GREMLIN Database
RS2 - 30S ribosomal protein S2
UniProt: P95993 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 231 (180)
Sequences: 2542 (1112)
Seq/√Len: 82.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
111_Q115_E3.6271.00
170_F186_A3.4761.00
95_Q143_K3.2181.00
88_F168_V3.2101.00
146_L201_L3.1431.00
145_L160_A2.9651.00
204_Q208_E2.8451.00
113_F116_V2.8031.00
81_R84_I2.7851.00
47_V186_A2.5831.00
113_F199_W2.5381.00
170_F197_L2.5131.00
89_L168_V2.4531.00
47_V193_S2.4301.00
161_A179_Y2.4151.00
89_L201_L2.3881.00
73_L173_T2.3371.00
82_L200_A2.2871.00
122_L130_T2.1881.00
88_F144_V2.1261.00
57_Y178_D2.1161.00
186_A197_L2.0801.00
144_V168_V2.0601.00
42_Y47_V2.0271.00
62_V173_T2.0001.00
74_D77_K1.9281.00
116_V203_R1.9051.00
101_A106_A1.8661.00
147_V167_I1.7331.00
86_A204_Q1.7211.00
96_D143_K1.7041.00
61_F81_R1.6821.00
158_K162_K1.6761.00
106_A194_L1.6751.00
116_V206_L1.6291.00
171_A183_I1.5801.00
161_A181_D1.5220.99
117_V205_I1.5110.99
86_A201_L1.5020.99
199_W203_R1.4900.99
55_T176_K1.4870.99
88_F182_L1.4740.99
89_L144_V1.4660.99
98_I131_F1.4480.99
154_T158_K1.4350.99
84_I87_K1.3950.99
169_A180_I1.3810.99
109_P113_F1.3800.99
151_R175_A1.3540.99
113_F202_A1.3430.99
92_Y211_V1.3190.99
88_F91_R1.2970.98
150_P180_I1.2770.98
172_D189_K1.2760.98
89_L205_I1.2720.98
82_L197_L1.2230.98
77_K81_R1.2040.97
37_V82_L1.1850.97
146_L198_Y1.1790.97
86_A200_A1.1700.97
150_P169_A1.1680.97
143_K166_P1.1660.97
171_A180_I1.1620.97
53_S65_V1.1420.96
195_A199_W1.1410.96
112_K195_A1.1330.96
81_R185_P1.1160.96
148_S170_F1.1150.96
51_T189_K1.1050.96
145_L156_A1.0910.95
57_Y176_K1.0700.95
107_Y124_G1.0640.95
97_I205_I1.0520.94
74_D105_Y1.0520.94
51_T172_D1.0420.94
205_I209_R1.0390.94
37_V200_A1.0240.93
36_L86_A1.0190.93
168_V182_L1.0130.93
90_S211_V1.0080.93
41_T44_S1.0080.93
119_S209_R1.0010.93
203_R206_L0.9990.92
149_D152_T0.9930.92
91_R168_V0.9930.92
113_F195_A0.9920.92
90_S207_R0.9840.92
197_L201_L0.9830.92
111_Q123_V0.9800.92
103_R106_A0.9790.92
106_A148_S0.9600.91
46_G49_I0.9600.91
57_Y134_P0.9500.90
42_Y82_L0.9480.90
134_P138_T0.9480.90
112_K115_E0.9460.90
157_I167_I0.9410.90
127_I130_T0.9350.90
125_R128_P0.9270.89
114_A119_S0.9270.89
171_A175_A0.9250.89
160_A167_I0.9210.89
100_V131_F0.9140.89
116_V202_A0.9030.88
41_T200_A0.9030.88
97_I144_V0.9000.88
158_K161_A0.8700.86
96_D120_R0.8650.86
133_N159_E0.8600.85
98_I145_L0.8590.85
109_P192_K0.8560.85
186_A193_S0.8540.85
180_I183_I0.8430.84
212_I215_D0.8410.84
161_A167_I0.8290.83
117_V206_L0.8220.83
103_R153_D0.8200.83
63_Y76_R0.8130.82
64_R82_L0.8110.82
85_A183_I0.8090.82
90_S93_D0.8040.81
113_F203_R0.8030.81
206_L210_R0.8030.81
120_R150_P0.8020.81
109_P195_A0.7990.81
147_V160_A0.7980.81
61_F183_I0.7910.80
109_P194_L0.7900.80
66_R196_L0.7900.80
96_D139_Y0.7800.79
87_K90_S0.7790.79
148_S153_D0.7770.79
79_D83_R0.7760.79
193_S197_L0.7730.79
38_P41_T0.7700.78
108_R112_K0.7700.78
117_V202_A0.7700.78
157_I180_I0.7670.78
39_V79_D0.7590.77
51_T188_N0.7560.77
184_I197_L0.7500.77
94_P212_I0.7490.77
91_R169_A0.7460.76
149_D153_D0.7400.76
151_R174_D0.7390.76
103_R149_D0.7380.75
154_T179_Y0.7360.75
184_I201_L0.7320.75
172_D188_N0.7290.75
96_D118_G0.7240.74
82_L86_A0.7170.73
109_P198_Y0.7170.73
86_A197_L0.7160.73
72_V75_V0.7150.73
95_Q120_R0.7120.73
114_A174_D0.7080.72
127_I134_P0.7070.72
131_F163_V0.7000.72
124_G210_R0.7000.72
179_Y183_I0.6980.71
119_S205_I0.6970.71
211_V214_P0.6960.71
141_E165_I0.6950.71
118_G206_L0.6930.71
95_Q182_L0.6890.70
46_G192_K0.6860.70
208_E212_I0.6850.70
106_A153_D0.6850.70
89_L146_L0.6840.70
129_G133_N0.6840.70
96_D140_I0.6840.70
118_G209_R0.6820.70
213_P216_G0.6810.69
53_S69_G0.6800.69
41_T172_D0.6790.69
61_F182_L0.6760.69
59_E71_Y0.6700.68
141_E144_V0.6630.67
39_V47_V0.6590.67
147_V157_I0.6510.66
138_T141_E0.6500.66
107_Y123_V0.6490.66
200_A206_L0.6480.66
74_D94_P0.6450.65
96_D119_S0.6450.65
38_P162_K0.6430.65
62_V73_L0.6420.65
77_K80_E0.6360.64
56_K59_E0.6350.64
48_H142_P0.6330.64
125_R159_E0.6280.63
155_Q158_K0.6210.62
54_C62_V0.6190.62
102_S122_L0.6190.62
198_Y201_L0.6180.62
210_R213_P0.6160.62
135_Y138_T0.6150.62
87_K91_R0.6140.62
65_V205_I0.6140.62
129_G132_T0.6140.62
70_L190_G0.6100.61
81_R87_K0.6090.61
91_R144_V0.6070.61
56_K134_P0.6060.61
127_I139_Y0.6050.60
58_M71_Y0.6050.60
212_I216_G0.6020.60
146_L184_I0.6020.60
196_L200_A0.5980.59
154_T157_I0.5970.59
76_R81_R0.5950.59
58_M62_V0.5930.59
140_I157_I0.5910.59
82_L193_S0.5890.58
110_V148_S0.5890.58
99_V110_V0.5890.58
49_I66_R0.5890.58
103_R148_S0.5870.58
113_F117_V0.5870.58
150_P200_A0.5860.58
123_V193_S0.5860.58
129_G159_E0.5840.58
100_V145_L0.5840.58
205_I208_E0.5830.58
152_T169_A0.5760.57
89_L97_I0.5720.56
37_V79_D0.5710.56
127_I163_V0.5690.56
102_S159_E0.5680.56
83_R211_V0.5670.55
97_I119_S0.5650.55
210_R214_P0.5620.55
90_S108_R0.5620.55
198_Y202_A0.5620.55
120_R144_V0.5590.54
43_L66_R0.5580.54
206_L212_I0.5580.54
150_P171_A0.5580.54
115_E121_A0.5560.54
128_P189_K0.5560.54
82_L214_P0.5500.53
104_P128_P0.5490.53
77_K171_A0.5490.53
40_D44_S0.5460.53
40_D73_L0.5450.53
88_F209_R0.5450.53
156_A167_I0.5420.52
148_S198_Y0.5400.52
84_I182_L0.5400.52
175_A181_D0.5390.52
127_I147_V0.5330.51
150_P179_Y0.5330.51
60_S77_K0.5290.50
77_K180_I0.5260.50
112_K116_V0.5240.50
102_S189_K0.5220.50
41_T199_W0.5180.49
106_A149_D0.5180.49
122_L135_Y0.5170.49
82_L170_F0.5170.49
97_I209_R0.5160.49
206_L209_R0.5140.49
119_S144_V0.5130.48
81_R183_I0.5110.48
48_H190_G0.5090.48
157_I171_A0.5080.48
81_R171_A0.5050.47
97_I166_P0.5050.47
38_P196_L0.5020.47
93_D139_Y0.5000.47
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3j38A 1 0.8745 100 0.14 Contact Map
3j7aC 1 0.8398 100 0.143 Contact Map
4ujpB 1 0.8831 100 0.144 Contact Map
4w23A 1 0.8874 100 0.147 Contact Map
3j60A 1 0.8485 100 0.147 Contact Map
3zeyC 1 0.8745 100 0.15 Contact Map
3bchA 1 0.8485 100 0.153 Contact Map
4bpeB 1 0.8571 100 0.154 Contact Map
3j20B 1 0.8701 100 0.158 Contact Map
1vi6A 2 0.8398 100 0.174 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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