PGP1 - SULSO - GREMLIN Contacts

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PGP1 - Phosphoglycolate phosphatase 1

UniProt:	P95967	Sequences: MIKLVLVDLDGTLTEDRESTRIDLDAIYAIRLLQKSGIKVSLVSGNSYPILRGLYTYLYLDGGFVAENGCIVFYKEKYRMCRQMEQSLVDEFKSLFKLRDTWQNEYRECDFGFVPAKITDEMINWAKERNLYIKSSGYAVHIAYNPAGKRIGVEKLLQLLGLKKEDVAAIGDSSTDIELFQQVGFKVAVGNADDELKDIADYITSNKSGKGVREFVDKLLKGEFDGIK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	228 (215)
Sequences:	11995 (9850)
Seq/√Len:	671.8

ECOLI - COF YIGL YBJI YBHA YIDA SUPH MPGP
BACSU - YXEH YCSE YWPJ YHAX YITU NTDB YKRA YWTE
HALSA - PGP
SULSO - PGP1 PGP2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
205_S	214_E	4.004	1.00
16_D	208_S	3.151	1.00
169_A	183_V	3.064	1.00
206_N	209_G	2.709	1.00
3_K	166_D	2.677	1.00
180_F	186_K	2.582	1.00
7_V	40_V	2.437	1.00
157_L	167_V	2.417	1.00
25_D	210_K	2.401	1.00
15_E	19_S	2.358	1.00
44_S	51_L	2.303	1.00
194_D	198_D	2.290	1.00
23_D	210_K	2.243	1.00
181_Q	199_I	2.233	1.00
154_E	182_Q	2.232	1.00
15_E	21_R	2.186	1.00
25_D	217_D	2.119	1.00
164_K	182_Q	1.987	1.00
148_G	178_E	1.981	1.00
174_S	195_E	1.879	1.00
174_S	193_D	1.803	1.00
163_K	166_D	1.753	1.00
32_L	217_D	1.737	1.00
33_L	38_I	1.733	1.00
177_I	199_I	1.712	1.00
85_E	88_L	1.693	1.00
24_L	28_Y	1.684	1.00
177_I	196_L	1.672	1.00
32_L	35_K	1.658	1.00
6_L	153_V	1.658	1.00
155_K	159_L	1.647	1.00
186_K	201_D	1.637	1.00
187_V	215_F	1.632	1.00
4_L	41_S	1.615	1.00
150_R	182_Q	1.607	1.00
30_I	40_V	1.604	1.00
188_A	200_A	1.592	1.00
155_K	158_Q	1.590	1.00
185_F	202_Y	1.575	1.00
205_S	209_G	1.553	1.00
169_A	179_L	1.546	1.00
32_L	36_S	1.544	1.00
185_F	201_D	1.530	1.00
27_I	57_Y	1.521	1.00
6_L	43_V	1.507	1.00
9_L	14_T	1.499	1.00
28_Y	32_L	1.492	1.00
151_I	154_E	1.487	1.00
154_E	158_Q	1.473	1.00
153_V	179_L	1.442	1.00
202_Y	215_F	1.437	1.00
86_Q	90_D	1.430	1.00
123_I	127_K	1.421	1.00
194_D	197_K	1.414	1.00
97_K	114_V	1.410	1.00
39_K	160_L	1.409	1.00
7_V	170_I	1.373	1.00
82_R	155_K	1.357	1.00
88_L	130_N	1.350	1.00
170_I	212_V	1.346	1.00
25_D	214_E	1.337	1.00
202_Y	219_L	1.332	1.00
196_L	199_I	1.320	1.00
74_Y	77_K	1.313	1.00
188_A	192_A	1.312	1.00
170_I	215_F	1.309	1.00
34_Q	61_D	1.294	1.00
23_D	26_A	1.280	1.00
165_E	184_G	1.272	1.00
177_I	181_Q	1.268	1.00
27_I	31_R	1.265	1.00
88_L	91_E	1.264	1.00
157_L	164_K	1.260	1.00
212_V	216_V	1.257	1.00
26_A	210_K	1.233	1.00
41_S	63_G	1.227	1.00
82_R	144_Y	1.208	1.00
195_E	198_D	1.199	1.00
202_Y	218_K	1.199	1.00
29_A	213_R	1.189	1.00
91_E	130_N	1.184	1.00
34_Q	62_G	1.179	1.00
164_K	167_V	1.176	1.00
204_T	215_F	1.162	1.00
187_V	204_T	1.141	1.00
132_Y	178_E	1.136	1.00
215_F	219_L	1.132	1.00
190_G	206_N	1.123	1.00
31_R	35_K	1.121	1.00
25_D	29_A	1.119	1.00
197_K	203_I	1.097	1.00
148_G	151_I	1.095	1.00
29_A	217_D	1.092	1.00
169_A	180_F	1.083	1.00
74_Y	78_Y	1.078	1.00
180_F	196_L	1.077	1.00
65_V	152_G	1.076	1.00
213_R	217_D	1.076	1.00
41_S	156_L	1.071	1.00
118_I	121_E	1.065	1.00
168_A	219_L	1.063	1.00
167_V	183_V	1.055	1.00
16_D	207_K	1.054	1.00
15_E	208_S	1.053	1.00
168_A	215_F	1.051	1.00
120_D	124_N	1.049	1.00
204_T	211_G	1.046	1.00
4_L	162_L	1.045	1.00
168_A	187_V	1.039	1.00
63_G	160_L	1.039	1.00
5_V	216_V	1.026	1.00
173_S	193_D	1.022	1.00
72_V	155_K	1.020	1.00
9_L	54_L	1.013	1.00
214_E	218_K	1.003	1.00
187_V	202_Y	0.995	1.00
5_V	38_I	0.990	1.00
191_N	207_K	0.989	1.00
192_A	197_K	0.983	1.00
157_L	182_Q	0.980	1.00
164_K	184_G	0.979	1.00
31_R	34_Q	0.977	1.00
156_L	160_L	0.970	1.00
130_N	145_N	0.967	1.00
6_L	167_V	0.964	1.00
48_Y	66_A	0.963	1.00
168_A	185_F	0.960	1.00
150_R	178_E	0.959	1.00
5_V	33_L	0.957	1.00
4_L	157_L	0.952	1.00
124_N	127_K	0.950	1.00
215_F	218_K	0.942	1.00
183_V	186_K	0.937	1.00
88_L	131_L	0.935	1.00
24_L	27_I	0.934	1.00
6_L	41_S	0.934	1.00
66_A	71_I	0.933	1.00
121_E	125_W	0.921	1.00
193_D	196_L	0.920	1.00
70_C	147_A	0.916	1.00
121_E	124_N	0.912	1.00
4_L	167_V	0.910	1.00
154_E	164_K	0.906	1.00
144_Y	147_A	0.900	1.00
72_V	152_G	0.898	1.00
13_L	26_A	0.892	1.00
43_V	65_V	0.892	1.00
31_R	59_Y	0.890	1.00
7_V	212_V	0.888	1.00
90_D	94_S	0.887	1.00
82_R	146_P	0.883	1.00
132_Y	148_G	0.883	1.00
134_K	143_A	0.883	1.00
38_I	168_A	0.882	1.00
190_G	197_K	0.876	1.00
115_P	118_I	0.872	1.00
87_S	91_E	0.871	1.00
91_E	94_S	0.860	1.00
132_Y	146_P	0.859	1.00
205_S	211_G	0.858	1.00
28_Y	31_R	0.856	1.00
39_K	63_G	0.844	1.00
174_S	177_I	0.844	1.00
26_A	213_R	0.843	1.00
77_K	80_M	0.842	1.00
188_A	196_L	0.838	1.00
48_Y	73_F	0.834	1.00
33_L	40_V	0.833	1.00
95_L	99_R	0.833	1.00
120_D	123_I	0.833	1.00
157_L	184_G	0.832	1.00
63_G	74_Y	0.831	1.00
63_G	156_L	0.828	1.00
189_V	211_G	0.828	1.00
47_S	67_E	0.827	1.00
143_A	148_G	0.825	1.00
5_V	168_A	0.824	1.00
214_E	217_D	0.823	1.00
13_L	30_I	0.819	1.00
157_L	162_L	0.818	1.00
65_V	156_L	0.818	1.00
153_V	183_V	0.812	1.00
93_K	97_K	0.808	1.00
189_V	204_T	0.808	1.00
91_E	95_L	0.806	1.00
190_G	205_S	0.798	1.00
107_R	110_D	0.796	1.00
66_A	73_F	0.788	1.00
67_E	141_H	0.788	1.00
52_R	56_T	0.775	1.00
25_D	213_R	0.770	1.00
189_V	192_A	0.768	1.00
26_A	29_A	0.766	1.00
74_Y	79_R	0.759	1.00
190_G	209_G	0.751	1.00
133_I	142_I	0.743	1.00
150_R	154_E	0.738	1.00
151_I	155_K	0.737	1.00
184_G	201_D	0.734	1.00
147_A	151_I	0.725	1.00
81_C	108_E	0.725	1.00
95_L	125_W	0.723	1.00
9_L	42_L	0.720	1.00
116_A	120_D	0.720	1.00
44_S	66_A	0.719	1.00
167_V	182_Q	0.718	1.00
119_T	123_I	0.717	1.00
84_M	144_Y	0.716	1.00
167_V	184_G	0.714	1.00
7_V	13_L	0.712	1.00
117_K	120_D	0.712	1.00
13_L	22_I	0.711	1.00
205_S	218_K	0.711	1.00
76_E	79_R	0.709	1.00
195_E	199_I	0.704	1.00
45_G	175_T	0.702	1.00
180_F	199_I	0.701	1.00
43_V	179_L	0.701	1.00
153_V	169_A	0.696	1.00
51_L	66_A	0.691	1.00
29_A	32_L	0.689	1.00
48_Y	52_R	0.689	1.00
33_L	216_V	0.686	1.00
26_A	30_I	0.686	1.00
15_E	23_D	0.685	1.00
68_N	141_H	0.683	1.00
104_N	111_F	0.682	1.00
172_D	192_A	0.681	1.00
125_W	128_E	0.676	1.00
166_D	184_G	0.670	1.00
87_S	90_D	0.668	1.00
154_E	157_L	0.665	1.00
63_G	75_K	0.659	1.00
9_L	13_L	0.658	1.00
129_R	145_N	0.655	1.00
132_Y	145_N	0.653	1.00
107_R	112_G	0.652	1.00
73_F	78_Y	0.649	1.00
42_L	51_L	0.648	1.00
70_C	144_Y	0.647	1.00
25_D	28_Y	0.642	1.00
99_R	125_W	0.636	1.00
204_T	214_E	0.633	1.00
51_L	64_F	0.627	1.00
75_K	79_R	0.626	1.00
172_D	189_V	0.626	1.00
202_Y	214_E	0.624	1.00
67_E	70_C	0.623	1.00
38_I	166_D	0.621	1.00
124_N	128_E	0.619	1.00
15_E	207_K	0.618	1.00
19_S	208_S	0.616	1.00
94_S	98_L	0.616	1.00
4_L	156_L	0.610	1.00
178_E	181_Q	0.609	1.00
67_E	139_A	0.606	1.00
192_A	196_L	0.603	1.00
39_K	62_G	0.601	1.00
186_K	200_A	0.601	1.00
135_S	141_H	0.600	1.00
191_N	197_K	0.599	1.00
170_I	187_V	0.595	1.00
202_Y	205_S	0.591	1.00
22_I	27_I	0.590	1.00
196_L	200_A	0.588	1.00
47_S	50_I	0.584	1.00
9_L	51_L	0.583	1.00
13_L	207_K	0.582	1.00
89_V	93_K	0.581	1.00
64_F	75_K	0.577	1.00
186_K	196_L	0.573	1.00
34_Q	59_Y	0.573	1.00
55_Y	64_F	0.573	1.00
133_I	140_V	0.573	1.00
92_F	96_F	0.573	1.00
104_N	113_F	0.570	1.00
132_Y	143_A	0.569	1.00
98_L	101_T	0.567	1.00
146_P	151_I	0.564	1.00
68_N	175_T	0.561	1.00
191_N	206_N	0.559	1.00
11_G	189_V	0.555	1.00
188_A	199_I	0.554	1.00
5_V	170_I	0.554	1.00
131_L	134_K	0.550	1.00
67_E	71_I	0.549	1.00
117_K	121_E	0.549	1.00
136_S	173_S	0.547	1.00
118_I	122_M	0.545	1.00
98_L	125_W	0.541	1.00
48_Y	67_E	0.541	1.00
169_A	186_K	0.538	1.00
50_I	139_A	0.538	1.00
12_T	175_T	0.537	1.00
13_L	42_L	0.534	1.00
22_I	26_A	0.533	1.00
180_F	200_A	0.532	1.00
170_I	204_T	0.529	1.00
103_Q	107_R	0.529	1.00
185_F	215_F	0.529	1.00
205_S	215_F	0.528	1.00
72_V	156_L	0.525	0.99
174_S	196_L	0.523	0.99
71_I	108_E	0.522	0.99
13_L	212_V	0.521	0.99
29_A	33_L	0.520	0.99
28_Y	217_D	0.520	0.99
136_S	139_A	0.520	0.99
75_K	78_Y	0.517	0.99
177_I	180_F	0.515	0.99
22_I	46_N	0.514	0.99
106_Y	112_G	0.514	0.99
42_L	55_Y	0.511	0.99
162_L	167_V	0.511	0.99
109_C	112_G	0.507	0.99
189_V	207_K	0.507	0.99
39_K	162_L	0.506	0.99
33_L	213_R	0.504	0.99
97_K	103_Q	0.503	0.99
72_V	159_L	0.502	0.99
156_L	159_L	0.500	0.99
107_R	113_F	0.500	0.99

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1nrwA	1	0.9518	100	0.206	Contact Map
3pgvA	3	0.9605	100	0.229	Contact Map
2b30A	2	0.9737	100	0.24	Contact Map
3l7yA	1	0.9649	100	0.243	Contact Map
1nf2A	4	0.9737	100	0.247	Contact Map
1l6rA	2	0.9605	100	0.249	Contact Map
1rkqA	1	0.9649	100	0.25	Contact Map
3fzqA	2	0.9561	100	0.253	Contact Map
1rlmA	1	0.9868	100	0.253	Contact Map
4qjbA	1	0.9649	100	0.258	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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