GREMLIN Database
RL10 - 50S ribosomal protein L10
UniProt: P96039 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 338 (295)
Sequences: 578 (355)
Seq/√Len: 20.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
129_A162_D5.2061.00
257_A267_S4.5591.00
308_A312_K4.4441.00
173_P176_A3.7441.00
131_D156_K3.5561.00
57_K105_F3.2561.00
305_Q308_A3.2281.00
32_N96_K3.1071.00
275_A279_A3.0220.99
27_L59_T2.9640.99
311_E315_E2.9450.99
272_I279_A2.9230.99
15_S19_E2.8430.99
138_P182_K2.7960.99
120_K171_V2.6340.98
128_P162_D2.6090.98
88_G95_T2.6010.98
309_A312_K2.4850.97
312_K315_E2.4770.97
305_Q309_A2.4670.97
263_I268_A2.3270.96
26_E30_N2.2150.95
284_T287_G2.2130.95
124_E168_P2.1360.94
39_L62_V2.1240.94
308_A314_E2.1120.94
309_A313_K2.0240.92
127_I162_D2.0240.92
96_K223_A1.9700.91
303_Q307_P1.8770.89
14_A230_L1.8630.88
85_Y196_V1.8450.88
272_I276_V1.8440.88
301_Q306_Q1.8400.88
302_S306_Q1.8310.87
233_E259_E1.8020.87
227_A230_L1.7590.85
273_S280_Y1.7540.85
308_A313_K1.7360.84
164_V167_K1.6590.82
269_Q273_S1.6580.81
303_Q306_Q1.6510.81
289_K300_Q1.6270.80
286_I290_V1.6110.80
282_L286_I1.5890.79
254_I270_A1.5860.78
286_I291_D1.5850.78
35_L194_I1.5780.78
266_E269_Q1.5750.78
309_A314_E1.5600.77
229_T233_E1.5550.77
143_F150_T1.5530.77
305_Q312_K1.5500.77
285_A288_G1.5480.77
300_Q304_S1.5430.76
71_A138_P1.5290.76
22_K26_E1.5000.74
306_Q314_E1.4970.74
267_S270_A1.4960.74
306_Q312_K1.4810.73
299_V307_P1.4800.73
211_L257_A1.4640.73
82_L247_S1.4540.72
28_I60_I1.4450.71
301_Q312_K1.4390.71
301_Q307_P1.4280.71
44_A172_I1.4230.70
45_D49_E1.4130.70
276_V280_Y1.4130.70
291_D307_P1.4070.69
257_A262_Y1.4030.69
14_A18_L1.4030.69
300_Q305_Q1.4000.69
31_S59_T1.3960.69
243_K246_I1.3830.68
123_E168_P1.3790.68
42_F46_K1.3700.67
126_V162_D1.3540.66
272_I280_Y1.3370.65
94_F148_V1.3340.65
305_Q311_E1.3270.65
115_A172_I1.3210.64
167_K170_D1.3130.64
126_V164_V1.3130.64
39_L92_F1.3030.63
43_P223_A1.2970.63
129_A211_L1.2890.62
104_M108_N1.2820.62
192_L212_D1.2780.62
161_K250_F1.2600.61
307_P312_K1.2600.61
301_Q305_Q1.2590.61
19_E22_K1.2550.60
145_K175_E1.2510.60
220_I224_Y1.2490.60
127_I207_E1.2410.59
34_I130_G1.2410.59
231_A239_P1.2300.59
207_E213_L1.2280.59
124_E170_D1.2280.59
174_A207_E1.2180.58
299_V302_S1.2180.58
112_R156_K1.2170.58
37_G93_I1.2090.57
86_L108_N1.2060.57
164_V169_G1.1860.56
250_F253_A1.1830.56
307_P313_K1.1740.55
217_R221_T1.1630.54
148_V159_V1.1630.54
48_H202_L1.1580.54
310_E315_E1.1490.53
140_L150_T1.1450.53
304_S307_P1.1430.53
246_I291_D1.1410.53
89_P144_G1.1400.53
130_G137_G1.1310.52
23_E84_Q1.1170.51
310_E314_E1.0870.49
20_E24_L1.0840.49
93_I247_S1.0810.49
241_V245_T1.0770.49
246_I253_A1.0710.48
77_I80_E1.0710.48
311_E314_E1.0670.48
36_I86_L1.0660.48
257_A263_I1.0640.48
206_A255_A1.0620.48
243_K267_S1.0580.47
247_S265_P1.0560.47
124_E149_Q1.0530.47
148_V163_T1.0480.47
64_K190_V1.0380.46
73_K214_E1.0360.46
73_K126_V1.0330.46
109_Y157_V1.0330.46
264_T267_S1.0320.46
20_E63_T1.0250.45
175_E255_A1.0220.45
275_A278_K1.0180.45
14_A284_T1.0110.44
194_I225_R1.0100.44
137_G147_K1.0070.44
57_K97_D1.0050.44
45_D48_H1.0040.44
272_I275_A1.0030.44
151_K160_V1.0020.44
26_E302_S1.0010.44
215_G218_S0.9990.44
19_E214_E0.9920.43
138_P153_Q0.9880.43
25_T74_N0.9840.43
308_A315_E0.9780.42
85_Y203_V0.9770.42
18_L234_I0.9760.42
250_F254_I0.9720.42
156_K182_K0.9660.41
42_F72_A0.9640.41
103_N210_K0.9620.41
39_L47_L0.9590.41
256_L259_E0.9540.41
26_E116_M0.9470.40
84_Q220_I0.9460.40
283_A291_D0.9450.40
300_Q312_K0.9380.40
71_A181_Q0.9370.40
113_R144_G0.9290.39
52_K249_V0.9290.39
241_V244_F0.9280.39
101_I256_L0.9250.39
183_L242_L0.9240.39
26_E218_S0.9230.39
299_V311_E0.9180.38
114_Y191_K0.9140.38
144_G152_V0.9120.38
106_F190_V0.9110.38
42_F145_K0.9030.38
67_L183_L0.9010.37
133_G156_K0.8990.37
93_I290_V0.8990.37
46_K113_R0.8930.37
309_A315_E0.8930.37
70_I147_K0.8920.37
274_K277_A0.8870.37
217_R224_Y0.8840.36
116_M311_E0.8810.36
116_M207_E0.8710.36
306_Q315_E0.8630.35
303_Q313_K0.8630.35
186_M204_I0.8620.35
281_A284_T0.8600.35
303_Q312_K0.8530.34
300_Q308_A0.8500.34
91_V158_H0.8490.34
133_G141_S0.8490.34
36_I73_K0.8480.34
272_I278_K0.8470.34
96_K160_V0.8450.34
282_L299_V0.8440.34
71_A74_N0.8350.33
26_E96_K0.8350.33
276_V279_A0.8340.33
133_G162_D0.8330.33
38_N247_S0.8270.33
166_A212_D0.8250.33
274_K278_K0.8250.33
299_V312_K0.8250.33
144_G210_K0.8200.33
310_E313_K0.8170.32
15_S85_Y0.8150.32
114_Y273_S0.8140.32
70_I160_V0.8120.32
251_K255_A0.8080.32
220_I223_A0.8070.32
227_A240_D0.8060.32
95_T131_D0.8050.32
36_I159_V0.7960.31
82_L214_E0.7940.31
66_T206_A0.7920.31
300_Q303_Q0.7920.31
93_I106_F0.7920.31
277_A280_Y0.7900.31
165_V176_A0.7900.31
95_T156_K0.7830.30
37_G91_V0.7830.30
228_F241_V0.7810.30
249_V254_I0.7780.30
305_Q313_K0.7760.30
165_V267_S0.7730.30
15_S169_G0.7700.30
248_K252_N0.7690.30
90_N157_V0.7690.30
60_I195_K0.7680.30
303_Q308_A0.7650.29
257_A260_I0.7640.29
246_I280_Y0.7620.29
90_N195_K0.7610.29
166_A170_D0.7560.29
88_G204_I0.7560.29
231_A256_L0.7550.29
307_P310_E0.7530.29
140_L144_G0.7500.29
146_L173_P0.7460.28
34_I60_I0.7440.28
204_I221_T0.7420.28
171_V199_H0.7400.28
96_K204_I0.7380.28
302_S305_Q0.7330.28
82_L191_K0.7320.28
28_I255_A0.7320.28
82_L101_I0.7320.28
283_A287_G0.7300.28
46_K157_V0.7280.27
114_Y197_A0.7230.27
288_G302_S0.7210.27
155_G187_P0.7170.27
146_L158_H0.7100.27
307_P311_E0.7090.26
135_P149_Q0.7030.26
42_F250_F0.7010.26
60_I96_K0.6950.26
254_I267_S0.6930.26
72_A76_G0.6930.26
122_E143_F0.6920.26
127_I185_I0.6910.26
65_N237_P0.6910.26
145_K172_I0.6910.26
81_K84_Q0.6910.26
157_V160_V0.6900.26
194_I258_S0.6900.26
157_V162_D0.6890.25
162_D268_A0.6880.25
213_L217_R0.6860.25
150_T179_I0.6850.25
148_V151_K0.6830.25
70_I206_A0.6820.25
102_T202_L0.6820.25
166_A174_A0.6810.25
20_E190_V0.6810.25
281_A290_V0.6790.25
49_E53_K0.6790.25
44_A163_T0.6790.25
134_M184_G0.6770.25
125_V262_Y0.6730.25
49_E52_K0.6720.25
304_S309_A0.6690.24
41_G119_D0.6670.24
274_K280_Y0.6660.24
73_K198_Y0.6640.24
28_I116_M0.6630.24
64_K103_N0.6610.24
154_D214_E0.6610.24
123_E129_A0.6590.24
36_I57_K0.6580.24
198_Y215_G0.6580.24
30_N168_P0.6570.24
18_L22_K0.6530.24
306_Q309_A0.6520.24
70_I115_A0.6500.24
56_G59_T0.6480.23
71_A110_K0.6480.23
113_R189_Y0.6470.23
97_D192_L0.6450.23
172_I175_E0.6420.23
26_E304_S0.6410.23
254_I258_S0.6400.23
199_H204_I0.6390.23
77_I81_K0.6380.23
91_V273_S0.6340.23
88_G231_A0.6340.23
129_A145_K0.6320.23
162_D215_G0.6300.23
39_L68_F0.6300.23
46_K201_G0.6300.23
41_G63_T0.6270.22
130_G153_Q0.6270.22
42_F111_L0.6260.22
299_V308_A0.6240.22
206_A213_L0.6240.22
250_F266_E0.6230.22
54_L134_M0.6200.22
26_E309_A0.6200.22
304_S308_A0.6190.22
303_Q309_A0.6190.22
21_V67_L0.6180.22
37_G41_G0.6180.22
79_I117_P0.6170.22
57_K102_T0.6170.22
13_V16_W0.6170.22
27_L94_F0.6160.22
125_V206_A0.6160.22
76_G79_I0.6160.22
195_K247_S0.6150.22
261_G271_V0.6150.22
258_S262_Y0.6150.22
15_S18_L0.6140.22
302_S315_E0.6140.22
62_V76_G0.6140.22
257_A266_E0.6110.22
86_L147_K0.6100.22
141_S150_T0.6100.22
112_R186_M0.6100.22
36_I170_D0.6080.22
28_I36_I0.6080.22
93_I145_K0.6060.22
65_N192_L0.6060.22
116_M148_V0.6060.22
168_P207_E0.6050.21
50_I198_Y0.6050.21
38_N166_A0.6050.21
255_A259_E0.6030.21
178_P189_Y0.6000.21
117_P160_V0.5990.21
99_P243_K0.5990.21
157_V299_V0.5940.21
28_I76_G0.5920.21
36_I224_Y0.5900.21
195_K270_A0.5890.21
137_G249_V0.5870.21
223_A258_S0.5870.21
253_A256_L0.5840.21
64_K87_T0.5830.21
301_Q315_E0.5820.20
86_L166_A0.5800.20
97_D102_T0.5790.20
172_I237_P0.5790.20
58_A147_K0.5780.20
200_E213_L0.5770.20
116_M159_V0.5770.20
162_D168_P0.5760.20
137_G166_A0.5760.20
149_Q159_V0.5750.20
39_L200_E0.5740.20
183_L234_I0.5740.20
49_E120_K0.5740.20
134_M148_V0.5730.20
130_G138_P0.5660.20
38_N193_K0.5640.20
215_G219_N0.5640.20
263_I267_S0.5630.20
23_E27_L0.5620.20
237_P245_T0.5600.20
141_S285_A0.5590.20
135_P138_P0.5570.19
107_E249_V0.5550.19
115_A155_G0.5520.19
86_L258_S0.5510.19
273_S278_K0.5510.19
104_M161_K0.5500.19
244_F251_K0.5500.19
226_N242_L0.5490.19
120_K206_A0.5480.19
137_G223_A0.5480.19
25_T258_S0.5480.19
27_L31_S0.5470.19
228_F244_F0.5460.19
35_L106_F0.5460.19
86_L93_I0.5460.19
141_S194_I0.5420.19
86_L92_F0.5410.19
60_I164_V0.5410.19
16_W19_E0.5400.19
175_E228_F0.5380.19
46_K144_G0.5380.19
42_F154_D0.5360.19
147_K223_A0.5350.19
80_E92_F0.5340.18
232_V248_K0.5330.18
35_L93_I0.5320.18
21_V157_V0.5310.18
79_I253_A0.5300.18
170_D246_I0.5290.18
59_T313_K0.5280.18
54_L111_L0.5270.18
47_L93_I0.5260.18
284_T302_S0.5250.18
31_S80_E0.5240.18
134_M137_G0.5230.18
159_V168_P0.5210.18
92_F133_G0.5200.18
161_K198_Y0.5180.18
97_D272_I0.5170.18
32_N218_S0.5170.18
19_E29_K0.5150.18
32_N181_Q0.5140.18
66_T201_G0.5120.18
56_G225_R0.5110.18
131_D141_S0.5080.17
16_W262_Y0.5070.17
214_E282_L0.5050.17
163_T264_T0.5050.17
192_L246_I0.5050.17
114_Y133_G0.5040.17
147_K256_L0.5040.17
69_K216_Y0.5040.17
20_E61_K0.5020.17
214_E218_S0.5010.17
252_N269_Q0.5000.17
170_D243_K0.5000.17
32_N36_I0.5000.17
48_H135_P0.5000.17
82_L204_I0.5000.17
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vq8G 1 0.003 100 0.214 Contact Map
3j21k 1 0.6095 100 0.234 Contact Map
3j3bq 1 0.8195 100 0.259 Contact Map
3j61q 1 0.7604 100 0.267 Contact Map
4ujti 1 0.4142 100 0.271 Contact Map
3a1yG 1 0.6065 100 0.307 Contact Map
4hubG 1 0.6095 100 0.38 Contact Map
3jsyA 1 0.6154 100 0.457 Contact Map
4w22q 1 0.5888 100 0.475 Contact Map
3j65n 1 0.6272 100 0.521 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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