GREMLIN Database
GPT - Putative UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase
UniProt: P96000 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 322 (295)
Sequences: 6692 (4554)
Seq/√Len: 265.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
256_R273_L5.2531.00
174_A309_A4.0971.00
166_G302_W3.9801.00
275_W289_M3.5401.00
176_A194_L3.4511.00
193_A230_I3.3301.00
99_R102_V3.3151.00
85_L110_A2.7841.00
169_I197_I2.7051.00
37_D40_K2.6421.00
114_L229_A2.5751.00
54_I215_P2.5291.00
92_L96_F2.4381.00
83_S222_F2.4331.00
17_S202_A2.4311.00
173_S197_I2.3741.00
55_I87_A2.3601.00
17_S57_G2.2891.00
293_K296_Q2.1621.00
55_I84_L2.1371.00
165_V200_L2.0941.00
82_S225_A2.0061.00
245_I308_F2.0001.00
59_I84_L1.9741.00
196_A226_L1.9471.00
260_K268_D1.9321.00
25_I29_K1.9251.00
89_L106_L1.9211.00
154_F168_G1.9051.00
57_G61_G1.9001.00
112_V116_V1.8961.00
165_V204_L1.8891.00
168_G172_L1.8831.00
146_A228_G1.8711.00
6_I194_L1.8561.00
192_I226_L1.8231.00
260_K273_L1.7661.00
103_R107_P1.7421.00
58_F196_A1.7241.00
14_F205_I1.7191.00
21_T53_G1.7181.00
16_I57_G1.7151.00
115_I143_I1.7081.00
267_V273_L1.7071.00
112_V143_I1.6841.00
252_I256_R1.6701.00
196_A223_I1.6461.00
82_S114_L1.6431.00
172_L196_A1.6191.00
208_K299_I1.5891.00
18_Y205_I1.5781.00
176_A193_A1.5751.00
126_I129_L1.5751.00
169_I201_S1.5691.00
260_K269_S1.5681.00
91_L95_I1.5541.00
167_M305_E1.5511.00
179_G234_G1.5421.00
137_F140_I1.5251.00
103_R221_Y1.5101.00
54_I199_S1.5061.00
12_I65_L1.5021.00
261_G270_S1.5011.00
27_Q30_K1.4951.00
24_V53_G1.4941.00
292_F300_I1.4831.00
9_P195_S1.4761.00
104_A107_P1.4751.00
180_L190_G1.4721.00
170_I302_W1.4261.00
136_I140_I1.4181.00
22_V26_R1.3981.00
108_I143_I1.3941.00
165_V169_I1.3751.00
108_I147_L1.3631.00
171_M227_I1.3611.00
115_I142_I1.3421.00
55_I222_F1.3371.00
172_L197_I1.3351.00
171_M305_E1.3191.00
168_G223_I1.3031.00
161_N210_P1.3001.00
61_G195_S1.2961.00
145_F149_I1.2931.00
21_T213_I1.2911.00
88_F92_L1.2711.00
142_I232_I1.2651.00
155_N217_N1.2651.00
87_A218_V1.2631.00
26_R30_K1.2491.00
200_L223_I1.2361.00
138_Y142_I1.2301.00
78_A117_Y1.2291.00
209_Y295_Y1.2221.00
27_Q31_S1.2181.00
172_L227_I1.2151.00
108_I112_V1.2121.00
34_V45_E1.2091.00
14_F202_A1.2081.00
282_L286_V1.2011.00
159_G283_T1.1991.00
79_V189_A1.1951.00
59_I80_I1.1911.00
18_Y202_A1.1841.00
54_I200_L1.1831.00
13_S198_F1.1821.00
144_P148_T1.1731.00
172_L193_A1.1701.00
296_Q300_I1.1631.00
254_K258_N1.1501.00
81_L113_P1.1491.00
170_I309_A1.1451.00
299_I303_G1.1441.00
111_S147_L1.1411.00
26_R29_K1.1381.00
179_G189_A1.1331.00
154_F164_G1.1281.00
114_L146_A1.1281.00
202_A206_F1.1251.00
23_W26_R1.1231.00
142_I146_A1.1191.00
86_I111_S1.1181.00
89_L110_A1.1151.00
10_I198_F1.1141.00
305_E309_A1.1111.00
115_I139_Y1.1101.00
152_N155_N1.1051.00
46_I214_F1.0861.00
259_F269_S1.0761.00
25_I212_K1.0751.00
85_L106_L1.0691.00
176_A197_I1.0691.00
111_S143_I1.0621.00
165_V215_P1.0571.00
222_F226_L1.0491.00
170_I305_E1.0491.00
146_A229_A1.0481.00
145_F231_G1.0391.00
121_H125_S1.0381.00
21_T202_A1.0361.00
58_F83_S1.0351.00
107_P221_Y1.0331.00
116_V120_G1.0331.00
252_I301_L1.0321.00
86_I225_A1.0311.00
156_M257_T1.0311.00
42_D214_F1.0311.00
157_L167_M1.0291.00
168_G200_L1.0271.00
22_V206_F1.0231.00
171_M243_L1.0201.00
46_I211_A1.0141.00
195_S198_F1.0141.00
121_H124_I1.0001.00
82_S110_A0.9991.00
90_G221_Y0.9981.00
39_N42_D0.9981.00
86_I110_A0.9971.00
83_S226_L0.9961.00
35_G40_K0.9911.00
160_L298_V0.9871.00
150_T221_Y0.9811.00
292_F296_Q0.9801.00
58_F199_S0.9771.00
104_A108_I0.9761.00
204_L208_K0.9751.00
176_A179_G0.9631.00
57_G60_A0.9571.00
111_S146_A0.9561.00
16_I61_G0.9541.00
137_F141_I0.9501.00
10_I194_L0.9451.00
82_S229_A0.9431.00
198_F202_A0.9421.00
17_S21_T0.9411.00
174_A313_V0.9361.00
20_T53_G0.9331.00
284_H287_M0.9291.00
176_A180_L0.9281.00
172_L200_L0.9251.00
107_P152_N0.9231.00
173_S177_Y0.9201.00
55_I83_S0.9161.00
176_A190_G0.9151.00
275_W288_K0.9141.00
209_Y294_E0.9121.00
103_R106_L0.9091.00
205_I300_I0.9051.00
170_I306_A0.8971.00
13_S199_S0.8941.00
175_L231_G0.8921.00
48_L218_V0.8901.00
179_G190_G0.8891.00
16_I60_A0.8861.00
86_I106_L0.8861.00
168_G227_I0.8841.00
81_L85_L0.8821.00
96_F99_R0.8801.00
23_W27_Q0.8801.00
174_A243_L0.8771.00
19_I23_W0.8751.00
167_M246_P0.8711.00
249_V282_L0.8661.00
62_S76_I0.8641.00
272_R275_W0.8631.00
308_F312_A0.8611.00
79_V229_A0.8571.00
104_A147_L0.8551.00
148_T257_T0.8531.00
107_P150_T0.8491.00
15_F19_I0.8451.00
304_M308_F0.8420.99
271_G275_W0.8400.99
138_Y141_I0.8370.99
124_I128_F0.8280.99
101_S105_F0.8260.99
260_K271_G0.8240.99
135_G140_I0.8240.99
171_M309_A0.8170.99
14_F18_Y0.8140.99
169_I200_L0.8120.99
103_R150_T0.8070.99
16_I20_T0.8030.99
164_G223_I0.8010.99
39_N276_D0.8000.99
8_L12_I0.7990.99
177_Y313_V0.7970.99
175_L234_G0.7930.99
146_A150_T0.7920.99
125_S128_F0.7910.99
9_P61_G0.7890.99
37_D41_P0.7870.99
157_L283_T0.7820.99
214_F217_N0.7810.99
286_V301_L0.7800.99
103_R156_M0.7800.99
111_S115_I0.7790.99
276_D288_K0.7790.99
261_G272_R0.7740.99
79_V83_S0.7730.99
201_S205_I0.7720.99
79_V226_L0.7700.99
249_V304_M0.7690.99
124_I127_P0.7680.99
84_L88_F0.7680.99
141_I145_F0.7680.99
107_P147_L0.7580.99
155_N214_F0.7560.99
303_G307_I0.7550.99
133_N137_F0.7510.99
85_L89_L0.7510.99
177_Y181_T0.7490.99
122_S133_N0.7480.99
256_R260_K0.7470.99
58_F222_F0.7440.99
154_F171_M0.7440.99
209_Y298_V0.7410.99
243_L312_A0.7390.99
14_F201_S0.7390.99
87_A222_F0.7380.99
17_S54_I0.7350.99
9_P191_L0.7350.99
145_F148_T0.7340.99
13_S61_G0.7320.99
165_V203_F0.7310.99
208_K295_Y0.7300.99
92_L95_I0.7290.99
103_R217_N0.7260.98
250_E283_T0.7210.98
170_I174_A0.7210.98
123_I133_N0.7200.98
18_Y206_F0.7190.98
52_I218_V0.7160.98
28_A213_I0.7140.98
259_F268_D0.7140.98
148_T254_K0.7130.98
254_K257_T0.7090.98
102_V105_F0.7080.98
38_I41_P0.7040.98
182_H186_T0.7040.98
140_I143_I0.7030.98
152_N217_N0.6970.98
20_T57_G0.6960.98
192_I230_I0.6960.98
259_F280_H0.6940.98
292_F297_V0.6930.98
190_G194_L0.6930.98
86_I107_P0.6920.98
58_F62_S0.6910.98
286_V292_F0.6910.98
156_M251_F0.6880.98
125_S129_L0.6880.98
270_S273_L0.6860.98
203_F215_P0.6840.98
298_V302_W0.6810.98
124_I129_L0.6800.98
49_L91_L0.6790.98
172_L226_L0.6770.98
256_R259_F0.6730.98
74_R117_Y0.6720.98
300_I303_G0.6700.97
310_V314_I0.6660.97
35_G48_L0.6640.97
28_A33_F0.6570.97
307_I311_I0.6570.97
149_I228_G0.6560.97
10_I197_I0.6550.97
160_L297_V0.6540.97
12_I61_G0.6530.97
36_K45_E0.6480.97
7_L11_L0.6480.97
256_R280_H0.6470.97
41_P294_E0.6450.97
91_L218_V0.6440.97
86_I150_T0.6420.97
225_A229_A0.6420.97
268_D271_G0.6410.97
294_E298_V0.6390.97
25_I28_A0.6380.97
28_A34_V0.6380.97
175_L193_A0.6360.97
13_S57_G0.6350.97
248_V251_F0.6350.97
148_T153_A0.6340.96
256_R274_Y0.6300.96
293_K297_V0.6300.96
232_I236_M0.6300.96
123_I131_P0.6300.96
158_E215_P0.6300.96
114_L225_A0.6290.96
154_F244_Y0.6280.96
253_L283_T0.6270.96
164_G215_P0.6250.96
250_E254_K0.6210.96
238_T241_A0.6200.96
205_I303_G0.6180.96
49_L95_I0.6170.96
10_I14_F0.6160.96
133_N136_I0.6110.96
114_L118_S0.6090.96
142_I148_T0.6090.96
62_S192_I0.6070.95
139_Y142_I0.6060.95
175_L243_L0.6050.95
41_P287_M0.6040.95
11_L15_F0.6030.95
215_P223_I0.6020.95
34_V48_L0.6010.95
89_L221_Y0.6000.95
112_V139_Y0.5980.95
83_S192_I0.5960.95
191_L195_S0.5950.95
29_K33_F0.5950.95
119_V139_Y0.5940.95
169_I173_S0.5930.95
25_I213_I0.5910.95
153_A251_F0.5880.95
255_L258_N0.5880.95
164_G203_F0.5870.95
158_E219_G0.5860.95
38_I42_D0.5790.94
40_K46_I0.5780.94
189_A233_A0.5770.94
111_S228_G0.5750.94
121_H128_F0.5750.94
24_V28_A0.5730.94
28_A47_P0.5720.94
100_Q104_A0.5720.94
36_K44_P0.5710.94
121_H129_L0.5710.94
143_I148_T0.5710.94
50_G203_F0.5710.94
87_A91_L0.5700.94
113_P117_Y0.5700.94
287_M297_V0.5680.94
134_F138_Y0.5680.94
257_T261_G0.5680.94
295_Y299_I0.5670.94
161_N215_P0.5670.94
97_N274_Y0.5650.93
52_I87_A0.5630.93
99_R103_R0.5630.93
161_N284_H0.5630.93
261_G268_D0.5620.93
32_R36_K0.5600.93
158_E164_G0.5580.93
309_A312_A0.5560.93
311_I315_L0.5560.93
123_I127_P0.5540.93
31_S95_I0.5530.93
287_M290_G0.5510.93
72_S75_V0.5510.93
61_G65_L0.5510.93
86_I221_Y0.5500.93
54_I58_F0.5500.93
218_V221_Y0.5470.92
20_T56_A0.5470.92
166_G298_V0.5470.92
37_D288_K0.5460.92
157_L253_L0.5460.92
251_F255_L0.5460.92
100_Q258_N0.5430.92
61_G64_S0.5430.92
69_D72_S0.5430.92
282_L301_L0.5380.92
123_I126_I0.5370.92
58_F172_L0.5350.91
55_I59_I0.5330.91
164_G253_L0.5310.91
144_P147_L0.5310.91
166_G170_I0.5280.91
122_S125_S0.5260.91
297_V301_L0.5230.91
12_I64_S0.5210.90
48_L294_E0.5200.90
107_P220_T0.5190.90
197_I200_L0.5190.90
131_P134_F0.5180.90
139_Y143_I0.5160.90
203_F214_F0.5150.90
140_I145_F0.5140.90
205_I212_K0.5140.90
163_L298_V0.5130.90
280_H284_H0.5130.90
57_G199_S0.5130.90
69_D74_R0.5130.90
231_G240_L0.5120.90
98_V106_L0.5110.90
156_M261_G0.5110.90
40_K287_M0.5090.89
150_T225_A0.5080.89
24_V27_Q0.5070.89
132_I135_G0.5070.89
121_H127_P0.5050.89
171_M244_Y0.5040.89
156_M221_Y0.5040.89
246_P305_E0.5020.89
62_S68_T0.5010.89
153_A257_T0.5010.89
172_L176_A0.5010.89
93_D155_N0.5000.89
120_G138_Y0.5000.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4j72A 2 0.8975 100 0.207 Contact Map
4xp4A 1 0.7205 10.6 0.964 Contact Map
2ls4A 1 0.0745 8.3 0.965 Contact Map
1iq5B 1 0.0745 4.3 0.969 Contact Map
2jlnA 1 0.1087 4.1 0.97 Contact Map
4m5bA 1 0.5839 2.8 0.972 Contact Map
4djkA 2 0.1149 2.7 0.973 Contact Map
1ckkB 1 0.0807 2.6 0.973 Contact Map
2b2hA 3 0.1615 2.5 0.973 Contact Map
1ifkA 9 0.0994 2.5 0.973 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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