.31
28_A44_A0.9940.31
8_L98_A0.9900.31
92_P95_E0.9780.30
16_E55_K0.9720.30
93_S98_A0.9490.29
5_Y50_I0.9480.29
31_I37_R0.9460.29
72_Q76_A0.9460.29
51_D54_L0.9210.28
41_V53_V0.9160.27
52_E82_E0.9140.27
38_L85_K0.9020.27
92_P97_I0.8960.27
21_A43_A0.8960.27
53_V59_A0.8730.26
1_M50_I0.8630.25
29_A40_A0.8550.25
81_K88_E0.8490.25
16_E49_N0.8440.25
79_E84_K0.8370.24
5_Y9_L0.8360.24
32_S56_N0.8360.24
53_V58_A0.8330.24
28_A65_A0.8320.24
49_N102_A0.8320.24
74_Q77_A0.8160.23
43_A86_E0.8100.23
15_K24_N0.8080.23
69_Q87_E0.8050.23
76_A84_K0.8050.23
22_L96_E0.7950.23
14_K47_E0.7920.23
55_K80_K0.7870.22
26_L43_A0.7820.22
4_I99_S0.7770.22
75_P85_K0.7690.22
65_A70_A0.7610.21
55_K84_K0.7550.21
37_R44_A0.7400.21
27_T62_V0.7390.21
18_S74_Q0.7330.20
52_E62_V0.7310.20
90_K93_S0.7290.20
3_Y37_R0.7210.20
34_D98_A0.7160.20
42_V61_P0.7150.20
54_L58_A0.7140.20
7_S97_I0.7120.20
28_A43_A0.7110.20
26_L92_P0.7080.20
3_Y39_K0.7070.20
25_V33_V0.7060.19
48_V86_E0.7050.19
95_E103_S0.7020.19
25_V78_E0.6960.19
59_A62_V0.6960.19
20_D23_K0.6910.19
12_S98_A0.6910.19
72_Q82_E0.6900.19
69_Q83_E0.6860.19
3_Y104_L0.6830.19
7_S36_V0.6810.19
101_L105_F0.6800.19
4_I41_V0.6710.18
24_N88_E0.6620.18
47_E55_K0.6530.18
17_I26_L0.6500.18
27_T44_A0.6500.18
93_S97_I0.6470.18
13_A58_A0.6420.17
44_A55_K0.6380.17
40_A44_A0.6300.17
68_P86_E0.6280.17
54_L102_A0.6160.17
4_I69_Q0.6160.17
11_H15_K0.6110.16
19_E50_I0.5970.16
90_K96_E0.5970.16
73_A76_A0.5950.16
21_A35_E0.5940.16
63_A70_A0.5940.16
21_A94_E0.5820.16
60_M64_V0.5820.16
14_K91_G0.5810.16
4_I7_S0.5810.16
84_K87_E0.5750.15
6_A35_E0.5650.15
13_A29_A0.5570.15
100_G105_F0.5550.15
66_A72_Q0.5480.15
8_L24_N0.5440.15
27_T99_S0.5440.15
16_E38_L0.5430.15
12_S40_A0.5400.15
24_N34_D0.5370.14
56_N102_A0.5270.14
9_L103_S0.5200.14
34_D47_E0.5090.14
86_E89_K0.5070.14
5_Y29_A0.5050.14
92_P96_E0.5010.13
43_A92_P0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3j3bu 1 0.5189 99.8 0.51 Contact Map
3izsv 1 0.5377 99.8 0.515 Contact Map
3j3bs 1 0.5377 99.8 0.52 Contact Map
3j61s 1 0.5283 99.7 0.524 Contact Map
3izst 1 0.5283 99.7 0.543 Contact Map
3j61u 2 0.5472 99.7 0.561 Contact Map
3a1yA 3 0.5472 99.5 0.604 Contact Map
1vq8G 1 0.0094 99.4 0.628 Contact Map
3j21k 1 0 98.1 0.767 Contact Map
3wy9C 1 0.2453 97.5 0.799 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0058 seconds.