GREMLIN Database
SYK - Lysine--tRNA ligase
UniProt: P95970 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 494 (431)
Sequences: 9614 (4850)
Seq/√Len: 233.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
186_K281_D4.5201.00
112_K129_D3.9421.00
85_L127_V3.7721.00
184_Y241_F3.6611.00
51_P54_F3.6451.00
55_N112_K3.5791.00
57_S112_K3.5701.00
182_F281_D3.5061.00
177_R181_E3.4331.00
55_N128_K3.2681.00
181_E185_S3.2541.00
177_R184_Y3.1801.00
110_G131_Q2.9721.00
229_L240_V2.9161.00
178_E289_K2.8521.00
178_E285_S2.7541.00
270_A274_D2.7101.00
412_T457_G2.6701.00
171_I471_T2.5141.00
195_I247_F2.3921.00
49_H122_E2.3811.00
358_K362_K2.3381.00
233_I456_T2.3191.00
85_L111_V2.3171.00
336_E340_K2.3041.00
179_I263_L2.2801.00
137_L450_S2.2701.00
175_I467_V2.2001.00
59_A110_G2.1711.00
209_K218_D2.1611.00
83_L125_L2.1391.00
176_I463_I2.0951.00
55_N114_D2.0821.00
376_D388_H2.0801.00
180_R190_E2.0721.00
195_I244_G2.0651.00
402_I407_V2.0031.00
114_D128_K2.0011.00
181_E184_Y1.9771.00
53_M114_D1.9671.00
285_S289_K1.9421.00
284_K307_G1.9331.00
267_W270_A1.9281.00
173_Y184_Y1.9211.00
56_I125_L1.9091.00
182_F285_S1.9021.00
181_E289_K1.9001.00
272_Y396_E1.8861.00
313_S316_D1.8861.00
336_E339_K1.8711.00
421_D425_R1.8711.00
168_A473_N1.8661.00
182_F186_K1.8621.00
277_N281_D1.8471.00
275_I457_G1.8231.00
179_I282_L1.8201.00
265_L459_L1.8131.00
389_R396_E1.8051.00
182_F282_L1.7961.00
422_K426_E1.7871.00
178_E286_V1.7781.00
185_S285_S1.7581.00
417_P421_D1.7561.00
373_F400_M1.7501.00
353_G356_I1.7361.00
116_F126_L1.7311.00
388_H396_E1.7291.00
313_S376_D1.7081.00
316_D320_E1.7011.00
58_T83_L1.6971.00
365_T368_L1.6851.00
166_R170_E1.6851.00
191_V232_Y1.6831.00
320_E330_S1.6731.00
211_H216_N1.6631.00
77_F82_K1.6261.00
283_L400_M1.6261.00
271_D274_D1.6211.00
170_E189_I1.6091.00
295_K304_D1.5941.00
422_K425_R1.5891.00
421_D446_V1.5711.00
327_E330_S1.5671.00
62_V109_I1.5601.00
188_F267_W1.5581.00
57_S110_G1.5351.00
167_K171_I1.5341.00
151_R158_D1.5281.00
417_P450_S1.5201.00
315_Y319_S1.4941.00
312_I317_S1.4841.00
387_P416_D1.4831.00
114_D126_L1.4801.00
436_E440_P1.4761.00
174_T177_R1.4751.00
75_D82_K1.4751.00
187_G239_K1.4671.00
62_V103_V1.4651.00
48_S51_P1.4551.00
267_W278_L1.4441.00
439_H447_R1.4411.00
412_T415_N1.4191.00
62_V74_V1.4161.00
287_V470_V1.4051.00
163_D167_K1.4041.00
387_P419_L1.4021.00
211_H218_D1.4001.00
127_V130_Y1.3931.00
273_N277_N1.3921.00
174_T289_K1.3901.00
246_V262_L1.3731.00
175_I286_V1.3701.00
328_S370_N1.3681.00
169_M237_F1.3641.00
263_L463_I1.3601.00
316_D319_S1.3541.00
164_N473_N1.3531.00
364_V368_L1.3451.00
357_E361_D1.3451.00
310_K370_N1.3451.00
288_K292_N1.3371.00
447_R450_S1.3271.00
103_V109_I1.3261.00
178_E181_E1.3241.00
270_A457_G1.3231.00
379_I423_L1.3141.00
277_N328_S1.3111.00
178_E290_V1.3111.00
321_I367_T1.3081.00
333_E336_E1.3081.00
70_K89_V1.3031.00
174_T294_T1.2941.00
183_L263_L1.2891.00
273_N311_R1.2881.00
312_I374_I1.2831.00
239_K267_W1.2811.00
115_L123_L1.2791.00
400_M408_A1.2711.00
58_T76_I1.2641.00
416_D419_L1.2621.00
167_K170_E1.2531.00
315_Y394_L1.2521.00
421_D443_K1.2481.00
170_E174_T1.2371.00
391_K394_L1.2361.00
183_L265_L1.2341.00
169_M481_P1.2331.00
111_V127_V1.2311.00
45_G48_S1.2241.00
110_G133_L1.2221.00
419_L422_K1.2181.00
181_E285_S1.2121.00
71_A86_Y1.2051.00
154_H447_R1.2011.00
171_I290_V1.1971.00
435_D439_H1.1941.00
225_L246_V1.1921.00
388_H394_L1.1861.00
78_D81_E1.1811.00
88_R91_E1.1691.00
179_I463_I1.1651.00
434_G437_E1.1611.00
115_L125_L1.1571.00
423_L426_E1.1561.00
310_K320_E1.1371.00
425_R437_E1.1361.00
166_R237_F1.1351.00
64_N75_D1.1311.00
183_L282_L1.1261.00
74_V85_L1.1221.00
385_C411_Y1.1201.00
339_K351_V1.1071.00
72_S97_D1.1051.00
190_E241_F1.1021.00
104_G107_D1.0991.00
191_V237_F1.0971.00
49_H52_F1.0871.00
87_M127_V1.0871.00
103_V130_Y1.0871.00
175_I470_V1.0851.00
227_L444_D1.0831.00
225_L262_L1.0801.00
279_T461_I1.0781.00
339_K345_P1.0761.00
281_D284_K1.0741.00
283_L466_I1.0731.00
179_I286_V1.0731.00
87_M92_L1.0721.00
206_K212_V1.0651.00
280_E284_K1.0641.00
43_S80_G1.0621.00
328_S331_D1.0591.00
175_I463_I1.0591.00
58_T125_L1.0581.00
174_T184_Y1.0571.00
379_I387_P1.0561.00
102_Y135_K1.0541.00
186_K278_L1.0491.00
371_P402_I1.0461.00
80_G83_L1.0441.00
251_D486_S1.0371.00
48_S119_M1.0361.00
286_V290_V1.0351.00
63_A77_F1.0341.00
192_E245_K1.0241.00
77_F106_G1.0221.00
270_A275_I1.0211.00
47_K51_P1.0171.00
76_I109_I1.0141.00
180_R241_F1.0121.00
334_L338_M1.0121.00
40_I54_F1.0081.00
88_R126_L1.0001.00
171_I175_I0.9991.00
206_K488_K0.9901.00
103_V132_L0.9861.00
74_V109_I0.9791.00
159_F169_M0.9731.00
473_N479_V0.9721.00
284_K306_E0.9701.00
147_S150_F0.9691.00
196_V219_W0.9681.00
276_M311_R0.9661.00
343_L346_R0.9651.00
288_K304_D0.9601.00
108_I134_S0.9591.00
225_L244_G0.9581.00
376_D394_L0.9561.00
282_L286_V0.9551.00
473_N478_E0.9551.00
421_D450_S0.9541.00
327_E331_D0.9521.00
232_Y481_P0.9511.00
182_F278_L0.9501.00
58_T111_V0.9491.00
308_P311_R0.9481.00
225_L228_Y0.9461.00
327_E370_N0.9461.00
80_G238_N0.9441.00
318_L356_I0.9441.00
173_Y177_R0.9411.00
171_I174_T0.9401.00
134_S453_M0.9401.00
281_D285_S0.9391.00
56_I115_L0.9371.00
176_I190_E0.9361.00
359_L363_L0.9321.00
280_E328_S0.9301.00
288_K294_T0.9291.00
234_I453_M0.9291.00
279_T459_L0.9251.00
272_Y276_M0.9231.00
209_K220_Y0.9201.00
417_P446_V0.9191.00
387_P415_N0.9161.00
255_T405_M0.9161.00
98_K101_I0.9161.00
319_S323_G0.9161.00
317_S374_I0.9141.00
274_D277_N0.9091.00
357_E381_T0.9041.00
234_I449_L0.9021.00
337_L341_Y0.8950.99
453_M456_T0.8920.99
156_Y447_R0.8910.99
231_R482_F0.8900.99
176_I263_L0.8890.99
289_K293_S0.8880.99
200_Y440_P0.8850.99
87_M100_F0.8850.99
294_T306_E0.8850.99
96_Y99_F0.8850.99
83_L115_L0.8810.99
233_I453_M0.8800.99
217_E487_S0.8800.99
113_G125_L0.8780.99
96_Y100_F0.8770.99
275_I459_L0.8760.99
212_V219_W0.8760.99
98_K102_Y0.8740.99
421_D435_D0.8730.99
330_S333_E0.8720.99
164_N168_A0.8700.99
63_A82_K0.8700.99
436_E441_Y0.8670.99
265_L279_T0.8660.99
91_E126_L0.8660.99
171_I291_T0.8650.99
279_T408_A0.8650.99
95_K98_K0.8620.99
99_F102_Y0.8610.99
272_Y376_D0.8600.99
390_N393_G0.8590.99
356_I359_L0.8560.99
443_K447_R0.8540.99
79_E170_E0.8530.99
337_L340_K0.8530.99
414_L419_L0.8510.99
352_R356_I0.8490.99
61_R269_Y0.8420.99
107_D135_K0.8410.99
312_I372_T0.8370.99
424_F442_D0.8360.99
289_K292_N0.8360.99
331_D335_K0.8320.99
284_K294_T0.8280.99
68_H71_A0.8230.99
461_I466_I0.8190.99
104_G135_K0.8170.99
379_I395_V0.8170.99
323_G326_V0.8140.99
335_K350_Y0.8140.99
97_D100_F0.8120.99
407_V466_I0.8120.99
67_R72_S0.8110.99
342_N345_P0.8100.99
405_M469_L0.8090.99
44_Q47_K0.8090.99
108_I454_P0.8070.99
91_E128_K0.8060.99
353_G357_E0.8050.99
386_K415_N0.8050.99
468_M476_I0.8040.99
188_F239_K0.8000.99
111_V125_L0.8000.99
198_P228_Y0.7990.99
423_L433_R0.7990.99
178_E182_F0.7940.99
195_I225_L0.7920.99
435_D442_D0.7910.99
280_E311_R0.7900.99
270_A278_L0.7830.99
65_I72_S0.7820.99
43_S83_L0.7820.99
168_A471_T0.7810.99
41_A54_F0.7800.99
418_I421_D0.7790.99
67_R70_K0.7760.99
376_D396_E0.7750.98
74_V87_M0.7750.98
287_V305_F0.7740.98
351_V354_L0.7730.98
286_V289_K0.7690.98
231_R448_A0.7680.98
186_K239_K0.7680.98
357_E360_F0.7660.98
309_F400_M0.7660.98
338_M341_Y0.7640.98
382_T397_R0.7640.98
280_E308_P0.7630.98
265_L275_I0.7630.98
414_L423_L0.7580.98
433_R441_Y0.7570.98
77_F163_D0.7550.98
58_T85_L0.7540.98
335_K339_K0.7530.98
356_I360_F0.7510.98
74_V127_V0.7500.98
374_I401_F0.7490.98
421_D437_E0.7480.98
364_V367_T0.7460.98
270_A412_T0.7440.98
351_V380_E0.7410.98
175_I290_V0.7400.98
97_D101_I0.7390.98
354_L357_E0.7390.98
196_V210_T0.7390.98
418_I422_K0.7380.98
173_Y241_F0.7380.98
99_F130_Y0.7360.98
195_I245_K0.7360.98
285_S288_K0.7340.98
265_L278_L0.7330.98
309_F371_P0.7330.98
162_N165_A0.7320.98
425_R435_D0.7310.98
443_K446_V0.7310.98
343_L367_T0.7300.98
100_F130_Y0.7260.98
323_G353_G0.7260.98
303_I403_A0.7240.98
397_R409_N0.7210.98
212_V488_K0.7210.98
333_E337_L0.7190.98
317_S320_E0.7180.98
332_N336_E0.7170.98
276_M375_T0.7150.97
85_L109_I0.7140.97
112_K128_K0.7120.97
312_I321_I0.7100.97
338_M355_M0.7100.97
64_N105_R0.7100.97
72_S100_F0.7090.97
341_Y359_L0.7090.97
386_K389_R0.7060.97
76_I85_L0.7050.97
398_F410_A0.7030.97
54_F115_L0.7030.97
332_N352_R0.7020.97
284_K308_P0.7010.97
290_V470_V0.7000.97
330_S376_D0.6980.97
46_N119_M0.6970.97
108_I269_Y0.6970.97
341_Y363_L0.6960.97
132_L135_K0.6950.97
254_V475_S0.6940.97
386_K396_E0.6900.97
471_T479_V0.6890.97
156_Y451_Y0.6870.97
165_A478_E0.6870.97
272_Y388_H0.6860.97
62_V65_I0.6840.97
287_V369_T0.6830.97
171_I467_V0.6830.97
173_Y189_I0.6820.97
88_R116_F0.6820.97
330_S375_T0.6810.97
165_A168_A0.6800.97
485_I488_K0.6800.97
47_K123_L0.6790.97
338_M343_L0.6780.97
65_I74_V0.6740.96
353_G360_F0.6740.96
389_R393_G0.6740.96
467_V471_T0.6730.96
233_I268_A0.6730.96
419_L423_L0.6720.96
317_S321_I0.6720.96
52_F123_L0.6700.96
152_Y478_E0.6700.96
158_D162_N0.6680.96
387_P414_L0.6660.96
243_I463_I0.6650.96
396_E412_T0.6640.96
199_V220_Y0.6630.96
377_Y401_F0.6630.96
92_L96_Y0.6630.96
306_E310_K0.6630.96
447_R488_K0.6620.96
382_T411_Y0.6610.96
400_M461_I0.6610.96
276_M373_F0.6610.96
319_S333_E0.6600.96
234_I445_F0.6600.96
135_K418_I0.6600.96
79_E238_N0.6600.96
183_L278_L0.6590.96
235_G454_P0.6590.96
322_L326_V0.6590.96
279_T398_F0.6580.96
172_R192_E0.6580.96
163_D166_R0.6570.96
389_R392_P0.6560.96
107_D132_L0.6560.96
288_K291_T0.6550.96
42_K51_P0.6550.96
155_R159_F0.6530.96
174_T293_S0.6530.96
332_N335_K0.6510.96
193_T242_E0.6510.96
283_L309_F0.6440.95
176_I192_E0.6430.95
201_G222_R0.6430.95
135_K416_D0.6390.95
358_K361_D0.6390.95
284_K288_K0.6380.95
271_D412_T0.6360.95
96_Y130_Y0.6360.95
91_E114_D0.6360.95
150_F154_H0.6350.95
43_S46_N0.6350.95
273_N276_M0.6350.95
181_E293_S0.6350.95
201_G224_A0.6330.95
367_T472_N0.6320.95
278_L281_D0.6320.95
87_M130_Y0.6310.95
183_L459_L0.6310.95
303_I369_T0.6310.95
415_N453_M0.6300.95
284_K309_F0.6290.95
388_H391_K0.6280.95
65_I105_R0.6280.95
118_T122_E0.6280.95
252_I485_I0.6280.95
143_W146_L0.6270.95
275_I279_T0.6260.95
312_I320_E0.6190.94
314_M318_L0.6180.94
80_G170_E0.6150.94
267_W274_D0.6150.94
42_K46_N0.6140.94
318_L321_I0.6140.94
353_G361_D0.6130.94
307_G311_R0.6110.94
408_A461_I0.6110.94
138_I450_S0.6090.94
71_A116_F0.6080.94
388_H393_G0.6060.94
399_E409_N0.6030.93
164_N478_E0.6030.93
189_I237_F0.6020.93
157_V447_R0.6010.93
346_R350_Y0.6010.93
380_E393_G0.6010.93
192_E261_T0.5990.93
159_F235_G0.5990.93
44_Q48_S0.5980.93
420_Q449_L0.5980.93
143_W164_N0.5970.93
275_I278_L0.5940.93
172_R464_D0.5890.93
441_Y446_V0.5890.93
193_T225_L0.5880.93
272_Y375_T0.5880.93
405_M475_S0.5880.93
193_T229_L0.5870.93
291_T303_I0.5860.92
360_F374_I0.5860.92
90_D126_L0.5860.92
60_G85_L0.5860.92
66_R75_D0.5850.92
373_F398_F0.5850.92
322_L325_D0.5840.92
283_L461_I0.5820.92
176_I243_I0.5810.92
148_P152_Y0.5810.92
40_I44_Q0.5810.92
183_L241_F0.5800.92
329_M334_L0.5800.92
276_M279_T0.5790.92
408_A459_L0.5790.92
317_S364_V0.5760.92
188_F225_L0.5760.92
360_F364_V0.5760.92
382_T385_C0.5750.92
348_N351_V0.5750.92
304_D307_G0.5720.92
445_F449_L0.5720.92
115_L124_S0.5710.91
275_I398_F0.5700.91
48_S122_E0.5700.91
361_D366_P0.5680.91
68_H72_S0.5680.91
447_R451_Y0.5680.91
246_V263_L0.5680.91
43_S47_K0.5660.91
117_Y120_K0.5630.91
380_E383_P0.5620.91
159_F237_F0.5610.91
276_M409_N0.5600.91
229_L242_E0.5590.91
108_I133_L0.5580.91
179_I243_I0.5570.90
54_F114_D0.5560.90
473_N476_I0.5550.90
197_Q228_Y0.5540.90
449_L453_M0.5530.90
186_K285_S0.5530.90
386_K419_L0.5530.90
346_R349_Q0.5530.90
272_Y412_T0.5520.90
65_I104_G0.5510.90
200_Y220_Y0.5500.90
227_L445_F0.5500.90
229_L234_I0.5500.90
103_V107_D0.5490.90
83_L123_L0.5490.90
437_E441_Y0.5490.90
136_A451_Y0.5480.90
388_H392_P0.5480.90
107_D136_A0.5470.90
169_M232_Y0.5460.90
168_A478_E0.5460.90
89_V97_D0.5440.89
184_Y187_G0.5440.89
312_I316_D0.5440.89
291_T470_V0.5430.89
334_L337_L0.5430.89
99_F103_V0.5430.89
319_S322_L0.5420.89
267_W275_I0.5420.89
91_E96_Y0.5410.89
321_I330_S0.5400.89
257_N480_I0.5400.89
182_F286_V0.5390.89
295_K306_E0.5390.89
359_L362_K0.5390.89
107_D134_S0.5390.89
225_L243_I0.5380.89
174_T178_E0.5380.89
275_I410_A0.5370.89
421_D441_Y0.5350.89
276_M280_E0.5350.89
164_N167_K0.5350.89
252_I484_M0.5340.89
337_L368_L0.5340.89
365_T370_N0.5330.88
392_P419_L0.5330.88
276_M398_F0.5330.88
72_S96_Y0.5330.88
437_E440_P0.5330.88
182_F185_S0.5320.88
44_Q52_F0.5300.88
276_M328_S0.5280.88
353_G359_L0.5280.88
217_E484_M0.5270.88
311_R317_S0.5260.88
87_M91_E0.5260.88
198_P217_E0.5250.88
387_P422_K0.5250.88
219_W484_M0.5230.88
372_T400_M0.5220.87
282_L461_I0.5220.87
183_L186_K0.5210.87
349_Q352_R0.5210.87
328_S372_T0.5210.87
46_N51_P0.5210.87
332_N391_K0.5200.87
348_N352_R0.5200.87
424_F435_D0.5200.87
86_Y124_S0.5200.87
231_R444_D0.5190.87
42_K47_K0.5190.87
61_R236_G0.5170.87
226_E413_E0.5170.87
139_E142_D0.5150.87
277_N311_R0.5150.87
331_D352_R0.5140.87
59_A133_L0.5140.87
175_I466_I0.5130.87
410_A459_L0.5110.86
319_S325_D0.5100.86
380_E395_V0.5090.86
156_Y448_A0.5070.86
171_I306_E0.5060.86
47_K125_L0.5060.86
157_V451_Y0.5060.86
377_Y404_G0.5040.86
151_R168_A0.5040.86
355_M359_L0.5030.85
146_L150_F0.5030.85
172_R261_T0.5020.85
245_K261_T0.5000.85
329_M337_L0.5000.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pg3A 2 0.9474 100 0.138 Contact Map
4ex5A 2 0.9757 100 0.141 Contact Map
4up7A 2 0.9879 100 0.143 Contact Map
4ycuA 3 0.9838 100 0.148 Contact Map
3a74A 4 0.9777 100 0.153 Contact Map
1e1oA 2 0.9696 100 0.158 Contact Map
3i7fA 2 0.8907 100 0.212 Contact Map
1eovA 2 0.917 100 0.226 Contact Map
1l0wA 2 0.8806 100 0.226 Contact Map
1c0aA 1 0.8806 100 0.234 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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