GREMLIN Database
Y066 - MEMO1 family protein SSO0066
UniProt: P95994 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 284 (265)
Sequences: 1069 (903)
Seq/√Len: 55.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
195_S242_I4.4131.00
83_I140_I4.0391.00
69_Y143_Q3.6041.00
53_V143_Q3.4811.00
64_V262_A3.2281.00
24_E149_Y3.0511.00
68_S279_A2.9061.00
198_N206_T2.8311.00
111_K156_K2.7711.00
61_S65_A2.7691.00
80_V113_D2.7261.00
216_K224_G2.6451.00
258_I278_L2.6421.00
214_I280_A2.6251.00
203_H263_T2.6191.00
112_V117_L2.5911.00
221_D224_G2.5871.00
207_M211_E2.4931.00
101_G114_E2.4851.00
102_E109_S2.4311.00
87_N92_G2.3631.00
202_P205_I2.3151.00
104_E109_S2.3051.00
218_Q258_I2.2891.00
201_D209_K2.2371.00
174_A248_L2.2291.00
258_I280_A2.2281.00
72_L190_V2.1631.00
152_D155_F2.1461.00
52_I242_I2.1101.00
64_V260_K2.0891.00
214_I258_I2.0871.00
50_F245_S2.0771.00
227_E231_G2.0731.00
51_F192_L2.0041.00
13_E22_Q2.0031.00
112_V157_I2.0031.00
236_L242_I1.9831.00
53_V69_Y1.9471.00
27_F66_A1.9351.00
198_N201_D1.9141.00
256_A282_F1.9121.00
27_F149_Y1.8911.00
107_L148_Q1.8881.00
80_V189_I1.8841.00
113_D156_K1.8610.99
147_L155_F1.8410.99
79_D188_D1.8110.99
20_K149_Y1.7610.99
218_Q280_A1.7530.99
4_L104_E1.7510.99
83_I157_I1.7450.99
85_G139_S1.7270.99
174_A247_I1.7240.99
51_F68_S1.7180.99
67_H260_K1.6280.99
7_V11_F1.6070.98
203_H271_K1.6070.98
82_I189_I1.5910.98
214_I261_H1.5800.98
53_V68_S1.5750.98
110_V155_F1.5590.98
9_G14_S1.5440.98
87_N161_V1.5410.98
11_F142_V1.5310.98
197_M236_L1.4980.98
214_I278_L1.4860.97
151_F155_F1.4700.97
78_P190_V1.4660.97
196_D199_H1.4490.97
49_L189_I1.4430.97
116_V158_V1.4110.96
117_L158_V1.3900.96
222_Y246_L1.3090.95
22_Q26_S1.2970.94
245_S282_F1.2800.94
99_P131_E1.2700.94
174_A178_Y1.2620.93
81_V147_L1.2590.93
16_P20_K1.2490.93
119_Q122_M1.2220.92
56_A61_S1.2140.92
204_E207_M1.2130.92
263_T266_D1.2030.92
85_G140_I1.1840.91
95_V160_I1.1780.91
56_A60_Y1.1770.91
259_L281_R1.1390.89
19_L58_Y1.1330.89
56_A277_Y1.1210.88
80_V156_K1.1130.88
23_I26_S1.1020.88
162_I241_P1.0990.87
110_V157_I1.0960.87
84_L162_I1.0930.87
57_G61_S1.0810.87
13_E18_K1.0800.87
2_R102_E1.0760.86
175_D251_K1.0750.86
225_L242_I1.0520.85
63_P262_A1.0500.85
15_D18_K1.0480.85
241_P248_L1.0460.85
178_Y252_L1.0410.84
58_Y142_V1.0380.84
160_I177_I1.0310.84
214_I218_Q1.0260.84
5_P148_Q1.0250.83
197_M213_A1.0240.83
206_T274_V1.0230.83
98_W112_V1.0170.83
27_F150_F1.0160.83
219_Q224_G1.0130.83
67_H259_L1.0080.82
55_H88_H1.0070.82
201_D206_T1.0040.82
199_H210_D1.0000.82
95_V162_I0.9980.82
213_A236_L0.9980.82
140_I144_L0.9970.82
264_S277_Y0.9930.82
81_V190_V0.9910.81
116_V120_L0.9900.81
102_E111_K0.9880.81
57_G60_Y0.9780.81
105_T148_Q0.9640.80
64_V67_H0.9530.79
206_T261_H0.9480.78
196_D210_D0.9470.78
198_N261_H0.9460.78
7_V142_V0.9440.78
57_G65_A0.9300.77
56_A275_V0.9280.77
120_L160_I0.9240.77
137_E238_G0.9220.76
57_G195_S0.9220.76
265_G271_K0.9210.76
98_W101_G0.9180.76
200_Y265_G0.9170.76
197_M235_T0.9170.76
83_I144_L0.9130.76
203_H207_M0.9070.75
265_G274_V0.9070.75
213_A234_V0.9000.75
162_I240_G0.8990.75
222_Y247_I0.8990.75
145_P264_S0.8970.74
52_I214_I0.8950.74
103_W157_I0.8840.73
46_R49_L0.8750.73
65_A145_P0.8740.72
49_L186_D0.8730.72
11_F56_A0.8710.72
256_A280_A0.8690.72
262_A266_D0.8610.71
130_E133_S0.8570.71
203_H266_D0.8570.71
56_A65_A0.8560.71
18_K22_Q0.8560.71
55_H196_D0.8480.70
83_I143_Q0.8460.70
23_I27_F0.8430.70
72_L192_L0.8430.70
203_H265_G0.8410.70
211_E215_E0.8400.69
223_R227_E0.8370.69
3_R134_H0.8330.69
82_I181_I0.8330.69
61_S195_S0.8320.69
6_A134_H0.8260.68
224_G227_E0.8250.68
80_V116_V0.8180.67
97_A121_V0.8140.67
115_E156_K0.8070.66
121_V128_D0.8050.66
193_A245_S0.8050.66
213_A228_V0.8040.66
90_G133_S0.8040.66
82_I180_V0.8030.66
148_Q155_F0.8020.66
80_V186_D0.7970.65
215_E218_Q0.7970.65
56_A264_S0.7960.65
72_L151_F0.7930.65
198_N274_V0.7890.65
178_Y248_L0.7870.64
202_P206_T0.7850.64
225_L236_L0.7850.64
110_V147_L0.7800.64
86_P241_P0.7790.64
237_C275_V0.7780.64
116_V189_I0.7780.64
57_G264_S0.7750.63
162_I244_V0.7730.63
88_H196_D0.7720.63
57_G86_P0.7690.63
246_L282_F0.7670.62
105_T108_G0.7650.62
26_S62_G0.7610.62
116_V180_V0.7600.62
23_I149_Y0.7570.61
114_E118_M0.7550.61
56_A145_P0.7530.61
259_L279_A0.7520.61
58_Y146_F0.7510.61
270_P273_S0.7470.60
186_D189_I0.7400.60
201_D205_I0.7400.60
29_H63_P0.7390.60
204_E208_K0.7380.59
20_K24_E0.7370.59
144_L157_I0.7350.59
155_F220_L0.7300.59
263_T276_G0.7290.58
11_F57_G0.7280.58
180_V191_V0.7250.58
197_M276_G0.7250.58
200_Y273_S0.7240.58
165_Q240_G0.7240.58
89_T136_Y0.7220.58
56_A195_S0.7190.57
92_G96_S0.7190.57
57_G196_D0.7190.57
202_P274_V0.7170.57
74_S190_V0.7170.57
82_I191_V0.7160.57
69_Y72_L0.7140.57
166_T169_I0.7130.57
218_Q278_L0.7060.56
170_A240_G0.7040.56
92_G161_V0.7020.56
87_N90_G0.7000.55
92_G130_E0.6980.55
101_G117_L0.6960.55
158_V193_A0.6940.55
61_S145_P0.6900.54
85_G134_H0.6880.54
174_A244_V0.6870.54
201_D234_V0.6860.54
48_N51_F0.6860.54
201_D274_V0.6840.54
5_P104_E0.6840.54
64_V108_G0.6820.53
217_I225_L0.6810.53
4_L135_L0.6810.53
220_L256_A0.6800.53
193_A244_V0.6790.53
60_Y65_A0.6770.53
27_F30_N0.6750.53
2_R101_G0.6740.53
171_E223_R0.6740.53
197_M217_I0.6730.53
80_V158_V0.6720.52
217_I258_I0.6710.52
57_G145_P0.6680.52
89_T134_H0.6670.52
258_I261_H0.6650.52
173_L244_V0.6650.52
17_K77_K0.6630.51
22_Q59_I0.6620.51
225_L229_V0.6610.51
71_Y281_R0.6570.51
179_K186_D0.6530.50
11_F134_H0.6520.50
194_S264_S0.6500.50
23_I146_F0.6490.50
62_G65_A0.6480.50
11_F145_P0.6470.50
123_E179_K0.6460.50
66_A279_A0.6460.50
133_S161_V0.6450.49
236_L276_G0.6440.49
15_D218_Q0.6430.49
201_D235_T0.6420.49
165_Q244_V0.6390.49
67_H262_A0.6380.49
73_A76_G0.6370.49
76_G152_D0.6360.49
55_H237_C0.6350.48
241_P244_V0.6340.48
178_Y251_K0.6330.48
205_I209_K0.6290.48
71_Y259_L0.6290.48
97_A120_L0.6290.48
142_V200_Y0.6280.48
142_V276_G0.6270.48
60_Y145_P0.6250.47
26_S63_P0.6250.47
65_A143_Q0.6240.47
239_Y243_M0.6160.46
62_G264_S0.6160.46
23_I58_Y0.6140.46
61_S277_Y0.6140.46
261_H278_L0.6140.46
158_V232_K0.6120.46
82_I116_V0.6110.46
86_P137_E0.6110.46
7_V10_S0.6110.46
88_H237_C0.6110.46
79_D154_N0.6100.46
60_Y264_S0.6050.45
145_P277_Y0.6040.45
12_Y141_E0.6030.45
248_L252_L0.6000.45
23_I150_F0.5950.44
63_P66_A0.5910.44
207_M261_H0.5910.44
229_V239_Y0.5900.44
213_A225_L0.5880.43
11_F277_Y0.5870.43
235_T243_M0.5850.43
197_M280_A0.5830.43
120_L126_V0.5820.43
215_E219_Q0.5800.43
181_I252_L0.5800.43
5_P11_F0.5790.42
61_S264_S0.5790.42
270_P274_V0.5770.42
56_A196_D0.5750.42
221_D250_K0.5750.42
94_Y227_E0.5720.42
79_D187_K0.5720.42
69_Y146_F0.5720.42
11_F200_Y0.5710.42
98_W117_L0.5710.42
16_P257_Y0.5700.41
66_A150_F0.5700.41
108_G148_Q0.5690.41
138_H196_D0.5670.41
57_G200_Y0.5670.41
52_I280_A0.5670.41
195_S237_C0.5660.41
212_E232_K0.5650.41
57_G277_Y0.5640.41
165_Q169_I0.5630.41
171_E175_D0.5630.41
82_I186_D0.5620.41
195_S236_L0.5620.41
208_K215_E0.5600.40
201_D261_H0.5580.40
205_I208_K0.5580.40
11_F274_V0.5580.40
98_W103_W0.5570.40
216_K228_V0.5550.40
109_S121_V0.5550.40
131_E248_L0.5540.40
56_A86_P0.5530.40
23_I83_I0.5520.40
157_I233_D0.5510.39
195_S264_S0.5490.39
212_E228_V0.5460.39
92_G240_G0.5440.39
111_K154_N0.5430.39
92_G163_M0.5430.39
84_L241_P0.5410.38
56_A142_V0.5400.38
140_I159_P0.5400.38
217_I280_A0.5390.38
86_P238_G0.5390.38
195_S235_T0.5380.38
78_P188_D0.5380.38
90_G161_V0.5370.38
56_A200_Y0.5360.38
94_Y230_E0.5350.38
185_S188_D0.5330.38
97_A127_I0.5310.37
47_D157_I0.5280.37
86_P264_S0.5280.37
233_D240_G0.5250.37
11_F58_Y0.5240.37
49_L181_I0.5230.37
268_S271_K0.5230.37
92_G225_L0.5230.37
228_V235_T0.5210.36
237_C241_P0.5200.36
141_E275_V0.5200.36
164_M193_A0.5200.36
16_P118_M0.5200.36
218_Q256_A0.5200.36
60_Y200_Y0.5170.36
3_R85_G0.5170.36
11_F127_I0.5160.36
28_R168_E0.5160.36
119_Q223_R0.5160.36
97_A116_V0.5150.36
69_Y150_F0.5150.36
98_W157_I0.5140.36
119_Q279_A0.5140.36
47_D255_K0.5140.36
139_S238_G0.5120.36
134_H274_V0.5120.36
259_L282_F0.5080.35
3_R9_G0.5080.35
86_P195_S0.5070.35
26_S67_H0.5060.35
78_P155_F0.5050.35
6_A188_D0.5020.35
56_A237_C0.5000.34
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3bczA 1 0.9472 100 0.21 Contact Map
3vsjA 1 0.8239 100 0.573 Contact Map
3vsjB 2 0.8134 100 0.597 Contact Map
1b4uB 2 0.8134 99.9 0.695 Contact Map
3wraA 2 0.8063 99.9 0.727 Contact Map
2pw6A 2 0.757 99.9 0.734 Contact Map
5by3A 1 0.4437 19.6 0.964 Contact Map
4wesB 2 0.9296 15.6 0.965 Contact Map
2ebfX 1 0.507 14.9 0.966 Contact Map
1or7A 2 0.2887 10.2 0.968 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0089 seconds.