GREMLIN Database
PGP1 - Phosphoglycolate phosphatase 1
UniProt: P95967 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 228 (215)
Sequences: 11995 (9850)
Seq/√Len: 671.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
205_S214_E4.0041.00
16_D208_S3.1511.00
169_A183_V3.0641.00
206_N209_G2.7091.00
3_K166_D2.6771.00
180_F186_K2.5821.00
7_V40_V2.4371.00
157_L167_V2.4171.00
25_D210_K2.4011.00
15_E19_S2.3581.00
44_S51_L2.3031.00
194_D198_D2.2901.00
23_D210_K2.2431.00
181_Q199_I2.2331.00
154_E182_Q2.2321.00
15_E21_R2.1861.00
25_D217_D2.1191.00
164_K182_Q1.9871.00
148_G178_E1.9811.00
174_S195_E1.8791.00
174_S193_D1.8031.00
163_K166_D1.7531.00
32_L217_D1.7371.00
33_L38_I1.7331.00
177_I199_I1.7121.00
85_E88_L1.6931.00
24_L28_Y1.6841.00
177_I196_L1.6721.00
32_L35_K1.6581.00
6_L153_V1.6581.00
155_K159_L1.6471.00
186_K201_D1.6371.00
187_V215_F1.6321.00
4_L41_S1.6151.00
150_R182_Q1.6071.00
30_I40_V1.6041.00
188_A200_A1.5921.00
155_K158_Q1.5901.00
185_F202_Y1.5751.00
205_S209_G1.5531.00
169_A179_L1.5461.00
32_L36_S1.5441.00
185_F201_D1.5301.00
27_I57_Y1.5211.00
6_L43_V1.5071.00
9_L14_T1.4991.00
28_Y32_L1.4921.00
151_I154_E1.4871.00
154_E158_Q1.4731.00
153_V179_L1.4421.00
202_Y215_F1.4371.00
86_Q90_D1.4301.00
123_I127_K1.4211.00
194_D197_K1.4141.00
97_K114_V1.4101.00
39_K160_L1.4091.00
7_V170_I1.3731.00
82_R155_K1.3571.00
88_L130_N1.3501.00
170_I212_V1.3461.00
25_D214_E1.3371.00
202_Y219_L1.3321.00
196_L199_I1.3201.00
74_Y77_K1.3131.00
188_A192_A1.3121.00
170_I215_F1.3091.00
34_Q61_D1.2941.00
23_D26_A1.2801.00
165_E184_G1.2721.00
177_I181_Q1.2681.00
27_I31_R1.2651.00
88_L91_E1.2641.00
157_L164_K1.2601.00
212_V216_V1.2571.00
26_A210_K1.2331.00
41_S63_G1.2271.00
82_R144_Y1.2081.00
195_E198_D1.1991.00
202_Y218_K1.1991.00
29_A213_R1.1891.00
91_E130_N1.1841.00
34_Q62_G1.1791.00
164_K167_V1.1761.00
204_T215_F1.1621.00
187_V204_T1.1411.00
132_Y178_E1.1361.00
215_F219_L1.1321.00
190_G206_N1.1231.00
31_R35_K1.1211.00
25_D29_A1.1191.00
197_K203_I1.0971.00
148_G151_I1.0951.00
29_A217_D1.0921.00
169_A180_F1.0831.00
74_Y78_Y1.0781.00
180_F196_L1.0771.00
65_V152_G1.0761.00
213_R217_D1.0761.00
41_S156_L1.0711.00
118_I121_E1.0651.00
168_A219_L1.0631.00
167_V183_V1.0551.00
16_D207_K1.0541.00
15_E208_S1.0531.00
168_A215_F1.0511.00
120_D124_N1.0491.00
204_T211_G1.0461.00
4_L162_L1.0451.00
168_A187_V1.0391.00
63_G160_L1.0391.00
5_V216_V1.0261.00
173_S193_D1.0221.00
72_V155_K1.0201.00
9_L54_L1.0131.00
214_E218_K1.0031.00
187_V202_Y0.9951.00
5_V38_I0.9901.00
191_N207_K0.9891.00
192_A197_K0.9831.00
157_L182_Q0.9801.00
164_K184_G0.9791.00
31_R34_Q0.9771.00
156_L160_L0.9701.00
130_N145_N0.9671.00
6_L167_V0.9641.00
48_Y66_A0.9631.00
168_A185_F0.9601.00
150_R178_E0.9591.00
5_V33_L0.9571.00
4_L157_L0.9521.00
124_N127_K0.9501.00
215_F218_K0.9421.00
183_V186_K0.9371.00
88_L131_L0.9351.00
24_L27_I0.9341.00
6_L41_S0.9341.00
66_A71_I0.9331.00
121_E125_W0.9211.00
193_D196_L0.9201.00
70_C147_A0.9161.00
121_E124_N0.9121.00
4_L167_V0.9101.00
154_E164_K0.9061.00
144_Y147_A0.9001.00
72_V152_G0.8981.00
13_L26_A0.8921.00
43_V65_V0.8921.00
31_R59_Y0.8901.00
7_V212_V0.8881.00
90_D94_S0.8871.00
82_R146_P0.8831.00
132_Y148_G0.8831.00
134_K143_A0.8831.00
38_I168_A0.8821.00
190_G197_K0.8761.00
115_P118_I0.8721.00
87_S91_E0.8711.00
91_E94_S0.8601.00
132_Y146_P0.8591.00
205_S211_G0.8581.00
28_Y31_R0.8561.00
39_K63_G0.8441.00
174_S177_I0.8441.00
26_A213_R0.8431.00
77_K80_M0.8421.00
188_A196_L0.8381.00
48_Y73_F0.8341.00
33_L40_V0.8331.00
95_L99_R0.8331.00
120_D123_I0.8331.00
157_L184_G0.8321.00
63_G74_Y0.8311.00
63_G156_L0.8281.00
189_V211_G0.8281.00
47_S67_E0.8271.00
143_A148_G0.8251.00
5_V168_A0.8241.00
214_E217_D0.8231.00
13_L30_I0.8191.00
157_L162_L0.8181.00
65_V156_L0.8181.00
153_V183_V0.8121.00
93_K97_K0.8081.00
189_V204_T0.8081.00
91_E95_L0.8061.00
190_G205_S0.7981.00
107_R110_D0.7961.00
66_A73_F0.7881.00
67_E141_H0.7881.00
52_R56_T0.7751.00
25_D213_R0.7701.00
189_V192_A0.7681.00
26_A29_A0.7661.00
74_Y79_R0.7591.00
190_G209_G0.7511.00
133_I142_I0.7431.00
150_R154_E0.7381.00
151_I155_K0.7371.00
184_G201_D0.7341.00
147_A151_I0.7251.00
81_C108_E0.7251.00
95_L125_W0.7231.00
9_L42_L0.7201.00
116_A120_D0.7201.00
44_S66_A0.7191.00
167_V182_Q0.7181.00
119_T123_I0.7171.00
84_M144_Y0.7161.00
167_V184_G0.7141.00
7_V13_L0.7121.00
117_K120_D0.7121.00
13_L22_I0.7111.00
205_S218_K0.7111.00
76_E79_R0.7091.00
195_E199_I0.7041.00
45_G175_T0.7021.00
180_F199_I0.7011.00
43_V179_L0.7011.00
153_V169_A0.6961.00
51_L66_A0.6911.00
29_A32_L0.6891.00
48_Y52_R0.6891.00
33_L216_V0.6861.00
26_A30_I0.6861.00
15_E23_D0.6851.00
68_N141_H0.6831.00
104_N111_F0.6821.00
172_D192_A0.6811.00
125_W128_E0.6761.00
166_D184_G0.6701.00
87_S90_D0.6681.00
154_E157_L0.6651.00
63_G75_K0.6591.00
9_L13_L0.6581.00
129_R145_N0.6551.00
132_Y145_N0.6531.00
107_R112_G0.6521.00
73_F78_Y0.6491.00
42_L51_L0.6481.00
70_C144_Y0.6471.00
25_D28_Y0.6421.00
99_R125_W0.6361.00
204_T214_E0.6331.00
51_L64_F0.6271.00
75_K79_R0.6261.00
172_D189_V0.6261.00
202_Y214_E0.6241.00
67_E70_C0.6231.00
38_I166_D0.6211.00
124_N128_E0.6191.00
15_E207_K0.6181.00
19_S208_S0.6161.00
94_S98_L0.6161.00
4_L156_L0.6101.00
178_E181_Q0.6091.00
67_E139_A0.6061.00
192_A196_L0.6031.00
39_K62_G0.6011.00
186_K200_A0.6011.00
135_S141_H0.6001.00
191_N197_K0.5991.00
170_I187_V0.5951.00
202_Y205_S0.5911.00
22_I27_I0.5901.00
196_L200_A0.5881.00
47_S50_I0.5841.00
9_L51_L0.5831.00
13_L207_K0.5821.00
89_V93_K0.5811.00
64_F75_K0.5771.00
186_K196_L0.5731.00
34_Q59_Y0.5731.00
55_Y64_F0.5731.00
133_I140_V0.5731.00
92_F96_F0.5731.00
104_N113_F0.5701.00
132_Y143_A0.5691.00
98_L101_T0.5671.00
146_P151_I0.5641.00
68_N175_T0.5611.00
191_N206_N0.5591.00
11_G189_V0.5551.00
188_A199_I0.5541.00
5_V170_I0.5541.00
131_L134_K0.5501.00
67_E71_I0.5491.00
117_K121_E0.5491.00
136_S173_S0.5471.00
118_I122_M0.5451.00
98_L125_W0.5411.00
48_Y67_E0.5411.00
169_A186_K0.5381.00
50_I139_A0.5381.00
12_T175_T0.5371.00
13_L42_L0.5341.00
22_I26_A0.5331.00
180_F200_A0.5321.00
170_I204_T0.5291.00
103_Q107_R0.5291.00
185_F215_F0.5291.00
205_S215_F0.5281.00
72_V156_L0.5250.99
174_S196_L0.5230.99
71_I108_E0.5220.99
13_L212_V0.5210.99
29_A33_L0.5200.99
28_Y217_D0.5200.99
136_S139_A0.5200.99
75_K78_Y0.5170.99
177_I180_F0.5150.99
22_I46_N0.5140.99
106_Y112_G0.5140.99
42_L55_Y0.5110.99
162_L167_V0.5110.99
109_C112_G0.5070.99
189_V207_K0.5070.99
39_K162_L0.5060.99
33_L213_R0.5040.99
97_K103_Q0.5030.99
72_V159_L0.5020.99
156_L159_L0.5000.99
107_R113_F0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1nrwA 1 0.9518 100 0.206 Contact Map
3pgvA 3 0.9605 100 0.229 Contact Map
2b30A 2 0.9737 100 0.24 Contact Map
3l7yA 1 0.9649 100 0.243 Contact Map
1nf2A 4 0.9737 100 0.247 Contact Map
1l6rA 2 0.9605 100 0.249 Contact Map
1rkqA 1 0.9649 100 0.25 Contact Map
3fzqA 2 0.9561 100 0.253 Contact Map
1rlmA 1 0.9868 100 0.253 Contact Map
4qjbA 1 0.9649 100 0.258 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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