GREMLIN Database
DPOL3 - DNA polymerase 3
UniProt: P95979 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 764 (687)
Sequences: 1999 (1153)
Seq/√Len: 44.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
559_I563_N8.5011.00
559_I566_Y7.2031.00
563_N566_Y7.1561.00
413_K536_D5.5371.00
614_N652_E5.4671.00
308_P344_L5.3881.00
642_K647_E5.1331.00
192_M218_F4.7071.00
559_I562_I4.1661.00
189_I243_I4.1571.00
638_S642_K3.9531.00
557_E561_K3.9141.00
317_E320_R3.7601.00
466_S474_D3.6851.00
320_R324_N3.6611.00
87_T96_C3.5891.00
562_I566_Y3.5471.00
556_N559_I3.3361.00
43_Y123_D3.2951.00
643_L653_L3.2641.00
222_I230_I3.2101.00
73_R388_G3.2101.00
171_V218_F3.1711.00
210_D213_K3.1381.00
709_P712_L3.0781.00
206_D217_R3.0391.00
453_S456_I2.9171.00
558_L566_Y2.9091.00
615_I639_T2.9091.00
208_G217_R2.8701.00
618_K622_E2.7791.00
527_I531_K2.7181.00
72_K81_D2.6981.00
211_D246_R2.6641.00
79_I84_L2.6201.00
308_P337_E2.6161.00
239_P338_N2.5231.00
217_R220_D2.4891.00
706_R720_D2.4661.00
361_G382_R2.4651.00
212_L216_R2.4611.00
558_L563_N2.4261.00
695_V719_I2.4251.00
457_S460_K2.4231.00
387_S471_T2.4111.00
318_I322_W2.4091.00
708_E712_L2.4081.00
317_E321_Y2.3881.00
226_D258_R2.3801.00
72_K79_I2.3791.00
166_L229_I2.3641.00
683_G686_I2.3421.00
634_K638_S2.3401.00
234_D239_P2.2981.00
556_N563_N2.2861.00
722_E726_D2.2591.00
556_N566_Y2.2421.00
377_E505_R2.2181.00
337_E340_R2.2141.00
561_K565_L2.2131.00
383_T475_E2.2111.00
302_N309_S2.2031.00
576_Y597_D2.1581.00
558_L562_I2.1291.00
474_D478_N2.1291.00
232_V235_S2.0870.99
696_I723_Y2.0470.99
702_P705_D2.0350.99
696_I707_A2.0320.99
558_L565_L2.0220.99
383_T386_K2.0200.99
258_R277_R1.9910.99
617_R621_E1.9710.99
644_R722_E1.9690.99
226_D277_R1.9680.99
742_N745_S1.9490.99
560_T564_S1.9420.99
46_I85_I1.9290.99
229_I350_L1.9210.99
678_K712_L1.9140.99
318_I321_Y1.8800.99
467_G470_K1.8490.99
674_T678_K1.8340.99
193_S339_A1.8250.99
588_A601_K1.8170.98
174_Q338_N1.8100.98
422_V546_F1.8060.98
90_P93_I1.7940.98
172_D334_Y1.7920.98
69_T84_L1.7860.98
452_Y456_I1.7790.98
556_N560_T1.7670.98
79_I82_A1.7650.98
621_E625_I1.7570.98
642_K648_F1.7530.98
320_R323_D1.7520.98
379_S491_L1.7450.98
294_H299_D1.7360.98
656_W691_K1.7290.98
437_N442_T1.7200.98
318_I324_N1.7110.98
79_I85_I1.7080.98
556_N562_I1.6940.98
317_E322_W1.6810.97
525_F528_D1.6790.97
67_Q86_Q1.6780.97
496_N512_A1.6760.97
301_S341_S1.6750.97
559_I565_L1.6570.97
125_D386_K1.6480.97
239_P310_R1.6470.97
169_I194_L1.6400.97
173_F192_M1.6310.97
168_T229_I1.6260.97
635_L639_T1.6240.97
170_G342_I1.6240.97
310_R338_N1.6140.97
174_Q239_P1.6110.97
234_D238_L1.6040.97
338_N516_D1.5910.96
641_I645_R1.5870.96
458_N461_F1.5860.96
602_G734_K1.5860.96
219_V223_L1.5770.96
698_K718_R1.5770.96
536_D548_T1.5730.96
321_Y325_E1.5670.96
618_K621_E1.5650.96
436_F522_I1.5620.96
174_Q310_R1.5510.96
74_K79_I1.5500.96
426_S571_K1.5410.96
457_S461_F1.5400.96
245_E248_S1.5350.96
172_D338_N1.5350.96
90_P116_Y1.5280.95
710_F713_V1.5140.95
469_Y499_V1.5130.95
604_E672_F1.5120.95
682_S686_I1.5110.95
437_N467_G1.5100.95
208_G214_I1.5050.95
452_Y455_P1.4990.95
314_K318_I1.4890.95
477_S492_I1.4880.95
41_R67_Q1.4820.95
234_D283_T1.4710.94
406_K409_I1.4710.94
554_K557_E1.4680.94
628_D631_K1.4670.94
629_V632_A1.4630.94
340_R344_L1.4600.94
540_A544_L1.4430.94
311_Y333_E1.4400.94
710_F714_K1.4310.94
265_S269_Y1.4290.94
583_D735_L1.4270.93
42_P111_D1.4220.93
90_P94_K1.4130.93
512_A519_S1.4110.93
293_G613_R1.4110.93
169_I222_I1.4030.93
454_S460_K1.3950.93
116_Y123_D1.3920.93
615_I635_L1.3910.93
126_L250_L1.3880.93
574_I597_D1.3850.92
561_K564_S1.3750.92
476_L488_I1.3720.92
609_C727_Q1.3660.92
574_I589_G1.3650.92
174_Q238_L1.3640.92
384_A441_D1.3620.92
238_L338_N1.3540.92
384_A468_L1.3530.92
234_D338_N1.3530.92
312_S338_N1.3450.91
172_D239_P1.3450.91
659_I673_V1.3430.91
78_N85_I1.3360.91
189_I194_L1.3330.91
169_I218_F1.3310.91
191_V194_L1.3260.91
321_Y324_N1.3210.91
50_G72_K1.3210.91
422_V589_G1.3040.90
356_L487_V1.3030.90
409_I584_N1.2970.90
265_S270_G1.2910.89
119_R123_D1.2910.89
442_T467_G1.2890.89
174_Q334_Y1.2870.89
622_E631_K1.2850.89
406_K516_D1.2830.89
541_N585_N1.2830.89
292_L300_V1.2810.89
459_Y462_K1.2770.89
228_D277_R1.2770.89
460_K463_R1.2630.88
317_E324_N1.2580.88
662_D665_E1.2540.88
191_V332_R1.2540.88
282_L342_I1.2520.88
174_Q234_D1.2490.88
580_L588_A1.2420.88
588_A624_L1.2370.87
657_A694_Y1.2370.87
130_T153_D1.2350.87
173_F234_D1.2340.87
522_I526_I1.2340.87
577_K594_D1.2330.87
533_S561_K1.2330.87
152_L155_I1.2300.87
43_Y119_R1.2240.87
310_R341_S1.2220.87
455_P460_K1.2220.87
353_Y364_L1.2210.87
320_R325_E1.2040.86
172_D310_R1.2000.86
73_R390_L1.1960.86
212_L250_L1.1890.85
234_D310_R1.1860.85
46_I109_I1.1790.85
618_K635_L1.1790.85
381_I391_I1.1770.85
298_I309_S1.1760.85
310_R334_Y1.1760.85
136_V139_V1.1740.84
314_K317_E1.1740.84
670_L673_V1.1730.84
425_I431_L1.1700.84
79_I83_L1.1650.84
732_T736_L1.1650.84
480_R485_I1.1650.84
558_L561_K1.1630.84
265_S268_T1.1620.84
47_I110_F1.1580.84
404_I409_I1.1560.83
317_E325_E1.1510.83
109_I112_A1.1490.83
427_S490_E1.1480.83
296_D301_S1.1460.83
132_F136_V1.1440.83
530_I558_L1.1370.82
662_D688_K1.1360.82
498_Y504_A1.1340.82
522_I568_L1.1240.82
223_L256_I1.1230.82
297_L338_N1.1180.81
530_I545_I1.1150.81
634_K637_K1.1150.81
129_F354_S1.1130.81
306_I341_S1.1040.81
287_V295_V1.1030.80
701_G705_D1.0990.80
586_R602_G1.0980.80
242_Y246_R1.0960.80
278_L364_L1.0930.80
75_Y78_N1.0920.80
483_N488_I1.0910.80
123_D388_G1.0900.80
355_E358_K1.0880.80
678_K708_E1.0860.79
729_F744_E1.0850.79
383_T472_F1.0840.79
523_I545_I1.0810.79
363_P366_K1.0810.79
334_Y338_N1.0800.79
607_N657_A1.0800.79
524_R528_D1.0760.79
663_L677_R1.0750.79
436_F568_L1.0740.79
173_F189_I1.0740.79
68_I83_L1.0720.79
526_I545_I1.0690.78
78_N84_L1.0690.78
338_N406_K1.0670.78
285_L349_L1.0660.78
459_Y463_R1.0660.78
216_R220_D1.0650.78
111_D114_I1.0570.78
467_G471_T1.0560.77
560_T566_Y1.0560.77
133_R138_E1.0520.77
130_T134_A1.0490.77
235_S279_N1.0490.77
66_L72_K1.0480.77
87_T93_I1.0450.77
373_G507_Y1.0430.77
460_K514_A1.0430.77
392_P415_G1.0360.76
643_L728_I1.0340.76
551_S554_K1.0320.76
70_K74_K1.0270.75
228_D258_R1.0260.75
422_V574_I1.0260.75
93_I97_R1.0260.75
89_T94_K1.0250.75
238_L283_T1.0250.75
651_E714_K1.0240.75
561_K566_Y1.0200.75
612_A731_E1.0190.75
195_W343_Y1.0170.75
193_S335_S1.0140.75
615_I619_I1.0110.74
377_E498_Y1.0100.74
297_L310_R1.0100.74
167_R225_Y1.0100.74
403_K502_V1.0090.74
197_K343_Y1.0040.74
643_L725_V1.0030.74
633_I741_V1.0030.74
319_S323_D1.0020.74
322_W325_E0.9980.73
90_P96_C0.9950.73
44_F93_I0.9950.73
531_K536_D0.9940.73
89_T93_I0.9900.73
496_N519_S0.9900.73
421_Y547_V0.9890.73
226_D361_G0.9860.72
546_F589_G0.9850.72
338_N341_S0.9830.72
244_T248_S0.9800.72
37_D120_Y0.9790.72
494_S516_D0.9770.72
239_P334_Y0.9740.72
193_S196_S0.9720.71
602_G605_D0.9720.71
432_V522_I0.9710.71
709_P713_V0.9710.71
675_A707_A0.9700.71
562_I565_L0.9700.71
134_A142_D0.9700.71
534_G552_R0.9680.71
676_A720_D0.9620.71
94_K134_A0.9580.70
387_S468_L0.9540.70
608_L612_A0.9480.69
278_L381_I0.9460.69
87_T94_K0.9440.69
172_D234_D0.9430.69
70_K73_R0.9390.69
581_V599_A0.9370.69
173_F341_S0.9370.69
172_D297_L0.9350.68
54_E67_Q0.9330.68
677_R680_I0.9310.68
500_H512_A0.9280.68
217_R224_N0.9280.68
655_T727_Q0.9260.68
727_Q730_R0.9260.68
170_G339_A0.9240.67
556_N561_K0.9230.67
411_Q434_R0.9210.67
525_F529_L0.9200.67
289_E486_K0.9190.67
701_G708_E0.9190.67
455_P463_R0.9190.67
315_W319_S0.9180.67
35_V39_N0.9180.67
489_E497_D0.9150.67
505_R602_G0.9150.67
420_V690_S0.9140.67
67_Q70_K0.9110.66
312_S315_W0.9100.66
293_G299_D0.9080.66
297_L334_Y0.9070.66
406_K415_G0.9070.66
90_P112_A0.9020.66
284_G287_V0.9000.65
222_I256_I0.8980.65
500_H544_L0.8960.65
723_Y734_K0.8950.65
298_I302_N0.8940.65
639_T642_K0.8920.65
282_L346_G0.8910.65
172_D238_L0.8900.65
414_V583_D0.8890.64
497_D542_D0.8890.64
313_F317_E0.8880.64
476_L676_A0.8870.64
612_A727_Q0.8860.64
51_N66_L0.8850.64
703_L723_Y0.8850.64
659_I663_L0.8850.64
579_L589_G0.8820.64
55_I66_L0.8810.64
420_V538_I0.8770.63
281_D406_K0.8750.63
530_I562_I0.8730.63
230_I308_P0.8730.63
189_I246_R0.8690.63
598_I601_K0.8670.62
426_S569_D0.8670.62
636_V725_V0.8650.62
215_I464_E0.8650.62
414_V517_E0.8640.62
604_E607_N0.8640.62
602_G616_K0.8640.62
542_D600_R0.8610.62
360_V579_L0.8600.62
130_T243_I0.8590.62
184_P189_I0.8530.61
331_I423_L0.8530.61
310_R335_S0.8510.61
39_N67_Q0.8500.61
190_V193_S0.8500.61
76_L79_I0.8500.61
88_S142_D0.8500.61
722_E747_K0.8490.61
435_K567_N0.8480.61
194_L221_Y0.8470.61
528_D532_S0.8460.61
54_E66_L0.8450.60
426_S470_K0.8450.60
453_S463_R0.8450.60
431_L539_L0.8440.60
449_D698_K0.8430.60
94_K97_R0.8430.60
425_I476_L0.8420.60
318_I325_E0.8410.60
427_S544_L0.8400.60
48_Y83_L0.8400.60
115_R118_M0.8400.60
170_G231_F0.8390.60
43_Y84_L0.8380.60
619_I692_I0.8370.60
211_D214_I0.8370.60
35_V134_A0.8370.60
238_L310_R0.8370.60
243_I254_I0.8370.60
89_T92_Q0.8360.60
479_V482_S0.8360.60
55_I83_L0.8350.60
287_V658_K0.8350.60
70_K79_I0.8340.59
686_I691_K0.8330.59
135_E154_K0.8320.59
610_E613_R0.8310.59
557_E565_L0.8310.59
630_K634_K0.8300.59
608_L730_R0.8300.59
497_D543_L0.8280.59
228_D276_G0.8280.59
67_Q80_V0.8230.58
243_I258_R0.8210.58
219_V255_D0.8200.58
432_V568_L0.8200.58
209_I213_K0.8130.57
452_Y457_S0.8130.57
77_G80_V0.8100.57
316_Y321_Y0.8100.57
359_I488_I0.8090.57
79_I86_Q0.8090.57
733_L737_K0.8050.57
175_I190_V0.8040.57
136_V141_F0.8040.57
133_R390_L0.8030.57
277_R537_V0.8030.57
82_A86_Q0.8030.57
402_S405_K0.8020.56
401_P405_K0.8010.56
219_V247_A0.8000.56
543_L600_R0.8000.56
234_D301_S0.8000.56
210_D216_R0.7990.56
500_H672_F0.7990.56
171_V240_W0.7980.56
404_I500_H0.7960.56
89_T95_K0.7950.56
335_S339_A0.7930.56
371_S586_R0.7920.55
92_Q95_K0.7910.55
238_L334_Y0.7910.55
395_M728_I0.7910.55
104_N107_K0.7910.55
601_K616_K0.7900.55
449_D454_S0.7890.55
95_K99_K0.7890.55
640_V644_R0.7870.55
233_Y345_L0.7870.55
41_R46_I0.7860.55
239_P516_D0.7850.55
457_S462_K0.7840.55
356_L360_V0.7830.55
699_G706_R0.7820.55
97_R100_I0.7810.54
215_I243_I0.7810.54
439_A442_T0.7810.54
50_G66_L0.7810.54
173_F243_I0.7800.54
507_Y691_K0.7800.54
315_W318_I0.7800.54
72_K94_K0.7800.54
725_V729_F0.7780.54
91_T98_E0.7780.54
96_C99_K0.7770.54
430_S600_R0.7760.54
297_L487_V0.7750.54
450_D464_E0.7750.54
321_Y330_I0.7740.54
55_I79_I0.7740.54
498_Y506_W0.7710.53
175_I242_Y0.7690.53
196_S225_Y0.7690.53
84_L87_T0.7680.53
404_I509_R0.7670.53
285_L350_L0.7670.53
497_D600_R0.7670.53
84_L88_S0.7620.53
215_I247_A0.7620.53
67_Q88_S0.7620.53
274_I349_L0.7610.53
91_T94_K0.7610.53
551_S555_V0.7600.52
310_R406_K0.7590.52
71_V88_S0.7580.52
492_I606_M0.7570.52
489_E542_D0.7560.52
94_K98_E0.7550.52
453_S459_Y0.7550.52
661_R665_E0.7550.52
598_I604_E0.7540.52
614_N618_K0.7540.52
75_Y79_I0.7530.52
420_V579_L0.7530.52
174_Q341_S0.7510.52
331_I359_I0.7500.51
141_F562_I0.7500.51
96_C103_L0.7490.51
317_E323_D0.7480.51
297_L406_K0.7480.51
174_Q297_L0.7460.51
682_S685_L0.7450.51
88_S97_R0.7440.51
428_V519_S0.7440.51
194_L218_F0.7440.51
66_L144_F0.7430.51
155_I159_Y0.7420.51
230_I274_I0.7410.51
236_D279_N0.7400.51
720_D731_E0.7400.51
560_T563_N0.7400.51
185_R245_E0.7390.50
530_I581_V0.7380.50
55_I71_V0.7380.50
383_T387_S0.7360.50
440_P616_K0.7340.50
111_D119_R0.7330.50
425_I539_L0.7320.50
304_L345_L0.7320.50
172_D516_D0.7290.49
219_V252_V0.7270.49
86_Q123_D0.7260.49
610_E614_N0.7250.49
336_I570_V0.7250.49
371_S501_W0.7250.49
126_L614_N0.7250.49
455_P461_F0.7240.49
222_I528_D0.7230.49
174_Q335_S0.7220.49
380_L487_V0.7210.49
168_T231_F0.7210.49
501_W589_G0.7210.49
528_D531_K0.7200.49
489_E543_L0.7170.48
216_R252_V0.7160.48
49_E52_E0.7150.48
608_L727_Q0.7150.48
492_I498_Y0.7140.48
44_F621_E0.7140.48
693_G709_P0.7120.48
197_K531_K0.7120.48
68_I71_V0.7110.48
424_D429_Y0.7110.48
539_L544_L0.7090.48
220_D634_K0.7090.48
557_E564_S0.7080.47
203_F336_I0.7070.47
655_T734_K0.7070.47
501_W574_I0.7070.47
128_P361_G0.7060.47
42_P49_E0.7060.47
74_K390_L0.7060.47
187_D193_S0.7040.47
240_W689_D0.7020.47
412_P520_N0.7020.47
52_E55_I0.7010.47
356_L375_R0.6990.47
281_D494_S0.6980.46
603_E731_E0.6970.46
51_N54_E0.6960.46
410_I558_L0.6960.46
439_A609_C0.6950.46
233_Y663_L0.6950.46
622_E625_I0.6950.46
724_Y727_Q0.6950.46
626_S746_L0.6940.46
55_I253_K0.6940.46
334_Y341_S0.6920.46
239_P283_T0.6910.46
431_L483_N0.6900.46
423_L558_L0.6890.46
234_D516_D0.6890.46
497_D544_L0.6880.46
645_R651_E0.6880.46
663_L670_L0.6870.45
540_A546_F0.6860.45
226_D276_G0.6860.45
605_D666_Y0.6840.45
605_D609_C0.6820.45
47_I82_A0.6810.45
335_S736_L0.6810.45
586_R653_L0.6790.45
458_N463_R0.6790.45
544_L547_V0.6780.45
276_G427_S0.6770.44
589_G602_G0.6770.44
542_D585_N0.6750.44
233_Y300_V0.6740.44
505_R734_K0.6720.44
655_T723_Y0.6710.44
473_L515_F0.6710.44
588_A623_I0.6710.44
126_L132_F0.6690.44
693_G710_F0.6690.44
539_L546_F0.6670.44
313_F321_Y0.6660.43
501_W578_S0.6660.43
678_K707_A0.6650.43
322_W328_R0.6640.43
112_A393_I0.6640.43
384_A499_V0.6630.43
282_L515_F0.6630.43
87_T90_P0.6630.43
438_I568_L0.6620.43
570_V591_S0.6610.43
440_P582_L0.6600.43
53_N85_I0.6590.43
135_E153_D0.6570.43
222_I654_I0.6560.42
86_Q100_I0.6560.42
66_L69_T0.6560.42
379_S407_N0.6550.42
406_K585_N0.6550.42
633_I745_S0.6550.42
629_V741_V0.6540.42
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311_Y330_I0.6520.42
499_V612_A0.6510.42
407_N426_S0.6500.42
674_T677_R0.6500.42
40_F43_Y0.6490.42
603_E616_K0.6490.42
561_K651_E0.6490.42
589_G597_D0.6480.42
47_I80_V0.6470.42
239_P406_K0.6470.42
68_I189_I0.6460.42
352_T379_S0.6450.41
166_L380_L0.6450.41
494_S571_K0.6450.41
694_Y724_Y0.6450.41
35_V96_C0.6440.41
449_D634_K0.6440.41
613_R617_R0.6440.41
371_S530_I0.6440.41
114_I119_R0.6410.41
53_N301_S0.6410.41
228_D607_N0.6410.41
247_A653_L0.6410.41
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231_F650_N0.6400.41
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402_S406_K0.6330.40
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104_N108_G0.6290.40
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456_I459_Y0.6280.40
496_N599_A0.6280.40
234_D341_S0.6280.40
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657_A672_F0.6260.40
432_V707_A0.6250.40
469_Y694_Y0.6250.40
609_C612_A0.6250.40
729_F747_K0.6250.40
223_L255_D0.6240.40
485_I520_N0.6240.40
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661_R696_I0.6230.39
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466_S471_T0.6180.39
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423_L566_Y0.6170.39
192_M713_V0.6160.39
741_V744_E0.6160.39
650_N698_K0.6160.39
385_T391_I0.6160.39
189_I193_S0.6160.39
461_F599_A0.6140.39
278_L388_G0.6130.38
297_L516_D0.6130.38
705_D711_F0.6120.38
301_S553_D0.6120.38
489_E600_R0.6120.38
73_R385_T0.6100.38
639_T648_F0.6090.38
345_L697_V0.6090.38
423_L559_I0.6080.38
561_K638_S0.6080.38
425_I508_S0.6070.38
375_R492_I0.6070.38
185_R192_M0.6070.38
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440_P499_V0.6060.38
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259_K262_S0.6050.38
35_V51_N0.6040.38
178_K188_P0.6030.38
136_V144_F0.6030.38
240_W268_T0.6020.38
366_K374_N0.6020.38
596_I621_E0.6010.37
82_A426_S0.5990.37
138_E142_D0.5990.37
606_M691_K0.5990.37
88_S92_Q0.5990.37
298_I301_S0.5980.37
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330_I333_E0.5940.37
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485_I497_D0.5900.36
41_R55_I0.5890.36
195_W339_A0.5890.36
375_R609_C0.5890.36
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336_I340_R0.5700.35
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137_N142_D0.5690.35
214_I411_Q0.5690.35
699_G705_D0.5690.35
450_D466_S0.5690.35
136_V140_K0.5690.35
679_A701_G0.5680.34
633_I742_N0.5680.34
282_L439_A0.5680.34
379_S472_F0.5680.34
427_S504_A0.5670.34
119_R122_L0.5660.34
78_N81_D0.5660.34
103_L107_K0.5660.34
50_G55_I0.5660.34
430_S542_D0.5660.34
66_L76_L0.5650.34
455_P517_E0.5640.34
374_N407_N0.5630.34
46_I89_T0.5620.34
67_Q143_G0.5610.34
173_F334_Y0.5610.34
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674_T707_A0.5600.34
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41_R86_Q0.5590.34
435_K499_V0.5590.34
585_N600_R0.5590.34
406_K494_S0.5580.34
416_I743_E0.5570.34
281_D516_D0.5570.34
410_I540_A0.5570.34
118_M122_L0.5560.33
337_E344_L0.5560.33
440_P506_W0.5560.33
553_D681_Q0.5560.33
301_S479_V0.5560.33
96_C101_S0.5560.33
53_N74_K0.5560.33
171_V230_I0.5550.33
409_I415_G0.5550.33
488_I492_I0.5550.33
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131_W192_M0.5540.33
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234_D406_K0.5530.33
335_S338_N0.5520.33
79_I88_S0.5520.33
40_F116_Y0.5520.33
188_P242_Y0.5520.33
125_D144_F0.5510.33
49_E55_I0.5500.33
93_I119_R0.5490.33
594_D625_I0.5490.33
224_N681_Q0.5490.33
627_K644_R0.5490.33
740_G743_E0.5490.33
48_Y51_N0.5480.33
521_E525_F0.5480.33
277_R588_A0.5480.33
69_T86_Q0.5480.33
233_Y282_L0.5470.33
492_I607_N0.5470.33
410_I604_E0.5470.33
595_K638_S0.5470.33
698_K720_D0.5470.33
695_V747_K0.5460.33
255_D263_E0.5450.33
458_N514_A0.5440.32
82_A390_L0.5440.32
223_L391_I0.5440.32
427_S430_S0.5440.32
439_A520_N0.5440.32
416_I738_P0.5430.32
609_C723_Y0.5430.32
109_I393_I0.5430.32
484_K601_K0.5430.32
47_I74_K0.5420.32
100_I554_K0.5420.32
426_S505_R0.5410.32
220_D224_N0.5410.32
55_I70_K0.5410.32
124_F132_F0.5400.32
238_L406_K0.5400.32
637_K746_L0.5390.32
611_L728_I0.5390.32
204_S224_N0.5380.32
306_I473_L0.5380.32
168_T350_L0.5380.32
511_I574_I0.5380.32
118_M374_N0.5370.32
527_I643_L0.5370.32
720_D724_Y0.5370.32
669_Q674_T0.5370.32
270_G552_R0.5370.32
55_I74_K0.5360.32
128_P132_F0.5360.32
274_I650_N0.5360.32
576_Y612_A0.5350.32
470_K607_N0.5350.32
37_D45_Y0.5350.32
512_A599_A0.5340.32
295_V428_V0.5340.32
294_H494_S0.5330.32
348_Y433_I0.5330.32
199_G222_I0.5330.32
630_K633_I0.5330.32
431_L724_Y0.5320.31
585_N605_D0.5320.31
412_P523_I0.5310.31
238_L516_D0.5310.31
69_T73_R0.5310.31
173_F239_P0.5310.31
223_L735_L0.5310.31
403_K420_V0.5310.31
230_I253_K0.5310.31
141_F144_F0.5300.31
285_L353_Y0.5300.31
189_I219_V0.5300.31
172_D406_K0.5290.31
673_V690_S0.5290.31
292_L606_M0.5290.31
70_K565_L0.5290.31
361_G727_Q0.5280.31
404_I512_A0.5270.31
659_I672_F0.5270.31
477_S734_K0.5260.31
415_G487_V0.5260.31
740_G745_S0.5260.31
189_I638_S0.5260.31
231_F282_L0.5250.31
68_I78_N0.5230.31
173_F215_I0.5230.31
281_D338_N0.5230.31
328_R589_G0.5220.31
190_V331_I0.5220.31
430_S543_L0.5220.31
187_D371_S0.5210.31
541_N584_N0.5210.31
129_F285_L0.5200.30
599_A724_Y0.5200.30
229_I278_L0.5200.30
355_E691_K0.5190.30
231_F433_I0.5190.30
373_G501_W0.5190.30
253_K262_S0.5190.30
81_D556_N0.5190.30
44_F47_I0.5180.30
231_F343_Y0.5180.30
111_D123_D0.5180.30
546_F579_L0.5180.30
529_L533_S0.5180.30
605_D727_Q0.5170.30
232_V239_P0.5170.30
247_A699_G0.5170.30
47_I68_I0.5170.30
189_I196_S0.5170.30
588_A676_A0.5160.30
412_P581_V0.5150.30
448_C451_C0.5150.30
98_E117_T0.5150.30
297_L409_I0.5140.30
299_D521_E0.5140.30
420_V679_A0.5140.30
723_Y727_Q0.5140.30
54_E136_V0.5130.30
70_K81_D0.5130.30
424_D542_D0.5130.30
186_K209_I0.5120.30
604_E696_I0.5120.30
377_E501_W0.5120.30
729_F743_E0.5110.30
427_S477_S0.5110.30
135_E212_L0.5100.30
633_I637_K0.5100.30
133_R139_V0.5100.30
174_Q301_S0.5100.30
455_P514_A0.5090.30
384_A440_P0.5090.30
663_L666_Y0.5090.30
301_S344_L0.5080.29
601_K606_M0.5080.29
115_R658_K0.5080.29
373_G440_P0.5080.29
372_W494_S0.5070.29
682_S687_S0.5070.29
422_V579_L0.5060.29
436_F523_I0.5060.29
638_S641_I0.5060.29
573_K640_V0.5060.29
374_N498_Y0.5050.29
227_P602_G0.5040.29
216_R265_S0.5040.29
659_I675_A0.5030.29
429_Y587_Y0.5030.29
582_L670_L0.5030.29
55_I138_E0.5020.29
42_P89_T0.5020.29
372_W602_G0.5020.29
259_K275_S0.5010.29
183_N186_K0.5010.29
167_R722_E0.5010.29
426_S492_I0.5010.29
54_E88_S0.5000.29
545_I550_G0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1qhtA 1 0.8704 100 0.197 Contact Map
3iayA 1 0.9647 100 0.2 Contact Map
4qclA 1 0.9581 100 0.234 Contact Map
2gv9A 1 0.9634 100 0.236 Contact Map
4fvmA 1 0.9202 100 0.239 Contact Map
4m8oA 1 0.9385 100 0.252 Contact Map
1s5jA 1 0.8181 100 0.252 Contact Map
3k59A 1 0.9202 100 0.268 Contact Map
3qexA 1 0.8927 100 0.328 Contact Map
2py5A 2 0.5812 100 0.66 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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