GREMLIN Database
SPT5 - Transcription elongation factor Spt5
UniProt: P96036 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 152 (134)
Sequences: 468 (306)
Seq/√Len: 26.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
36_K64_L4.5241.00
26_L51_V3.7291.00
113_T134_S2.8021.00
58_L62_K2.7541.00
50_Y128_V2.4680.99
18_Q21_N2.4140.99
22_V70_N2.3900.99
104_E133_E2.3490.98
113_T136_F2.2900.98
53_L71_A2.2450.98
9_Y87_I2.1920.97
103_V115_A2.1180.97
65_I71_A2.1100.97
52_V79_L2.0610.96
108_G112_G1.9470.95
38_I64_L1.9180.95
104_E134_S1.8930.94
102_V117_V1.7800.92
9_Y84_I1.7740.92
7_R64_L1.7400.91
105_V108_G1.7190.90
53_L124_K1.6600.89
104_E114_Q1.6460.88
17_G29_R1.6180.88
23_A43_V1.5790.86
116_Q130_N1.4870.83
26_L29_R1.4740.82
133_E136_F1.4460.81
113_T133_E1.4260.80
40_A122_E1.4180.79
104_E110_F1.4120.79
49_G54_E1.4080.79
86_K96_T1.3950.78
27_E31_K1.3840.78
11_A50_Y1.3660.77
93_V129_L1.3290.75
23_A41_I1.3210.74
29_R38_I1.2990.73
110_F113_T1.2980.73
52_V136_F1.2970.73
65_I120_V1.2850.72
20_I45_P1.2800.72
82_D85_L1.2770.72
104_E113_T1.2520.70
110_F134_S1.2440.70
97_V117_V1.2340.69
23_A42_I1.2320.69
99_P115_A1.2260.69
20_I41_I1.2160.68
18_Q70_N1.2140.68
37_G60_I1.2120.68
78_L118_I1.2120.68
114_Q134_S1.1670.65
10_Y58_L1.1660.65
94_G129_L1.1610.64
19_E49_G1.1130.61
97_V121_E1.0930.60
121_E128_V1.0860.59
9_Y85_L1.0690.58
114_Q133_E1.0630.57
102_V114_Q1.0580.57
42_I87_I1.0410.56
71_A96_T1.0360.55
97_V109_P1.0260.55
22_V68_I1.0240.54
109_P129_L1.0180.54
16_G52_V1.0140.54
102_V134_S1.0070.53
18_Q42_I1.0060.53
28_E89_S0.9970.52
12_I65_I0.9950.52
11_A87_I0.9900.52
115_A131_I0.9860.52
113_T130_N0.9750.51
21_N123_A0.9700.50
51_V55_A0.9660.50
55_A67_G0.9660.50
121_E124_K0.9560.49
49_G126_E0.9190.47
15_V72_R0.9190.47
59_H97_V0.9090.46
34_N63_P0.9060.46
105_V112_G0.9020.45
6_M83_E0.8990.45
30_I36_K0.8880.44
56_E112_G0.8850.44
111_R129_L0.8740.43
22_V50_Y0.8670.43
12_I53_L0.8500.42
80_P83_E0.8470.41
31_K50_Y0.8470.41
68_I100_G0.8430.41
25_M131_I0.8310.40
43_V47_L0.8310.40
27_E30_I0.8280.40
15_V18_Q0.8190.39
102_V108_G0.8190.39
33_N127_V0.8190.39
110_F133_E0.8040.38
102_V133_E0.8010.38
64_L67_G0.8000.38
79_L117_V0.7950.38
50_Y101_D0.7950.38
26_L70_N0.7880.37
106_I133_E0.7870.37
18_Q87_I0.7860.37
88_V125_G0.7840.37
47_L52_V0.7780.37
86_K112_G0.7700.36
52_V114_Q0.7620.35
24_L111_R0.7620.35
61_V80_P0.7510.35
91_K115_A0.7470.34
58_L68_I0.7440.34
106_I113_T0.7410.34
42_I134_S0.7400.34
35_I60_I0.7400.34
110_F114_Q0.7360.34
85_L88_V0.7350.34
72_R105_V0.7310.33
13_K42_I0.7310.33
73_G126_E0.7310.33
105_V115_A0.7290.33
79_L114_Q0.7190.33
35_I61_V0.7150.32
51_V123_A0.7150.32
55_A60_I0.7140.32
89_S97_V0.7010.31
67_G132_L0.7000.31
42_I123_A0.6980.31
125_G135_A0.6930.31
10_Y114_Q0.6910.31
35_I64_L0.6890.31
42_I85_L0.6890.31
27_E116_Q0.6750.30
39_Y81_R0.6680.29
8_N105_V0.6680.29
58_L63_P0.6660.29
49_G127_V0.6630.29
41_I102_V0.6610.29
100_G112_G0.6570.29
97_V101_D0.6460.28
21_N127_V0.6450.28
21_N33_N0.6420.28
23_A72_R0.6410.28
106_I134_S0.6400.28
37_G56_E0.6370.27
103_V117_V0.6300.27
28_E37_G0.6260.27
71_A132_L0.6180.26
130_N136_F0.6080.26
52_V104_E0.6080.26
96_T121_E0.6060.26
50_Y68_I0.5990.25
35_I127_V0.5950.25
12_I20_I0.5930.25
110_F115_A0.5920.25
82_D127_V0.5900.25
82_D90_R0.5880.25
29_R98_K0.5870.25
55_A92_T0.5830.24
128_V131_I0.5800.24
17_G118_I0.5780.24
27_E79_L0.5750.24
93_V96_T0.5710.24
61_V65_I0.5710.24
16_G41_I0.5700.24
59_H86_K0.5690.24
5_N77_G0.5670.23
93_V112_G0.5640.23
84_I87_I0.5630.23
73_G119_R0.5590.23
80_P95_P0.5560.23
8_N77_G0.5550.23
14_V19_E0.5540.23
88_V105_V0.5520.23
79_L116_Q0.5510.23
118_I127_V0.5500.23
9_Y47_L0.5490.23
89_S137_P0.5480.22
52_V133_E0.5440.22
22_V103_V0.5440.22
77_G97_V0.5400.22
113_T137_P0.5390.22
41_I60_I0.5350.22
110_F131_I0.5340.22
10_Y40_A0.5340.22
11_A75_A0.5290.22
38_I116_Q0.5280.21
83_E113_T0.5270.21
91_K125_G0.5260.21
20_I24_L0.5260.21
13_K50_Y0.5190.21
6_M114_Q0.5160.21
30_I88_V0.5140.21
26_L74_L0.5080.20
70_N119_R0.5050.20
29_R67_G0.5050.20
97_V127_V0.5040.20
24_L116_Q0.5020.20
54_E110_F0.5000.20
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3h7hB 1 0.5855 100 0.428 Contact Map
2exuA 2 0.6118 99.9 0.455 Contact Map
3p8bB 2 0.9605 99.9 0.5 Contact Map
2lq8A 1 0.9539 99.7 0.606 Contact Map
2jvvA 1 0.375 99.7 0.61 Contact Map
1m1hA 1 0.5658 99.5 0.66 Contact Map
2ougA 1 0.7697 99.5 0.669 Contact Map
3lpeA 1 0.5526 99.5 0.675 Contact Map
2xhcA 1 0.9539 99.3 0.71 Contact Map
1nz9A 1 0.3816 97.8 0.817 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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