GREMLIN Database
RS4 - 30S ribosomal protein S4
UniProt: P95987 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 181 (167)
Sequences: 613 (357)
Seq/√Len: 27.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
110_V131_I4.5271.00
143_Y149_E3.2901.00
130_H159_S3.1071.00
82_L101_L3.0791.00
166_P169_S2.6761.00
14_P17_P2.5160.99
32_K99_Q2.4390.99
36_R40_E2.4160.99
56_R94_L2.3740.99
31_G120_Y2.2920.98
63_P66_R2.2710.98
109_I153_I2.1850.98
107_Q126_I2.1840.98
78_L147_V2.1570.98
52_R56_R2.0750.97
97_T100_D2.0090.96
30_L41_I1.9770.96
113_K116_S1.9500.96
52_R55_A1.9180.95
83_L93_I1.8810.95
107_Q123_R1.8290.94
133_V143_Y1.8010.93
103_E112_K1.7880.93
89_T124_Q1.7640.93
118_T121_Q1.6800.91
121_Q124_Q1.6730.90
34_G123_R1.6700.90
109_I112_K1.6560.90
90_V106_L1.6140.89
20_K24_G1.6110.89
133_V142_G1.6110.89
14_P34_G1.5890.88
77_L82_L1.5760.87
133_V153_I1.4950.84
6_K9_K1.4440.82
23_I27_Q1.4280.82
89_T92_D1.4190.81
33_Y96_L1.4130.81
16_H19_I1.4090.81
119_I126_I1.3820.79
35_L98_E1.3770.79
107_Q110_V1.3650.79
61_L65_E1.3640.78
58_L69_R1.3550.78
33_Y103_E1.3390.77
34_G40_E1.3250.76
33_Y83_L1.3220.76
6_K10_K1.2790.74
19_I56_R1.2370.71
35_L42_W1.2370.71
41_I97_T1.2330.71
121_Q125_L1.2260.71
20_K131_I1.2190.70
53_H82_L1.2150.70
32_K97_T1.2130.70
64_A72_Q1.1990.69
88_A92_D1.1970.69
36_R39_R1.1870.68
27_Q120_Y1.1610.66
66_R70_E1.1600.66
70_E89_T1.1600.66
41_I45_Q1.1380.65
58_L90_V1.1320.64
23_I36_R1.1160.63
98_E150_E1.1150.63
36_R123_R1.1070.62
35_L40_E1.0970.62
17_P59_L1.0880.61
136_K142_G1.0850.61
108_T119_I1.0810.61
155_Y159_S1.0740.60
109_I151_N1.0720.60
8_R11_W1.0680.60
35_L94_L1.0610.59
7_S127_T1.0550.59
148_D161_F1.0530.59
132_A156_Y1.0490.58
72_Q114_G1.0490.58
163_S167_V1.0420.58
12_E15_G1.0360.57
26_E122_A1.0250.56
17_P26_E1.0200.56
125_L149_E1.0200.56
47_I101_L1.0120.55
16_H22_R1.0020.55
142_G147_V1.0000.55
61_L66_R0.9910.54
101_L150_E0.9900.54
87_T92_D0.9860.53
90_V93_I0.9730.53
93_I96_L0.9720.52
42_W58_L0.9700.52
40_E123_R0.9660.52
119_I125_L0.9660.52
132_A140_S0.9580.51
91_D94_L0.9560.51
4_P171_Q0.9540.51
28_E143_Y0.9530.51
146_N149_E0.9410.50
8_R18_W0.9270.49
55_A71_K0.9090.48
138_V153_I0.9040.47
15_G19_I0.9030.47
5_K10_K0.8930.46
100_D151_N0.8760.45
55_A92_D0.8750.45
134_N154_D0.8730.45
76_K80_M0.8700.45
7_S64_A0.8660.44
14_P55_A0.8600.44
80_M144_I0.8590.44
47_I144_I0.8590.44
66_R134_N0.8580.44
35_L108_T0.8530.43
118_T128_H0.8500.43
147_V151_N0.8470.43
44_A101_L0.8450.43
127_T132_A0.8420.43
51_F83_L0.8370.42
167_V171_Q0.8350.42
132_A152_L0.8310.42
92_D124_Q0.8310.42
22_R35_L0.8270.41
60_A88_A0.8200.41
117_N131_I0.8190.41
113_K151_N0.8150.41
93_I110_V0.8140.41
51_F73_L0.8100.40
110_V115_L0.8090.40
94_L123_R0.7990.39
25_Y45_Q0.7980.39
93_I156_Y0.7980.39
27_Q31_G0.7950.39
53_H57_S0.7930.39
19_I53_H0.7900.39
4_P127_T0.7890.39
13_T138_V0.7830.38
84_K161_F0.7780.38
113_K167_V0.7730.38
16_H37_N0.7710.37
27_Q91_D0.7680.37
75_G79_K0.7670.37
164_R167_V0.7660.37
22_R94_L0.7650.37
34_G124_Q0.7630.37
115_L131_I0.7610.37
20_K73_L0.7590.37
91_D124_Q0.7520.36
64_A90_V0.7430.35
21_E30_L0.7410.35
62_P66_R0.7400.35
155_Y162_K0.7390.35
41_I136_K0.7360.35
49_R53_H0.7320.35
51_F101_L0.7170.34
97_T133_V0.7150.33
102_L111_Y0.7140.33
94_L121_Q0.7080.33
29_L36_R0.7070.33
8_R129_G0.7070.33
34_G38_K0.7060.33
73_L77_L0.7000.32
82_L118_T0.6960.32
14_P24_G0.6960.32
89_T119_I0.6950.32
59_L70_E0.6930.32
14_P123_R0.6930.32
9_K14_P0.6890.32
161_F169_S0.6870.32
19_I25_Y0.6810.31
26_E93_I0.6760.31
6_K18_W0.6730.31
22_R120_Y0.6720.31
119_I124_Q0.6720.31
13_T48_I0.6710.31
48_I98_E0.6700.31
7_S10_K0.6670.30
49_R52_R0.6610.30
108_T145_V0.6610.30
32_K109_I0.6580.30
151_N154_D0.6570.30
51_F93_I0.6540.29
137_R156_Y0.6500.29
134_N155_Y0.6490.29
41_I102_L0.6470.29
42_W49_R0.6460.29
16_H42_W0.6410.29
44_A147_V0.6400.29
52_R96_L0.6390.29
94_L102_L0.6340.28
72_Q76_K0.6330.28
27_Q66_R0.6330.28
106_L153_I0.6300.28
132_A135_G0.6300.28
138_V163_S0.6290.28
165_P169_S0.6280.28
31_G73_L0.6280.28
39_R42_W0.6270.28
37_N96_L0.6250.28
84_K117_N0.6240.28
120_Y124_Q0.6230.28
56_R60_A0.6210.27
56_R79_K0.6200.27
75_G92_D0.6170.27
76_K103_E0.6040.26
30_L86_E0.6030.26
13_T32_K0.6010.26
20_K125_L0.6010.26
62_P65_E0.5980.26
26_E35_L0.5960.26
61_L81_G0.5910.26
61_L112_K0.5910.26
37_N42_W0.5910.26
116_S160_S0.5880.25
129_G137_R0.5790.25
30_L136_K0.5780.25
58_L88_A0.5760.25
37_N56_R0.5720.25
115_L133_V0.5710.24
24_G28_E0.5700.24
39_R96_L0.5660.24
134_N151_N0.5650.24
29_L79_K0.5640.24
103_E154_D0.5620.24
164_R169_S0.5580.24
132_A155_Y0.5550.24
134_N165_P0.5550.24
95_S162_K0.5540.24
56_R59_L0.5540.24
19_I28_E0.5530.23
53_H96_L0.5480.23
67_A70_E0.5410.23
50_K126_I0.5400.23
34_G119_I0.5400.23
55_A121_Q0.5290.22
38_K107_Q0.5240.22
83_L126_I0.5200.22
27_Q64_A0.5190.22
50_K98_E0.5170.22
133_V157_V0.5160.22
79_K84_K0.5150.21
17_P23_I0.5130.21
59_L89_T0.5090.21
42_W48_I0.5090.21
35_L38_K0.5050.21
31_G76_K0.5050.21
134_N152_L0.5030.21
25_Y30_L0.5020.21
19_I49_R0.5000.21
155_Y160_S0.5000.21
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zey6 1 0.989 100 0.339 Contact Map
4bpeD 2 0.9779 100 0.365 Contact Map
3j80J 1 0.989 100 0.378 Contact Map
4ujpK 1 0.9945 100 0.388 Contact Map
3j38J 1 0.9779 100 0.415 Contact Map
3j20D 1 0.9503 100 0.418 Contact Map
3j7aE 1 0.989 100 0.428 Contact Map
3bbnD 1 0.768 98.9 0.822 Contact Map
2cqjA 1 0.3923 98.8 0.826 Contact Map
1c05A 1 0.6851 98.6 0.841 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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