PELO - SULSO - GREMLIN Contacts

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PELO - Protein pelota homolog

UniProt:	P96026	Sequences: MRILEFDEKRQAVKLHIESEDDLWLLHLILEKDDKVVAKTTRDVGLGKESRRIPMTIILKVDYTEFQEFTNRLRIHGIIEDAPERFGIKGAHHTINLDIGDEIIIIKQQWNKYVLDRLKRQANKRSRIIIALVDFDEYLIAIPFEQGIKILSEKSLRPLNEEEGIIEQNALEIATELAEYVKQYDPDAILLAGPGFFKEEVSKKVNAILKNKKIYIDSVSSATRAGLHEVLKRDIIDKIMTDYEIAIGAKKMEKAMELLAKQPELVTYGLEQVKNAIEMGAVETVLVIEDLLSSDEQERLTIERMLEDIENKRGEVILVPKESPIYFELKNLTGILAILRFRIN	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	344 (331)
Sequences:	877 (585)
Seq/√Len:	32.1

HALSA - PELO RF1
SULSO - PELO RF1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
309_I	314_G	9.085	1.00
131_A	140_I	5.251	1.00
277_I	282_V	5.232	1.00
192_A	230_V	4.042	1.00
170_A	201_V	3.943	1.00
131_A	177_L	3.610	1.00
201_V	204_K	3.567	1.00
191_L	202_S	3.182	1.00
62_D	92_H	3.131	1.00
329_L	336_L	3.100	1.00
283_E	340_R	3.081	1.00
267_T	337_A	2.752	1.00
275_N	278_E	2.595	1.00
284_T	317_I	2.589	1.00
36_V	59_L	2.583	1.00
258_L	338_I	2.562	1.00
271_E	275_N	2.409	0.99
133_V	201_V	2.396	0.99
49_E	52_R	2.378	0.99
129_I	181_V	2.353	0.99
273_V	337_A	2.320	0.99
141_A	227_L	2.287	0.99
200_E	203_K	2.251	0.99
255_A	332_L	2.205	0.99
308_D	311_N	2.164	0.99
282_V	285_V	2.148	0.99
141_A	150_I	2.121	0.98
221_S	341_F	2.094	0.98
181_V	186_P	2.085	0.98
138_Y	173_I	2.051	0.98
40_T	93_H	2.048	0.98
201_V	205_V	2.035	0.98
282_V	337_A	2.023	0.98
217_D	230_V	2.008	0.98
254_K	258_L	1.999	0.98
134_D	156_L	1.981	0.97
36_V	75_I	1.902	0.97
111_N	114_V	1.883	0.97
304_R	308_D	1.872	0.96
130_I	192_A	1.854	0.96
247_I	315_E	1.853	0.96
186_P	189_I	1.840	0.96
73_L	90_G	1.836	0.96
25_L	117_R	1.815	0.96
130_I	141_A	1.804	0.96
78_I	92_H	1.792	0.95
42_R	93_H	1.753	0.95
262_Q	265_L	1.716	0.94
300_L	304_R	1.716	0.94
134_D	222_A	1.702	0.94
26_L	31_E	1.666	0.93
133_V	143_P	1.662	0.93
60_K	80_E	1.659	0.93
34_D	107_K	1.657	0.93
251_K	317_I	1.657	0.93
129_I	186_P	1.646	0.93
159_L	165_I	1.611	0.92
248_G	320_P	1.611	0.92
48_K	54_P	1.609	0.92
21_D	25_L	1.591	0.92
133_V	193_G	1.580	0.91
15_L	105_I	1.567	0.91
170_A	177_L	1.552	0.90
283_E	315_E	1.550	0.90
130_I	230_V	1.548	0.90
255_A	259_L	1.543	0.90
93_H	107_K	1.541	0.90
264_E	342_R	1.532	0.90
48_K	52_R	1.532	0.90
35_K	60_K	1.508	0.89
138_Y	169_N	1.480	0.88
98_D	101_D	1.478	0.88
79_I	247_I	1.472	0.88
141_A	149_K	1.465	0.88
194_P	229_E	1.457	0.87
63_Y	76_H	1.440	0.87
48_K	55_M	1.411	0.86
195_G	229_E	1.406	0.85
198_K	216_I	1.404	0.85
279_M	343_I	1.402	0.85
284_T	315_E	1.401	0.85
258_L	265_L	1.393	0.85
14_K	102_E	1.384	0.85
193_G	222_A	1.368	0.84
223_T	226_G	1.354	0.83
199_E	216_I	1.347	0.83
118_L	257_E	1.345	0.83
43_D	50_S	1.345	0.83
258_L	263_P	1.340	0.83
26_L	97_L	1.336	0.82
13_V	118_L	1.330	0.82
208_I	211_N	1.325	0.82
22_D	42_R	1.322	0.82
240_M	335_I	1.313	0.81
30_L	61_V	1.296	0.80
252_M	319_V	1.293	0.80
39_K	54_P	1.280	0.80
127_R	187_D	1.280	0.80
148_I	231_L	1.277	0.79
136_D	169_N	1.270	0.79
170_A	204_K	1.259	0.78
132_L	227_L	1.256	0.78
130_I	190_L	1.222	0.76
132_L	222_A	1.221	0.76
22_D	34_D	1.218	0.76
140_I	290_D	1.214	0.76
49_E	55_M	1.203	0.75
258_L	264_E	1.199	0.75
171_L	204_K	1.195	0.75
62_D	78_I	1.182	0.74
33_D	42_R	1.177	0.73
36_V	116_D	1.166	0.73
16_H	102_E	1.164	0.73
154_K	321_K	1.164	0.73
189_I	214_I	1.160	0.72
257_E	261_K	1.153	0.72
14_K	17_I	1.152	0.72
24_W	94_T	1.145	0.71
173_I	189_I	1.144	0.71
45_G	48_K	1.144	0.71
254_K	257_E	1.137	0.71
22_D	66_F	1.135	0.71
42_R	110_W	1.132	0.70
195_G	198_K	1.120	0.70
169_N	201_V	1.118	0.69
280_G	324_P	1.117	0.69
122_A	205_V	1.113	0.69
18_E	22_D	1.109	0.69
118_L	177_L	1.097	0.68
221_S	225_A	1.089	0.67
15_L	103_I	1.088	0.67
159_L	259_L	1.074	0.66
293_S	323_S	1.073	0.66
232_K	253_E	1.070	0.66
190_L	239_I	1.069	0.66
43_D	79_I	1.065	0.66
38_A	95_I	1.065	0.66
169_N	173_I	1.063	0.66
126_S	187_D	1.063	0.66
49_E	261_K	1.061	0.65
94_T	107_K	1.061	0.65
153_E	223_T	1.056	0.65
24_W	28_L	1.055	0.65
134_D	169_N	1.054	0.65
141_A	193_G	1.049	0.64
194_P	198_K	1.045	0.64
285_V	336_L	1.044	0.64
168_Q	172_E	1.040	0.64
286_L	319_V	1.035	0.63
140_I	176_E	1.034	0.63
275_N	279_M	1.025	0.63
10_R	14_K	1.021	0.62
165_I	197_F	1.016	0.62
171_L	175_T	1.014	0.62
169_N	323_S	1.004	0.61
167_E	171_L	1.001	0.61
64_T	132_L	0.998	0.61
218_S	221_S	0.995	0.60
100_G	199_E	0.994	0.60
56_T	60_K	0.990	0.60
6_F	119_K	0.984	0.59
202_S	216_I	0.983	0.59
22_D	105_I	0.981	0.59
240_M	243_Y	0.977	0.59
76_H	94_T	0.973	0.59
208_I	343_I	0.967	0.58
276_A	343_I	0.966	0.58
122_A	178_A	0.963	0.58
220_S	229_E	0.958	0.57
11_Q	110_W	0.957	0.57
71_N	99_I	0.954	0.57
44_V	50_S	0.951	0.57
60_K	64_T	0.949	0.57
314_G	337_A	0.948	0.57
37_V	46_L	0.946	0.56
26_L	343_I	0.945	0.56
22_D	276_A	0.945	0.56
262_Q	342_R	0.943	0.56
177_L	205_V	0.938	0.56
181_V	251_K	0.931	0.55
129_I	177_L	0.931	0.55
33_D	343_I	0.929	0.55
290_D	330_K	0.925	0.55
9_K	46_L	0.925	0.55
33_D	40_T	0.919	0.54
175_T	183_Q	0.913	0.54
116_D	186_P	0.904	0.53
139_L	223_T	0.897	0.52
136_D	243_Y	0.894	0.52
74_R	94_T	0.891	0.52
212_K	278_E	0.890	0.52
252_M	324_P	0.888	0.52
326_Y	336_L	0.888	0.52
17_I	26_L	0.885	0.51
267_T	272_Q	0.884	0.51
24_W	34_D	0.883	0.51
21_D	141_A	0.882	0.51
36_V	40_T	0.878	0.51
97_L	103_I	0.874	0.51
41_T	54_P	0.873	0.50
216_I	337_A	0.872	0.50
320_P	326_Y	0.870	0.50
248_G	266_V	0.869	0.50
286_L	329_L	0.868	0.50
334_G	339_L	0.867	0.50
205_V	311_N	0.865	0.50
320_P	336_L	0.861	0.49
116_D	310_E	0.860	0.49
313_R	316_V	0.857	0.49
235_I	265_L	0.849	0.48
134_D	193_G	0.843	0.48
60_K	254_K	0.842	0.48
26_L	29_I	0.834	0.47
215_Y	230_V	0.834	0.47
121_Q	196_F	0.830	0.47
57_I	93_H	0.829	0.47
193_G	198_K	0.828	0.47
50_S	54_P	0.826	0.47
191_L	213_K	0.825	0.46
67_Q	144_F	0.825	0.46
270_L	273_V	0.823	0.46
130_I	224_R	0.821	0.46
8_E	38_A	0.820	0.46
140_I	219_V	0.818	0.46
17_I	101_D	0.813	0.46
30_L	36_V	0.812	0.45
288_I	330_K	0.812	0.45
284_T	307_E	0.810	0.45
30_L	55_M	0.809	0.45
287_V	301_T	0.804	0.45
34_D	42_R	0.801	0.45
80_E	287_V	0.799	0.44
243_Y	319_V	0.798	0.44
194_P	268_Y	0.787	0.43
118_L	205_V	0.783	0.43
98_D	138_Y	0.780	0.43
136_D	225_A	0.779	0.43
290_D	297_Q	0.779	0.43
284_T	290_D	0.775	0.42
15_L	63_Y	0.772	0.42
254_K	315_E	0.771	0.42
138_Y	154_K	0.770	0.42
13_V	227_L	0.768	0.42
151_L	180_Y	0.767	0.42
14_K	104_I	0.762	0.41
22_D	29_I	0.760	0.41
96_N	101_D	0.760	0.41
199_E	203_K	0.758	0.41
40_T	74_R	0.757	0.41
10_R	41_T	0.757	0.41
139_L	153_E	0.757	0.41
252_M	272_Q	0.756	0.41
191_L	198_K	0.754	0.41
223_T	333_T	0.751	0.41
252_M	256_M	0.751	0.41
11_Q	273_V	0.750	0.40
48_K	53_I	0.748	0.40
220_S	241_T	0.747	0.40
254_K	284_T	0.747	0.40
255_A	338_I	0.743	0.40
330_K	338_I	0.743	0.40
18_E	27_H	0.742	0.40
35_K	80_E	0.742	0.40
78_I	277_I	0.739	0.40
275_N	287_V	0.739	0.40
323_S	326_Y	0.737	0.39
24_W	195_G	0.737	0.39
255_A	262_Q	0.737	0.39
172_E	176_E	0.737	0.39
220_S	259_L	0.736	0.39
248_G	326_Y	0.736	0.39
170_A	186_P	0.731	0.39
288_I	321_K	0.729	0.39
192_A	236_I	0.728	0.39
35_K	145_E	0.728	0.39
129_I	189_I	0.728	0.39
133_V	222_A	0.726	0.39
16_H	60_K	0.724	0.38
137_E	224_R	0.723	0.38
32_K	314_G	0.722	0.38
160_N	200_E	0.721	0.38
185_D	238_K	0.720	0.38
177_L	201_V	0.717	0.38
259_L	333_T	0.714	0.38
137_E	222_A	0.713	0.38
85_R	90_G	0.710	0.37
256_M	310_E	0.709	0.37
238_K	297_Q	0.709	0.37
95_I	191_L	0.706	0.37
274_K	301_T	0.706	0.37
34_D	293_S	0.701	0.37
116_D	254_K	0.695	0.36
268_Y	337_A	0.692	0.36
74_R	340_R	0.691	0.36
99_I	162_E	0.690	0.36
115_L	119_K	0.688	0.36
206_N	282_V	0.684	0.35
57_I	95_I	0.679	0.35
273_V	291_L	0.679	0.35
170_A	197_F	0.679	0.35
143_P	274_K	0.678	0.35
79_I	91_A	0.676	0.35
15_L	265_L	0.673	0.35
15_L	81_D	0.673	0.35
178_A	284_T	0.672	0.34
80_E	202_S	0.672	0.34
55_M	84_E	0.670	0.34
206_N	209_L	0.669	0.34
226_G	229_E	0.668	0.34
257_E	330_K	0.666	0.34
53_I	56_T	0.666	0.34
335_I	343_I	0.666	0.34
23_L	67_Q	0.665	0.34
38_A	93_H	0.664	0.34
40_T	108_Q	0.664	0.34
186_P	259_L	0.662	0.34
60_K	122_A	0.661	0.34
277_I	308_D	0.661	0.34
188_A	201_V	0.659	0.33
94_T	148_I	0.659	0.33
34_D	329_L	0.658	0.33
135_F	166_I	0.657	0.33
148_I	160_N	0.656	0.33
217_D	242_D	0.655	0.33
130_I	336_L	0.655	0.33
141_A	226_G	0.654	0.33
33_D	45_G	0.654	0.33
113_Y	303_E	0.653	0.33
252_M	333_T	0.653	0.33
192_A	227_L	0.652	0.33
180_Y	321_K	0.650	0.33
22_D	36_V	0.650	0.33
254_K	327_F	0.650	0.33
39_K	113_Y	0.648	0.33
300_L	307_E	0.644	0.32
227_L	325_I	0.644	0.32
266_V	314_G	0.643	0.32
104_I	289_E	0.642	0.32
216_I	253_E	0.642	0.32
171_L	290_D	0.640	0.32
211_N	343_I	0.639	0.32
281_A	285_V	0.639	0.32
130_I	227_L	0.636	0.32
193_G	218_S	0.634	0.32
98_D	248_G	0.633	0.32
49_E	54_P	0.632	0.32
259_L	268_Y	0.631	0.31
110_W	115_L	0.629	0.31
75_I	188_A	0.628	0.31
66_F	74_R	0.627	0.31
176_E	180_Y	0.627	0.31
190_L	342_R	0.626	0.31
319_V	328_E	0.626	0.31
20_E	182_K	0.626	0.31
265_L	287_V	0.623	0.31
51_R	55_M	0.622	0.31
13_V	262_Q	0.621	0.31
128_I	220_S	0.620	0.31
271_E	274_K	0.620	0.31
260_A	311_N	0.619	0.31
274_K	287_V	0.618	0.31
275_N	294_S	0.618	0.31
207_A	304_R	0.616	0.30
152_S	180_Y	0.616	0.30
270_L	277_I	0.615	0.30
33_D	41_T	0.612	0.30
11_Q	115_L	0.612	0.30
14_K	189_I	0.610	0.30
67_Q	266_V	0.610	0.30
167_E	271_E	0.607	0.30
18_E	21_D	0.607	0.30
191_L	216_I	0.604	0.30
107_K	110_W	0.604	0.30
113_Y	221_S	0.604	0.30
245_I	324_P	0.602	0.29
61_V	106_I	0.602	0.29
135_F	226_G	0.599	0.29
155_S	318_L	0.599	0.29
270_L	274_K	0.598	0.29
189_I	271_E	0.597	0.29
194_P	220_S	0.596	0.29
282_V	333_T	0.595	0.29
173_I	263_P	0.594	0.29
174_A	205_V	0.593	0.29
30_L	103_I	0.591	0.29
309_I	316_V	0.591	0.29
8_E	338_I	0.588	0.28
258_L	266_V	0.588	0.28
121_Q	182_K	0.587	0.28
249_A	308_D	0.587	0.28
295_D	299_R	0.587	0.28
41_T	44_V	0.587	0.28
203_K	207_A	0.586	0.28
144_F	149_K	0.586	0.28
156_L	172_E	0.584	0.28
59_L	108_Q	0.584	0.28
266_V	338_I	0.582	0.28
127_R	305_M	0.581	0.28
97_L	285_V	0.581	0.28
26_L	30_L	0.580	0.28
96_N	268_Y	0.580	0.28
6_F	14_K	0.577	0.28
150_I	224_R	0.577	0.28
175_T	206_N	0.577	0.28
161_E	255_A	0.576	0.28
56_T	254_K	0.575	0.28
251_K	287_V	0.573	0.27
198_K	218_S	0.573	0.27
36_V	42_R	0.570	0.27
13_V	321_K	0.570	0.27
178_A	184_Y	0.569	0.27
284_T	341_F	0.569	0.27
230_V	322_E	0.569	0.27
61_V	207_A	0.566	0.27
8_E	11_Q	0.566	0.27
64_T	75_I	0.565	0.27
129_I	145_E	0.563	0.27
252_M	255_A	0.562	0.27
299_R	330_K	0.562	0.27
15_L	101_D	0.561	0.27
266_V	287_V	0.560	0.27
295_D	301_T	0.559	0.27
140_I	264_E	0.557	0.26
303_E	307_E	0.556	0.26
155_S	315_E	0.556	0.26
256_M	328_E	0.556	0.26
191_L	205_V	0.555	0.26
131_A	280_G	0.553	0.26
17_I	135_F	0.551	0.26
195_G	219_V	0.551	0.26
95_I	117_R	0.549	0.26
79_I	127_R	0.548	0.26
139_L	222_A	0.547	0.26
22_D	67_Q	0.546	0.26
268_Y	326_Y	0.544	0.26
24_W	42_R	0.544	0.26
53_I	131_A	0.543	0.26
28_L	44_V	0.543	0.26
210_K	297_Q	0.541	0.25
6_F	115_L	0.541	0.25
237_D	342_R	0.540	0.25
39_K	52_R	0.540	0.25
289_E	322_E	0.538	0.25
276_A	285_V	0.536	0.25
40_T	110_W	0.534	0.25
54_P	57_I	0.534	0.25
30_L	116_D	0.533	0.25
90_G	107_K	0.531	0.25
48_K	226_G	0.531	0.25
198_K	263_P	0.531	0.25
230_V	236_I	0.530	0.25
26_L	296_E	0.529	0.25
230_V	305_M	0.529	0.25
44_V	107_K	0.529	0.25
29_I	66_F	0.525	0.24
289_E	319_V	0.525	0.24
143_P	338_I	0.524	0.24
174_A	186_P	0.524	0.24
301_T	307_E	0.524	0.24
287_V	306_L	0.523	0.24
250_K	253_E	0.520	0.24
319_V	325_I	0.519	0.24
193_G	322_E	0.519	0.24
73_L	100_G	0.518	0.24
32_K	59_L	0.518	0.24
37_V	81_D	0.517	0.24
144_F	341_F	0.517	0.24
125_R	206_N	0.517	0.24
254_K	330_K	0.515	0.24
38_A	253_E	0.513	0.24
136_D	195_G	0.513	0.24
260_A	316_V	0.513	0.24
209_L	278_E	0.512	0.24
19_S	97_L	0.512	0.24
302_I	331_N	0.511	0.24
190_L	270_L	0.511	0.24
271_E	343_I	0.511	0.24
131_A	174_A	0.511	0.24
34_D	93_H	0.510	0.24
99_I	198_K	0.510	0.24
23_L	74_R	0.510	0.24
324_P	327_F	0.508	0.23
219_V	341_F	0.508	0.23
34_D	66_F	0.508	0.23
138_Y	170_A	0.508	0.23
247_I	317_I	0.508	0.23
329_L	339_L	0.507	0.23
119_K	297_Q	0.507	0.23
307_E	313_R	0.505	0.23
177_L	210_K	0.504	0.23
166_I	328_E	0.503	0.23
210_K	226_G	0.502	0.23
76_H	92_H	0.502	0.23
61_V	250_K	0.501	0.23
72_R	228_H	0.500	0.23
247_I	271_E	0.500	0.23

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2qi2A	1	0.8983	100	0.147	Contact Map
3mcaB	1	0.907	100	0.157	Contact Map
3obyA	1	0.9099	100	0.159	Contact Map
2vgnA	1	0.9535	100	0.177	Contact Map
3obwA	2	0.9331	100	0.178	Contact Map
3wxmB	1	0.9971	100	0.196	Contact Map
3j15A	1	0.9942	100	0.198	Contact Map
4crnX	1	0.9797	100	0.388	Contact Map
3e20C	1	0.625	100	0.389	Contact Map
1dt9A	1	0.9622	100	0.414	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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