GREMLIN Database
PELO - Protein pelota homolog
UniProt: P96026 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 344 (331)
Sequences: 877 (585)
Seq/√Len: 32.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
309_I314_G9.0851.00
131_A140_I5.2511.00
277_I282_V5.2321.00
192_A230_V4.0421.00
170_A201_V3.9431.00
131_A177_L3.6101.00
201_V204_K3.5671.00
191_L202_S3.1821.00
62_D92_H3.1311.00
329_L336_L3.1001.00
283_E340_R3.0811.00
267_T337_A2.7521.00
275_N278_E2.5951.00
284_T317_I2.5891.00
36_V59_L2.5831.00
258_L338_I2.5621.00
271_E275_N2.4090.99
133_V201_V2.3960.99
49_E52_R2.3780.99
129_I181_V2.3530.99
273_V337_A2.3200.99
141_A227_L2.2870.99
200_E203_K2.2510.99
255_A332_L2.2050.99
308_D311_N2.1640.99
282_V285_V2.1480.99
141_A150_I2.1210.98
221_S341_F2.0940.98
181_V186_P2.0850.98
138_Y173_I2.0510.98
40_T93_H2.0480.98
201_V205_V2.0350.98
282_V337_A2.0230.98
217_D230_V2.0080.98
254_K258_L1.9990.98
134_D156_L1.9810.97
36_V75_I1.9020.97
111_N114_V1.8830.97
304_R308_D1.8720.96
130_I192_A1.8540.96
247_I315_E1.8530.96
186_P189_I1.8400.96
73_L90_G1.8360.96
25_L117_R1.8150.96
130_I141_A1.8040.96
78_I92_H1.7920.95
42_R93_H1.7530.95
262_Q265_L1.7160.94
300_L304_R1.7160.94
134_D222_A1.7020.94
26_L31_E1.6660.93
133_V143_P1.6620.93
60_K80_E1.6590.93
34_D107_K1.6570.93
251_K317_I1.6570.93
129_I186_P1.6460.93
159_L165_I1.6110.92
248_G320_P1.6110.92
48_K54_P1.6090.92
21_D25_L1.5910.92
133_V193_G1.5800.91
15_L105_I1.5670.91
170_A177_L1.5520.90
283_E315_E1.5500.90
130_I230_V1.5480.90
255_A259_L1.5430.90
93_H107_K1.5410.90
264_E342_R1.5320.90
48_K52_R1.5320.90
35_K60_K1.5080.89
138_Y169_N1.4800.88
98_D101_D1.4780.88
79_I247_I1.4720.88
141_A149_K1.4650.88
194_P229_E1.4570.87
63_Y76_H1.4400.87
48_K55_M1.4110.86
195_G229_E1.4060.85
198_K216_I1.4040.85
279_M343_I1.4020.85
284_T315_E1.4010.85
258_L265_L1.3930.85
14_K102_E1.3840.85
193_G222_A1.3680.84
223_T226_G1.3540.83
199_E216_I1.3470.83
118_L257_E1.3450.83
43_D50_S1.3450.83
258_L263_P1.3400.83
26_L97_L1.3360.82
13_V118_L1.3300.82
208_I211_N1.3250.82
22_D42_R1.3220.82
240_M335_I1.3130.81
30_L61_V1.2960.80
252_M319_V1.2930.80
39_K54_P1.2800.80
127_R187_D1.2800.80
148_I231_L1.2770.79
136_D169_N1.2700.79
170_A204_K1.2590.78
132_L227_L1.2560.78
130_I190_L1.2220.76
132_L222_A1.2210.76
22_D34_D1.2180.76
140_I290_D1.2140.76
49_E55_M1.2030.75
258_L264_E1.1990.75
171_L204_K1.1950.75
62_D78_I1.1820.74
33_D42_R1.1770.73
36_V116_D1.1660.73
16_H102_E1.1640.73
154_K321_K1.1640.73
189_I214_I1.1600.72
257_E261_K1.1530.72
14_K17_I1.1520.72
24_W94_T1.1450.71
173_I189_I1.1440.71
45_G48_K1.1440.71
254_K257_E1.1370.71
22_D66_F1.1350.71
42_R110_W1.1320.70
195_G198_K1.1200.70
169_N201_V1.1180.69
280_G324_P1.1170.69
122_A205_V1.1130.69
18_E22_D1.1090.69
118_L177_L1.0970.68
221_S225_A1.0890.67
15_L103_I1.0880.67
159_L259_L1.0740.66
293_S323_S1.0730.66
232_K253_E1.0700.66
190_L239_I1.0690.66
43_D79_I1.0650.66
38_A95_I1.0650.66
169_N173_I1.0630.66
126_S187_D1.0630.66
49_E261_K1.0610.65
94_T107_K1.0610.65
153_E223_T1.0560.65
24_W28_L1.0550.65
134_D169_N1.0540.65
141_A193_G1.0490.64
194_P198_K1.0450.64
285_V336_L1.0440.64
168_Q172_E1.0400.64
286_L319_V1.0350.63
140_I176_E1.0340.63
275_N279_M1.0250.63
10_R14_K1.0210.62
165_I197_F1.0160.62
171_L175_T1.0140.62
169_N323_S1.0040.61
167_E171_L1.0010.61
64_T132_L0.9980.61
218_S221_S0.9950.60
100_G199_E0.9940.60
56_T60_K0.9900.60
6_F119_K0.9840.59
202_S216_I0.9830.59
22_D105_I0.9810.59
240_M243_Y0.9770.59
76_H94_T0.9730.59
208_I343_I0.9670.58
276_A343_I0.9660.58
122_A178_A0.9630.58
220_S229_E0.9580.57
11_Q110_W0.9570.57
71_N99_I0.9540.57
44_V50_S0.9510.57
60_K64_T0.9490.57
314_G337_A0.9480.57
37_V46_L0.9460.56
26_L343_I0.9450.56
22_D276_A0.9450.56
262_Q342_R0.9430.56
177_L205_V0.9380.56
181_V251_K0.9310.55
129_I177_L0.9310.55
33_D343_I0.9290.55
290_D330_K0.9250.55
9_K46_L0.9250.55
33_D40_T0.9190.54
175_T183_Q0.9130.54
116_D186_P0.9040.53
139_L223_T0.8970.52
136_D243_Y0.8940.52
74_R94_T0.8910.52
212_K278_E0.8900.52
252_M324_P0.8880.52
326_Y336_L0.8880.52
17_I26_L0.8850.51
267_T272_Q0.8840.51
24_W34_D0.8830.51
21_D141_A0.8820.51
36_V40_T0.8780.51
97_L103_I0.8740.51
41_T54_P0.8730.50
216_I337_A0.8720.50
320_P326_Y0.8700.50
248_G266_V0.8690.50
286_L329_L0.8680.50
334_G339_L0.8670.50
205_V311_N0.8650.50
320_P336_L0.8610.49
116_D310_E0.8600.49
313_R316_V0.8570.49
235_I265_L0.8490.48
134_D193_G0.8430.48
60_K254_K0.8420.48
26_L29_I0.8340.47
215_Y230_V0.8340.47
121_Q196_F0.8300.47
57_I93_H0.8290.47
193_G198_K0.8280.47
50_S54_P0.8260.47
191_L213_K0.8250.46
67_Q144_F0.8250.46
270_L273_V0.8230.46
130_I224_R0.8210.46
8_E38_A0.8200.46
140_I219_V0.8180.46
17_I101_D0.8130.46
30_L36_V0.8120.45
288_I330_K0.8120.45
284_T307_E0.8100.45
30_L55_M0.8090.45
287_V301_T0.8040.45
34_D42_R0.8010.45
80_E287_V0.7990.44
243_Y319_V0.7980.44
194_P268_Y0.7870.43
118_L205_V0.7830.43
98_D138_Y0.7800.43
136_D225_A0.7790.43
290_D297_Q0.7790.43
284_T290_D0.7750.42
15_L63_Y0.7720.42
254_K315_E0.7710.42
138_Y154_K0.7700.42
13_V227_L0.7680.42
151_L180_Y0.7670.42
14_K104_I0.7620.41
22_D29_I0.7600.41
96_N101_D0.7600.41
199_E203_K0.7580.41
40_T74_R0.7570.41
10_R41_T0.7570.41
139_L153_E0.7570.41
252_M272_Q0.7560.41
191_L198_K0.7540.41
223_T333_T0.7510.41
252_M256_M0.7510.41
11_Q273_V0.7500.40
48_K53_I0.7480.40
220_S241_T0.7470.40
254_K284_T0.7470.40
255_A338_I0.7430.40
330_K338_I0.7430.40
18_E27_H0.7420.40
35_K80_E0.7420.40
78_I277_I0.7390.40
275_N287_V0.7390.40
323_S326_Y0.7370.39
24_W195_G0.7370.39
255_A262_Q0.7370.39
172_E176_E0.7370.39
220_S259_L0.7360.39
248_G326_Y0.7360.39
170_A186_P0.7310.39
288_I321_K0.7290.39
192_A236_I0.7280.39
35_K145_E0.7280.39
129_I189_I0.7280.39
133_V222_A0.7260.39
16_H60_K0.7240.38
137_E224_R0.7230.38
32_K314_G0.7220.38
160_N200_E0.7210.38
185_D238_K0.7200.38
177_L201_V0.7170.38
259_L333_T0.7140.38
137_E222_A0.7130.38
85_R90_G0.7100.37
256_M310_E0.7090.37
238_K297_Q0.7090.37
95_I191_L0.7060.37
274_K301_T0.7060.37
34_D293_S0.7010.37
116_D254_K0.6950.36
268_Y337_A0.6920.36
74_R340_R0.6910.36
99_I162_E0.6900.36
115_L119_K0.6880.36
206_N282_V0.6840.35
57_I95_I0.6790.35
273_V291_L0.6790.35
170_A197_F0.6790.35
143_P274_K0.6780.35
79_I91_A0.6760.35
15_L265_L0.6730.35
15_L81_D0.6730.35
178_A284_T0.6720.34
80_E202_S0.6720.34
55_M84_E0.6700.34
206_N209_L0.6690.34
226_G229_E0.6680.34
257_E330_K0.6660.34
53_I56_T0.6660.34
335_I343_I0.6660.34
23_L67_Q0.6650.34
38_A93_H0.6640.34
40_T108_Q0.6640.34
186_P259_L0.6620.34
60_K122_A0.6610.34
277_I308_D0.6610.34
188_A201_V0.6590.33
94_T148_I0.6590.33
34_D329_L0.6580.33
135_F166_I0.6570.33
148_I160_N0.6560.33
217_D242_D0.6550.33
130_I336_L0.6550.33
141_A226_G0.6540.33
33_D45_G0.6540.33
113_Y303_E0.6530.33
252_M333_T0.6530.33
192_A227_L0.6520.33
180_Y321_K0.6500.33
22_D36_V0.6500.33
254_K327_F0.6500.33
39_K113_Y0.6480.33
300_L307_E0.6440.32
227_L325_I0.6440.32
266_V314_G0.6430.32
104_I289_E0.6420.32
216_I253_E0.6420.32
171_L290_D0.6400.32
211_N343_I0.6390.32
281_A285_V0.6390.32
130_I227_L0.6360.32
193_G218_S0.6340.32
98_D248_G0.6330.32
49_E54_P0.6320.32
259_L268_Y0.6310.31
110_W115_L0.6290.31
75_I188_A0.6280.31
66_F74_R0.6270.31
176_E180_Y0.6270.31
190_L342_R0.6260.31
319_V328_E0.6260.31
20_E182_K0.6260.31
265_L287_V0.6230.31
51_R55_M0.6220.31
13_V262_Q0.6210.31
128_I220_S0.6200.31
271_E274_K0.6200.31
260_A311_N0.6190.31
274_K287_V0.6180.31
275_N294_S0.6180.31
207_A304_R0.6160.30
152_S180_Y0.6160.30
270_L277_I0.6150.30
33_D41_T0.6120.30
11_Q115_L0.6120.30
14_K189_I0.6100.30
67_Q266_V0.6100.30
167_E271_E0.6070.30
18_E21_D0.6070.30
191_L216_I0.6040.30
107_K110_W0.6040.30
113_Y221_S0.6040.30
245_I324_P0.6020.29
61_V106_I0.6020.29
135_F226_G0.5990.29
155_S318_L0.5990.29
270_L274_K0.5980.29
189_I271_E0.5970.29
194_P220_S0.5960.29
282_V333_T0.5950.29
173_I263_P0.5940.29
174_A205_V0.5930.29
30_L103_I0.5910.29
309_I316_V0.5910.29
8_E338_I0.5880.28
258_L266_V0.5880.28
121_Q182_K0.5870.28
249_A308_D0.5870.28
295_D299_R0.5870.28
41_T44_V0.5870.28
203_K207_A0.5860.28
144_F149_K0.5860.28
156_L172_E0.5840.28
59_L108_Q0.5840.28
266_V338_I0.5820.28
127_R305_M0.5810.28
97_L285_V0.5810.28
26_L30_L0.5800.28
96_N268_Y0.5800.28
6_F14_K0.5770.28
150_I224_R0.5770.28
175_T206_N0.5770.28
161_E255_A0.5760.28
56_T254_K0.5750.28
251_K287_V0.5730.27
198_K218_S0.5730.27
36_V42_R0.5700.27
13_V321_K0.5700.27
178_A184_Y0.5690.27
284_T341_F0.5690.27
230_V322_E0.5690.27
61_V207_A0.5660.27
8_E11_Q0.5660.27
64_T75_I0.5650.27
129_I145_E0.5630.27
252_M255_A0.5620.27
299_R330_K0.5620.27
15_L101_D0.5610.27
266_V287_V0.5600.27
295_D301_T0.5590.27
140_I264_E0.5570.26
303_E307_E0.5560.26
155_S315_E0.5560.26
256_M328_E0.5560.26
191_L205_V0.5550.26
131_A280_G0.5530.26
17_I135_F0.5510.26
195_G219_V0.5510.26
95_I117_R0.5490.26
79_I127_R0.5480.26
139_L222_A0.5470.26
22_D67_Q0.5460.26
268_Y326_Y0.5440.26
24_W42_R0.5440.26
53_I131_A0.5430.26
28_L44_V0.5430.26
210_K297_Q0.5410.25
6_F115_L0.5410.25
237_D342_R0.5400.25
39_K52_R0.5400.25
289_E322_E0.5380.25
276_A285_V0.5360.25
40_T110_W0.5340.25
54_P57_I0.5340.25
30_L116_D0.5330.25
90_G107_K0.5310.25
48_K226_G0.5310.25
198_K263_P0.5310.25
230_V236_I0.5300.25
26_L296_E0.5290.25
230_V305_M0.5290.25
44_V107_K0.5290.25
29_I66_F0.5250.24
289_E319_V0.5250.24
143_P338_I0.5240.24
174_A186_P0.5240.24
301_T307_E0.5240.24
287_V306_L0.5230.24
250_K253_E0.5200.24
319_V325_I0.5190.24
193_G322_E0.5190.24
73_L100_G0.5180.24
32_K59_L0.5180.24
37_V81_D0.5170.24
144_F341_F0.5170.24
125_R206_N0.5170.24
254_K330_K0.5150.24
38_A253_E0.5130.24
136_D195_G0.5130.24
260_A316_V0.5130.24
209_L278_E0.5120.24
19_S97_L0.5120.24
302_I331_N0.5110.24
190_L270_L0.5110.24
271_E343_I0.5110.24
131_A174_A0.5110.24
34_D93_H0.5100.24
99_I198_K0.5100.24
23_L74_R0.5100.24
324_P327_F0.5080.23
219_V341_F0.5080.23
34_D66_F0.5080.23
138_Y170_A0.5080.23
247_I317_I0.5080.23
329_L339_L0.5070.23
119_K297_Q0.5070.23
307_E313_R0.5050.23
177_L210_K0.5040.23
166_I328_E0.5030.23
210_K226_G0.5020.23
76_H92_H0.5020.23
61_V250_K0.5010.23
72_R228_H0.5000.23
247_I271_E0.5000.23
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qi2A 1 0.8983 100 0.147 Contact Map
3mcaB 1 0.907 100 0.157 Contact Map
3obyA 1 0.9099 100 0.159 Contact Map
2vgnA 1 0.9535 100 0.177 Contact Map
3obwA 2 0.9331 100 0.178 Contact Map
3wxmB 1 0.9971 100 0.196 Contact Map
3j15A 1 0.9942 100 0.198 Contact Map
4crnX 1 0.9797 100 0.388 Contact Map
3e20C 1 0.625 100 0.389 Contact Map
1dt9A 1 0.9622 100 0.414 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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