GREMLIN Database
IDI2 - Isopentenyl-diphosphate delta-isomerase
UniProt: P95997 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 368 (324)
Sequences: 1073 (806)
Seq/√Len: 44.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
283_A321_L4.8471.00
332_N335_A4.4381.00
86_E119_T3.9011.00
97_Q146_M3.7221.00
204_A261_V3.2241.00
199_I215_F3.2141.00
177_E180_R3.1971.00
58_I91_P2.9581.00
141_Q187_S2.8371.00
43_S170_E2.6801.00
218_S273_S2.6151.00
87_K311_E2.5621.00
100_A146_M2.4391.00
199_I204_A2.4091.00
83_E307_K2.3631.00
176_L210_Y2.3341.00
33_I256_A2.3141.00
159_A327_L2.3051.00
183_S212_I2.2391.00
299_V314_F2.1551.00
80_I306_G2.1271.00
60_A318_I2.0910.99
56_K150_D2.0470.99
83_E116_V2.0130.99
79_R116_V2.0040.99
88_F311_E1.9870.99
34_L287_A1.9720.99
15_A228_I1.9510.99
28_F255_A1.9480.99
136_G139_E1.9340.99
276_I293_A1.9080.99
75_G108_E1.8990.99
126_L154_V1.8450.99
12_V74_L1.8410.99
65_T153_A1.8360.99
13_E17_F1.8340.99
282_A293_A1.8330.99
106_A109_S1.8190.99
64_V85_A1.7920.98
183_S210_Y1.7850.98
214_N269_F1.7670.98
99_V110_F1.7480.98
205_K209_S1.7380.98
192_V207_L1.7360.98
94_V97_Q1.7340.98
113_V122_I1.7010.98
80_I303_A1.7010.98
204_A215_F1.7010.98
29_L255_A1.6990.98
287_A341_I1.6890.98
258_I272_G1.6880.98
278_S281_D1.6880.98
92_M122_I1.6840.98
154_V179_L1.6820.98
88_F314_F1.6750.98
180_R184_K1.6700.97
37_Q203_T1.6680.97
26_S30_N1.6550.97
46_E172_Q1.6440.97
137_L185_E1.6270.97
41_G329_G1.6260.97
140_F152_I1.6100.97
117_A120_I1.5840.97
201_M260_E1.5830.96
27_T255_A1.5560.96
144_I188_V1.5540.96
84_V314_F1.5510.96
58_I121_P1.5330.96
38_G199_I1.5330.96
43_S46_E1.5270.96
84_V307_K1.5200.96
208_Y268_A1.5000.95
295_M317_I1.5000.95
12_V77_I1.4970.95
39_F156_L1.4690.95
137_L186_L1.4590.94
10_E13_E1.4560.94
277_R298_P1.4370.94
141_Q145_Q1.4370.94
94_V147_I1.4280.94
156_L192_V1.4250.94
47_I326_M1.4230.94
183_S190_I1.4160.94
107_R142_D1.4090.93
331_K335_A1.4010.93
215_F268_A1.3960.93
138_K141_Q1.3890.93
325_M333_V1.3690.92
246_N280_L1.3660.92
99_V106_A1.3620.92
123_I153_A1.3580.92
80_I307_K1.3550.92
283_A328_T1.3460.92
291_D337_K1.3440.92
107_R111_T1.3420.92
142_D145_Q1.3410.92
279_G324_T1.3400.91
36_H250_W1.3400.91
135_Y139_E1.3390.91
159_A226_I1.3250.91
115_K148_E1.3140.91
29_L285_A1.3120.91
90_I314_F1.3070.90
181_D185_E1.2980.90
84_V310_L1.2960.90
81_I85_A1.2940.90
66_G93_G1.2880.90
144_I152_I1.2810.90
65_T273_S1.2730.89
202_E260_E1.2700.89
163_F226_I1.2520.88
276_I285_A1.2460.88
46_E331_K1.2430.88
126_L135_Y1.2430.88
302_S310_L1.2430.88
298_P313_F1.2390.88
279_G317_I1.2280.87
151_A191_I1.2270.87
128_M179_L1.2260.87
199_I257_S1.2260.87
297_L301_K1.2170.87
75_G109_S1.2160.87
303_A306_G1.2110.87
272_G285_A1.2060.86
65_T294_G1.2020.86
63_M292_I1.1980.86
271_V292_I1.1950.86
30_N278_S1.1850.85
63_M271_V1.1850.85
50_K57_E1.1820.85
123_I151_A1.1750.85
308_E312_Q1.1720.85
36_H252_V1.1650.84
38_G203_T1.1610.84
114_R122_I1.1500.84
66_G153_A1.1440.83
94_V113_V1.1440.83
72_N76_R1.1420.83
65_T216_D1.1400.83
34_L341_I1.1360.83
166_E232_R1.1320.83
79_R115_K1.1310.83
276_I295_M1.1300.83
302_S313_F1.1210.82
52_K55_R1.1190.82
179_L212_I1.1180.82
253_P256_A1.1150.82
52_K57_E1.1130.82
192_V212_I1.1110.82
79_R83_E1.0990.81
75_G79_R1.0980.81
42_I326_M1.0950.81
277_R281_D1.0890.80
100_A143_A1.0820.80
12_V162_V1.0670.79
64_V81_I1.0660.79
59_S89_G1.0600.78
129_P154_V1.0590.78
140_F154_V1.0570.78
27_T30_N1.0480.78
97_Q143_A1.0480.78
138_K142_D1.0460.77
88_F315_R1.0430.77
62_I317_I1.0380.77
182_I190_I1.0370.77
76_R79_R1.0330.77
88_F299_V1.0320.76
65_T296_A1.0270.76
28_F253_P1.0260.76
98_R164_Q1.0240.76
299_V310_L1.0170.75
124_A152_I1.0140.75
200_S203_T1.0060.75
121_P150_D1.0040.74
313_F317_I1.0040.74
287_A339_S1.0010.74
123_I191_I0.9990.74
93_G153_A0.9880.73
88_F318_I0.9870.73
42_I47_I0.9850.73
49_T325_M0.9820.73
282_A317_I0.9780.72
179_L207_L0.9660.72
153_A164_Q0.9650.71
37_Q206_L0.9620.71
42_I46_E0.9580.71
154_V182_I0.9500.70
117_A225_W0.9500.70
97_Q147_I0.9430.70
6_N10_E0.9390.69
126_L143_A0.9350.69
5_V106_A0.9340.69
220_Q253_P0.9290.69
29_L254_T0.9240.68
195_S218_S0.9210.68
191_I271_V0.9160.67
261_V265_I0.9130.67
283_A324_T0.9110.67
53_F292_I0.9050.67
180_R210_Y0.9040.66
65_T164_Q0.9020.66
159_A197_N0.9000.66
199_I261_V0.8980.66
182_I186_L0.8960.66
269_F291_D0.8930.65
58_I292_I0.8900.65
30_N277_R0.8890.65
255_A276_I0.8880.65
41_G173_I0.8850.65
62_I318_I0.8830.65
325_M336_L0.8830.65
276_I282_A0.8730.64
10_E232_R0.8720.64
65_T93_G0.8690.63
334_E337_K0.8660.63
282_A321_L0.8630.63
18_E227_A0.8630.63
279_G320_E0.8620.63
83_E87_K0.8590.62
56_K121_P0.8590.62
84_V89_G0.8570.62
15_A297_L0.8540.62
9_V73_E0.8530.62
80_I83_E0.8530.62
83_E86_E0.8480.61
246_N279_G0.8380.60
218_S296_A0.8380.60
258_I291_D0.8360.60
246_N320_E0.8360.60
31_D343_I0.8340.60
42_I331_K0.8330.60
286_I333_V0.8320.60
76_R80_I0.8310.60
29_L284_K0.8300.60
171_Y195_S0.8280.60
303_A310_L0.8270.59
127_G165_P0.8190.59
201_M263_Y0.8170.59
272_G290_A0.8030.57
287_A320_E0.8020.57
88_F91_P0.7990.57
153_A216_D0.7960.57
109_S113_V0.7960.57
82_A92_M0.7940.56
98_R129_P0.7920.56
162_V169_P0.7900.56
129_P164_Q0.7880.56
32_V255_A0.7870.56
279_G283_A0.7830.55
82_A113_V0.7830.55
252_V257_S0.7830.55
285_A293_A0.7830.55
37_Q340_S0.7800.55
92_M113_V0.7800.55
217_T292_I0.7770.55
13_E18_E0.7750.55
35_V200_S0.7730.54
137_L181_D0.7720.54
77_I143_A0.7680.54
306_G309_S0.7660.54
97_Q100_A0.7610.53
10_E92_M0.7600.53
97_Q124_A0.7570.53
88_F310_L0.7560.53
9_V71_R0.7550.53
202_E340_S0.7550.53
27_T253_P0.7550.53
315_R319_F0.7520.52
44_F326_M0.7510.52
84_V303_A0.7510.52
71_R74_L0.7450.52
228_I231_I0.7440.52
140_F144_I0.7420.51
9_V74_L0.7420.51
49_T60_A0.7400.51
164_Q225_W0.7390.51
258_I262_R0.7380.51
230_M233_D0.7370.51
98_R135_Y0.7310.50
98_R102_E0.7310.50
87_K315_R0.7260.50
94_V100_A0.7260.50
32_V284_K0.7250.50
14_I18_E0.7220.49
12_V296_A0.7210.49
197_N327_L0.7210.49
34_L339_S0.7170.49
25_S33_I0.7150.49
120_I164_Q0.7130.49
141_Q185_E0.7090.48
176_L206_L0.7080.48
39_F207_L0.7080.48
64_V288_L0.7050.48
307_K310_L0.7030.48
247_F324_T0.7030.48
129_P225_W0.7010.47
127_G135_Y0.7000.47
45_S169_P0.6970.47
159_A163_F0.6960.47
187_S308_E0.6950.47
262_R291_D0.6860.46
101_I135_Y0.6850.46
106_A110_F0.6830.46
29_L276_I0.6820.46
335_A338_R0.6820.46
16_A304_I0.6810.45
120_I225_W0.6750.45
62_I295_M0.6720.45
334_E342_V0.6720.45
12_V304_I0.6700.44
140_F143_A0.6690.44
57_E334_E0.6650.44
207_L215_F0.6650.44
8_K11_H0.6620.44
110_F310_L0.6620.44
311_E315_R0.6610.44
169_P326_M0.6610.44
44_F322_K0.6600.43
158_P327_L0.6590.43
179_L192_V0.6590.43
43_S172_Q0.6580.43
111_T270_L0.6580.43
156_L179_L0.6570.43
82_A124_A0.6570.43
34_L328_T0.6560.43
172_Q179_L0.6530.43
25_S220_Q0.6530.43
263_Y266_P0.6510.43
56_K120_I0.6480.42
18_E231_I0.6440.42
267_D337_K0.6430.42
19_N301_K0.6430.42
71_R94_V0.6430.42
5_V103_K0.6420.42
104_A107_R0.6420.42
260_E342_V0.6400.42
203_T257_S0.6400.42
208_Y215_F0.6350.41
121_P151_A0.6340.41
117_A164_Q0.6340.41
37_Q202_E0.6330.41
230_M244_A0.6320.41
159_A247_F0.6310.41
177_E184_K0.6310.41
13_E16_A0.6310.41
86_E117_A0.6290.40
15_A225_W0.6260.40
258_I270_L0.6260.40
35_V260_E0.6260.40
204_A265_I0.6240.40
7_R11_H0.6240.40
10_E14_I0.6200.40
4_I99_V0.6200.40
316_K320_E0.6190.40
201_M205_K0.6190.40
48_N332_N0.6180.39
165_P232_R0.6170.39
224_N249_D0.6170.39
166_E228_I0.6170.39
60_A90_I0.6160.39
299_V313_F0.6150.39
33_I249_D0.6150.39
224_N320_E0.6130.39
88_F147_I0.6100.39
54_F214_N0.6090.39
73_E76_R0.6060.38
100_A107_R0.6030.38
14_I231_I0.6030.38
141_Q186_L0.6000.38
194_E273_S0.5990.38
163_F244_A0.5980.38
49_T333_V0.5960.37
7_R232_R0.5940.37
129_P178_R0.5940.37
147_I204_A0.5940.37
233_D244_A0.5930.37
71_R110_F0.5920.37
309_S312_Q0.5920.37
4_I94_V0.5910.37
114_R120_I0.5910.37
208_Y267_D0.5910.37
315_R318_I0.5870.37
101_I143_A0.5870.37
40_P64_V0.5850.36
253_P258_I0.5840.36
64_V314_F0.5820.36
144_I195_S0.5820.36
156_L199_I0.5820.36
108_E111_T0.5810.36
265_I268_A0.5800.36
153_A197_N0.5800.36
40_P158_P0.5780.36
16_A301_K0.5770.36
101_I146_M0.5770.36
97_Q158_P0.5750.36
59_S318_I0.5730.35
183_S213_K0.5720.35
217_T270_L0.5720.35
111_T142_D0.5710.35
42_I329_G0.5700.35
328_T339_S0.5680.35
93_G164_Q0.5650.35
49_T321_L0.5630.34
114_R151_A0.5630.34
126_L186_L0.5610.34
234_I262_R0.5600.34
163_F233_D0.5590.34
276_I321_L0.5590.34
86_E116_V0.5590.34
145_Q184_K0.5580.34
49_T322_K0.5580.34
144_I147_I0.5570.34
162_V327_L0.5570.34
65_T225_W0.5560.34
16_A300_L0.5550.34
295_M313_F0.5550.34
226_I327_L0.5550.34
283_A287_A0.5550.34
101_I186_L0.5540.34
12_V99_V0.5530.34
65_T129_P0.5520.34
15_A71_R0.5520.34
44_F319_F0.5510.33
54_F292_I0.5500.33
191_I214_N0.5490.33
56_K154_V0.5490.33
153_A225_W0.5470.33
282_A285_A0.5460.33
98_R127_G0.5460.33
250_W294_G0.5450.33
5_V215_F0.5430.33
124_A149_A0.5420.33
164_Q279_G0.5420.33
139_E142_D0.5410.33
66_G225_W0.5410.33
142_D148_E0.5400.33
71_R106_A0.5400.33
46_E332_N0.5390.32
12_V235_R0.5360.32
173_I177_E0.5340.32
53_F280_L0.5320.32
164_Q324_T0.5320.32
114_R118_P0.5300.32
102_E135_Y0.5300.32
66_G254_T0.5290.32
39_F249_D0.5280.31
37_Q41_G0.5280.31
286_I339_S0.5270.31
246_N278_S0.5270.31
180_R308_E0.5260.31
5_V154_V0.5260.31
183_S211_G0.5240.31
334_E338_R0.5240.31
318_I322_K0.5210.31
122_I147_I0.5200.31
72_N105_E0.5190.31
121_P214_N0.5180.31
138_K145_Q0.5170.31
314_F318_I0.5170.31
158_P171_Y0.5160.31
162_V326_M0.5160.31
92_M120_I0.5150.30
215_F261_V0.5140.30
9_V13_E0.5140.30
122_I136_G0.5140.30
114_R117_A0.5130.30
119_T334_E0.5130.30
102_E110_F0.5120.30
4_I164_Q0.5110.30
21_D297_L0.5100.30
113_V227_A0.5100.30
35_V342_V0.5080.30
99_V109_S0.5080.30
330_S339_S0.5080.30
118_P122_I0.5080.30
164_Q326_M0.5070.30
75_G110_F0.5070.30
308_E332_N0.5060.30
38_G257_S0.5060.30
173_I329_G0.5060.30
180_R201_M0.5050.30
81_I299_V0.5040.30
313_F316_K0.5020.29
244_A320_E0.5020.29
33_I342_V0.5000.29
115_K301_K0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3vkjA 4 0.9837 100 0.452 Contact Map
3sr7A 3 0.7473 100 0.518 Contact Map
1p0kA 4 0.837 100 0.522 Contact Map
4n02A 3 0.8995 100 0.524 Contact Map
1vcfA 3 0.8207 100 0.559 Contact Map
1ea0A 1 0.9022 100 0.681 Contact Map
1ofdA 1 0.9158 100 0.685 Contact Map
2qr6A 3 0.8043 100 0.692 Contact Map
1p4cA 3 0.8261 100 0.708 Contact Map
2nliA 4 0.8234 100 0.717 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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