GREMLIN Database
DNAG - DNA primase DnaG
UniProt: P95980 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 406 (385)
Sequences: 180 (125)
Seq/√Len: 6.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
217_A232_L4.7650.98
219_L226_D3.5090.90
171_L230_K3.4930.89
40_F113_L3.1940.84
325_G343_I3.1490.83
178_A258_E2.9950.80
207_N212_K2.9220.78
322_T361_D2.8960.78
249_R258_E2.8810.77
216_I266_M2.7120.73
362_G367_R2.6980.72
364_I382_G2.6780.72
24_V161_A2.5830.69
366_Q370_D2.5680.68
24_V195_E2.5180.67
229_L242_V2.4960.66
13_F58_V2.4780.65
8_D117_I2.3850.62
369_L395_V2.3550.61
83_I201_I2.3270.60
312_I328_Y2.3090.60
315_E326_V2.2800.59
121_K149_G2.2760.58
19_V159_L2.2700.58
215_V219_L2.2580.58
116_I158_R2.2550.58
360_F380_I2.2220.56
116_I365_T2.2090.56
16_E145_A2.1570.54
241_F249_R2.1420.54
64_K72_P2.1400.53
128_S250_E2.1370.53
67_G86_M2.1260.53
366_Q392_P2.1140.53
370_D392_P2.0900.52
135_I142_I2.0130.49
61_K99_K2.0110.49
74_N139_I2.0050.49
10_R147_K1.9730.47
321_G361_D1.9720.47
99_K255_T1.9550.47
73_S78_I1.9520.47
195_E232_L1.9240.46
207_N242_V1.8370.42
65_S355_V1.8200.42
19_V195_E1.8080.41
147_K223_H1.8060.41
365_T382_G1.7800.40
13_F100_F1.7770.40
138_V243_A1.7710.40
325_G338_V1.7690.40
217_A239_I1.7560.40
325_G347_L1.7540.39
217_A229_L1.7420.39
257_K261_K1.7400.39
170_N216_I1.7400.39
128_S256_G1.6940.37
71_I165_V1.6550.36
197_A234_S1.6460.36
245_A254_L1.6380.36
173_I201_I1.6370.35
19_V229_L1.6320.35
98_S151_I1.6290.35
372_A386_G1.6290.35
16_E254_L1.6190.35
271_Q360_F1.6070.34
161_A229_L1.5470.33
74_N328_Y1.5370.32
173_I230_K1.5210.32
149_G200_R1.5200.32
98_S122_G1.5160.32
30_G184_L1.5120.31
224_G241_F1.5090.31
195_E229_L1.5090.31
44_E48_K1.5010.31
102_L397_I1.5000.31
37_G105_I1.4930.31
11_L161_A1.4870.31
75_L135_I1.4780.30
214_T266_M1.4770.30
37_G197_A1.4710.30
63_G189_K1.4690.30
312_I332_W1.4650.30
182_N257_K1.4560.30
145_A380_I1.4450.29
19_V193_A1.4340.29
239_I322_T1.4210.29
367_R399_T1.4160.28
24_V242_V1.4140.28
362_G384_R1.4100.28
42_L172_I1.3970.28
77_R132_S1.3870.28
329_D340_V1.3840.28
9_I169_P1.3780.27
34_N168_D1.3760.27
16_E381_I1.3740.27
12_R185_R1.3730.27
11_L239_I1.3720.27
181_I200_R1.3500.27
105_I191_V1.3390.26
369_L397_I1.3310.26
142_I267_M1.3300.26
271_Q382_G1.3220.26
96_Y188_Y1.3180.26
65_S77_R1.3120.25
143_S315_E1.3090.25
16_E382_G1.3050.25
83_I144_S1.3040.25
137_E241_F1.3000.25
90_V227_L1.2990.25
318_K322_T1.2980.25
93_V116_I1.2850.25
39_E249_R1.2780.25
122_G207_N1.2650.24
51_L165_V1.2640.24
11_L100_F1.2620.24
68_E81_A1.2590.24
323_L384_R1.2540.24
39_E121_K1.2410.24
194_V234_S1.2330.23
367_R372_A1.2310.23
197_A216_I1.2300.23
362_G386_G1.2260.23
315_E318_K1.2220.23
341_R365_T1.2180.23
40_F48_K1.2180.23
107_D240_D1.2130.23
81_A157_E1.2110.23
86_M382_G1.2100.23
323_L365_T1.2090.23
69_I134_D1.2070.23
96_Y216_I1.2070.23
116_I400_F1.2050.23
188_Y260_A1.2020.23
66_E253_E1.2000.22
329_D399_T1.1870.22
71_I311_N1.1860.22
259_I265_N1.1860.22
323_L341_R1.1850.22
323_L361_D1.1850.22
329_D372_A1.1840.22
326_V337_K1.1830.22
15_V96_Y1.1770.22
141_E153_E1.1680.22
16_E226_D1.1650.22
36_F123_I1.1640.22
381_I399_T1.1580.21
21_K250_E1.1550.21
180_V191_V1.1550.21
369_L391_R1.1550.21
58_V236_N1.1530.21
96_Y197_A1.1480.21
329_D333_N1.1480.21
37_G146_V1.1420.21
165_V185_R1.1420.21
319_L338_V1.1370.21
92_K234_S1.1370.21
341_R360_F1.1370.21
25_I58_V1.1360.21
55_I99_K1.1340.21
82_L139_I1.1330.21
117_I382_G1.1280.21
173_I239_I1.1250.21
13_F227_L1.1240.21
93_V232_L1.1230.21
78_I397_I1.1200.21
34_N138_V1.1170.20
340_V346_K1.1170.20
48_K59_K1.1070.20
328_Y332_W1.1070.20
70_I141_E1.1060.20
166_D213_K1.1060.20
164_D247_I1.1060.20
28_I253_E1.1030.20
162_G246_P1.1020.20
123_I230_K1.0980.20
151_I181_I1.0910.20
164_D170_N1.0910.20
34_N223_H1.0870.20
137_E258_E1.0860.20
229_L342_D1.0830.20
134_D213_K1.0780.20
122_G205_L1.0770.19
349_A377_I1.0720.19
163_P224_G1.0660.19
20_E230_K1.0630.19
40_F135_I1.0620.19
55_I256_G1.0540.19
206_I253_E1.0450.19
133_L137_E1.0450.19
188_Y194_V1.0350.19
81_A191_V1.0330.19
206_I209_S1.0260.18
244_R382_G1.0220.18
201_I346_K1.0180.18
55_I113_L1.0170.18
77_R97_N1.0130.18
337_K389_N1.0110.18
213_K258_E1.0110.18
82_L127_W1.0050.18
55_I81_A1.0010.18
102_L374_Q0.9990.18
117_I242_V0.9970.18
39_E104_E0.9960.18
137_E340_V0.9960.18
5_M260_A0.9960.18
69_I212_K0.9950.18
77_R258_E0.9920.18
49_G182_N0.9900.18
93_V195_E0.9890.18
100_F371_L0.9870.18
74_N96_Y0.9860.17
362_G399_T0.9820.17
209_S259_I0.9760.17
347_L372_A0.9750.17
159_L255_T0.9730.17
370_D390_K0.9720.17
22_T237_V0.9700.17
5_M61_K0.9660.17
297_S351_E0.9620.17
331_N368_L0.9620.17
363_V384_R0.9580.17
25_I67_G0.9560.17
123_I249_R0.9510.17
34_N169_P0.9480.17
96_Y164_D0.9440.17
294_P297_S0.9420.17
294_P303_V0.9400.17
233_L375_K0.9400.17
118_E242_V0.9390.17
82_L90_V0.9370.16
319_L372_A0.9360.16
25_I242_V0.9350.16
157_E380_I0.9340.16
56_V231_E0.9290.16
116_I387_G0.9270.16
116_I255_T0.9250.16
173_I264_S0.9250.16
373_S395_V0.9190.16
64_K69_I0.9170.16
50_R321_G0.9150.16
160_P202_P0.9050.16
91_D382_G0.9020.16
86_M188_Y0.9010.16
83_I234_S0.9010.16
72_P362_G0.8990.16
4_Q10_R0.8980.16
46_Q73_S0.8920.16
224_G266_M0.8910.16
8_D331_N0.8880.16
193_A229_L0.8840.15
343_I364_I0.8820.15
121_K217_A0.8800.15
39_E192_I0.8800.15
147_K197_A0.8780.15
269_L334_L0.8730.15
229_L232_L0.8710.15
20_E195_E0.8670.15
343_I360_F0.8670.15
18_I339_Q0.8670.15
40_F189_K0.8660.15
143_S369_L0.8620.15
60_T264_S0.8620.15
10_R128_S0.8610.15
24_V65_S0.8590.15
48_K74_N0.8560.15
165_V350_Y0.8510.15
20_E83_I0.8480.15
77_R173_I0.8480.15
160_P380_I0.8470.15
62_G397_I0.8440.15
82_L181_I0.8430.15
367_R386_G0.8420.15
302_Q376_N0.8370.15
113_L266_M0.8350.15
250_E253_E0.8340.15
5_M47_D0.8330.14
63_G96_Y0.8320.14
192_I204_T0.8310.14
39_E57_E0.8290.14
72_P250_E0.8290.14
48_K113_L0.8250.14
214_T390_K0.8240.14
41_D390_K0.8230.14
96_Y234_S0.8200.14
342_D380_I0.8200.14
143_S377_I0.8200.14
102_L138_V0.8140.14
48_K69_I0.8130.14
258_E270_T0.8130.14
21_K241_F0.8130.14
321_G360_F0.8120.14
138_V169_P0.8110.14
13_F327_L0.8100.14
11_L102_L0.8080.14
92_K96_Y0.8070.14
137_E178_A0.8060.14
324_E337_K0.8060.14
83_I128_S0.8060.14
72_P182_N0.8050.14
148_V154_Y0.8020.14
201_I282_A0.7990.14
294_P305_Q0.7990.14
358_I369_L0.7970.14
61_K66_E0.7970.14
319_L375_K0.7940.14
91_D138_V0.7920.14
164_D213_K0.7910.14
92_K384_R0.7910.14
74_N121_K0.7910.14
261_K265_N0.7910.14
216_I236_N0.7880.14
70_I153_E0.7870.14
100_F342_D0.7860.14
192_I380_I0.7830.14
59_K71_I0.7820.14
77_R178_A0.7810.14
341_R347_L0.7810.14
47_D55_I0.7810.14
195_E265_N0.7800.14
195_E358_I0.7800.14
100_F325_G0.7800.14
232_L347_L0.7800.14
15_V234_S0.7790.14
116_I316_I0.7790.14
385_I398_L0.7720.13
91_D243_A0.7710.13
186_Y259_I0.7710.13
10_R68_E0.7700.13
130_E365_T0.7700.13
22_T67_G0.7690.13
113_L234_S0.7690.13
16_E77_R0.7680.13
83_I370_D0.7670.13
320_P390_K0.7650.13
277_Q318_K0.7620.13
347_L355_V0.7610.13
366_Q390_K0.7600.13
44_E384_R0.7600.13
92_K266_M0.7590.13
215_V337_K0.7570.13
134_D365_T0.7570.13
169_P239_I0.7560.13
42_L82_L0.7550.13
233_L269_L0.7550.13
19_V255_T0.7540.13
84_A93_V0.7530.13
324_E368_L0.7480.13
169_P253_E0.7440.13
166_D191_V0.7430.13
93_V366_Q0.7400.13
41_D150_E0.7400.13
292_E295_I0.7380.13
85_A180_V0.7380.13
47_D81_A0.7370.13
8_D219_L0.7360.13
132_S259_I0.7360.13
86_M96_Y0.7300.13
121_K232_L0.7260.13
128_S147_K0.7240.13
122_G377_I0.7240.13
106_E184_L0.7240.13
19_V122_G0.7200.13
161_A193_A0.7190.13
123_I127_W0.7150.12
157_E317_K0.7130.12
64_K124_L0.7090.12
236_N376_N0.7080.12
329_D367_R0.7050.12
39_E69_I0.7040.12
113_L264_S0.7020.12
115_K219_L0.6990.12
343_I348_E0.6980.12
189_K234_S0.6970.12
99_K330_N0.6960.12
173_I365_T0.6940.12
82_L106_E0.6940.12
244_R366_Q0.6940.12
113_L197_A0.6940.12
93_V178_A0.6930.12
16_E397_I0.6910.12
253_E355_V0.6900.12
209_S257_K0.6900.12
25_I86_M0.6900.12
245_A306_I0.6880.12
329_D397_I0.6840.12
53_R107_D0.6830.12
106_E113_L0.6780.12
4_Q147_K0.6770.12
118_E351_E0.6760.12
50_R212_K0.6750.12
16_E347_L0.6740.12
117_I142_I0.6720.12
205_L277_Q0.6710.12
164_D189_K0.6710.12
124_L395_V0.6710.12
96_Y189_K0.6700.12
64_K343_I0.6700.12
233_L259_I0.6680.12
69_I255_T0.6670.12
192_I290_K0.6660.12
86_M135_I0.6660.12
213_K343_I0.6620.12
150_E271_Q0.6620.12
39_E359_I0.6610.12
371_L387_G0.6580.12
138_V293_K0.6580.12
117_I315_E0.6570.12
240_D248_G0.6570.12
117_I267_M0.6560.12
46_Q230_K0.6560.12
171_L334_L0.6560.12
166_D365_T0.6550.12
22_T48_K0.6540.12
39_E71_I0.6530.12
86_M137_E0.6530.12
113_L135_I0.6520.11
250_E326_V0.6510.11
60_T236_N0.6500.11
63_G194_V0.6460.11
101_E239_I0.6460.11
96_Y194_V0.6450.11
292_E330_N0.6440.11
130_E178_A0.6440.11
245_A367_R0.6420.11
92_K188_Y0.6420.11
347_L386_G0.6410.11
21_K203_E0.6410.11
277_Q283_I0.6410.11
200_R395_V0.6400.11
239_I296_Q0.6390.11
204_T400_F0.6390.11
325_G380_I0.6390.11
74_N136_K0.6360.11
325_G345_P0.6320.11
152_T338_V0.6290.11
83_I148_V0.6290.11
25_I136_K0.6290.11
201_I355_V0.6240.11
73_S173_I0.6240.11
157_E161_A0.6240.11
54_I310_Q0.6230.11
365_T399_T0.6220.11
86_M216_I0.6220.11
298_E302_Q0.6210.11
68_E219_L0.6190.11
223_H377_I0.6180.11
80_T162_G0.6160.11
243_A382_G0.6150.11
298_E364_I0.6150.11
217_A328_Y0.6140.11
38_D65_S0.6120.11
358_I371_L0.6120.11
96_Y170_N0.6110.11
206_I257_K0.6110.11
50_R150_E0.6080.11
106_E189_K0.6080.11
57_E154_Y0.6070.11
82_L142_I0.6060.11
21_K247_I0.6060.11
148_V152_T0.6040.11
22_T39_E0.6020.11
74_N332_W0.6020.11
134_D178_A0.6010.11
90_V147_K0.6000.11
123_I375_K0.6000.11
254_L365_T0.5970.11
44_E149_G0.5960.11
22_T127_W0.5950.11
58_V71_I0.5950.11
122_G368_L0.5940.11
169_P392_P0.5940.11
365_T391_R0.5940.11
92_K216_I0.5920.11
293_K335_I0.5920.11
50_R68_E0.5920.11
47_D74_N0.5920.11
186_Y209_S0.5910.11
142_I359_I0.5910.11
367_R382_G0.5910.11
137_E165_V0.5900.11
173_I215_V0.5880.11
238_K264_S0.5880.11
272_Y290_K0.5870.11
96_Y143_S0.5860.11
300_T305_Q0.5850.11
134_D215_V0.5850.11
368_L378_K0.5830.11
373_S377_I0.5830.11
241_F395_V0.5830.11
15_V227_L0.5820.10
192_I317_K0.5820.10
154_Y166_D0.5820.10
245_A399_T0.5810.10
51_L368_L0.5810.10
295_I303_V0.5800.10
18_I60_T0.5800.10
390_K397_I0.5800.10
191_V226_D0.5790.10
321_G342_D0.5760.10
11_L377_I0.5740.10
101_E146_V0.5740.10
28_I44_E0.5730.10
133_L136_K0.5720.10
62_G140_N0.5710.10
143_S216_I0.5710.10
147_K178_A0.5710.10
368_L376_N0.5690.10
16_E61_K0.5680.10
125_S327_L0.5680.10
41_D234_S0.5670.10
18_I67_G0.5660.10
249_R337_K0.5660.10
241_F384_R0.5630.10
80_T124_L0.5630.10
25_I197_A0.5630.10
19_V161_A0.5620.10
241_F358_I0.5600.10
51_L369_L0.5600.10
122_G140_N0.5580.10
44_E73_S0.5560.10
41_D392_P0.5560.10
249_R380_I0.5560.10
40_F197_A0.5560.10
40_F89_S0.5550.10
57_E130_E0.5550.10
150_E181_I0.5540.10
158_R203_E0.5530.10
86_M214_T0.5530.10
113_L256_G0.5500.10
4_Q77_R0.5480.10
321_G375_K0.5480.10
166_D374_Q0.5470.10
85_A218_F0.5450.10
194_V209_S0.5440.10
132_S137_E0.5440.10
47_D382_G0.5430.10
65_S319_L0.5430.10
161_A262_A0.5430.10
329_D386_G0.5410.10
65_S78_I0.5390.10
215_V386_G0.5390.10
241_F266_M0.5390.10
164_D191_V0.5360.10
67_G217_A0.5350.10
344_I382_G0.5320.10
341_R382_G0.5310.10
333_N363_V0.5300.10
50_R145_A0.5300.10
57_E249_R0.5300.10
50_R210_K0.5290.10
161_A204_T0.5250.10
44_E393_Q0.5230.10
318_K344_I0.5230.10
372_A382_G0.5230.10
219_L269_L0.5210.10
72_P244_R0.5180.10
71_I86_M0.5180.10
189_K214_T0.5170.10
113_L189_K0.5160.10
212_K242_V0.5150.10
13_F25_I0.5150.10
307_T314_E0.5130.10
323_L363_V0.5120.10
106_E234_S0.5110.10
244_R250_E0.5110.10
216_I326_V0.5100.10
188_Y384_R0.5090.10
312_I337_K0.5080.10
68_E125_S0.5080.10
171_L264_S0.5070.10
270_T303_V0.5060.09
295_I347_L0.5060.09
361_D381_I0.5050.09
128_S223_H0.5040.09
207_N210_K0.5020.09
131_K219_L0.5000.09
112_K121_K0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2fcjA 2 0.2759 99.8 0.885 Contact Map
1t6t1 2 0.2709 99.3 0.921 Contact Map
4edgA 1 0.6108 98.3 0.945 Contact Map
1dd9A 1 0.5788 98.1 0.948 Contact Map
2au3A 1 0.6404 98 0.949 Contact Map
1nuiA 1 0.4631 78.7 0.974 Contact Map
1y02A 1 0.0837 41.3 0.98 Contact Map
1vddA 7 0.4335 27.3 0.982 Contact Map
3ir9A 2 0.3571 26.4 0.982 Contact Map
1q57A 3 0.665 25.6 0.982 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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