GREMLIN Database
RL18E - 50S ribosomal protein L18e
UniProt: P95990 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 119 (111)
Sequences: 180 (131)
Seq/√Len: 12.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
52_T72_H5.8961.00
28_K32_E3.8600.99
48_I64_V3.3780.98
48_I74_V3.3230.98
49_N71_D3.0950.97
32_E41_P2.6220.92
95_Q105_T2.3750.87
89_I94_G2.3710.87
56_D115_R2.2820.85
99_I102_A1.9860.75
49_N72_H1.9510.74
81_F96_A1.8370.69
15_I18_L1.7830.67
64_V81_F1.7100.64
19_E34_S1.6230.59
46_Y51_H1.6080.59
64_V89_I1.5950.58
102_A114_V1.5560.56
54_P72_H1.5400.55
66_G84_S1.5290.55
55_N59_V1.4930.53
28_K41_P1.4930.53
8_N18_L1.4770.52
25_L116_L1.4120.49
34_S79_L1.3830.47
77_I99_I1.3730.47
59_V96_A1.3670.46
5_G12_R1.3340.45
8_N29_V1.3210.44
20_K40_R1.2620.41
25_L49_N1.2480.40
46_Y50_E1.2450.40
29_V74_V1.2380.40
42_Y60_V1.2380.40
86_I90_R1.2340.40
76_V94_G1.2260.39
108_D111_G1.2140.39
21_S25_L1.2010.38
6_S40_R1.1940.38
102_A108_D1.1910.38
43_I117_M1.1710.37
83_K87_E1.1600.36
48_I51_H1.1540.36
55_N103_L1.1470.36
7_T18_L1.1330.35
16_R19_E1.1130.34
42_Y56_D1.1060.34
51_H81_F1.0760.32
11_V24_P1.0670.32
46_Y69_K1.0580.32
37_S88_K1.0390.31
16_R45_L1.0280.30
74_V81_F1.0200.30
14_L98_S1.0090.29
102_A109_F0.9940.29
23_K109_F0.9810.28
5_G16_R0.9730.28
14_L115_R0.9690.28
10_T14_L0.9620.27
11_V31_E0.9620.27
24_P29_V0.9410.27
47_K79_L0.9360.26
57_I87_E0.9340.26
28_K73_E0.9330.26
20_K80_D0.9230.26
8_N97_M0.9180.26
40_R47_K0.9020.25
78_A81_F0.9000.25
57_I104_E0.8970.25
15_I89_I0.8940.25
40_R79_L0.8890.25
42_Y100_Y0.8850.24
31_E87_E0.8840.24
7_T38_R0.8810.24
36_P47_K0.8600.24
77_I108_D0.8590.23
20_K36_P0.8510.23
74_V86_I0.8450.23
52_T71_D0.8440.23
73_E101_K0.8350.23
43_I112_R0.8340.23
6_S9_I0.8150.22
13_K113_S0.8000.21
77_I102_A0.7990.21
50_E70_L0.7830.21
6_S56_D0.7790.21
8_N63_K0.7790.21
22_K29_V0.7740.20
9_I56_D0.7430.19
13_K31_E0.7390.19
31_E39_K0.7220.19
25_L110_K0.7220.19
45_L80_D0.7210.19
39_K45_L0.7180.19
45_L104_E0.7060.18
49_N70_L0.7010.18
20_K93_G0.6970.18
21_S24_P0.6900.18
86_I113_S0.6870.18
42_Y77_I0.6860.18
54_P73_E0.6810.18
33_L78_A0.6760.17
5_G40_R0.6730.17
101_K110_K0.6640.17
60_V64_V0.6560.17
57_I75_T0.6530.17
94_G114_V0.6520.17
6_S32_E0.6500.17
83_K102_A0.6450.17
13_K20_K0.6420.16
31_E91_A0.6400.16
52_T58_V0.6400.16
6_S16_R0.6350.16
53_K114_V0.6300.16
16_R34_S0.6270.16
12_R16_R0.6250.16
16_R92_S0.6240.16
77_I112_R0.6230.16
90_R113_S0.6220.16
73_E87_E0.6200.16
71_D79_L0.6090.16
47_K55_N0.6090.16
53_K72_H0.6060.15
27_R97_M0.6040.15
19_E96_A0.6020.15
10_T100_Y0.5980.15
53_K104_E0.5980.15
25_L100_Y0.5960.15
60_V117_M0.5930.15
104_E112_R0.5870.15
29_V60_V0.5840.15
50_E67_I0.5710.15
27_R90_R0.5690.14
8_N48_I0.5660.14
35_I58_V0.5640.14
28_K99_I0.5610.14
58_V76_V0.5610.14
14_L100_Y0.5580.14
91_A113_S0.5550.14
112_R116_L0.5550.14
90_R95_Q0.5540.14
72_H75_T0.5530.14
53_K67_I0.5490.14
23_K67_I0.5470.14
87_E104_E0.5450.14
84_S95_Q0.5420.14
52_T115_R0.5370.14
12_R70_L0.5340.14
54_P83_K0.5330.14
99_I109_F0.5270.13
6_S39_K0.5240.13
14_L117_M0.5240.13
15_I33_L0.5190.13
24_P116_L0.5180.13
43_I81_F0.5150.13
45_L57_I0.5140.13
44_N94_G0.5130.13
29_V39_K0.5120.13
70_L80_D0.5080.13
31_E40_R0.5060.13
59_V114_V0.5040.13
44_N88_K0.5020.13
11_V29_V0.5020.13
31_E66_G0.5020.13
54_P98_S0.5010.13
18_L30_A0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3j21P 1 0.9748 100 0.438 Contact Map
1vq8O 1 0.9328 100 0.467 Contact Map
4w20Q 1 0.9832 100 0.469 Contact Map
4ujrD 1 0.9832 100 0.473 Contact Map
3j39Q 1 0.9832 100 0.474 Contact Map
1vx7S 1 0.9832 100 0.476 Contact Map
3j61Q 1 0.9832 100 0.477 Contact Map
3zf7I 1 0.9832 100 0.479 Contact Map
4a17N 1 0.9832 100 0.48 Contact Map
1vq8L 1 0.8151 99.3 0.725 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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