Y066 - SULSO - GREMLIN Contacts

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Y066 - MEMO1 family protein SSO0066

UniProt:	P95994	Sequences: MRRLPAVAGSFYESDPKKLKMQIEWSFRHNIGPRDIPKQSYEKKKRDNLFFIVPHAGYIYSGPVAAHSYYYLASEGKPDVVIILGPNHTGLGSYVSAWPKGEWETPLGSVKVDEEVLMQLVMESEVIDLEEKSHLYEHSIEVQLPFLQYFFDDNFKIVPIVIMMQTPEIAEFLADAIYKVIQKYSDKDIVVLASSDMNHYDPHEITMKKDEEAIEKIQQLDYRGLYEVVEGKDVTLCGYGPIMVSLILAKKLGKKAYILKHATSGDTSGPKDSVVGYLAARFGS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	284 (265)
Sequences:	1069 (903)
Seq/√Len:	55.5

SULSO - Y066

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
195_S	242_I	4.413	1.00
83_I	140_I	4.039	1.00
69_Y	143_Q	3.604	1.00
53_V	143_Q	3.481	1.00
64_V	262_A	3.228	1.00
24_E	149_Y	3.051	1.00
68_S	279_A	2.906	1.00
198_N	206_T	2.831	1.00
111_K	156_K	2.771	1.00
61_S	65_A	2.769	1.00
80_V	113_D	2.726	1.00
216_K	224_G	2.645	1.00
258_I	278_L	2.642	1.00
214_I	280_A	2.625	1.00
203_H	263_T	2.619	1.00
112_V	117_L	2.591	1.00
221_D	224_G	2.587	1.00
207_M	211_E	2.493	1.00
101_G	114_E	2.485	1.00
102_E	109_S	2.431	1.00
87_N	92_G	2.363	1.00
202_P	205_I	2.315	1.00
104_E	109_S	2.305	1.00
218_Q	258_I	2.289	1.00
201_D	209_K	2.237	1.00
174_A	248_L	2.229	1.00
258_I	280_A	2.228	1.00
72_L	190_V	2.163	1.00
152_D	155_F	2.146	1.00
52_I	242_I	2.110	1.00
64_V	260_K	2.089	1.00
214_I	258_I	2.087	1.00
50_F	245_S	2.077	1.00
227_E	231_G	2.073	1.00
51_F	192_L	2.004	1.00
13_E	22_Q	2.003	1.00
112_V	157_I	2.003	1.00
236_L	242_I	1.983	1.00
53_V	69_Y	1.947	1.00
27_F	66_A	1.935	1.00
198_N	201_D	1.914	1.00
256_A	282_F	1.912	1.00
27_F	149_Y	1.891	1.00
107_L	148_Q	1.888	1.00
80_V	189_I	1.884	1.00
113_D	156_K	1.861	0.99
147_L	155_F	1.841	0.99
79_D	188_D	1.811	0.99
20_K	149_Y	1.761	0.99
218_Q	280_A	1.753	0.99
4_L	104_E	1.751	0.99
83_I	157_I	1.745	0.99
85_G	139_S	1.727	0.99
174_A	247_I	1.724	0.99
51_F	68_S	1.718	0.99
67_H	260_K	1.628	0.99
7_V	11_F	1.607	0.98
203_H	271_K	1.607	0.98
82_I	189_I	1.591	0.98
214_I	261_H	1.580	0.98
53_V	68_S	1.575	0.98
110_V	155_F	1.559	0.98
9_G	14_S	1.544	0.98
87_N	161_V	1.541	0.98
11_F	142_V	1.531	0.98
197_M	236_L	1.498	0.98
214_I	278_L	1.486	0.97
151_F	155_F	1.470	0.97
78_P	190_V	1.466	0.97
196_D	199_H	1.449	0.97
49_L	189_I	1.443	0.97
116_V	158_V	1.411	0.96
117_L	158_V	1.390	0.96
222_Y	246_L	1.309	0.95
22_Q	26_S	1.297	0.94
245_S	282_F	1.280	0.94
99_P	131_E	1.270	0.94
174_A	178_Y	1.262	0.93
81_V	147_L	1.259	0.93
16_P	20_K	1.249	0.93
119_Q	122_M	1.222	0.92
56_A	61_S	1.214	0.92
204_E	207_M	1.213	0.92
263_T	266_D	1.203	0.92
85_G	140_I	1.184	0.91
95_V	160_I	1.178	0.91
56_A	60_Y	1.177	0.91
259_L	281_R	1.139	0.89
19_L	58_Y	1.133	0.89
56_A	277_Y	1.121	0.88
80_V	156_K	1.113	0.88
23_I	26_S	1.102	0.88
162_I	241_P	1.099	0.87
110_V	157_I	1.096	0.87
84_L	162_I	1.093	0.87
57_G	61_S	1.081	0.87
13_E	18_K	1.080	0.87
2_R	102_E	1.076	0.86
175_D	251_K	1.075	0.86
225_L	242_I	1.052	0.85
63_P	262_A	1.050	0.85
15_D	18_K	1.048	0.85
241_P	248_L	1.046	0.85
178_Y	252_L	1.041	0.84
58_Y	142_V	1.038	0.84
160_I	177_I	1.031	0.84
214_I	218_Q	1.026	0.84
5_P	148_Q	1.025	0.83
197_M	213_A	1.024	0.83
206_T	274_V	1.023	0.83
98_W	112_V	1.017	0.83
27_F	150_F	1.016	0.83
219_Q	224_G	1.013	0.83
67_H	259_L	1.008	0.82
55_H	88_H	1.007	0.82
201_D	206_T	1.004	0.82
199_H	210_D	1.000	0.82
95_V	162_I	0.998	0.82
213_A	236_L	0.998	0.82
140_I	144_L	0.997	0.82
264_S	277_Y	0.993	0.82
81_V	190_V	0.991	0.81
116_V	120_L	0.990	0.81
102_E	111_K	0.988	0.81
57_G	60_Y	0.978	0.81
105_T	148_Q	0.964	0.80
64_V	67_H	0.953	0.79
206_T	261_H	0.948	0.78
196_D	210_D	0.947	0.78
198_N	261_H	0.946	0.78
7_V	142_V	0.944	0.78
57_G	65_A	0.930	0.77
56_A	275_V	0.928	0.77
120_L	160_I	0.924	0.77
137_E	238_G	0.922	0.76
57_G	195_S	0.922	0.76
265_G	271_K	0.921	0.76
98_W	101_G	0.918	0.76
200_Y	265_G	0.917	0.76
197_M	235_T	0.917	0.76
83_I	144_L	0.913	0.76
203_H	207_M	0.907	0.75
265_G	274_V	0.907	0.75
213_A	234_V	0.900	0.75
162_I	240_G	0.899	0.75
222_Y	247_I	0.899	0.75
145_P	264_S	0.897	0.74
52_I	214_I	0.895	0.74
103_W	157_I	0.884	0.73
46_R	49_L	0.875	0.73
65_A	145_P	0.874	0.72
49_L	186_D	0.873	0.72
11_F	56_A	0.871	0.72
256_A	280_A	0.869	0.72
262_A	266_D	0.861	0.71
130_E	133_S	0.857	0.71
203_H	266_D	0.857	0.71
56_A	65_A	0.856	0.71
18_K	22_Q	0.856	0.71
55_H	196_D	0.848	0.70
83_I	143_Q	0.846	0.70
23_I	27_F	0.843	0.70
72_L	192_L	0.843	0.70
203_H	265_G	0.841	0.70
211_E	215_E	0.840	0.69
223_R	227_E	0.837	0.69
3_R	134_H	0.833	0.69
82_I	181_I	0.833	0.69
61_S	195_S	0.832	0.69
6_A	134_H	0.826	0.68
224_G	227_E	0.825	0.68
80_V	116_V	0.818	0.67
97_A	121_V	0.814	0.67
115_E	156_K	0.807	0.66
121_V	128_D	0.805	0.66
193_A	245_S	0.805	0.66
213_A	228_V	0.804	0.66
90_G	133_S	0.804	0.66
82_I	180_V	0.803	0.66
148_Q	155_F	0.802	0.66
80_V	186_D	0.797	0.65
215_E	218_Q	0.797	0.65
56_A	264_S	0.796	0.65
72_L	151_F	0.793	0.65
198_N	274_V	0.789	0.65
178_Y	248_L	0.787	0.64
202_P	206_T	0.785	0.64
225_L	236_L	0.785	0.64
110_V	147_L	0.780	0.64
86_P	241_P	0.779	0.64
237_C	275_V	0.778	0.64
116_V	189_I	0.778	0.64
57_G	264_S	0.775	0.63
162_I	244_V	0.773	0.63
88_H	196_D	0.772	0.63
57_G	86_P	0.769	0.63
246_L	282_F	0.767	0.62
105_T	108_G	0.765	0.62
26_S	62_G	0.761	0.62
116_V	180_V	0.760	0.62
23_I	149_Y	0.757	0.61
114_E	118_M	0.755	0.61
56_A	145_P	0.753	0.61
259_L	279_A	0.752	0.61
58_Y	146_F	0.751	0.61
270_P	273_S	0.747	0.60
186_D	189_I	0.740	0.60
201_D	205_I	0.740	0.60
29_H	63_P	0.739	0.60
204_E	208_K	0.738	0.59
20_K	24_E	0.737	0.59
144_L	157_I	0.735	0.59
155_F	220_L	0.730	0.59
263_T	276_G	0.729	0.58
11_F	57_G	0.728	0.58
180_V	191_V	0.725	0.58
197_M	276_G	0.725	0.58
200_Y	273_S	0.724	0.58
165_Q	240_G	0.724	0.58
89_T	136_Y	0.722	0.58
56_A	195_S	0.719	0.57
92_G	96_S	0.719	0.57
57_G	196_D	0.719	0.57
202_P	274_V	0.717	0.57
74_S	190_V	0.717	0.57
82_I	191_V	0.716	0.57
69_Y	72_L	0.714	0.57
166_T	169_I	0.713	0.57
218_Q	278_L	0.706	0.56
170_A	240_G	0.704	0.56
92_G	161_V	0.702	0.56
87_N	90_G	0.700	0.55
92_G	130_E	0.698	0.55
101_G	117_L	0.696	0.55
158_V	193_A	0.694	0.55
61_S	145_P	0.690	0.54
85_G	134_H	0.688	0.54
174_A	244_V	0.687	0.54
201_D	234_V	0.686	0.54
48_N	51_F	0.686	0.54
201_D	274_V	0.684	0.54
5_P	104_E	0.684	0.54
64_V	108_G	0.682	0.53
217_I	225_L	0.681	0.53
4_L	135_L	0.681	0.53
220_L	256_A	0.680	0.53
193_A	244_V	0.679	0.53
60_Y	65_A	0.677	0.53
27_F	30_N	0.675	0.53
2_R	101_G	0.674	0.53
171_E	223_R	0.674	0.53
197_M	217_I	0.673	0.53
80_V	158_V	0.672	0.52
217_I	258_I	0.671	0.52
57_G	145_P	0.668	0.52
89_T	134_H	0.667	0.52
258_I	261_H	0.665	0.52
173_L	244_V	0.665	0.52
17_K	77_K	0.663	0.51
22_Q	59_I	0.662	0.51
225_L	229_V	0.661	0.51
71_Y	281_R	0.657	0.51
179_K	186_D	0.653	0.50
11_F	134_H	0.652	0.50
194_S	264_S	0.650	0.50
23_I	146_F	0.649	0.50
62_G	65_A	0.648	0.50
11_F	145_P	0.647	0.50
123_E	179_K	0.646	0.50
66_A	279_A	0.646	0.50
133_S	161_V	0.645	0.49
236_L	276_G	0.644	0.49
15_D	218_Q	0.643	0.49
201_D	235_T	0.642	0.49
165_Q	244_V	0.639	0.49
67_H	262_A	0.638	0.49
73_A	76_G	0.637	0.49
76_G	152_D	0.636	0.49
55_H	237_C	0.635	0.48
241_P	244_V	0.634	0.48
178_Y	251_K	0.633	0.48
205_I	209_K	0.629	0.48
71_Y	259_L	0.629	0.48
97_A	120_L	0.629	0.48
142_V	200_Y	0.628	0.48
142_V	276_G	0.627	0.48
60_Y	145_P	0.625	0.47
26_S	63_P	0.625	0.47
65_A	143_Q	0.624	0.47
239_Y	243_M	0.616	0.46
62_G	264_S	0.616	0.46
23_I	58_Y	0.614	0.46
61_S	277_Y	0.614	0.46
261_H	278_L	0.614	0.46
158_V	232_K	0.612	0.46
82_I	116_V	0.611	0.46
86_P	137_E	0.611	0.46
7_V	10_S	0.611	0.46
88_H	237_C	0.611	0.46
79_D	154_N	0.610	0.46
60_Y	264_S	0.605	0.45
145_P	277_Y	0.604	0.45
12_Y	141_E	0.603	0.45
248_L	252_L	0.600	0.45
23_I	150_F	0.595	0.44
63_P	66_A	0.591	0.44
207_M	261_H	0.591	0.44
229_V	239_Y	0.590	0.44
213_A	225_L	0.588	0.43
11_F	277_Y	0.587	0.43
235_T	243_M	0.585	0.43
197_M	280_A	0.583	0.43
120_L	126_V	0.582	0.43
215_E	219_Q	0.580	0.43
181_I	252_L	0.580	0.43
5_P	11_F	0.579	0.42
61_S	264_S	0.579	0.42
270_P	274_V	0.577	0.42
56_A	196_D	0.575	0.42
221_D	250_K	0.575	0.42
94_Y	227_E	0.572	0.42
79_D	187_K	0.572	0.42
69_Y	146_F	0.572	0.42
11_F	200_Y	0.571	0.42
98_W	117_L	0.571	0.42
16_P	257_Y	0.570	0.41
66_A	150_F	0.570	0.41
108_G	148_Q	0.569	0.41
138_H	196_D	0.567	0.41
57_G	200_Y	0.567	0.41
52_I	280_A	0.567	0.41
195_S	237_C	0.566	0.41
212_E	232_K	0.565	0.41
57_G	277_Y	0.564	0.41
165_Q	169_I	0.563	0.41
171_E	175_D	0.563	0.41
82_I	186_D	0.562	0.41
195_S	236_L	0.562	0.41
208_K	215_E	0.560	0.40
201_D	261_H	0.558	0.40
205_I	208_K	0.558	0.40
11_F	274_V	0.558	0.40
98_W	103_W	0.557	0.40
216_K	228_V	0.555	0.40
109_S	121_V	0.555	0.40
131_E	248_L	0.554	0.40
56_A	86_P	0.553	0.40
23_I	83_I	0.552	0.40
157_I	233_D	0.551	0.39
195_S	264_S	0.549	0.39
212_E	228_V	0.546	0.39
92_G	240_G	0.544	0.39
111_K	154_N	0.543	0.39
92_G	163_M	0.543	0.39
84_L	241_P	0.541	0.38
56_A	142_V	0.540	0.38
140_I	159_P	0.540	0.38
217_I	280_A	0.539	0.38
86_P	238_G	0.539	0.38
195_S	235_T	0.538	0.38
78_P	188_D	0.538	0.38
90_G	161_V	0.537	0.38
56_A	200_Y	0.536	0.38
94_Y	230_E	0.535	0.38
185_S	188_D	0.533	0.38
97_A	127_I	0.531	0.37
47_D	157_I	0.528	0.37
86_P	264_S	0.528	0.37
233_D	240_G	0.525	0.37
11_F	58_Y	0.524	0.37
49_L	181_I	0.523	0.37
268_S	271_K	0.523	0.37
92_G	225_L	0.523	0.37
228_V	235_T	0.521	0.36
237_C	241_P	0.520	0.36
141_E	275_V	0.520	0.36
164_M	193_A	0.520	0.36
16_P	118_M	0.520	0.36
218_Q	256_A	0.520	0.36
60_Y	200_Y	0.517	0.36
3_R	85_G	0.517	0.36
11_F	127_I	0.516	0.36
28_R	168_E	0.516	0.36
119_Q	223_R	0.516	0.36
97_A	116_V	0.515	0.36
69_Y	150_F	0.515	0.36
98_W	157_I	0.514	0.36
119_Q	279_A	0.514	0.36
47_D	255_K	0.514	0.36
139_S	238_G	0.512	0.36
134_H	274_V	0.512	0.36
259_L	282_F	0.508	0.35
3_R	9_G	0.508	0.35
86_P	195_S	0.507	0.35
26_S	67_H	0.506	0.35
78_P	155_F	0.505	0.35
6_A	188_D	0.502	0.35
56_A	237_C	0.500	0.34

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3bczA	1	0.9472	100	0.21	Contact Map
3vsjA	1	0.8239	100	0.573	Contact Map
3vsjB	2	0.8134	100	0.597	Contact Map
1b4uB	2	0.8134	99.9	0.695	Contact Map
3wraA	2	0.8063	99.9	0.727	Contact Map
2pw6A	2	0.757	99.9	0.734	Contact Map
5by3A	1	0.4437	19.6	0.964	Contact Map
4wesB	2	0.9296	15.6	0.965	Contact Map
2ebfX	1	0.507	14.9	0.966	Contact Map
1or7A	2	0.2887	10.2	0.968	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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