GREMLIN Database
SYY - Tyrosine--tRNA ligase
UniProt: P95982 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 366 (281)
Sequences: 7532 (3557)
Seq/√Len: 212.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
256_S259_D4.7031.00
39_K70_N3.6671.00
346_S349_K3.6531.00
341_E345_K2.8711.00
72_T115_N2.8411.00
62_K66_E2.7831.00
70_N115_N2.7651.00
313_E317_T2.6891.00
315_E319_I2.5361.00
41_Y74_L2.5191.00
318_Y331_T2.5101.00
338_E341_E2.4691.00
95_M99_Y2.3941.00
138_N165_L2.3481.00
102_E351_P2.3201.00
312_E315_E2.2991.00
312_E316_R2.1901.00
261_E265_M2.1441.00
345_K349_K2.1331.00
310_D313_E2.0761.00
67_A113_K2.0601.00
316_R319_I2.0421.00
265_M330_K2.0091.00
142_A165_L1.9761.00
316_R320_E1.9521.00
326_M330_K1.9341.00
255_D259_D1.9271.00
349_K353_F1.9181.00
255_D263_K1.9111.00
257_R337_N1.9031.00
209_V212_H1.8691.00
41_Y76_A1.8041.00
89_D92_L1.7521.00
261_E333_A1.7421.00
109_V114_L1.7391.00
49_L258_E1.7381.00
176_F200_A1.7321.00
264_I336_L1.7321.00
39_K72_T1.6901.00
309_K313_E1.6781.00
107_Y343_I1.6691.00
257_R341_E1.6651.00
344_R348_E1.6641.00
117_V178_L1.6631.00
106_N109_V1.6551.00
162_A166_I1.6411.00
117_V121_D1.6381.00
46_P80_A1.6311.00
311_Y315_E1.6171.00
321_G327_D1.6081.00
313_E316_R1.6061.00
72_T180_L1.6011.00
61_V64_L1.6001.00
309_K317_T1.5981.00
252_F255_D1.5671.00
44_F104_I1.5631.00
105_K350_K1.5481.00
176_F203_M1.5471.00
327_D330_K1.5381.00
141_L162_A1.5201.00
260_V337_N1.5091.00
77_A120_D1.5031.00
110_D113_K1.4901.00
348_E351_P1.4901.00
38_L181_D1.4841.00
272_G281_Q1.4771.00
42_I57_W1.4761.00
277_N281_Q1.4581.00
46_P75_R1.4521.00
127_D130_A1.4471.00
75_R101_V1.4051.00
103_V347_L1.4001.00
333_A337_N1.4001.00
291_Y332_T1.3981.00
317_T331_T1.3911.00
98_D101_V1.3851.00
261_E334_R1.3771.00
172_V196_A1.3771.00
276_N285_Y1.3671.00
190_R214_P1.3621.00
93_I96_A1.3511.00
78_W123_V1.3371.00
200_A208_I1.3211.00
63_D66_E1.3191.00
92_L95_M1.3031.00
347_L351_P1.3001.00
97_A118_D1.2981.00
133_I166_I1.2941.00
314_L318_Y1.2921.00
251_I264_I1.2901.00
138_N142_A1.2891.00
88_G246_K1.2741.00
262_R266_G1.2501.00
308_F317_T1.2441.00
101_V105_K1.2431.00
331_T335_K1.2331.00
277_N280_L1.2331.00
288_F314_L1.2311.00
208_I212_H1.2301.00
260_V340_L1.2271.00
127_D131_L1.2241.00
123_V126_K1.2201.00
275_E278_P1.2161.00
99_Y351_P1.2101.00
294_V335_K1.2061.00
41_Y180_L1.1971.00
62_K65_V1.1931.00
42_I184_L1.1871.00
181_D210_S1.1841.00
277_N295_K1.1821.00
92_L96_A1.1791.00
63_D67_A1.1771.00
118_D121_D1.1641.00
259_D262_R1.1571.00
332_T335_K1.1561.00
324_H327_D1.1551.00
96_A99_Y1.1541.00
125_E178_L1.1471.00
41_Y72_T1.1461.00
310_D331_T1.1451.00
334_R338_E1.1421.00
281_Q284_K1.1371.00
60_K64_L1.1331.00
257_R344_R1.1301.00
95_M98_D1.1291.00
77_A121_D1.1251.00
129_W133_I1.1221.00
61_V65_V1.1181.00
37_K70_N1.1031.00
78_W126_K1.0891.00
261_E337_N1.0831.00
258_E261_E1.0781.00
193_H210_S1.0711.00
39_K180_L1.0641.00
337_N341_E1.0561.00
43_G74_L1.0521.00
123_V127_D1.0511.00
294_V339_I1.0501.00
246_K249_S1.0491.00
44_F57_W1.0481.00
139_A195_L1.0411.00
120_D124_K1.0331.00
162_A169_A1.0301.00
308_F312_E1.0221.00
72_T117_V1.0211.00
277_N285_Y1.0111.00
348_E352_E1.0031.00
44_F58_T0.9981.00
58_T104_I0.9961.00
38_L69_I0.9961.00
335_K338_E0.9951.00
325_P328_L0.9921.00
57_W213_T0.9851.00
99_Y103_V0.9691.00
100_A104_I0.9661.00
60_K339_I0.9661.00
44_F50_F0.9591.00
98_D102_E0.9591.00
93_I97_A0.9551.00
128_Y170_M0.9551.00
342_P345_K0.9541.00
84_D88_G0.9541.00
94_K98_D0.9491.00
138_N202_K0.9471.00
288_F311_Y0.9450.99
198_D201_E0.9440.99
327_D331_T0.9430.99
312_E319_I0.9200.99
179_D210_S0.9200.99
56_I293_F0.9090.99
330_K334_R0.9090.99
179_D204_G0.9080.99
318_Y321_G0.9080.99
43_G76_A0.9060.99
218_G221_G0.9000.99
272_G275_E0.8970.99
317_T320_E0.8970.99
56_I294_V0.8910.99
96_A103_V0.8900.99
288_F292_N0.8900.99
91_N95_M0.8890.99
218_G222_G0.8860.99
307_E310_D0.8860.99
349_K352_E0.8830.99
50_F104_I0.8820.99
40_G61_V0.8820.99
318_Y328_L0.8790.99
201_E205_K0.8780.99
337_N344_R0.8780.99
40_G64_L0.8690.99
74_L117_V0.8680.99
335_K339_I0.8650.99
64_L182_I0.8640.99
218_G249_S0.8630.99
50_F100_A0.8630.99
261_E330_K0.8570.99
200_A204_G0.8540.99
54_W58_T0.8490.99
345_K348_E0.8470.99
265_M333_A0.8460.99
350_K353_F0.8390.99
176_F204_G0.8380.99
91_N94_K0.8350.99
265_M326_M0.8330.99
311_Y314_L0.8300.99
289_P292_N0.8270.99
44_F59_Q0.8260.99
130_A134_K0.8250.99
64_L68_G0.8230.99
307_E335_K0.8220.99
337_N340_L0.8220.99
138_N147_A0.8210.99
253_V340_L0.8210.99
202_K206_K0.8200.99
273_V324_H0.8170.99
101_V104_I0.8170.99
95_M103_V0.8160.99
137_K140_S0.8150.99
61_V66_E0.8140.98
77_A97_A0.8110.98
49_L99_Y0.8110.98
256_S348_E0.8070.98
38_L182_I0.8060.98
190_R216_L0.8020.98
175_I196_A0.7950.98
145_K149_T0.7940.98
139_A143_R0.7940.98
318_Y325_P0.7940.98
136_A199_V0.7930.98
210_S213_T0.7910.98
77_A118_D0.7900.98
49_L96_A0.7900.98
38_L68_G0.7880.98
275_E280_L0.7860.98
59_Q107_Y0.7850.98
110_D114_L0.7850.98
288_F315_E0.7820.98
209_V213_T0.7810.98
111_V114_L0.7780.98
62_K104_I0.7770.98
254_N347_L0.7760.98
214_P217_V0.7740.98
292_N295_K0.7730.98
106_N110_D0.7730.98
290_R293_F0.7680.98
49_L252_F0.7630.98
308_F311_Y0.7630.98
135_V199_V0.7630.98
281_Q285_Y0.7610.98
310_D314_L0.7610.98
342_P346_S0.7520.97
132_V169_A0.7410.97
324_H328_L0.7390.97
94_K97_A0.7390.97
222_G246_K0.7340.97
141_L169_A0.7300.97
182_I215_L0.7300.97
128_Y131_L0.7220.97
176_F199_V0.7190.97
100_A103_V0.7190.97
308_F314_L0.7100.96
93_I101_V0.7080.96
62_K73_L0.7060.96
315_E318_Y0.7010.96
134_K163_S0.7000.96
334_R337_N0.6990.96
71_M114_L0.6960.96
140_S202_K0.6950.96
291_Y335_K0.6940.96
93_I103_V0.6930.96
217_V221_G0.6920.96
55_L60_K0.6910.96
257_R261_E0.6900.96
279_I285_Y0.6900.96
211_I214_P0.6900.96
287_I290_R0.6870.96
283_L315_E0.6860.96
284_K315_E0.6860.96
292_N311_Y0.6850.96
246_K250_A0.6810.96
285_Y318_Y0.6790.95
44_F62_K0.6790.95
291_Y328_L0.6770.95
140_S143_R0.6760.95
341_E344_R0.6760.95
283_L332_T0.6760.95
133_I161_D0.6740.95
292_N314_L0.6710.95
54_W57_W0.6710.95
268_Y283_L0.6680.95
128_Y173_S0.6640.95
39_K179_D0.6640.95
123_V173_S0.6640.95
154_R160_I0.6630.95
217_V222_G0.6610.95
264_I268_Y0.6580.95
49_L254_N0.6540.94
151_M154_R0.6520.94
94_K101_V0.6500.94
309_K314_L0.6470.94
295_K307_E0.6470.94
147_A194_M0.6430.94
115_N118_D0.6400.94
70_N113_K0.6380.94
149_T153_R0.6380.94
45_E100_A0.6330.93
64_L67_A0.6330.93
253_V343_I0.6320.93
207_K210_S0.6320.93
50_F54_W0.6320.93
149_T152_G0.6310.93
102_E105_K0.6300.93
331_T334_R0.6290.93
166_I169_A0.6260.93
128_Y132_V0.6260.93
52_I336_L0.6260.93
261_E264_I0.6260.93
123_V170_M0.6250.93
207_K212_H0.6250.93
281_Q295_K0.6230.93
74_L178_L0.6200.93
125_E177_Y0.6200.93
312_E320_E0.6190.93
99_Y347_L0.6180.93
309_K312_E0.6170.93
42_I62_K0.6130.92
336_L339_I0.6130.92
143_R198_D0.6120.92
321_G324_H0.6120.92
93_I100_A0.6120.92
307_E312_E0.6090.92
69_I182_I0.6060.92
96_A100_A0.6050.92
187_T222_G0.6040.92
148_L152_G0.6040.92
101_V116_I0.6010.92
258_E262_R0.5990.91
65_V71_M0.5990.91
275_E285_Y0.5980.91
310_D335_K0.5940.91
169_A199_V0.5900.91
264_I332_T0.5900.91
108_G111_V0.5900.91
52_I294_V0.5870.91
133_I162_A0.5870.91
49_L95_M0.5860.91
280_L285_Y0.5850.90
141_L165_L0.5830.90
257_R340_L0.5790.90
251_I267_A0.5780.90
171_Q196_A0.5770.90
73_L104_I0.5750.90
252_F263_K0.5740.90
339_I343_I0.5730.90
201_E207_K0.5720.89
36_E181_D0.5710.89
60_K63_D0.5710.89
330_K333_A0.5690.89
129_W166_I0.5690.89
346_S350_K0.5660.89
183_A193_H0.5650.89
172_V199_V0.5650.89
179_D206_K0.5620.89
40_G182_I0.5590.88
103_V254_N0.5570.88
194_M197_R0.5540.88
262_R265_M0.5530.88
154_R159_E0.5530.88
102_E347_L0.5500.88
311_Y318_Y0.5480.87
78_W131_L0.5470.87
105_K111_V0.5460.87
42_I73_L0.5450.87
269_C287_I0.5440.87
288_F318_Y0.5420.87
203_M208_I0.5420.87
162_A165_L0.5410.87
340_L344_R0.5410.87
280_L288_F0.5380.86
137_K161_D0.5370.86
105_K116_I0.5370.86
315_E320_E0.5350.86
317_T321_G0.5340.86
208_I213_T0.5340.86
133_I169_A0.5320.86
314_L320_E0.5320.86
147_A151_M0.5300.86
172_V176_F0.5270.85
278_P285_Y0.5270.85
307_E314_L0.5260.85
108_G112_G0.5260.85
282_I285_Y0.5250.85
276_N289_P0.5250.85
200_A203_M0.5240.85
140_S198_D0.5240.85
276_N280_L0.5210.85
288_F328_L0.5200.85
47_S104_I0.5190.84
287_I291_Y0.5180.84
242_M267_A0.5170.84
40_G184_L0.5170.84
133_I159_E0.5170.84
136_A139_A0.5130.84
209_V214_P0.5130.84
208_I211_I0.5130.84
93_I99_Y0.5120.84
201_E211_I0.5110.83
140_S159_E0.5100.83
292_N308_F0.5100.83
146_R194_M0.5100.83
104_I116_I0.5090.83
195_L199_V0.5090.83
47_S51_H0.5070.83
129_W162_A0.5070.83
344_R347_L0.5050.83
88_G245_S0.5050.83
65_V114_L0.5030.83
108_G113_K0.5020.82
217_V220_Q0.5010.82
136_A166_I0.5010.82
44_F54_W0.5010.82
328_L331_T0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2cycA 2 0.9508 100 0.188 Contact Map
3vgjA 2 0.9508 100 0.195 Contact Map
2cyaA 2 0.8934 100 0.198 Contact Map
1n3lA 2 0.8989 100 0.219 Contact Map
2dlcX 2 0.888 100 0.227 Contact Map
3p0jA 1 0.9317 100 0.232 Contact Map
3prhA 2 0.7842 100 0.242 Contact Map
3sz3A 2 0.8415 100 0.253 Contact Map
1h3fA 2 0.8361 100 0.255 Contact Map
3n9iA 2 0.8251 100 0.256 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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