IDI2 - SULSO - GREMLIN Contacts

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IDI2 - Isopentenyl-diphosphate delta-isomerase

UniProt:	P95997	Sequences: MPDIVNRKVEHVEIAAFENVDGLSSSTFLNDVILVHQGFPGISFSEINTKTKFFRKEISAPIMVTGMTGGRNELGRINRIIAEVAEKFGIPMGVGSQRVAIEKAEARESFTIVRKVAPTIPIIANLGMPQLVKGYGLKEFQDAIQMIEADAIAVHLNPAQEVFQPEGEPEYQIYALERLRDISKELSVPIIVKESGNGISMETAKLLYSYGIKNFDTSGQGGTNWIAIEMIRDIRRGNWKAESAKNFLDWGVPTAASIIEVRYSIPDAFLVGSGGIRSGLDAAKAIALGADIAGMALPVLKSAIEGKESLEQFFRKIIFELKATMMLTGSKNVEALKRSSIVILGKLKEWAEYRGINLSIYEKVRKRE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	368 (324)
Sequences:	1073 (806)
Seq/√Len:	44.8

BACSU - IDI2
HALSA - IDI2
SULSO - IDI2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
283_A	321_L	4.847	1.00
332_N	335_A	4.438	1.00
86_E	119_T	3.901	1.00
97_Q	146_M	3.722	1.00
204_A	261_V	3.224	1.00
199_I	215_F	3.214	1.00
177_E	180_R	3.197	1.00
58_I	91_P	2.958	1.00
141_Q	187_S	2.837	1.00
43_S	170_E	2.680	1.00
218_S	273_S	2.615	1.00
87_K	311_E	2.562	1.00
100_A	146_M	2.439	1.00
199_I	204_A	2.409	1.00
83_E	307_K	2.363	1.00
176_L	210_Y	2.334	1.00
33_I	256_A	2.314	1.00
159_A	327_L	2.305	1.00
183_S	212_I	2.239	1.00
299_V	314_F	2.155	1.00
80_I	306_G	2.127	1.00
60_A	318_I	2.091	0.99
56_K	150_D	2.047	0.99
83_E	116_V	2.013	0.99
79_R	116_V	2.004	0.99
88_F	311_E	1.987	0.99
34_L	287_A	1.972	0.99
15_A	228_I	1.951	0.99
28_F	255_A	1.948	0.99
136_G	139_E	1.934	0.99
276_I	293_A	1.908	0.99
75_G	108_E	1.899	0.99
126_L	154_V	1.845	0.99
12_V	74_L	1.841	0.99
65_T	153_A	1.836	0.99
13_E	17_F	1.834	0.99
282_A	293_A	1.833	0.99
106_A	109_S	1.819	0.99
64_V	85_A	1.792	0.98
183_S	210_Y	1.785	0.98
214_N	269_F	1.767	0.98
99_V	110_F	1.748	0.98
205_K	209_S	1.738	0.98
192_V	207_L	1.736	0.98
94_V	97_Q	1.734	0.98
113_V	122_I	1.701	0.98
80_I	303_A	1.701	0.98
204_A	215_F	1.701	0.98
29_L	255_A	1.699	0.98
287_A	341_I	1.689	0.98
258_I	272_G	1.688	0.98
278_S	281_D	1.688	0.98
92_M	122_I	1.684	0.98
154_V	179_L	1.682	0.98
88_F	314_F	1.675	0.98
180_R	184_K	1.670	0.97
37_Q	203_T	1.668	0.97
26_S	30_N	1.655	0.97
46_E	172_Q	1.644	0.97
137_L	185_E	1.627	0.97
41_G	329_G	1.626	0.97
140_F	152_I	1.610	0.97
117_A	120_I	1.584	0.97
201_M	260_E	1.583	0.96
27_T	255_A	1.556	0.96
144_I	188_V	1.554	0.96
84_V	314_F	1.551	0.96
58_I	121_P	1.533	0.96
38_G	199_I	1.533	0.96
43_S	46_E	1.527	0.96
84_V	307_K	1.520	0.96
208_Y	268_A	1.500	0.95
295_M	317_I	1.500	0.95
12_V	77_I	1.497	0.95
39_F	156_L	1.469	0.95
137_L	186_L	1.459	0.94
10_E	13_E	1.456	0.94
277_R	298_P	1.437	0.94
141_Q	145_Q	1.437	0.94
94_V	147_I	1.428	0.94
156_L	192_V	1.425	0.94
47_I	326_M	1.423	0.94
183_S	190_I	1.416	0.94
107_R	142_D	1.409	0.93
331_K	335_A	1.401	0.93
215_F	268_A	1.396	0.93
138_K	141_Q	1.389	0.93
325_M	333_V	1.369	0.92
246_N	280_L	1.366	0.92
99_V	106_A	1.362	0.92
123_I	153_A	1.358	0.92
80_I	307_K	1.355	0.92
283_A	328_T	1.346	0.92
291_D	337_K	1.344	0.92
107_R	111_T	1.342	0.92
142_D	145_Q	1.341	0.92
279_G	324_T	1.340	0.91
36_H	250_W	1.340	0.91
135_Y	139_E	1.339	0.91
159_A	226_I	1.325	0.91
115_K	148_E	1.314	0.91
29_L	285_A	1.312	0.91
90_I	314_F	1.307	0.90
181_D	185_E	1.298	0.90
84_V	310_L	1.296	0.90
81_I	85_A	1.294	0.90
66_G	93_G	1.288	0.90
144_I	152_I	1.281	0.90
65_T	273_S	1.273	0.89
202_E	260_E	1.270	0.89
163_F	226_I	1.252	0.88
276_I	285_A	1.246	0.88
46_E	331_K	1.243	0.88
126_L	135_Y	1.243	0.88
302_S	310_L	1.243	0.88
298_P	313_F	1.239	0.88
279_G	317_I	1.228	0.87
151_A	191_I	1.227	0.87
128_M	179_L	1.226	0.87
199_I	257_S	1.226	0.87
297_L	301_K	1.217	0.87
75_G	109_S	1.216	0.87
303_A	306_G	1.211	0.87
272_G	285_A	1.206	0.86
65_T	294_G	1.202	0.86
63_M	292_I	1.198	0.86
271_V	292_I	1.195	0.86
30_N	278_S	1.185	0.85
63_M	271_V	1.185	0.85
50_K	57_E	1.182	0.85
123_I	151_A	1.175	0.85
308_E	312_Q	1.172	0.85
36_H	252_V	1.165	0.84
38_G	203_T	1.161	0.84
114_R	122_I	1.150	0.84
66_G	153_A	1.144	0.83
94_V	113_V	1.144	0.83
72_N	76_R	1.142	0.83
65_T	216_D	1.140	0.83
34_L	341_I	1.136	0.83
166_E	232_R	1.132	0.83
79_R	115_K	1.131	0.83
276_I	295_M	1.130	0.83
302_S	313_F	1.121	0.82
52_K	55_R	1.119	0.82
179_L	212_I	1.118	0.82
253_P	256_A	1.115	0.82
52_K	57_E	1.113	0.82
192_V	212_I	1.111	0.82
79_R	83_E	1.099	0.81
75_G	79_R	1.098	0.81
42_I	326_M	1.095	0.81
277_R	281_D	1.089	0.80
100_A	143_A	1.082	0.80
12_V	162_V	1.067	0.79
64_V	81_I	1.066	0.79
59_S	89_G	1.060	0.78
129_P	154_V	1.059	0.78
140_F	154_V	1.057	0.78
27_T	30_N	1.048	0.78
97_Q	143_A	1.048	0.78
138_K	142_D	1.046	0.77
88_F	315_R	1.043	0.77
62_I	317_I	1.038	0.77
182_I	190_I	1.037	0.77
76_R	79_R	1.033	0.77
88_F	299_V	1.032	0.76
65_T	296_A	1.027	0.76
28_F	253_P	1.026	0.76
98_R	164_Q	1.024	0.76
299_V	310_L	1.017	0.75
124_A	152_I	1.014	0.75
200_S	203_T	1.006	0.75
121_P	150_D	1.004	0.74
313_F	317_I	1.004	0.74
287_A	339_S	1.001	0.74
123_I	191_I	0.999	0.74
93_G	153_A	0.988	0.73
88_F	318_I	0.987	0.73
42_I	47_I	0.985	0.73
49_T	325_M	0.982	0.73
282_A	317_I	0.978	0.72
179_L	207_L	0.966	0.72
153_A	164_Q	0.965	0.71
37_Q	206_L	0.962	0.71
42_I	46_E	0.958	0.71
154_V	182_I	0.950	0.70
117_A	225_W	0.950	0.70
97_Q	147_I	0.943	0.70
6_N	10_E	0.939	0.69
126_L	143_A	0.935	0.69
5_V	106_A	0.934	0.69
220_Q	253_P	0.929	0.69
29_L	254_T	0.924	0.68
195_S	218_S	0.921	0.68
191_I	271_V	0.916	0.67
261_V	265_I	0.913	0.67
283_A	324_T	0.911	0.67
53_F	292_I	0.905	0.67
180_R	210_Y	0.904	0.66
65_T	164_Q	0.902	0.66
159_A	197_N	0.900	0.66
199_I	261_V	0.898	0.66
182_I	186_L	0.896	0.66
269_F	291_D	0.893	0.65
58_I	292_I	0.890	0.65
30_N	277_R	0.889	0.65
255_A	276_I	0.888	0.65
41_G	173_I	0.885	0.65
62_I	318_I	0.883	0.65
325_M	336_L	0.883	0.65
276_I	282_A	0.873	0.64
10_E	232_R	0.872	0.64
65_T	93_G	0.869	0.63
334_E	337_K	0.866	0.63
282_A	321_L	0.863	0.63
18_E	227_A	0.863	0.63
279_G	320_E	0.862	0.63
83_E	87_K	0.859	0.62
56_K	121_P	0.859	0.62
84_V	89_G	0.857	0.62
15_A	297_L	0.854	0.62
9_V	73_E	0.853	0.62
80_I	83_E	0.853	0.62
83_E	86_E	0.848	0.61
246_N	279_G	0.838	0.60
218_S	296_A	0.838	0.60
258_I	291_D	0.836	0.60
246_N	320_E	0.836	0.60
31_D	343_I	0.834	0.60
42_I	331_K	0.833	0.60
286_I	333_V	0.832	0.60
76_R	80_I	0.831	0.60
29_L	284_K	0.830	0.60
171_Y	195_S	0.828	0.60
303_A	310_L	0.827	0.59
127_G	165_P	0.819	0.59
201_M	263_Y	0.817	0.59
272_G	290_A	0.803	0.57
287_A	320_E	0.802	0.57
88_F	91_P	0.799	0.57
153_A	216_D	0.796	0.57
109_S	113_V	0.796	0.57
82_A	92_M	0.794	0.56
98_R	129_P	0.792	0.56
162_V	169_P	0.790	0.56
129_P	164_Q	0.788	0.56
32_V	255_A	0.787	0.56
279_G	283_A	0.783	0.55
82_A	113_V	0.783	0.55
252_V	257_S	0.783	0.55
285_A	293_A	0.783	0.55
37_Q	340_S	0.780	0.55
92_M	113_V	0.780	0.55
217_T	292_I	0.777	0.55
13_E	18_E	0.775	0.55
35_V	200_S	0.773	0.54
137_L	181_D	0.772	0.54
77_I	143_A	0.768	0.54
306_G	309_S	0.766	0.54
97_Q	100_A	0.761	0.53
10_E	92_M	0.760	0.53
97_Q	124_A	0.757	0.53
88_F	310_L	0.756	0.53
9_V	71_R	0.755	0.53
202_E	340_S	0.755	0.53
27_T	253_P	0.755	0.53
315_R	319_F	0.752	0.52
44_F	326_M	0.751	0.52
84_V	303_A	0.751	0.52
71_R	74_L	0.745	0.52
228_I	231_I	0.744	0.52
140_F	144_I	0.742	0.51
9_V	74_L	0.742	0.51
49_T	60_A	0.740	0.51
164_Q	225_W	0.739	0.51
258_I	262_R	0.738	0.51
230_M	233_D	0.737	0.51
98_R	135_Y	0.731	0.50
98_R	102_E	0.731	0.50
87_K	315_R	0.726	0.50
94_V	100_A	0.726	0.50
32_V	284_K	0.725	0.50
14_I	18_E	0.722	0.49
12_V	296_A	0.721	0.49
197_N	327_L	0.721	0.49
34_L	339_S	0.717	0.49
25_S	33_I	0.715	0.49
120_I	164_Q	0.713	0.49
141_Q	185_E	0.709	0.48
176_L	206_L	0.708	0.48
39_F	207_L	0.708	0.48
64_V	288_L	0.705	0.48
307_K	310_L	0.703	0.48
247_F	324_T	0.703	0.48
129_P	225_W	0.701	0.47
127_G	135_Y	0.700	0.47
45_S	169_P	0.697	0.47
159_A	163_F	0.696	0.47
187_S	308_E	0.695	0.47
262_R	291_D	0.686	0.46
101_I	135_Y	0.685	0.46
106_A	110_F	0.683	0.46
29_L	276_I	0.682	0.46
335_A	338_R	0.682	0.46
16_A	304_I	0.681	0.45
120_I	225_W	0.675	0.45
62_I	295_M	0.672	0.45
334_E	342_V	0.672	0.45
12_V	304_I	0.670	0.44
140_F	143_A	0.669	0.44
57_E	334_E	0.665	0.44
207_L	215_F	0.665	0.44
8_K	11_H	0.662	0.44
110_F	310_L	0.662	0.44
311_E	315_R	0.661	0.44
169_P	326_M	0.661	0.44
44_F	322_K	0.660	0.43
158_P	327_L	0.659	0.43
179_L	192_V	0.659	0.43
43_S	172_Q	0.658	0.43
111_T	270_L	0.658	0.43
156_L	179_L	0.657	0.43
82_A	124_A	0.657	0.43
34_L	328_T	0.656	0.43
172_Q	179_L	0.653	0.43
25_S	220_Q	0.653	0.43
263_Y	266_P	0.651	0.43
56_K	120_I	0.648	0.42
18_E	231_I	0.644	0.42
267_D	337_K	0.643	0.42
19_N	301_K	0.643	0.42
71_R	94_V	0.643	0.42
5_V	103_K	0.642	0.42
104_A	107_R	0.642	0.42
260_E	342_V	0.640	0.42
203_T	257_S	0.640	0.42
208_Y	215_F	0.635	0.41
121_P	151_A	0.634	0.41
117_A	164_Q	0.634	0.41
37_Q	202_E	0.633	0.41
230_M	244_A	0.632	0.41
159_A	247_F	0.631	0.41
177_E	184_K	0.631	0.41
13_E	16_A	0.631	0.41
86_E	117_A	0.629	0.40
15_A	225_W	0.626	0.40
258_I	270_L	0.626	0.40
35_V	260_E	0.626	0.40
204_A	265_I	0.624	0.40
7_R	11_H	0.624	0.40
10_E	14_I	0.620	0.40
4_I	99_V	0.620	0.40
316_K	320_E	0.619	0.40
201_M	205_K	0.619	0.40
48_N	332_N	0.618	0.39
165_P	232_R	0.617	0.39
224_N	249_D	0.617	0.39
166_E	228_I	0.617	0.39
60_A	90_I	0.616	0.39
299_V	313_F	0.615	0.39
33_I	249_D	0.615	0.39
224_N	320_E	0.613	0.39
88_F	147_I	0.610	0.39
54_F	214_N	0.609	0.39
73_E	76_R	0.606	0.38
100_A	107_R	0.603	0.38
14_I	231_I	0.603	0.38
141_Q	186_L	0.600	0.38
194_E	273_S	0.599	0.38
163_F	244_A	0.598	0.38
49_T	333_V	0.596	0.37
7_R	232_R	0.594	0.37
129_P	178_R	0.594	0.37
147_I	204_A	0.594	0.37
233_D	244_A	0.593	0.37
71_R	110_F	0.592	0.37
309_S	312_Q	0.592	0.37
4_I	94_V	0.591	0.37
114_R	120_I	0.591	0.37
208_Y	267_D	0.591	0.37
315_R	318_I	0.587	0.37
101_I	143_A	0.587	0.37
40_P	64_V	0.585	0.36
253_P	258_I	0.584	0.36
64_V	314_F	0.582	0.36
144_I	195_S	0.582	0.36
156_L	199_I	0.582	0.36
108_E	111_T	0.581	0.36
265_I	268_A	0.580	0.36
153_A	197_N	0.580	0.36
40_P	158_P	0.578	0.36
16_A	301_K	0.577	0.36
101_I	146_M	0.577	0.36
97_Q	158_P	0.575	0.36
59_S	318_I	0.573	0.35
183_S	213_K	0.572	0.35
217_T	270_L	0.572	0.35
111_T	142_D	0.571	0.35
42_I	329_G	0.570	0.35
328_T	339_S	0.568	0.35
93_G	164_Q	0.565	0.35
49_T	321_L	0.563	0.34
114_R	151_A	0.563	0.34
126_L	186_L	0.561	0.34
234_I	262_R	0.560	0.34
163_F	233_D	0.559	0.34
276_I	321_L	0.559	0.34
86_E	116_V	0.559	0.34
145_Q	184_K	0.558	0.34
49_T	322_K	0.558	0.34
144_I	147_I	0.557	0.34
162_V	327_L	0.557	0.34
65_T	225_W	0.556	0.34
16_A	300_L	0.555	0.34
295_M	313_F	0.555	0.34
226_I	327_L	0.555	0.34
283_A	287_A	0.555	0.34
101_I	186_L	0.554	0.34
12_V	99_V	0.553	0.34
65_T	129_P	0.552	0.34
15_A	71_R	0.552	0.34
44_F	319_F	0.551	0.33
54_F	292_I	0.550	0.33
191_I	214_N	0.549	0.33
56_K	154_V	0.549	0.33
153_A	225_W	0.547	0.33
282_A	285_A	0.546	0.33
98_R	127_G	0.546	0.33
250_W	294_G	0.545	0.33
5_V	215_F	0.543	0.33
124_A	149_A	0.542	0.33
164_Q	279_G	0.542	0.33
139_E	142_D	0.541	0.33
66_G	225_W	0.541	0.33
142_D	148_E	0.540	0.33
71_R	106_A	0.540	0.33
46_E	332_N	0.539	0.32
12_V	235_R	0.536	0.32
173_I	177_E	0.534	0.32
53_F	280_L	0.532	0.32
164_Q	324_T	0.532	0.32
114_R	118_P	0.530	0.32
102_E	135_Y	0.530	0.32
66_G	254_T	0.529	0.32
39_F	249_D	0.528	0.31
37_Q	41_G	0.528	0.31
286_I	339_S	0.527	0.31
246_N	278_S	0.527	0.31
180_R	308_E	0.526	0.31
5_V	154_V	0.526	0.31
183_S	211_G	0.524	0.31
334_E	338_R	0.524	0.31
318_I	322_K	0.521	0.31
122_I	147_I	0.520	0.31
72_N	105_E	0.519	0.31
121_P	214_N	0.518	0.31
138_K	145_Q	0.517	0.31
314_F	318_I	0.517	0.31
158_P	171_Y	0.516	0.31
162_V	326_M	0.516	0.31
92_M	120_I	0.515	0.30
215_F	261_V	0.514	0.30
9_V	13_E	0.514	0.30
122_I	136_G	0.514	0.30
114_R	117_A	0.513	0.30
119_T	334_E	0.513	0.30
102_E	110_F	0.512	0.30
4_I	164_Q	0.511	0.30
21_D	297_L	0.510	0.30
113_V	227_A	0.510	0.30
35_V	342_V	0.508	0.30
99_V	109_S	0.508	0.30
330_S	339_S	0.508	0.30
118_P	122_I	0.508	0.30
164_Q	326_M	0.507	0.30
75_G	110_F	0.507	0.30
308_E	332_N	0.506	0.30
38_G	257_S	0.506	0.30
173_I	329_G	0.506	0.30
180_R	201_M	0.505	0.30
81_I	299_V	0.504	0.30
313_F	316_K	0.502	0.29
244_A	320_E	0.502	0.29
33_I	342_V	0.500	0.29
115_K	301_K	0.500	0.29

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3vkjA	4	0.9837	100	0.452	Contact Map
3sr7A	3	0.7473	100	0.518	Contact Map
1p0kA	4	0.837	100	0.522	Contact Map
4n02A	3	0.8995	100	0.524	Contact Map
1vcfA	3	0.8207	100	0.559	Contact Map
1ea0A	1	0.9022	100	0.681	Contact Map
1ofdA	1	0.9158	100	0.685	Contact Map
2qr6A	3	0.8043	100	0.692	Contact Map
1p4cA	3	0.8261	100	0.708	Contact Map
2nliA	4	0.8234	100	0.717	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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